{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T05:24:55Z","timestamp":1738992295699,"version":"3.37.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2002,11,1]],"date-time":"2002-11-01T00:00:00Z","timestamp":1036108800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":424,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia and the Princess Alexandra Hospital Research and Development Foundation"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Four animal models were used to quantitatively evaluate hepatic alterations in this study: (1) a carbon tetrachloride control group (phenobarbital treatment only), (2) a CCl<jats:sub>4<\/jats:sub>-treated group (phenobarbital with CCl<jats:sub>4<\/jats:sub> treatment), (3) an alcohol-treated group (liquid diet with alcohol treatment), and (4) a pair-fed alcohol control group (liquid diet only). At the end of induction, single-pass perfused livers were used to conduct multiple indicator dilution (MID) studies. Hepatic spaces (vascular space, extravascular albumin space, extravascular sucrose space, and cellular distribution volume) and water hepatocyte permeability\/surface area product were estimated from nonlinear regression of outflow concentration versus time profile data. The hepatic extraction ratio of <jats:sup>3<\/jats:sup>H-taurocholate was determined by the nonparametric moments method. Livers were then dissected for histopathologic analyses (<jats:italic toggle=\"yes\">e.g.<\/jats:italic>, fibrosis index, number of fenestrae). In these 4 models, CCl<jats:sub>4<\/jats:sub>-treated rats were found to have the smallest vascular space, extravascular albumin space, <jats:sup>3<\/jats:sup>H-taurocholate extraction, and water hepatocyte permeability\/surface area product but the largest extravascular sucrose space and cellular distribution volume. In addition, a linear relationship was found to exist between histopathologic analyses (fibrosis index or number of fenestrae) and hepatic spaces. The hepatic extraction ratio of <jats:sup>3<\/jats:sup>H-taurocholate and water hepatocyte permeability\/surface area product also correlated to the severity of fibrosis as defined by the fibrosis index. In conclusion, the multiple indicator dilution data obtained from the <jats:bold>in situ<\/jats:bold> perfused rat liver can be directly related to histopathologic analyses.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.36820","type":"journal-article","created":{"date-parts":[[2003,3,26]],"date-time":"2003-03-26T02:15:53Z","timestamp":1048644953000},"page":"1180-1189","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver"],"prefix":"10.1097","volume":"36","author":[{"given":"Daniel Y.","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kee","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clay","family":"Winterford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2002.36820-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0016-5085(82)80126-1","article-title":"High yield micronodular cirrhosis in the rat","volume":"83","author":"Proctor","year":"1982","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.36820-BIB2|cit2","first-page":"1360","article-title":"Gastric ethanol metabolism and gastritis: interactions with other drugs, Helicobacter pylori, and antibiotic therapy (1957-1997)-a review","volume":"21","author":"Lieber","year":"1997","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/jhep.2002.36820-BIB3|cit3","first-page":"913","article-title":"Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells","volume":"26","author":"Okuno","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB4|cit4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1357-2725(96)00118-5","article-title":"Tissue inhibitors of metalloproteinases in liver fibrosis","volume":"29","author":"Iredale","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1053\/jhep.2002.36820-BIB5|cit5","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1172\/JCI112186","article-title":"Hepatic microcirculation in the perfused cirrhotic rat liver","volume":"76","author":"Varin","year":"1985","journal-title":"J Clin Invest"},{"key":"10.1053\/jhep.2002.36820-BIB6|cit6","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1172\/JCI113828","article-title":"Determinants of hepatic function in liver cirrhosis in the rat. Multivariate analysis","volume":"82","author":"Reichen","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1053\/jhep.2002.36820-BIB7|cit7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/hep.510230104","article-title":"The hepatic microcirculation in the isolated perfused human liver","volume":"23","author":"Villeneuve","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB8|cit8","first-page":"738","article-title":"Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver","volume":"143","author":"Couvelard","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1053\/jhep.2002.36820-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1124\/jpet.301.3.1079","article-title":"Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity and nature of drug","volume":"301","author":"Hung","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/jhep.2002.36820-BIB10|cit10","first-page":"780","article-title":"Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process","volume":"297","author":"Hung","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/jhep.2002.36820-BIB11|cit11","first-page":"320","article-title":"Controlled induction of cirrhosis in the rat","volume":"64","author":"Proctor","year":"1983","journal-title":"Br J Exp Pathol"},{"key":"10.1053\/jhep.2002.36820-BIB12|cit12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000128407","article-title":"Standardized micronodular cirrhosis in the rat","volume":"16","author":"Proctor","year":"1984","journal-title":"Eur Surg Res"},{"key":"10.1053\/jhep.2002.36820-BIB13|cit13","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/S0168-8278(99)80195-0","article-title":"Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization","volume":"30","author":"Zimmermann","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.36820-BIB14|cit14","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep.1840160225","article-title":"Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis","volume":"16","author":"Kamimura","year":"1992","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB15|cit15","doi-asserted-by":"crossref","first-page":"335A","DOI":"10.1111\/j.1530-0277.1996.tb01803.x","article-title":"Role of Kupffer cell-derived reactive oxygen intermediates in alcoholic liver disease in rats in vivo","volume":"20","author":"Takeyama","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"issue":"8 Suppl","key":"10.1053\/jhep.2002.36820-BIB16|cit16","doi-asserted-by":"crossref","first-page":"162A","DOI":"10.1111\/j.1530-0277.1996.tb01768.x","article-title":"Oxidative stress in alcoholic liver injury","volume":"20","author":"Ishii","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1053\/jhep.2002.36820-BIB17|cit17","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1006\/jsre.1996.0376","article-title":"An optimized model for rat liver perfusion studies","volume":"66","author":"Cheung","year":"1996","journal-title":"J Surg Res"},{"key":"10.1053\/jhep.2002.36820-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/hep.1840160620","article-title":"Liver regeneration and the effect of exogenous putrescine on regenerative activity after partial hepatectomy in cirrhotic rats","volume":"16","author":"MacIntosh","year":"1992","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB19|cit19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/hep.510230420","article-title":"Kupffer cell inactivation prevents lipopolysaccharide-induced structural changes in the rat liver sinusoid: an electron-microscopic study","volume":"923","author":"Sarphie","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB20|cit20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2165\/00003088-199937050-00004","article-title":"Effects of liver disease on pharmacokinetics","volume":"37","author":"Rodighiero","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"10.1053\/jhep.2002.36820-BIB21|cit21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2165\/00003088-199529050-00005","article-title":"Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease: an update","volume":"29","author":"Morgan","year":"1995","journal-title":"Clin Pharmacokinet"},{"key":"10.1053\/jhep.2002.36820-BIB22|cit22","first-page":"384","article-title":"Effects of liver diseases on drug metabolism","volume":"51","author":"Paintaud","year":"1996","journal-title":"Therapie"},{"key":"10.1053\/jhep.2002.36820-BIB23|cit23","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0168-8278(99)80288-8","article-title":"Non-invasive diagnosis of esophageal varices in chronic liver diseases","volume":"31","author":"Pilette","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.36820-BIB24|cit24","first-page":"395","article-title":"Semiquantitative and qualitative assessment of hepatic iron in patients with chronic viral hepatitis: relation with grading, staging and haemochromatosis mutations","volume":"31","author":"Vergani","year":"1999","journal-title":"Ital J Gastroenterol Hepatol"},{"key":"10.1053\/jhep.2002.36820-BIB25|cit25","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1478-3231.1999.tb00038.x","article-title":"Hepatic stellate cell activation and liver fibrosis are associated with necroinflammatory injury and Th1-like response in chronic hepatitis C","volume":"19","author":"Baroni","year":"1999","journal-title":"Liver"},{"key":"10.1053\/jhep.2002.36820-BIB26|cit26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1478-3231.1999.tb00033.x","article-title":"Interobserver study of liver histopathology using the Ishak score in patients with chronic hepatitis C virus infection","volume":"19","author":"Westin","year":"1999","journal-title":"Liver"},{"key":"10.1053\/jhep.2002.36820-BIB27|cit27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-132-7-200004040-00002","article-title":"Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy","volume":"132","author":"Shiratori","year":"2000","journal-title":"Ann Intern Med"},{"key":"10.1053\/jhep.2002.36820-BIB28|cit28","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0016-5085(81)90018-4","article-title":"Correlation of intrahepatic pressure with collagen in the Disse space and hepatomegaly in humans and in the rat","volume":"80","author":"Orrego","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.36820-BIB29|cit29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1055\/s-2008-1040610","article-title":"Intrahepatic circulation in liver disease","volume":"6","author":"Huet","year":"1986","journal-title":"Semin Liver Dis"},{"key":"10.1053\/jhep.2002.36820-BIB30|cit30","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/hep.1840180412","article-title":"Clearance by the liver in cirrhosis. II. Characterization of propranolol uptake with the multiple-indicator dilution technique","volume":"18","author":"Gariepy","year":"1993","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB31|cit31","first-page":"1189","article-title":"Hepatic artery and portal vein vascularization of normal and cirrhotic rat liver","volume":"19","author":"Kassissia","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.36820-BIB32|cit32","first-page":"738","article-title":"Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver","volume":"143","author":"Couvelard","year":"1993","journal-title":"Am J Pathol"},{"volume-title":"Diseases of the Liver and Biliary System","year":"1993","key":"10.1053\/jhep.2002.36820-BIB33|cit33"},{"key":"10.1053\/jhep.2002.36820-BIB34|cit34","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00004728-200003000-00002","article-title":"Focal lesions in the cirrhotic liver: high resolution ex vivo MRI with pathologic correlation","volume":"24","author":"Krinsky","year":"2000","journal-title":"J Comput Assist Tomogr"},{"key":"10.1053\/jhep.2002.36820-BIB35|cit35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1042\/bj3160901","article-title":"Effect of antisense oligonucleotides on the expression of hepatocellular bile acid and organic anion uptake systems in Xenopus laevis oocytes","volume":"316","author":"Hagenbuch","year":"1996","journal-title":"Biochem J"},{"key":"10.1053\/jhep.2002.36820-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/0016-5085(91)90668-B","article-title":"Glucagon-induced alteration of serum bile acid level in patients with liver cirrhosis","volume":"100","author":"Tsujii","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.36820-BIB37|cit37","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00042737-199510000-00009","article-title":"Direct assessment of the mechanism for a raised serum bile acid level in chronic liver disease","volume":"7","author":"de Caestecker","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.36820","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.36820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200211000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:49:34Z","timestamp":1738943374000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200211000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2002.36820","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}