{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:13:51Z","timestamp":1789704831204,"version":"4.0.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4536,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The aim of our multicenter study was to assess the efficacy of ursodeoxycholic acid (UDCA) on the survival of patients with alcohol\u2013induced cirrhosis and jaundice. We included patients with histologically proven alcohol\u2013induced cirrhosis and serum bilirubin &gt;50 \u03bcmol\/L. After randomization, patients received either UDCA (13\u201315 mg\/kg\/d) or a placebo for 6 months. Two hundred twenty\u2013six patients (113 in each group) were included in 24 centers. There were 139 men and 87 women, mean age of 50.3 years. Seventy\u2013four percent had associated alcohol\u2013induced hepatitis, and 24% received a corticosteroid therapy. At inclusion, the 2 groups were comparable for the main clinical and biologic parameters, but serum bilirubin was higher in the UDCA group than in the placebo group (163 \u03bcmol\/L vs. 145 \u03bcmol\/L, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .03). The percentage of patients lost at follow\u2013up or who resumed their alcoholism during the study was comparable in the 2 groups. During the study, 55 patients died, 35 in the UDCA group and 20 in the placebo group. In the intention to treat analysis, the probability of survival at 6 months (Kaplan\u2013Meier method) was lower in the UDCA than in the P group (69% vs. 82%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = .04, log\u2013rank test). After adjustment on the bilirubin level at entry (Cox model), the independent predictive value of the treatment group did not reach the statistical level (RR = 1.64, CI 0.85\u20132.85; <jats:italic toggle=\"yes\">P<\/jats:italic> = .077). In conclusion, UDCA administered at the dose recommended in primary biliary cirrhosis has no beneficial effect on the 6\u2013month survival of patients with severe alcohol\u2013induced cirrhosis. An inappropriate dosage of UDCA cannot be excluded as an explanation for the lack of therapeutic benefit.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50118","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T20:06:02Z","timestamp":1049745962000},"page":"887-892","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":33,"title":["A Randomized Controlled Trial of Ursodeoxycholic Acid in Patients With Alcohol\u2013Induced Cirrhosis and Jaundice"],"prefix":"10.1097","volume":"37","author":[{"given":"Gilles","family":"Pelletier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Roulot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Davion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Masliah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Causse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Oberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Raabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Van 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