{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:11:12Z","timestamp":1777637472122,"version":"3.51.4"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4536,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Primary lymphoma of the liver (PLL) is rare. In some cases, the hepatic lymphoma has been diagnosed in patients who were infected by the hepatitis C virus (HCV). It has been suggested that HCV plays a role in the pathogenesis of lymphoma. The aim of our multicentric retrospective study was to assess the characteristics of PLL and to determine the prevalence of HCV infection in PLL. Thirty\u2013one immunocompetent patients (anti\u2013human immunodeficiency virus, anti\u2013human T\u2013cell leukemia\/lymphoma virus negative, no history of allograft) with PLL fulfilled the entire selection criteria. The liver biopsy specimens were reassessed by the same pathologist. The non\u2013Hodgkin's lymphomas were classified according to the World Health Organization classification. Blood samples were tested in 28 patients for antibodies to HCV, and HCV RNA was detected by reverse transcription polymerase chain reaction. In the majority of cases, the clinical, biologic, and radiologic data were nonspecific. Twenty\u2013seven of 31 patients presented a B\u2013cell lymphoma corresponding to the centroblastic morphologic variant of a diffuse, large B\u2013cell lymphoma (22 cases), a Burkitt's lymphoma (1 case), an extranodal marginal zone B\u2013cell lymphoma of mucosa\u2013associated lymphoid tissue type (3 cases), and unclassified, small B\u2013cell lymphoma (1 case). The 4 other cases were T\u2013cell lymphomas. The prevalence of HCV infection was 21% (6 of 28 cases). All of these patients were positive for HCV RNA by polymerase chain reaction in blood. Most of the HCV\u2013infected patients presented a high\u2013grade, B\u2013cell type lymphoma. In conclusion, our study confirms the rarity of PLL and demonstrates an increased prevalence of HCV infection. (Hepatology 2003;37:781\u2013787).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50121","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T20:06:02Z","timestamp":1049745962000},"page":"781-787","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":118,"title":["Primary Lymphoma of the Liver: Clinical\u2013Pathological Features and Relationship With Hcv Infection in French 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