{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:45:04Z","timestamp":1761630304546,"version":"3.30.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4536,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Although enhanced phosphorylative activity can be a requisite for later DNA synthesis during liver regeneration (LR), mitochondrial generation of reactive oxygen species could lead to altered mitochondrial membrane permeability during the prereplicative phase of LR. Therefore, the role of mitochondrial permeability transition (MPT) was evaluated during rat LR, induced by either partial hepatectomy (PH) or after CCl<jats:sub>4<\/jats:sub> administration. Parameters indicative of mitochondrial function and membrane potentials, those of oxidative stress, and <jats:italic toggle=\"yes\">in vivo<\/jats:italic> changes of the intramitochondrial pool of adenine nucleotides were determined. Twelve hours after PH, mitochondrial oxidative and phosphorylative activities and adenosine diphosphate (ADP) content were increased, reaching a maximal peak at 24 hours after surgery (maximal DNA synthesis). Parameters suggestive of oxidant stress were enhanced, but mitochondrial volume and membrane electrical potential remained unaltered. Interestingly, moderate mitochondrial swelling and depolarization were found at later post\u2013PH times (72 hours). In CCl<jats:sub>4<\/jats:sub>\u2013treated animals, it was found that an active liver cell necrosis delayed mitotic activity and mitochondrial uncoupled respiration. Starting 12 hours after CCl<jats:sub>4<\/jats:sub> intoxication, a drastic increase of inorganic phosphate occurred within swollen and strongly depolarized mitochondria, suggesting changes in the MPT. Despite expression of messenger RNA (mRNA) for mitochondrial transcription, factor A showed a similar time course in both experimental models. The so\u2013called augmenter liver regeneration was found significantly elevated only in PH rats. In conclusion, onset of MPT could be associated with cell necrosis and inflammation after CCl<jats:sub>4<\/jats:sub> treatment, whereas this mitochondrial event could constitute a putative effector mechanism, through which growth or inflammatory factors inhibiting cell proliferation could initiate LR termination. (Hepatology 2003;37:842\u2013851.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50145","type":"journal-article","created":{"date-parts":[[2003,4,7]],"date-time":"2003-04-07T20:06:02Z","timestamp":1049745962000},"page":"842-851","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":33,"title":["Changes in Mitochondrial Adenine Nucleotides and in Permeability Transition in Two Models of Rat Liver Regeneration"],"prefix":"10.1097","volume":"37","author":[{"given":"Rolando","family":"Hern\u00e1ndez-Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"S\u00e1nchez-Sevilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Mart\u00ednez-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myrna A.R.","family":"Dent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2003.50145-BIB1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/207762a0","volume":"207","author":"Clerici","year":"1960","journal-title":"Nature"},{"key":"10.1053\/jhep.2003.50145-BIB2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1073\/pnas.67.4.1695","volume":"67","author":"Malkin","year":"1970","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/jhep.2003.50145-BIB3","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/hep.1840060211","volume":"6","author":"Nishihira","year":"1986","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0014-5793(86)81110-3","volume":"209","author":"Buckle","year":"1985","journal-title":"FEBS Lett"},{"key":"10.1053\/jhep.2003.50145-BIB5","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/hep.1840210532","volume":"21","author":"Vendemiale","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB6","doi-asserted-by":"crossref","first-page":"3304","DOI":"10.1046\/j.1432-1033.2002.03010.x","volume":"269","author":"Guerrieri","year":"2002","journal-title":"Eur J Biochem"},{"key":"10.1053\/jhep.2003.50145-BIB7","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1002\/hep.510300620","volume":"30","author":"Ribeiro","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB8","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1084\/jem.183.4.1533","volume":"183","author":"Zamzami","year":"1996","journal-title":"J Exp Med"},{"key":"10.1053\/jhep.2003.50145-BIB9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/bj2270149","volume":"227","author":"Seitz","year":"1985","journal-title":"Biochem J"},{"key":"10.1053\/jhep.2003.50145-BIB10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/0014-5793(75)80811-8","volume":"52","author":"Siess","year":"1975","journal-title":"FEBS Lett"},{"key":"10.1053\/jhep.2003.50145-BIB11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.6297003","volume":"219","author":"Goyette","year":"1983","journal-title":"Science"},{"key":"10.1053\/jhep.2003.50145-BIB12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/hep.510240331","volume":"24","author":"Aguilar-Delf\u00edn","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB13","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1023\/A:1026601814082","volume":"44","author":"Morales-Gonz\u00e1lez","year":"1999","journal-title":"Dig Dis Sci"},{"key":"10.1053\/jhep.2003.50145-BIB14","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0003-9861(92)90151-L","volume":"294","author":"Hern\u00e1ndez-Mu\u00f1oz","year":"1992","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/jhep.2003.50145-BIB15","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0076-6879(79)55066-6","volume":"4","author":"Rottenberg","year":"1979","journal-title":"Methods Enzymol"},{"key":"10.1053\/jhep.2003.50145-BIB16","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1021\/ac50022a030","volume":"49","author":"Hoffman","year":"1977","journal-title":"Anal Chem"},{"key":"10.1053\/jhep.2003.50145-BIB17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0021-9258(19)67936-6","volume":"235","author":"Ames","year":"1960","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2003.50145-BIB18","first-page":"468","volume-title":"Methods in Enzymatic Analysis","author":"Sauer","year":"1984","unstructured":". Thymidine kinase. In: , , eds. Methods in Enzymatic Analysis. Deerfield Beach: Verlag Chemie, 1984:468-473."},{"key":"10.1053\/jhep.2003.50145-BIB19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-4165(94)90122-8","volume":"1200","author":"Hern\u00e1ndez-Mu\u00f1oz","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2003.50145-BIB20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal Biochem"},{"key":"10.1053\/jhep.2003.50145-BIB21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/hep.1840120210","volume":"12","author":"Hern\u00e1ndez-Mu\u00f1oz","year":"1990","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/hep.510290522","volume":"29","author":"Gandhi","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB23","doi-asserted-by":"crossref","first-page":"11356","DOI":"10.1016\/S0021-9258(18)82132-9","volume":"268","author":"Blondel","year":"1993","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2003.50145-BIB24","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/S0006-2952(99)00261-0","volume":"58","author":"Guti\u00e9rrez-Salinas","year":"1999","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/jhep.2003.50145-BIB25","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/hep.510290320","volume":"29","author":"Lee","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB26","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/oxfordjournals.jbchem.a131350","volume":"80","author":"Kamiyama","year":"1976","journal-title":"J Biochem"},{"key":"10.1053\/jhep.2003.50145-BIB27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1111\/j.1432-1033.1986.tb09510.x","volume":"155","author":"Buckle","year":"1986","journal-title":"Eur J Biochem"},{"key":"10.1053\/jhep.2003.50145-BIB28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/S0891-5849(98)00145-2","volume":"26","author":"Guerrieri","year":"1999","journal-title":"Free Rad Biol Med"},{"key":"10.1053\/jhep.2003.50145-BIB29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/abbi.1997.0396","volume":"349","author":"D\u00edaz-Mu\u00f1oz","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/jhep.2003.50145-BIB30","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1053\/jhep.2002.34742","volume":"36","author":"Corbin","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/10408447309082019","volume":"2","author":"Racknagel","year":"1973","journal-title":"Crit Rev Toxicol"},{"key":"10.1053\/jhep.2003.50145-BIB32","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0006-2952(85)90195-9","volume":"34","author":"Nakata","year":"1985","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/jhep.2003.50145-BIB33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1096\/fasebj.4.2.2298342","volume":"4","author":"Armendariz-Borunda","year":"1991","journal-title":"FASEB J"},{"key":"10.1053\/jhep.2003.50145-BIB34","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1006\/bbrc.1994.2234","volume":"203","author":"Bezerra","year":"1994","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1053\/jhep.2003.50145-BIB35","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0005-2728(94)90050-7","volume":"1188","author":"Inomoto","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2003.50145-BIB36","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1016\/S0021-9258(17)33220-9","volume":"251","author":"Hunter","year":"1976","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2003.50145-BIB37","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1074\/jbc.271.6.2929","volume":"27","author":"Kowaltowski","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2003.50145-BIB38","doi-asserted-by":"crossref","first-page":"18931","DOI":"10.1016\/S0021-9258(17)32256-1","volume":"269","author":"Lapidus","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2003.50145-BIB39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1023\/A:1022483018482","volume":"29","author":"Ch\u00e1vez","year":"1997","journal-title":"J Bioenerg Biomembr"},{"key":"10.1053\/jhep.2003.50145-BIB40","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0006-2952(91)90327-2","volume":"42","author":"Cai","year":"1991","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/jhep.2003.50145-BIB41","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.1840170418","volume":"17","author":"Mei","year":"1993","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB42","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1046\/j.1440-1746.1999.01992.x","volume":"14","author":"Zhang","year":"1999","journal-title":"Gastroenterol Hepatol"},{"key":"10.1053\/jhep.2003.50145-BIB43","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/hep.1840200328","volume":"20","author":"Francavilla","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2003.50145-BIB44","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/(SICI)1097-0061(19990915)15:12<1171::AID-YEA443>3.0.CO;2-T","volume":"15","author":"Becher","year":"1999","journal-title":"Yeast"},{"key":"10.1053\/jhep.2003.50145-BIB45","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/S1590-8658(00)80009-2","volume":"32","author":"Polimeno","year":"2000","journal-title":"Digest Liver Dis"},{"key":"10.1053\/jhep.2003.50145-BIB46","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2003.50145-BIB47","doi-asserted-by":"crossref","first-page":"7032","DOI":"10.1128\/MCB.15.12.7032","volume":"15","author":"Antoshechkin","year":"1995","journal-title":"Mol Cel Biol"},{"key":"10.1053\/jhep.2003.50145-BIB48","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1006\/bbrc.1998.8174","volume":"243","author":"Koyama","year":"1998","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1053\/jhep.2003.50145-BIB49","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/hep.510280318","volume":"28","author":"Grasl-Kraupp","year":"1998","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2003.50145","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200304000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:32:20Z","timestamp":1733052740000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200304000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2003.50145","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}