{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T14:21:00Z","timestamp":1779373260812,"version":"3.53.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>To elucidate the hematopoietic activity of recombinant human interleukin\u201311 (rhIL\u201311, [Neumega, Cambridge, MA]) in patients with cirrhosis and thrombocytopenia, we administered rhIL\u201311 at 50 \u03bcg\/kg\/d subcutaneously to 10 patients for 10 days with a 30\u2013day follow\u2013up period. All treated patients (n = 9) experienced a gradual, yet significant increase in their platelet count above the baseline value (<jats:italic toggle=\"yes\">P<\/jats:italic> \u2264 .01) reaching the peak value (median, 93,000\/\u03bcL; range, 60,000\u2013206,000\/\u03bcL) at a median of 13 days (range, 6\u201323 days). Eight patients (89%) had a significant increase of \u226550% over the baseline value (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). Moreover, further increases to \u226560,000\/\u03bcL, \u226580,000\/\u03bcL, and \u2265100,000\/\u03bcL were observed in 100%, 78%, and 33% of the patients, respectively. A subsequent decline in platelet count was observed at a median of 19 days (range, 7\u201326 days) after the occurrence of peak concentration. A significant increase in neutrophil count was also demonstrated starting on the third day of treatment (<jats:italic toggle=\"yes\">P<\/jats:italic> \u2264 .01). Concurrent with an increase in the serum level of fibrinogen, transaminase levels declined significantly during treatment period, while bilirubin levels continued to drop for up to 20 days after the initiation of treatment (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05). The most frequent effects were due to plasma volume expansion, including conjunctival redness and edema. In conclusion, rhIL\u201311 can improve platelet counts in patients with early cirrhosis and these patients could benefit from rhIL\u201311 treatment. However, given the high frequency of regimen\u2013related toxicity, the use of rhIL\u201311 in patients with cirrhosis should be administered with caution.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50160","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T05:21:15Z","timestamp":1052803275000},"page":"1165-1171","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":26,"title":["Recombinant Human Interleukin\u201311 Improves Thrombocytopenia in Patients With Cirrhosis"],"prefix":"10.1097","volume":"37","author":[{"given":"Reem","family":"Ghalib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"McClelland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Goss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ris\u00eb","family":"Stribling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Seu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yehuda Z.","family":"Patt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2003.50160-BIB1","first-page":"1754","volume-title":"Harrison's Principals of Internal Medicine","author":"Chung","year":"2001","unstructured":". 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