{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:09:40Z","timestamp":1785168580830,"version":"3.55.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Paracentesis\u2013induced circulatory dysfunction (PICD) is a recently described complication that can be prevented with the administration of plasma expanders. The aim of this study was to compare the efficacy of saline versus albumin in the prevention of PICD. Patients were randomized to receive albumin or saline after total paracentesis. Patients readmitted as a consequence of a second episode of tense ascites were treated with total paracentesis and the alternative plasma expander. After randomization, 35 patients received saline and 37 received albumin. Twenty\u2013one patients were readmitted for tense ascites and treated with the alternative expander. Significant increases in plasma renin activity (PRA) were found 24 hours and 6 days after paracentesis when saline was used (baseline, 5.6 \u00b1 5.7; 24 hours, 7.6 \u00b1 6.9; 6 days, 8.5 \u00b1 8.0 ng \u00b7 mL<jats:sup>-1<\/jats:sup> \u00b7 hr<jats:sup>-1<\/jats:sup>; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .05 and <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01 vs. baseline, respectively), whereas no significant changes were observed with albumin. The incidence of PICD was significantly higher in the saline group versus the albumin group (33.3% vs. 11.4%, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = .03). However, no significant differences were found when less than 6 L of ascitic fluid was evacuated (6.7% vs. 5.6% in the saline and albumin groups, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = .9). Similar results were observed when analyzing patients who received 2 consecutive paracentesis (<jats:italic toggle=\"yes\">i.e.<\/jats:italic>, a significant increase in PRA after saline [<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01] without significant variations after albumin). In conclusion, albumin is more effective than saline in the prevention of PICD. Saline is a valid alternative to albumin when less than 6 L of ascitic fluid is evacuated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50169","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T05:21:15Z","timestamp":1052803275000},"page":"1147-1153","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":168,"title":["Randomized Trial Comparing Albumin and Saline in the Prevention of Paracentesis\u2013Induced Circulatory Dysfunction in Cirrhotic Patients With 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