{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:52:56Z","timestamp":1789383176440,"version":"build-2803163510"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4506,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Embryonic stem (ES) cells provide a unique source for tissue regeneration. We examined whether mouse ES cells can efficiently differentiate into transplantable hepatocytes. ES cells were implanted into mouse livers 24 hours after carbon tetrachloride intoxication; ES\u2013derived cells with several hepatocyte\u2013cell\u2013markers were generated. They were able to grow <jats:italic toggle=\"yes\">in vitro<\/jats:italic> and showed morphology consistent with typical mature hepatocytes and expressed hepatocyte\u2013specific genes. After transplantation into the carbon tetrachloride\u2013injured mouse liver, ES\u2013derived green fluorescent protein\u2013positive cells were incorporated into liver tissue and rescued mice from hepatic injury. No teratoma formation was observed in the transplant recipients. In conclusion, ES cells can provide a valuable tool for studying the molecular basis for differentiation of hepatocytes and form the basis for cell therapies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2003.50202","type":"journal-article","created":{"date-parts":[[2003,5,13]],"date-time":"2003-05-13T05:21:15Z","timestamp":1052803275000},"page":"983-993","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":182,"title":["Differentiation of Embryonic Stem Cells Into Hepatocytes: Biological Functions and Therapeutic Application"],"prefix":"10.1097","volume":"37","author":[{"given":"Hanako","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Asari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Yamanokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Teratani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Terada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ochiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2003.50202-BIB1","first-page":"71","volume-title":"A Practical Approach","author":"Robertson","year":"1987","unstructured":"Teratocarcinoma and embryonic stem cells. 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