{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:34:22Z","timestamp":1789907662303,"version":"4.0.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4353,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      This study examined the role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstruction syndrome (SOS). SOS was induced in rats with monocrotaline. Monocrotaline caused hepatic vein NO to decrease by 30% at 24 hours and by 70% at 72 hours; this decrease persisted throughout late SOS. N\n                      <jats:sup>G<\/jats:sup>\n                      \u2013nitro\u2013L\u2013arginine methyl ester (L\u2013NAME), an inhibitor of NO synthase, exacerbated monocrotaline toxicity, whereas V\u2013PYRRO\/NO, a liver\u2013selective NO donor prodrug, restored NO levels, preserved sinusoidal endothelial cell (SEC) integrity and sinusoidal perfusion as assessed by\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      microscopy and electron microscopy, and prevented clinical and histologic evidence of SOS. NO production\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      by SEC and Kupffer cells, the 2 major liver cell sources of NO, decreases largely in parallel with loss of cell viability after exposure to monocrotaline. Increased matrix metalloproteinase (MMP) activity increases early on in SOS and this increase in activity has been implicated in initiating SOS. Infusion of V\u2013PYRRO\u2013NO prevented the monocrotaline\u2013induced increase in MMP\u20139. In conclusion, decreased hepatic NO production contributes to the development of SOS. Infusion of an NO donor preserves SEC integrity and prevents development of SOS. These findings show that a decrease in NO contributes to SOS by allowing up\u2013regulation of MMP activity, loss of sinusoidal integrity, and subsequent disruption of sinusoidal perfusion. (Hepatology 2003;38:900-908).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hep.1840380416","type":"journal-article","created":{"date-parts":[[2007,3,10]],"date-time":"2007-03-10T18:05:14Z","timestamp":1173549914000},"page":"900-908","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":117,"title":["Decreased Hepatic Nitric Oxide Production Contributes to the Development of Rat Sinusoidal Obstruction Syndrome"],"prefix":"10.1097","volume":"38","author":[{"given":"Laurie D.","family":"Deleve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary C.","family":"Kanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiya","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Bethea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret K.","family":"McCuskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoltan A.","family":"Tokes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"McCuskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840380416-BIB1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.7326\/0003-4819-118-4-199302150-00003","volume":"118","author":"McDonald","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840380416-BIB2","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S1083-8791(99)70006-6","volume":"5","author":"Lee","year":"1999","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1002\/hep.1840380416-BIB3","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/hep.1840190515","volume":"19","author":"Shulman","year":"1994","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840380416-BIB4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0002-9343(86)90266-4","volume":"81","author":"Rollins","year":"1986","journal-title":"Am J Med"},{"key":"10.1002\/hep.1840380416-BIB5","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hep.510290615","volume":"29","author":"DeLeve","year":"1999","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840380416-BIB6","first-page":"g1045","volume":"284","author":"DeLeve","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1002\/hep.1840380416-BIB7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1055\/s-2002-23204","volume":"22","author":"DeLeve","year":"2002","journal-title":"Semin Liver Dis"},{"key":"10.1002\/hep.1840380416-BIB8","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0016-5085(03)01056-4","volume":"125","author":"DeLeve","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840380416-BIB9","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1021\/jm9701031","volume":"40","author":"Saavedra","year":"1997","journal-title":"J Med Chem"},{"key":"10.1002\/hep.1840380416-BIB10","first-page":"247","volume-title":"Physical Techniques in Biology and Medicine Microvascular Technology","author":"McCuskey","year":"1986","unstructured":"Microscopic methods for studying the microvasculature of internal organs. 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