{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:17:23Z","timestamp":1788970643775,"version":"build-2803163510"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5540,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The results of the extensive use of in situ liver splitting in a pediatric liver transplant program are presented. All referred donors were considered for split liver, and when the donor-recipient body weight ratio (DRWR) was greater than 2, the grafts were split. A modified split-liver technique was adopted when the DRWR was 2 or less. Eighty liver procurements were attempted and 72 (90%) were performed, enabling 65 children to receive 42 split, 22 whole, and 8 reduced-size livers. The right portions of the grafts were transplanted by other centers into adults. Median patient waiting time was 22 days, with no mortality on the waiting list. After a median follow-up of 14 months, overall patient and graft survival rates were 85% and 81%, respectively. Fifty-eight children received a single allograft, whereas 7 children required retransplantation. Two-year actuarial survival rates were 85% for split-liver recipients, 84% for whole-liver recipients, and 67% for reduced-size liver recipients. Vascular complications developed in 18% of the patients, with no difference among the 3 groups with different technique. Biliary complications developed in 25% of the children, mainly in reduced-size and split-liver recipients. Patient and graft survival rates for right split-liver grafts were 84% and 79%, respectively. Adopting a liberal policy of liver splitting provides allografts of optimal quality for pediatric transplantation, allowing a dramatic decrease in the waiting list time. The in situ split-liver technique should be considered the method of choice for expanding the cadaveric liver donor pool.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2000.7570","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T17:39:23Z","timestamp":1048613963000},"page":"415-428","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":71,"title":["Extensive use of split liver for pediatric liver transplantation: A single-center experience"],"prefix":"10.1097","volume":"6","author":[{"given":"Marco","family":"Spada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Gridelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Colledan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Segalin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Lucianetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanda","family":"Petz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jlts.2000.7570-BIB1","first-page":"367","volume":"95","author":"Bismuth","year":"1984","journal-title":"Surgery"},{"key":"10.1053\/jlts.2000.7570-BIB2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1002\/hep.1840100520","volume":"10","author":"Emond","year":"1989","journal-title":"Hepatology"},{"key":"10.1053\/jlts.2000.7570-BIB3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00007890-198803000-00003","volume":"45","author":"Broelsch","year":"1988","journal-title":"Transplantation"},{"key":"10.1053\/jlts.2000.7570-BIB4","first-page":"532","volume":"111","author":"Houssin","year":"1992","journal-title":"Surgery"},{"key":"10.1053\/jlts.2000.7570-BIB5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/00000658-199009000-00015","volume":"212","author":"Broelsch","year":"1990","journal-title":"Ann Surg"},{"key":"10.1053\/jlts.2000.7570-BIB6","year":"1999","unstructured":"Centro Trasfusionale e di Immunologia dei Trapianti dell'Ospedale Maggiore Policlinico di Milano. 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