{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:54Z","timestamp":1786119474011,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5356,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Preexisting malignancy is considered a relative contraindication to orthotopic liver transplantation (OLT) because of the risk of tumor recurrence. The purpose of this study is to assess the outcome of OLT in patients with a preexistent malignant state. Of 1,097 OLTs performed between 1989 and 1999 at King\u2019s College Hospital (London, UK), 18 patients had a pretransplantation malignant state, including 6 cases of myeloproliferative disorder (MPD) presenting as Budd-Chiari syndrome. Those patients with solid-organ malignancies had their tumor detected at an early stage and underwent curative treatment before or during OLT. Patients were followed up for a median of 71 months (range, 1 to 119 months) post-OLT, and the rates of rejection and malignancy were compared with those of transplant recipients without preexisting malignancy during the same period. One patient had a recurrence of his primary malignancy (non-Hodgkin\u2019s lymphoma) after 27 months, whereas another patient developed a de novo posttransplant lymphoproliferative disorder after 57 months. One patient with MPD developed acute leukemia 72 months after OLT. In comparison, of 1,079 OLTs performed in patients without preexisting malignancy during the same period, there were 34 cases of de novo malignancies. The rate of rejection in patients with and without preexisting malignancy was similar. Successful medium-term outcome after OLT can be achieved in carefully selected patients with preexisting malignancy providing the malignancy is amenable to curative treatment before or at OLT. Primary MPDs responsible for Budd-Chiari syndrome should not be considered a contraindication to OLT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1053\/jlts.2001.20788","type":"journal-article","created":{"date-parts":[[2003,2,4]],"date-time":"2003-02-04T21:43:33Z","timestamp":1044395013000},"page":"11-15","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":35,"title":["Successful outcome of orthotopic liver transplantation in patients with preexisting malignant states"],"prefix":"10.1097","volume":"7","author":[{"given":"Sanjiv","family":"Saigal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parthi","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Muiesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Rela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Grady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jlts.2001.20788-BIB1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1097\/00007890-199304000-00011","volume":"55","author":"Penn","year":"1993","journal-title":"Transplantation"},{"key":"10.1053\/jlts.2001.20788-BIB2","first-page":"11","volume-title":"Liver transplantation?Practice and management","author":"Neuberger","year":"1994","unstructured":"General considerations. In: (eds). Liver transplantation?Practice and management. Great Britain: BMJ, 1994:11-24."},{"key":"10.1053\/jlts.2001.20788-BIB3","first-page":"236","volume-title":"Hematology (ed 4)","author":"Henderson","year":"1990","unstructured":"Acute leukemia: General considerations. In: (eds). Hematology (ed 4). New York: McGraw-Hill, 1990:236-251."},{"key":"10.1053\/jlts.2001.20788-BIB4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/lt.500020109","volume":"2","author":"Penn","year":"1996","journal-title":"Liver Transpl Surg"},{"key":"10.1053\/jlts.2001.20788-BIB5","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1237::AID-CNCR25>3.0.CO;2-5","volume":"83","author":"Kelly","year":"1998","journal-title":"Cancer"},{"key":"10.1053\/jlts.2001.20788-BIB6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00007890-199107000-00017","volume":"52","author":"Dillon","year":"1991","journal-title":"Transplantation"},{"key":"10.1053\/jlts.2001.20788-BIB7","first-page":"106","volume":"1","author":"Penn","year":"1969","journal-title":"Transplant Proc"},{"key":"10.1053\/jlts.2001.20788-BIB8","first-page":"1101","volume":"23","author":"Penn","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/jlts.2001.20788-BIB9","first-page":"3044","volume":"23","author":"Reyes","year":"1991","journal-title":"Transplant Proc"},{"key":"10.1053\/jlts.2001.20788-BIB10","first-page":"584","volume":"1","author":"Starzl","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/jlts.2001.20788-BIB11","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJM199012203232502","volume":"323","author":"Swinnen","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1053\/jlts.2001.20788-BIB12","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00007890-198804000-00011","volume":"45","author":"Ho","year":"1988","journal-title":"Transplantation"},{"key":"10.1053\/jlts.2001.20788-BIB13","first-page":"1793","volume":"27","author":"Dousset","year":"1995","journal-title":"Transplant Proc"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjlts.2001.20788","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ovid.com\/01445473-200101000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:14:42Z","timestamp":1786040082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01445473-200101000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jlts.2001.20788","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}