{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T05:16:26Z","timestamp":1737782186568,"version":"3.33.0"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4840,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:title>\n                           <jats:italic toggle=\"yes\">Abstract<\/jats:italic>\n                        <\/jats:title>\n          <jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>The prevalence of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) is not well established, as some reports suggest a low risk, whereas others indicate that HCC may be no less frequent than in other types of cirrhosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>We compared the incidence of HCC in a series of 140 patients with PBC (five men, 135 women, mean age 54 \u00b1 1.6 yr) followed-up for a mean of period of 5.6 \u00b1 0.4 yr with a group of patients with cirrhosis related to hepatitis C virus (HCV) who were matched for age, sex, and follow-up period. In all patients, HCC was prospectively screened by clinical, laboratory, and ultrasound procedures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Five patients with PBC (3.6%) developed HCC. All were in stage IV of the disease. The incidence of HCC in the 45 patients with late stages of the disease (III or IV) was 11.1%, similar to that found in patients with HCV-related cirrhosis, which was 15.0%. The relative risk for HCC in late stages of PBC was of 0.812 (95% CI, 0.229-2.883) with respect to HCV-related cirrhosis. The probability for developing HCC was significantly higher in patients with HCV-related cirrhosis than in PBC patients overall (p = 0.001), but was similar in patients with HCV-related cirrhosis and in patients with PBC in stages III and IV (p = ns).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>The risk for HCC in patients with late stages of PBC is similar to that in patients with HCV-related cirrhosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2002.0080570","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"570-571","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Yes, hepatocellular cancer does occur in primary biliary cirrhosis"],"prefix":"10.1097","volume":"8","author":[{"given":"Gregory J.","family":"Gores","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0168-8278(98)80065-2","volume":"29","author":"Roskams","year":"1998","journal-title":"J Hepatol"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0168-8278(00)80162-2","volume":"33","author":"Libbrecht","year":"2000","journal-title":"J Hepatol"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1002\/hep.510260508","volume":"26","author":"Jones","year":"1997","journal-title":"Hepatology"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/hep.510290511","volume":"29","author":"Nijhawan","year":"1999","journal-title":"Hepatology"},{"key":"BIB5","first-page":"1160","volume":"96","author":"Caballeria","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-8278(01)00130-1","volume":"35","author":"Bruix","year":"2001","journal-title":"J Hepatol"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjlts.2002.0080570","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200206000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:03:44Z","timestamp":1737731024000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200206000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jlts.2002.0080570","relation":{},"ISSN":["1527-6465"],"issn-type":[{"type":"print","value":"1527-6465"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}