{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T18:25:01Z","timestamp":1764699901177,"version":"3.33.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4932,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Liver transplant recipients administered gelatin (GEL) rather than human albumin solution (HAS) can become profoundly hypoalbuminemic in the early postoperative period and often have hepatic dysfunction at this time. The combined effect of these two abnormalities could be an increase in the unbound (active) concentration of low-extraction highly albumin-bound drugs, such as tacrolimus (TAC). This may increase the efficacy and\/or toxicity of such drugs. We prospectively compared the clinical outcome of 69 de novo liver transplant recipients randomized primarily to TAC or cyclosporine (CYA) and secondarily to HAS or GEL therapy during the first 14 days after liver transplantation. Antipyrine clearance on the 7th postoperative day was used as a measure of liver metabolic function. Serum albumin levels were significantly lower in both GEL arms than HAS arms during the first 14 days (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001). Although antipyrine clearance was similar in all four trial arms, it was intermediate between that found in historic healthy controls and patients with cirrhosis (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .0001). Serum creatinine concentrations were significantly greater in the TAC plus GEL arm than the other three arms (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001). The linearized treated acute rejection rate was significantly greater in the TAC plus HAS arm than the other three arms (relative risk, 2.02; 95% confidence interval, 1.07 to 3.78; <jats:italic toggle=\"yes\">P<\/jats:italic> = .03). These data indicate that excess nephrotoxicity can occur with TAC in liver transplant recipients with impaired hepatic metabolism who are administered GEL. In addition, supplementary albumin may reduce the efficacy of TAC in liver transplant recipients at a time when the risk for rejection is greatest.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2002.31347","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Influence of albumin supplementation on tacrolimus and cyclosporine therapy early after liver transplantation"],"prefix":"10.1097","volume":"8","author":[{"given":"Andrew","family":"Trull","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawn","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gimson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Friend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atholl","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Sharples","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/bmj.317.7153.235","volume":"317","year":"1998","journal-title":"BMJ"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/bja\/77.1.32","volume":"77","author":"Park","year":"1996","journal-title":"Br J Anaest"},{"key":"BIB3","first-page":"954","volume":"23","author":"Warty","year":"1991","journal-title":"Transplant Proc"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/rcm.1290090313","volume":"9","author":"Bakhtiar","year":"1995","journal-title":"Rapid Commun Mass Spectrom"},{"key":"BIB5","first-page":"1997","volume":"17","author":"Gurecki","year":"1985","journal-title":"Transplant Proc"},{"key":"BIB6","first-page":"5","volume-title":"Applied pharmacokinetics","author":"MacKichan","year":"1992","unstructured":"Influence of protein binding and use of unbound (free) drug concentrations. Principles of therapeutic drug monitoring. In: (eds). Applied pharmacokinetics. Vancouver, WA: Applied Therapeutics, 1992:5-1-5-48."},{"key":"BIB7","first-page":"690","volume":"21","author":"Piekoszewski","year":"1993","journal-title":"Drug Metab Dispos"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/clpt.1993.68","volume":"53","author":"Tan","year":"1993","journal-title":"Clin Pharmacol Ther"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1432-2277.1994.tb01303.x","volume":"7","author":"Undre","year":"1994","journal-title":"Transpl Int"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0140-6736(71)92738-3","volume":"2","author":"Lewis","year":"1971","journal-title":"Lancet"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/cpt1973144part1529","volume":"14","year":"1973","journal-title":"Clin Pharmacol Ther"},{"key":"BIB12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00560341","volume":"7","author":"Greenblatt","year":"1974","journal-title":"Eur J Clin Pharmacol"},{"key":"BIB13","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/cpt1975176685","volume":"17","author":"Blaschke","year":"1975","journal-title":"Clin Pharmacol Ther"},{"key":"BIB14","first-page":"57","volume":"22","author":"Jain","year":"1990","journal-title":"Transplant Proc"},{"key":"BIB15","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1056\/NEJM197706302962603","volume":"296","author":"Piafsky","year":"1977","journal-title":"N Engl J Med"},{"key":"BIB16","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00007890-199405820-00006","volume":"58","author":"Mueller","year":"1994","journal-title":"Transplantation"},{"key":"BIB17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(94)91766-3","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"BIB18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1365-2125.1995.tb05722.x","volume":"39","author":"Trull","year":"1995","journal-title":"Br J Clin Pharmacol"},{"key":"BIB19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S1053-0770(96)80187-X","volume":"10","author":"Johnsson","year":"1996","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"BIB20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0967-5868(97)90007-2","volume":"4","author":"Ingebrigtsen","year":"1997","journal-title":"J Clin Neurosci"},{"key":"BIB21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1365-2125.1984.tb02504.x","volume":"18","author":"Farrell","year":"1984","journal-title":"Br J Clin Pharmacol"},{"key":"BIB22","first-page":"543","volume-title":"Systemic pathology","volume":"11","author":"Wight","year":"1994","unstructured":"Pathology of liver transplantation. Liver, biliary tract and exocrine pancreas. In: (ed). Systemic pathology, vol 11. New York: Churchill Livingstone, 1994: 543-595."},{"key":"BIB23","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/00007890-199504270-00008","volume":"59","author":"Soin","year":"1995","journal-title":"Transplantation"},{"key":"BIB24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2165\/00003088-199120010-00004","volume":"20","author":"St Peter","year":"1991","journal-title":"Clin Pharmacokinet"},{"key":"BIB25","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.510280306","volume":"28","author":"Wiesner","year":"1998","journal-title":"Hepatology"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjlts.2002.31347","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200203000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:03:40Z","timestamp":1737731020000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200203000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jlts.2002.31347","relation":{},"ISSN":["1527-6465"],"issn-type":[{"type":"print","value":"1527-6465"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}