{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:18:37Z","timestamp":1778516317747,"version":"3.51.4"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4748,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Most transplant programs require abstinence of at least 6 months from alcohol and illicit drugs before orthotopic liver transplantation (OLT). However, there are no published data regarding OLT outcomes in patients who are currently on methadone maintenance treatment (MMT) as part of the treatment of their heroin addiction at the time of OLT. The objective of this study is to evaluate our experience regarding the outcome of OLT in patients with end-stage liver disease (ESLD) who were on MMT at the time of OLT. Between March 1993 and May 1999, a total of 185 patients with ESLD underwent OLT at our center. Five transplant recipients (2.7%) had a history of heroin abuse and had undergone drug and alcohol rehabilitation, but could not be weaned off methadone. Pre-OLT status, drug history, perioperative course, compliance with medical therapy, post-OLT follow-up, and patient and allograft survival were analyzed in detail in these patients. All patients on MMT underwent uneventful OLTs. Their compliance with medications and follow-up was excellent. One patient was weaned completely off methadone after OLT. Post-OLT mean hospital stay in this group was 43 \u00b1 25 days. Although the number of patients was small, long-term outcome of liver transplant recipients on MMT appears similar to that of patients not on MMT who underwent OLT during this period. Our results suggest cirrhotic patients on MMT should be considered for OLT if they meet the same psychosocial requirements as patients with alcohol abuse. Furthermore, it is not necessary for patients to be weaned off methadone before OLT.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2002.33976","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T00:50:07Z","timestamp":1051145407000},"page":"778-782","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":61,"title":["Liver transplantation for patients on methadone maintenance"],"prefix":"10.1097","volume":"8","author":[{"given":"Thirumalesh P.","family":"Kanchana","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosme","family":"Manzarbeitia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin C.","family":"Hails","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago J.","family":"Munoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth D.","family":"Rothstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(99)80381-X","volume":"31","author":"Alter","year":"1999","journal-title":"J Hepatol"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"s107","DOI":"10.1002\/hep.1840040725","volume":"4","year":"1984","journal-title":"Hepatology"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"s42","DOI":"10.1046\/j.1440-1746.1999.01876.x","volume":"14","author":"Keeffe","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"BIB4","first-page":"249","volume":"57","author":"Trotter","year":"1996","journal-title":"N C Med J"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/S0140-6736(99)90002-8","volume":"354","author":"Neuberger","year":"1999","journal-title":"Lancet"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2165\/00002018-200022030-00002","volume":"22","author":"Bell","year":"2000","journal-title":"Drug Saf"},{"key":"BIB7","first-page":"s107","volume":"113","author":"Hartel","year":"1998","journal-title":"Public Health Rep"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1001\/jama.285.8.1056","volume":"285","author":"Koch","year":"2001","journal-title":"JAMA"},{"key":"BIB9","first-page":"105","volume":"20","author":"Osorio","year":"1994","journal-title":"Hepatology"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/hep.1840110202","volume":"11","author":"Kumar","year":"1990","journal-title":"Hepatology"},{"key":"BIB11","series-title":"Heroin abuse","first-page":"97","volume-title":"National Institute on Drug Abuse","year":"1997","unstructured":"National Institute on Drug Abuse. Heroin abuse and addiction, research report series. Washington, DC: National Institutes of Health publication 97-4165, 1997. Available at: http:\/\/www.nida.nih.gov\/ResearchReports\/Heroin\/Heroin.html. Accessed: November 20, 2001."},{"key":"BIB12","volume-title":"National Institutes of Health: Consensus statement: Effective medical treatment of opiate addiction","year":"1997","unstructured":"National Institutes of Health: Consensus statement: Effective medical treatment of opiate addiction. Bethesda: National Institutes of Health, 1997. Available at: http:\/\/odp.od.nih.gov\/consensus\/cons\/108\/108_statement.htm. Accessed: November 20, 2001."},{"key":"BIB13","author":"Doherty","year":"1999","unstructured":"Association survey identifies greater numbers in methadone treatment. American Methadone Treatment Organization News Report, 1999. Available at: http:\/\/www.americanmethadone.org\/nr1999.htm#association. Accessed: November 20, 2001."},{"key":"BIB14","first-page":"364","volume":"108","author":"Chetwynd","year":"1995","journal-title":"N Z Med J"},{"key":"BIB15","doi-asserted-by":"crossref","first-page":"s6","DOI":"10.1097\/00042560-199802001-00003","volume":"18","author":"Alter","year":"1998","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"BIB16","year":"2001","unstructured":"NIH consensus panel recommends expanding access to and improving methadone treatment programs for heroin addiction. Available at: http:\/\/www.nih.gov\/news\/pr\/nov97\/od-19.htm. Accessed: November 20, 2001."},{"key":"BIB17","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0025-7125(05)70555-1","volume":"81","author":"Warner","year":"1997","journal-title":"Med Clin North Am"},{"key":"BIB18","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/bmj.310.6977.463a","volume":"310","author":"Poser","year":"1995","journal-title":"BMJ"},{"key":"BIB19","doi-asserted-by":"crossref","first-page":"819","DOI":"10.7326\/0003-4819-113-11-819","volume":"113","author":"Newman","year":"1990","journal-title":"Ann Intern Med"},{"key":"BIB20","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJM200107193450311","volume":"345","author":"Edlin","year":"2001","journal-title":"N Engl J Med"},{"key":"BIB21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1056\/NEJM200107193450312","volume":"345","author":"Davis","year":"2001","journal-title":"N Engl J Med"},{"key":"BIB22","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4613-9089-3","volume-title":"The effectiveness of methadone maintenance treatment","author":"Ball","year":"1991","unstructured":"The effectiveness of methadone maintenance treatment. New York: Springer-Verlag; 1991."},{"key":"BIB23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0740-5472(98)00059-2","volume":"17","author":"Newton","year":"1999","journal-title":"J Subst Abuse Treat"}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjlts.2002.33976","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200209000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:04:10Z","timestamp":1737731050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200209000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jlts.2002.33976","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9]]}}}