{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:55:26Z","timestamp":1777503326125,"version":"3.51.4"},"reference-count":81,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4536,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Osteoporosis remains a serious potential complication of liver transplantation, although its incidence may be significantly reduced by the use of lower doses of glucocorticoids. Additional factors likely to contribute to its pathogenesis include other immunosuppressive agents, particularly cyclosporin A and FK506, vitamin D insufficiency, secondary hyperparathyroidism, hypogonadism and pre-existing bone disease. Bone density assessment and spinal X-rays should be performed before transplantation to assess subsequent fracture risk and vitamin D and gonadal status assessed. Measures should be taken to optimise bone health prior to transplantation; in those with low bone mineral density and\/or previous fragility fracture, prophylaxis against bone loss after transplantation should be considered. Although anti-fracture efficacy has not been established for any agent there is evidence, mainly in patients undergoing other forms of solid organ transplantation, that repeated infusions of pamidronate may be effective in preventing bone loss.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2003.50044","type":"journal-article","created":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T20:14:53Z","timestamp":1053375293000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":93,"title":["Osteoporosis after liver transplantation"],"prefix":"10.1097","volume":"9","author":[{"given":"Juliet E.","family":"Compston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/qjmed\/92.10.547","volume":"92","author":"Neuberger","year":"1999","journal-title":"Quart J Med"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/0002-9343(93)90218-E","volume":"94","year":"1993","journal-title":"Am J Med"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF01623272","volume":"3","author":"Ross","year":"1993","journal-title":"Osteoporos Int"},{"key":"BIB4","first-page":"102","volume":"78","author":"Weaver","year":"1983","journal-title":"Am J Gastroenterol"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0168-8278(88)80467-7","volume":"6","author":"Haagsma","year":"1988","journal-title":"J Hepatol"},{"key":"BIB6","first-page":"1462","volume":"23","author":"Porayko","year":"1991","journal-title":"Transplant Proc"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1002\/hep.1840140215","volume":"14","author":"Eastell","year":"1991","journal-title":"Hepatology"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/hep.1840140407","volume":"14","author":"McDonald","year":"1991","journal-title":"Hepatology"},{"key":"BIB9","first-page":"2709","volume":"24","author":"Arnold","year":"1992","journal-title":"Transplant Proc"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0002-9343(94)90324-7","volume":"97","author":"Meys","year":"1994","journal-title":"Am J Med"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/rheumatology\/33.1.52","volume":"33","author":"Navasa","year":"1994","journal-title":"Brit J Rheumatol"},{"key":"BIB12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00042737-200012080-00013","volume":"12","author":"Ninkovic","year":"2000","journal-title":"Europ J Gastroenterol Hepatol"},{"key":"BIB13","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0041-1345(99)00075-5","volume":"31","author":"Taillandier","year":"1999","journal-title":"Transplant Proc"},{"key":"BIB14","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s001980070081","volume":"11","author":"Hamberg","year":"2000","journal-title":"Osteoporos Int"},{"key":"BIB15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s001980170094","volume":"12","author":"Monegal","year":"2001","journal-title":"Osteoporos Int"},{"key":"BIB16","first-page":"158","volume":"41","author":"Hawkins","year":"1994","journal-title":"Hepato-Gastroenterol"},{"key":"BIB17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00042737-199902000-00016","volume":"11","author":"Hussaini","year":"1999","journal-title":"Europ J Gastroenterol Hepatol"},{"key":"BIB18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0168-8278(02)00100-9","volume":"37","author":"Ninkovic","year":"2002","journal-title":"J Hepatol"},{"key":"BIB19","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(00)03641-2","volume":"357","author":"Leidig-Bruckner","year":"2001","journal-title":"Lancet"},{"key":"BIB20","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.3109\/00365529509101633","volume":"30","author":"Abdelhadi","year":"1995","journal-title":"Scand J Gastroenterol"},{"key":"BIB21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF01622737","volume":"6","author":"Riemens","year":"1996","journal-title":"Osteoporos Int"},{"key":"BIB22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/lt.500040413","volume":"4","author":"Floreani","year":"1998","journal-title":"Liver Transplant Surg"},{"key":"BIB23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gut.44.3.430","volume":"44","author":"Crosbie","year":"1999","journal-title":"Gut"},{"key":"BIB24","first-page":"171a","volume":"30","author":"Guichelaar","year":"1999","journal-title":"Gastroenterology"},{"key":"BIB25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s001980070109","volume":"11","author":"Giannini","year":"2000","journal-title":"Osteoporos Int"},{"key":"BIB26","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0899-9007(99)00121-5","volume":"15","author":"Keogh","year":"1999","journal-title":"Nutrition"},{"key":"BIB27","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/lt.500050507","volume":"5","author":"Feller","year":"1999","journal-title":"Liver Transplant Surg"},{"key":"BIB28","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/physrev.2001.81.1.419","volume":"81","author":"Compston","year":"2001","journal-title":"Physiol Rev"},{"key":"BIB29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02058664","volume":"3","author":"Frost","year":"1969","journal-title":"Calcif Tissue Res"},{"key":"BIB30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1359\/jbmr.1999.14.2.281","volume":"14","author":"Vedi","year":"1999","journal-title":"J Bone Miner Res"},{"key":"BIB31","first-page":"1497","volume":"82","author":"Shane","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"BIB32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s001980050207","volume":"10","author":"V\u00e4lim\u00e4ki","year":"1999","journal-title":"Osteoporos Int"},{"key":"BIB33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s001980170051","volume":"12","author":"Floreani","year":"2001","journal-title":"Osteoporos Int"},{"key":"BIB34","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI2799","volume":"102","author":"Weinstein","year":"1998","journal-title":"J Clin Invest"},{"key":"BIB35","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1172\/JCI0214538","volume":"109","author":"Weinstein","year":"2002","journal-title":"J Clin Invest"},{"key":"BIB36","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/archinte.1996.00440100065008","volume":"156","author":"Reid","year":"1996","journal-title":"Arch Intern Med"},{"key":"BIB37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF02563820","volume":"46","author":"Morris","year":"1990","journal-title":"Calcif Tissue Int"},{"key":"BIB38","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000180820","volume":"27","author":"Reid","year":"1987","journal-title":"Hormone Metab Res"},{"key":"BIB39","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1002\/jbmr.5650051204","volume":"5","author":"Sambrook","year":"1990","journal-title":"J Bone Miner Res"},{"key":"BIB40","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1359\/jbmr.2000.15.6.993","volume":"15","author":"Van Staa","year":"2000","journal-title":"J Bone Miner Res"},{"key":"BIB41","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF02678145","volume":"68","author":"Monegal","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"BIB42","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1016\/S0140-6736(00)04766-8","volume":"357","author":"Goffin","year":"2001","journal-title":"Lancet"},{"key":"BIB43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s001980200006","volume":"13","author":"Diaz-Guerra","year":"2002","journal-title":"Osteoporos Int"},{"key":"BIB44","first-page":"1740","volume":"81","author":"Shane","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"BIB45","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/00007890-199907270-00010","volume":"68","author":"Shane","year":"1999","journal-title":"Transplantation"},{"key":"BIB46","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/00007890-199404270-00016","volume":"57","author":"Cvetkovic","year":"1994","journal-title":"Transplantation"},{"key":"BIB47","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(88)91862-4","volume":"1","author":"Aubia","year":"1988","journal-title":"Lancet"},{"key":"BIB48","author":"Bourbigot","year":"1988","unstructured":"Bone histology in renal transplant patients receiving cyclosporin. Lancet 1988; 1048-1049."},{"key":"BIB49","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/jbmr.5650100513","volume":"10","author":"Romero","year":"1995","journal-title":"J Bone Miner Res"},{"key":"BIB50","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0168-8278(96)80243-1","volume":"25","author":"Compston","year":"1996","journal-title":"J Hepatol"},{"key":"BIB51","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s002239900205","volume":"60","author":"Monegal","year":"1997","journal-title":"Calcif Tissue Int"},{"key":"BIB52","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(77)92167-5","volume":"i","author":"Compston","year":"1977","journal-title":"Lancet"},{"key":"BIB53","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/ajcn\/36.5.1014","volume":"36","author":"Parfitt","year":"1982","journal-title":"Am J Clin Nutrit"},{"key":"BIB54","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/gut.27.9.1073","volume":"27","author":"Compston","year":"1986","journal-title":"Gut"},{"key":"BIB55","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s002239900622","volume":"64","author":"Crosbie","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"BIB56","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1136\/gut.31.1.82","volume":"31","author":"Diamond","year":"1990","journal-title":"Gut"},{"key":"BIB57","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00223-001-2028-4","volume":"69","author":"Ninkovic","year":"2001","journal-title":"Calcif Tissue Int"},{"key":"BIB58","author":"WHO Study group on Osteoporosis","year":"1994","unstructured":"WHO Study group on Osteoporosis. Assessment of fracture risk and its application to postmenopausal osteoporosis. World Health Organ Tech Rep Ser NO 843 1994."},{"key":"BIB59","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/hep.1840070127","volume":"7","author":"Stellon","year":"1987","journal-title":"Hepatology"},{"key":"BIB60","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/gut.29.3.378","volume":"29","author":"Stellon","year":"1988","journal-title":"Gut"},{"key":"BIB61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hep.1840040101","volume":"4","author":"Cuthbert","year":"1984","journal-title":"Hepatology"},{"key":"BIB62","first-page":"497","volume":"59","author":"Lalor","year":"1986","journal-title":"Quart J Med"},{"key":"BIB63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/hep.1840140209","volume":"14","author":"Hay","year":"1991","journal-title":"Hepatology"},{"key":"BIB64","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/8756-3282(93)90310-7","volume":"14","author":"Hodgson","year":"1993","journal-title":"Bone"},{"key":"BIB65","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/0006-291X(92)90251-F","volume":"189","author":"Sergeev","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"BIB66","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/382448a0","volume":"382","author":"Ducy","year":"1996","journal-title":"Nature"},{"key":"BIB67","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0168-8278(97)80048-7","volume":"26","author":"Wolfhagen","year":"1997","journal-title":"J Hepatol"},{"key":"BIB68","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0016-5085(97)70098-2","volume":"113","author":"Guanabens","year":"1997","journal-title":"Gastroenterology"},{"key":"BIB69","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1359\/jbmr.2001.16.1.72","volume":"16","author":"Goodman","year":"2001","journal-title":"J Bone Miner Res"},{"key":"BIB70","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/S0140-6736(00)05068-6","volume":"357","author":"Yu","year":"2001","journal-title":"Lancet"},{"key":"BIB71","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF00298990","volume":"57","author":"Valero","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"BIB72","first-page":"1226","volume":"27","author":"Neuhaus","year":"1995","journal-title":"Transplant Proc"},{"key":"BIB73","first-page":"3048","volume":"26","author":"Mathieu","year":"1994","journal-title":"Transplant Proc"},{"key":"BIB74","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/00007890-199810150-00003","volume":"66","author":"Cantorna","year":"1998","journal-title":"Transplantation"},{"key":"BIB75","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0168-8278(00)00093-3","volume":"34","author":"Hay","year":"2001","journal-title":"J Hepatol"},{"key":"BIB76","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/lt.500040508","volume":"4","author":"Reeves","year":"1998","journal-title":"Liver Transplant Surg"},{"key":"BIB77","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00223001126","volume":"67","author":"Bianda","year":"2000","journal-title":"Calcif Tissue Int"},{"key":"BIB78","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1164\/ajrccm.162.3.2002051","volume":"162","author":"Aris","year":"2000","journal-title":"Amer J Resp Crit Care Med"},{"key":"BIB79","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/S1053-2498(00)00132-7","volume":"19","author":"Trombetti","year":"2000","journal-title":"J Heart Lung Transplant"},{"key":"BIB80","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1046\/j.1523-1755.2000.00890.x","volume":"57","author":"Fan","year":"2000","journal-title":"Kidney Int"},{"key":"BIB81","author":"Compston","year":"2002","unstructured":"Mechanisms of bone loss and bone gain in untreated and treated osteoporosis. In: Hock J, ed. Osteoporosis. Endocrine 2002; 17:21-27."}],"container-title":["Liver Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjlts.2003.50044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01445473-200304000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T15:04:45Z","timestamp":1737731085000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01445473-200304000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":81,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003]]}},"URL":"https:\/\/doi.org\/10.1053\/jlts.2003.50044","relation":{},"ISSN":["1527-6465"],"issn-type":[{"value":"1527-6465","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}