{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:47:45Z","timestamp":1790156865964,"version":"4.0.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4567,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The aim of the study is to evaluate the effect of a single treatment with the molecular adsorbents recirculating system (MARS) on systemic hemodynamics and oxygen consumption (V\n                      <jats:italic toggle=\"yes\">O<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      ) in patients with hyperacute liver failure (HALF). In a controlled design, eight patients with HALF were assigned to a 6-hour MARS treatment, and five patients, to a control group that was mechanically cooled to match the MARS group. Systemic hemodynamic variables were determined hourly during the study period. In the MARS group, systemic vascular resistance index increased by 46% from 1,215 \u00b1 437 to 1,778 \u00b1 710 dynes \u00b7 s \u00b7 cm\n                      <jats:sup>\u22125<\/jats:sup>\n                      \u00b7 m\n                      <jats:sup>\u22122<\/jats:sup>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001), which significantly exceeded a 6% increase in the control group. Mean arterial pressure increased from 69 \u00b1 5 to 83 \u00b1 11 mm Hg in the MARS group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001) and was unchanged in the control group. Cardiac index decreased by 20% from 4.6 \u00b1 1.8 to 3.7 \u00b1 1.1 L\/min \u00b7 m\n                      <jats:sup>\u22122<\/jats:sup>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .0007) in the MARS group and by 7% in the control group. Heart rate decreased from 105 \u00b1 21 to 85 \u00b1 15 beats\/min in the MARS group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .0001) and was unchanged in the control group. In the MARS group, oxygen delivery decreased from 621 \u00b1 198 to 486 \u00b1 141 mL\/min \u00b7 m\n                      <jats:sup>\u22122<\/jats:sup>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05), and V\n                      <jats:italic toggle=\"yes\">O<\/jats:italic>\n                      2, from 142 \u00b1 31 to 112 \u00b121 mL\/min \u00b7 m\n                      <jats:sup>\u22122<\/jats:sup>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05). Arterial lactate and pH levels were unchanged. In conclusion, systemic hemodynamic values tend to normalize, whereas systemic V\n                      <jats:italic toggle=\"yes\">O<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      decreases during MARS treatment in patients with HALF. These effects cannot be explained by the degree of cooling associated with MARS.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1053\/jlts.2003.50051","type":"journal-article","created":{"date-parts":[[2003,4,23]],"date-time":"2003-04-23T20:50:07Z","timestamp":1051131007000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":187,"title":["Systemic hemodynamic effects of treatment with the molecular adsorbents recirculating system in patients with hyperacute liver failure: A prospective controlled trial"],"prefix":"10.1097","volume":"9","author":[{"given":"Lars E.","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Peter","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bent A.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fin Stolze","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1055\/s-2007-1007251","volume":"16","author":"Ellis","year":"1996","journal-title":"Semin Liver Dis"},{"key":"BIB2","first-page":"887","volume":"7","author":"Larsen","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00042737-199701000-00014","volume":"9","author":"Clemmesen","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S1089-3261(05)70134-3","volume":"4","author":"Kaptanoglu","year":"2000","journal-title":"Clin Liver Dis"},{"key":"BIB5","doi-asserted-by":"crossref","first-page":"s5","DOI":"10.1002\/hep.1840200704","volume":"20","author":"Williams","year":"1994","journal-title":"Hepatology"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s005340170045","volume":"8","author":"Hui","year":"2001","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1053\/jlts.2001.29108","volume":"7","author":"Schmidt","year":"2001","journal-title":"Liver Transpl"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1097\/00003246-200107000-00006","volume":"29","author":"Sorkine","year":"2001","journal-title":"Crit Care Med"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1067\/msy.2001.116671","volume":"130","author":"Awad","year":"2001","journal-title":"Surgery"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000170102","volume":"11","author":"Zucchelli","year":"1993","journal-title":"Blood Purif"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"s245","DOI":"10.1038\/ki.1993.184","volume":"43","author":"Davenport","year":"1993","journal-title":"Kidney Int"},{"key":"BIB12","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/S0140-6736(98)12440-6","volume":"354","author":"Jalan","year":"1999","journal-title":"Lancet"},{"key":"BIB13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0140-6736(93)91736-6","volume":"342","author":"O'Grady","year":"1993","journal-title":"Lancet"},{"key":"BIB14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(89)90081-4","volume":"97","author":"O'Grady","year":"1989","journal-title":"Gastroenterology"},{"key":"BIB15","first-page":"21","volume-title":"Applied Physiology. 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