{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:51:46Z","timestamp":1765039906876,"version":"3.33.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4322,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:sec>\n            <jats:title>Key points<\/jats:title>\n            <jats:p>1. Preclinical data from chimpanzees and studies in hepatitis B virus\/hepatitis C virus (HCV) coinfected transplant recipients suggest prophylactic HCV antibody therapy may have a role in the prevention of HCV recurrence.<\/jats:p>\n            <jats:p>2. There are insufficient data available to evaluate the efficacy of this therapeutic approach. A small study found no benefit. Other ongoing studies using alternative antibody preparations and more intensive dosing schedules are underway.<\/jats:p>\n            <jats:p>3. Preemptive antiviral therapy, started within the first 4 weeks posttransplantation and prior to the onset of clinical signs and symptoms, is effective in some patients (5-33%) and is not associated with an increased risk of acute rejection. Tolerability of antiviral agents in the early posttransplantation period may be a factor limiting treatment efficacy.<\/jats:p>\n            <jats:p>4. It is unclear whether the preemptive antiviral treatment is superior to delaying treatment until recurrent disease is present and controlled trials addressing this issue are needed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jlts.2003.50255","type":"journal-article","created":{"date-parts":[[2003,10,29]],"date-time":"2003-10-29T17:35:56Z","timestamp":1067448956000},"page":"S95-S100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":48,"title":["Prophylactic and preemptive therapies for hepatitis C virus-infected patients undergoing liver transplantation"],"prefix":"10.1097","volume":"9","author":[{"given":"Norah 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