{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:19:36Z","timestamp":1790918376326,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":4614,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2001,7]]},"DOI":"10.1053\/joca.2000.0411","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T09:56:27Z","timestamp":1032429387000},"page":"447-453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis"],"prefix":"10.1053","volume":"9","author":[{"given":"L.","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hjerpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.H.","family":"Brismar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/joca.2000.0411_RF1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/17453677008991540","article-title":"Experimental osteoarthritis in rabbits","volume":"41","author":"Hulth","year":"1970","journal-title":"Preliminary report. Acta Orthop Scand"},{"key":"10.1053\/joca.2000.0411_RF2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/ard.32.4.387","article-title":"Experimentally-induced osteoarthritis in the dog","volume":"32","author":"Pond","year":"1973","journal-title":"Ann Rheum Dis"},{"key":"10.1053\/joca.2000.0411_RF3","first-page":"104","article-title":"Histological cartilage changes in a rabbit model of osteoarthritis","volume":"14","author":"Vignon","year":"1987","journal-title":"J Rheumatol"},{"key":"10.1053\/joca.2000.0411_RF4","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/art.1780341214","article-title":"Osteoarthritis changes in canine articular cartilage, subchondral bone and synovium fifty-four months after transection of the anterior cruciate ligament","volume":"34","author":"Brandt","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF5","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(05)80318-8","article-title":"Characterization of a model of osteoarthritis in the rabbit knee","volume":"4","author":"Yoshioka","year":"1996","journal-title":"Osteoarthritis Cart"},{"key":"10.1053\/joca.2000.0411_RF6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/art.1780220208","article-title":"Cartilage proteoglycan alterations in an experimentally induced model of rabbit osteoarthritis","volume":"22","author":"Moskowitz","year":"1979","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF7","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/art.1780260709","article-title":"A new model of osteoarthritis in rabbits. I. Development of knee joint pathology following lateral meniscectomy and section of the fibular collateral and sesamoid ligaments","volume":"26","author":"Colombo","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF8","first-page":"2199","article-title":"Histomorphological and immunohistochemical evaluation of joint changes in a model of osteoarthritis induced by lateral meniscectomy in sheep","volume":"24","author":"Little","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1053\/joca.2000.0411_RF9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0232-1513(88)80061-6","article-title":"Degenerative changes in dog articular cartilage induced by a unilateral tibial valgus osteotomy","volume":"33","author":"Johnson","year":"1988","journal-title":"Exp Pathol"},{"key":"10.1053\/joca.2000.0411_RF10","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1002\/jor.1100080414","article-title":"Bone and cartilage changes following experimental varus and valgus angulation","volume":"8","author":"Wu","year":"1990","journal-title":"J Orthop Res"},{"key":"10.1053\/joca.2000.0411_RF11","first-page":"192","article-title":"Slowly progressive osteoarthritis after tibial valgus osteotomy in young beagle dogs","volume":"9","author":"Panula","year":"1997","journal-title":"Clin Orthop"},{"key":"10.1053\/joca.2000.0411_RF12","first-page":"302","article-title":"Articular cartilage thickness and glycosaminoglycan distribution in the canine knee joint after strenuous running exercise","volume":"9","author":"Kiviranta","year":"1992","journal-title":"Clin Orthop"},{"key":"10.1053\/joca.2000.0411_RF13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jor.1100020303","article-title":"Effects of mechanical loading on the tissues of the rabbit knee","volume":"2","author":"Radin","year":"1984","journal-title":"J Orthop Res"},{"key":"10.1053\/joca.2000.0411_RF14","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/art.1780310416","article-title":"Spontaneous cartilage degeneration in guinea-pigs","volume":"31","author":"Bendele","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/jor.1100130517","article-title":"Primary osteoarthrosis in guinea-pigs: a stereological study","volume":"13","author":"De Bri","year":"1995","journal-title":"J Orthop Res"},{"key":"10.1053\/joca.2000.0411_RF16","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1002\/art.1780401121","article-title":"Correlation of morphological and biochemical changes in the natural history of the spontaneous osteoarthrosis in guinea-pigs","volume":"40","author":"Wei","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2106\/00004623-197961030-00017","article-title":"Metabolic activity of articular cartilage in osteoarthritis. An in vitro study","volume":"61","author":"Thompson","year":"1979","journal-title":"J Bone Joint Surg (Am)"},{"key":"10.1053\/joca.2000.0411_RF18","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jor.1100020301","article-title":"Demonstration of increased proteoglycan turnover in cartilage explants from dogs with experimental osteoarthritis","volume":"2","author":"Carney","year":"1984","journal-title":"J Orthop Res"},{"key":"10.1053\/joca.2000.0411_RF19","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/jor.1100100307","article-title":"Increased release of matrix components from articular cartilage in experimental canine osteoarthritis","volume":"10","author":"Ratcliffe","year":"1992","journal-title":"J Orthop Res"},{"key":"10.1053\/joca.2000.0411_RF20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/00016359409029056","article-title":"Metabolic turnover of sulfated glycosaminoglycans and proteoglycans in rabbit temporomandibular joint cartilages with experimentally induced osteoarthrosis","volume":"52","author":"Axelsson","year":"1994","journal-title":"Acta Odont Scand"},{"key":"10.1053\/joca.2000.0411_RF21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1053\/joca.1998.0144","article-title":"Proteoglycan turnover during development of spontaneous osteoarthrosis in guinea-pigs","volume":"6","author":"Wei","year":"1998","journal-title":"Osteoarthritis Cart"},{"key":"10.1053\/joca.2000.0411_RF22","first-page":"428","article-title":"Hypertrophic repair of canine articular cartilage in osteoarthritis after anterior cruciate ligament transection","volume":"18","author":"Adams","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1053\/joca.2000.0411_RF23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/art.1780380410","article-title":"Increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype","volume":"38","author":"Venn","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF24","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1042\/bj1880823","article-title":"Biosynthesis of collagen and other matrix proteins by articular cartilage in experimental osteoarthrosis","volume":"188","author":"Eyre","year":"1980","journal-title":"Biochem J"},{"key":"10.1053\/joca.2000.0411_RF25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/03008209409061971","article-title":"Proteoglycan and collagen alterations in canine knee articular cartilage following 20km daily running exercise for 15 weeks","volume":"30","author":"Saamamen","year":"1994","journal-title":"Connect Tissue Res"},{"key":"10.1053\/joca.2000.0411_RF26","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/art.1780361018","article-title":"Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joints of beagle dogs","volume":"36","author":"Arokoski","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3109\/17453679808999046","article-title":"Mechanical load and primary guinea-pig osteoarthrosis","volume":"69","author":"Wei","year":"1998","journal-title":"Acta Orthop Scand"},{"key":"10.1053\/joca.2000.0411_RF28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/17453679209154757","article-title":"The articular cartilage after osteotomy for medial gonarthrosis. Biopsies after 2 years in 19 cases","volume":"63","author":"Bergenudd","year":"1992","journal-title":"Acta Orthop Scand"},{"key":"10.1053\/joca.2000.0411_RF29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00003086-199204000-00026","article-title":"Cartilage regeneration after proximal tibial osteotomy for medial gonarthrosis","volume":"277","author":"Odenbring","year":"1992","journal-title":"Clin Orthop"},{"key":"10.1053\/joca.2000.0411_RF30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bj2240059","article-title":"Characterization of proteoglycans from the calcified matrix of bovine bone","volume":"224","author":"Franz\u00e9n","year":"1984","journal-title":"Biochem J"},{"key":"10.1053\/joca.2000.0411_RF31","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0009-8981(67)90167-2","article-title":"Determination of hydroxyproline","volume":"18","author":"Stegeman","year":"1967","journal-title":"Clin Chim Acta"},{"key":"10.1053\/joca.2000.0411_RF32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/abio.1993.1198","article-title":"Size-dependent separation of proteoglycans by agarose gel electrophoresis","volume":"210","author":"Bj\u00f6rnsson","year":"1993","journal-title":"Anal Biochem"},{"key":"10.1053\/joca.2000.0411_RF33","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0021-9673(01)95313-0","article-title":"Determination of sulfated disaccharides from chondroitin sulfates by high-performance liquid chromatography","volume":"171","author":"Hjerpe","year":"1979","journal-title":"J Chromatogr"},{"key":"10.1053\/joca.2000.0411_RF34","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0021-9673(00)88025-5","article-title":"The determination of hyaluronic acid using high-performance liquid chromatography of chondroitinase digests","volume":"245","author":"Hjerpe","year":"1982","journal-title":"J Chromatogr"},{"key":"10.1053\/joca.2000.0411_RF35","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1002\/art.1780340916","article-title":"Effects of body weight restriction on the development and progression of spontaneous osteoarthritis in guinea-pigs","volume":"34","author":"Bendele","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/ard.36.2.121","article-title":"Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. I. Chemical composition","volume":"36","author":"Venn","year":"1977","journal-title":"Ann Rheum Dis"},{"key":"10.1053\/joca.2000.0411_RF37","doi-asserted-by":"crossref","unstructured":"Maroudas, A, Venn, M, Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage. II, Swelling Ann Rheum Dis, 1977, 36, 399, 406","DOI":"10.1136\/ard.36.5.399"},{"key":"10.1053\/joca.2000.0411_RF38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1006\/abbi.1997.0507","article-title":"Mechanical properties of the collagen network in human articular cartilage as measured by osmotic stress technique","volume":"351","author":"Basser","year":"1998","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/joca.2000.0411_RF39","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/1529-0131(199805)41:5<877::AID-ART16>3.0.CO;2-#","article-title":"Collagen 1 and collagen 3 expression in a guinea-pig model of osteoarthritis","volume":"41","author":"Huebner","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF40","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/art.1780260708","article-title":"Collagenolytic activity and collagen matrix breakdown of the articular cartilage in the Pond-Nuki dog model of osteoarthritis","volume":"26","author":"Pelletier","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1053\/joca.2000.0411_RF41","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/art.1780260110","article-title":"Collagenase and collagenolytic activity in human osteoarthritic cartilage","volume":"26","author":"Pelletier","year":"1983","journal-title":"Arthritis Rheum"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458400904114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458400904114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T02:58:29Z","timestamp":1761015509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458400904114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["S1063458400904114"],"URL":"https:\/\/doi.org\/10.1053\/joca.2000.0411","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2001,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of load on articular cartilage matrix and the development of guinea-pig osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/joca.2000.0411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}