{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:59Z","timestamp":1787004839800,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Pediatric Nursing"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1053\/jpdn.2000.8148","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:23:34Z","timestamp":1027668214000},"page":"242-249","source":"Crossref","is-referenced-by-count":77,"title":["Genetics of cleft lip and palate"],"prefix":"10.1053","volume":"15","author":[{"given":"Patricia L.","family":"Bender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/jpdn.2000.8148_NEWBIB1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1097\/00006534-199311000-00007","article-title":"Fetal cleft lip and palate: Sonographic diagnosis and postnatal outcomes","volume":"92","author":"Benacerraf","year":"1993","journal-title":"Plastics Reconstructive Surgery"},{"issue":"1","key":"10.1053\/jpdn.2000.8148_NEWBIB2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1597\/1545-1569(1999)036<0030:MGOTCP>2.3.CO;2","article-title":"Medical genetics on the cleft palate-craniofacial team: Understanding parental preferences","volume":"36","author":"Berk","year":"1999","journal-title":"Cleft Palate\u2014Craniofacial Journal"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB3","first-page":"37","article-title":"Familial risk of recurrence of cleft lip and palate","volume":"50","author":"Cembrano","year":"1995","journal-title":"Philippine Journal of Surgery Surgical Specialties"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB4","first-page":"694","article-title":"Economic costs of birth defects and cerebral palsy\u2014United States, 1992","volume":"44","author":"Center for Disease Control","year":"1995","journal-title":"Morbidity and Mortality Weekly Report"},{"issue":"3","key":"10.1053\/jpdn.2000.8148_NEWBIB5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/oxfordjournals.aje.a009799","article-title":"Oral clefts, transforming growth factor alpha gene variants, and maternal smoking: A population-based case-control study in Denmark, 1991-1994","volume":"149","author":"Christensen","year":"1999","journal-title":"American Journal of Epidemiology"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB6","first-page":"603","article-title":"Segregation analysis of cleft lip with or without cleft palate: A comparison of Danish and Japanese data","volume":"39","author":"Chung","year":"1986","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB7","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/gepi.1370040603","article-title":"Genetic epidemiology of cleft lip with of without cleft palate in the population of Hawaii","volume":"4","author":"Chung","year":"1987","journal-title":"Genetic Epidemiology"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/(SICI)1096-8628(19980827)79:1<42::AID-AJMG11>3.0.CO;2-M","article-title":"Racial and ethnic variations in the prevalence of orofacial clefts in California","volume":"79","author":"Croen","year":"1998","journal-title":"American Journal of Medical Genetics"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1159\/000266446","article-title":"Orofacial clefts in Hungary. Epidemiological and genetic data, primary prevention","volume":"49","author":"Czeizel","year":"1997","journal-title":"Folia Phoniatric"},{"issue":"2","key":"10.1053\/jpdn.2000.8148_NEWBIB10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00001665-199803000-00020","article-title":"Prenatal diagnosis: Evolution in craniofacial surgery","volume":"9","author":"DePonte","year":"1998","journal-title":"Journal of Craniofacial Surgery"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB11","series-title":"Inheritance of harelip and cleft palate","author":"Fogh-Anderson","year":"1942"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/oxfordjournals.aje.a009729","article-title":"Parental agricultural work and selected congenital malformations","volume":"149","author":"Garcia","year":"1999","journal-title":"American Journal of Epidemiology"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB13","series-title":"Syndromes of the head and neck","author":"Gorlin","year":"1990"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00006534-198506000-00001","article-title":"In utero cleft lip repair in A\/J mice","volume":"75","author":"Hallock","year":"1985","journal-title":"Plastics Reconstructive Surgery"},{"issue":"2S","key":"10.1053\/jpdn.2000.8148_NEWBIB15","first-page":"129","article-title":"Effects of ethanol on the cytoskeleton of migrating and differentiating neural crest cells: Possible role in teratogenesis","volume":"6","author":"Hassler","year":"1986","journal-title":"Journal of Craniofacial Genetics Developmental Biology"},{"issue":"5","key":"10.1053\/jpdn.2000.8148_NEWBIB16","first-page":"382","article-title":"Cleft lip and palate\u2014Prenatal diagnosis and counseling","volume":"63","author":"Hruskova","year":"1998","journal-title":"Ceska Gynekol"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB17","first-page":"367","article-title":"Lip and oral cavity","author":"Lettieri","year":"1993"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB18","series-title":"Human genetics: Concepts and applications","author":"Lewis","year":"1997"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB19","series-title":"The developing human","author":"Moore","year":"1993"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB20","first-page":"227","article-title":"Face facts: Genes, environment, and clefts","volume":"57","author":"Murray","year":"1995","journal-title":"American Journal of Human Genetics"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1597\/1545-1569(1997)034<0007:CAESOC>2.3.CO;2","article-title":"Clinical and epidemiologic studies of cleft lip and palate in the Philippines","volume":"34","author":"Murray","year":"1997","journal-title":"Cleft Palate\u2014Craniofacial Journal"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB22","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/(SICI)1097-4652(199810)177:1<36::AID-JCP4>3.0.CO;2-F","article-title":"Differential expression and biological activity of retinoic acid-induced TGFbeta isoforms in embryonic palate mesenchyme cells","volume":"177","author":"Nugent","year":"1998","journal-title":"Journal of Cell Physiology"},{"issue":"4","key":"10.1053\/jpdn.2000.8148_NEWBIB23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s004649901004","article-title":"Endoscopic intrauterine surgery in primates: Overcoming technical obstacles","volume":"13","author":"Oberg","year":"1999","journal-title":"Surgical Endoscopy"},{"issue":"1","key":"10.1053\/jpdn.2000.8148_NEWBIB24","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/(SICI)1096-9926(199901)59:1<39::AID-TERA9>3.0.CO;2-7","article-title":"Candidate gene for nonsyndromic cleft lip and palate and maternal cigarette smoking and alcohol consumption: Evaluation of genotype-environment interactions from a population-based case-control study of orofacial clefts","volume":"59","author":"Romitti","year":"1999","journal-title":"Teratolgy"},{"issue":"10R","key":"10.1053\/jpdn.2000.8148_NEWBIB25","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/hmg\/8.10.1853","article-title":"The many faces and factors of orofacial clefts","volume":"8","author":"Schutte","year":"1999","journal-title":"Human Molecular Genetics"},{"issue":"3","key":"10.1053\/jpdn.2000.8148_NEWBIB26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0022-3476(99)70453-1","article-title":"Maternal periconceptional alcohol consumption and risk for orofacial clefts","volume":"134","author":"Shaw","year":"1999","journal-title":"Journal of Pediatrics"},{"issue":"4","key":"10.1053\/jpdn.2000.8148_NEWBIB27","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1597\/1545-1569(1998)035<0366:ITAGOC>2.3.CO;2","article-title":"Infant TGF-alpha geneotype, orofacial clefts, and maternal periconceptional multivitamin use","volume":"35","author":"Shaw","year":"1998","journal-title":"Cleft Palate\u2014Craniofacial Journal"},{"issue":"3","key":"10.1053\/jpdn.2000.8148_NEWBIB28","first-page":"551","article-title":"Orofacial clefts, parental cigarette smoking, and transforming growth factor-alpha gene variants","volume":"58","author":"Shaw","year":"1996","journal-title":"American Journal of Human Genetics"},{"issue":"3","key":"10.1053\/jpdn.2000.8148_NEWBIB29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00006534-199909010-00001","article-title":"A long-term, controlled-outcome analysis of in utero versus neonatal cleft lip repair using an ovine model","volume":"104","author":"Stelnicki","year":"1999","journal-title":"Plastic & Reconstructive Surgery"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB30","series-title":"Human molecular genetics","author":"Strachan","year":"1996"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB31","series-title":"Genetics in medicine","author":"Thompson","year":"1991"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/02844318709083574","article-title":"Orofacial clefts in Czechoslovakia","volume":"21","author":"Tolarova","year":"1987","journal-title":"Scandinavian Journal of Plastics Reconstructive Surgery"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(82)91063-7","article-title":"Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip","volume":"2","author":"Tolarova","year":"1982","journal-title":"Lancet"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1096-8628(19980113)75:2<126::AID-AJMG2>3.0.CO;2-R","article-title":"Classification and birth prevalence of orofacial clefts","volume":"75","author":"Tolarova","year":"1998","journal-title":"American Journal of Medical Genetics"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB35","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/tera.1420510205","article-title":"Reduced recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and multivitamins","volume":"51","author":"Tolarova","year":"1995","journal-title":"Teratology"},{"issue":"11","key":"10.1053\/jpdn.2000.8148_NEWBIB36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s001060050334","article-title":"Fetal surgery in the head-neck area. Current status and new possibilities with the endoscope","volume":"46","author":"Wagner","year":"1998","journal-title":"HNO"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB37","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1001\/archpedi.1943.02010180058007","article-title":"Congenital malformations induced in rats by maternal nutritional deficiency","volume":"65","author":"Warkany","year":"1943","journal-title":"American Journal of Disabled Children"},{"key":"10.1053\/jpdn.2000.8148_NEWBIB38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/(SICI)1096-9926(199605)53:5<309::AID-TERA5>3.0.CO;2-W","article-title":"Review of the role of potential teratogens in the origin of human congenital malformations","volume":"53","author":"Wyszinski","year":"1996","journal-title":"Teratology"},{"issue":"2","key":"10.1053\/jpdn.2000.8148_NEWBIB39","first-page":"174","article-title":"Report on the newly formed international consortium for oral clefts genetics","volume":"36","author":"Wyszynski","year":"1999","journal-title":"Cleft Palate\u2014Craniofacial Journal"}],"container-title":["Journal of Pediatric Nursing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596300227255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0882596300227255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T17:58:40Z","timestamp":1555005520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0882596300227255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0882596300227255"],"URL":"https:\/\/doi.org\/10.1053\/jpdn.2000.8148","relation":{},"ISSN":["0882-5963"],"issn-type":[{"value":"0882-5963","type":"print"}],"subject":[],"published":{"date-parts":[[2000,8]]}}}