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Early detection and intervention are paramount to halt tissue damage and reduce the chance of permanent disability or disfigurement. This article provides an overview of known chemotherapeutic vesicants (mechlorethamine, mitomycin-C, doxorubi cin, daunomycin, vincristine and vinblastine), associated theories of tissue destruction, assessment techniques for peripheral intravenous sites, vascular access devices and central venous lines, current treatment strategies, and investigational therapies. A brief discussion of the legal implications of extrava sation injuries and recommended key points for medical record documentation are included.<\/jats:p>","DOI":"10.1053\/jpon.2000.8063","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T23:46:10Z","timestamp":1030232770000},"page":"135-148","source":"Crossref","is-referenced-by-count":66,"title":["Evaluation and Treatment of Chemotherapy Extravasation Injuries"],"prefix":"10.1177","volume":"17","author":[{"given":"Elizabeth","family":"Kassner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"atypb1","first-page":"693","volume":"18","author":"Alberts, D.S.","year":"1991","journal-title":"Oncology Nursing Forum"},{"key":"atypb2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1172\/JCI113285","volume":"81","author":"Averbuch, S.D.","year":"1988","journal-title":"Journal of Clinical Investigation"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.1.88"},{"key":"atypb4","first-page":"16","volume":"18","author":"Beason, R.","year":"1990","journal-title":"Journal of Intrauenous Nursing"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.1997.5257"},{"key":"atypb6","unstructured":"Bertelli, G., Dini, D., Forno, G.B., Gozza, A., Silvestro, S., Venturini, M., Rosso, R. & Pronzato, P. 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