{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:22:47Z","timestamp":1761488567965,"version":"3.38.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T00:00:00Z","timestamp":1083628800000},"content-version":"vor","delay-in-days":1950,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[1999,1]]},"abstract":"<jats:p><jats:bold>Objective\u2014<\/jats:bold>To investigate whether hypertonic saline infusion would prevent hypotension and pituitary\u2010adrenocortical axis activation during halothane anesthesia after acepromazine premedication and thiopental induction in sheep.<\/jats:p><jats:p><jats:bold>Study Design\u2014<\/jats:bold>Randomized crossover study.<\/jats:p><jats:p><jats:bold>Animals\u2014<\/jats:bold>Six Welsh Mountain ewes weighing 40 \u00b1 2 kg and aged 2 to 3 years.<\/jats:p><jats:p><jats:bold>Methods\u2014<\/jats:bold>The sheep were studied on two occasions with 2 weeks between anesthetics. After acepromazine premedication, anesthesia was induced with thiopental and maintained for 120 minutes with halothane. During the first 15 minutes of anesthesia, 7.5% saline (4 mL\/kg) was infused intravenously (HS group), but no infusion was given in the control (CONT) group. Sequential blood samples were taken for blood gas, cortisol, adenocorticotropic hormone (ACTH), glucose, and lactate assay.<\/jats:p><jats:p><jats:bold>Results\u2014<\/jats:bold>Hypotension developed in both treatments; blood pressure decreased to a nadir of 58 \u00b1 5 mm Hg in the HS group and to 63 \u00b1 4 mm Hg in the CONT group (<jats:styled-content><jats:italic>P<\/jats:italic>&gt; .05<\/jats:styled-content>). Plasma cortisol increased significantly in both groups, reaching a peak of 420 \u00b1 130 nmol\/L in HS and 483 \u00b1 157 nmol\/L in CONT (<jats:styled-content><jats:italic>P<\/jats:italic>&gt; .05<\/jats:styled-content>). ACTH increased similarly in both groups, reaching 128 \u00b1 64 pmol\/L in HS and 134 \u00b1 55 pmol\/L in CONT (<jats:styled-content><jats:italic>P<\/jats:italic>&gt; .05<\/jats:styled-content>). pH was slightly higher in CONT, but no other differences were detected between the two groups.<\/jats:p><jats:p><jats:bold>Conclusions\u2014<\/jats:bold>Hypertonic saline did not ameliorate the adrenocortical response during anesthesia; this may be a result of its failure to prevent the hypotension.<\/jats:p>","DOI":"10.1053\/jvet.1999.0077","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T15:29:29Z","timestamp":1287156569000},"page":"77-82","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Hypertonic Saline Infusion on the Adrenocortical Response to Thiopental\u2010Halothane Anesthesia in Sheep After Premedication with Acepromazine"],"prefix":"10.1111","volume":"28","author":[{"given":"Polly Margaret","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,5,4]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"611","article-title":"Cardiovascular effects of halothane in the horse","volume":"39","author":"Steffey EP","year":"1978","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_3_2","first-page":"197","article-title":"Circulatory effects of halothane and halothane\u2010nitrous oxide anesthesia in the dog: spontaneous ventilation","volume":"36","author":"Steffey EP","year":"1975","journal-title":"Am J Vet Res"},{"key":"e_1_2_6_4_2","first-page":"1247","article-title":"A sheep preparation for studying interactions between blood flow and drug disposition: III","volume":"56","author":"Runciman WB","year":"1984","journal-title":"effects of general and spinal anaesthesia on regional blood flow and oxygen tensions. 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