{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:15:20Z","timestamp":1777454120905,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,4,29]],"date-time":"2004-04-29T00:00:00Z","timestamp":1083196800000},"content-version":"vor","delay-in-days":1155,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:p><jats:bold>Objective\u2014<\/jats:bold>To document morphologic changes that occur in equine intestinal serosa after experimentally induced ischemia and subsequent reperfusion (jejunum, ascending colon) or after intraluminal distention and decompression (jejunum).<\/jats:p><jats:p><jats:bold>Study Design\u2014<\/jats:bold>Morphologic effects of ischemia\u2010reperfusion or intraluminal distention\u2010decompression determined on the serosal layer of the equine jejunum. The large colon serosa was evaluated after ischemia\u2010reperfusion injury.<\/jats:p><jats:p><jats:bold>Animals or Sample Population\u2014<\/jats:bold>Seven adult horses.<\/jats:p><jats:p><jats:bold>Methods\u2014<\/jats:bold>After induction of general anesthesia and ventral median celiotomy, ischemia was created by arteriovenous (AVO) and lumen occlusion of a 20\u2010cm segment of jejunum and ascending colon for 70 minutes, followed by a 60\u2010minute reperfusion period. Intraluminal distention (25 cm H<jats:sub>2<\/jats:sub>O) was created in a second 20\u2010cm jejunal segment and maintained within the abdomen for 120 minutes, followed by a 120\u2010minute decompression period. Seromuscular biopsies were obtained upon entering the abdomen and after the ischemic and reperfusion periods, and after the distention and decompression periods along with corresponding control seromuscular biopsies. Samples were processed and examined by light microscopy, transmission electron, and scanning electron microscopy.<\/jats:p><jats:p><jats:bold>Results\u2014<\/jats:bold>Ischemia and reperfusion, and intraluminal distention and decompression, resulted in severe morphologic changes in the seromuscular layer of equine jejunum. A similar period of ischemia\u2010reperfusion caused minimal changes in the ascending colon serosa.<\/jats:p><jats:p><jats:bold>Conclusion\u2014<\/jats:bold>Adult equine jejunum sustains more serosal damage than the ascending colon after similar periods of ischemia\u2010reperfusion injury. Intraluminal distention and subsequent decompression causes serosal damage in the equine jejunum.<\/jats:p><jats:p><jats:bold>Clinical Relevance\u2014<\/jats:bold>The small intestine is more susceptible to seromuscular layer damage than the ascending colon.<\/jats:p>","DOI":"10.1053\/jvet.2001.21393","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"114-125","source":"Crossref","is-referenced-by-count":50,"title":["Serosal Injury in the Equine Jejunum and Ascending Colon After Ischemia\u2010Reperfusion or Intraluminal Distention and Decompression"],"prefix":"10.1111","volume":"30","author":[{"given":"Robin M.","family":"Dabareiner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth E.","family":"Sullins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathaniel 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