{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:30:27Z","timestamp":1764225027789,"version":"3.38.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T00:00:00Z","timestamp":1082937600000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Veterinary Surgery"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:p><jats:bold>Objective\u2014<\/jats:bold>To report the use of sodium nitroprusside to induce deliberate hypotension to reduce hemorrhage and facilitate surgical ligation of complicated patent ductus arteriosus (PDA) in dogs.<\/jats:p><jats:p><jats:bold>Study Design\u2014<\/jats:bold>Retrospective study.<\/jats:p><jats:p><jats:bold>Animals\u2014<\/jats:bold>Six dogs.<\/jats:p><jats:p><jats:bold>Methods\u2014<\/jats:bold>Hemorrhage occurred during surgical ligation of PDA in 5 dogs. Surgical dissection and isolation of the PDA were very difficult in a sixth dog that was considered to be at increased risk for ductus rupture. Sodium nitroprusside (5 to 25 \u03bcg\/kg\/min intravenously) was administered to these 6 dogs to induce hypotension to reduce blood loss and facilitate surgical ligation of the PDA.<\/jats:p><jats:p><jats:bold>Results\u2014<\/jats:bold>Sodium nitroprusside infusion reduced blood pressure (mean arterial pressure, 45 to 60 mm Hg) within 5 to 10 minutes and hemorrhage from the PDA, facilitating its surgical ligation. Recovery from surgery and anesthesia was uneventful in all 6 dogs.<\/jats:p><jats:p><jats:bold>Conclusions\u2014<\/jats:bold>Sodium nitroprusside infusion can be used to induce deliberate hypotension in dogs to facilitate surgical ligation of PDA.<\/jats:p><jats:p><jats:bold>Clinical Relevance\u2014<\/jats:bold>Sodium nitroprusside infusion produces hypotension within 5 to 10 minutes and is easy to control, rapidly abates, and should help to facilitate surgical ligation of PDA.<\/jats:p>","DOI":"10.1053\/jvet.2003.50046","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T15:30:02Z","timestamp":1287156602000},"page":"336-340","source":"Crossref","is-referenced-by-count":9,"title":["Sodium Nitroprusside\u2010Induced Deliberate Hypotension to Facilitate Patent Ductus Arteriosus Ligation in Dogs"],"prefix":"10.1111","volume":"32","author":[{"given":"Suzanne 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