{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:50:40Z","timestamp":1789854640061,"version":"4.0.1"},"reference-count":68,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Progress in Cardiovascular Diseases"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1053\/pcad.2002.123782","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"469-478","source":"Crossref","is-referenced-by-count":48,"title":["Systemic and local inflammation in patients with unstable atherosclerotic plaques"],"prefix":"10.1053","volume":"44","author":[{"given":"James T.","family":"Willerson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/pcad.2002.123782_bib1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJM197608122950707","article-title":"The pathogenesis of atherosclerosis (first of two parts)","volume":"295","author":"Ross","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib3","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1001\/jama.256.20.2859","article-title":"Landmark article, July 18, 1953: Coronary disease among United States soldiers killed in action in Korea. Preliminary report","volume":"256","author":"Enos","year":"1986","journal-title":"JAMA"},{"key":"10.1053\/pcad.2002.123782_bib4","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1161\/01.ATV.13.9.1291","article-title":"Natural history of aortic and coronary atherosclerotic lesions in youth. Findings from the PDAY Study","volume":"13","author":"Pathobiological Determinants of Atherosclerosis in Youth PDAY Research Group","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"10.1053\/pcad.2002.123782_bib5","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1161\/01.CIR.102.16.1917","article-title":"Cytomegalovirus seropositivity and C-reactive protein have independent and combined predictive value for mortality in patients with angiographically demonstrated coronary artery disease","volume":"102","author":"Muhlestein","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/S0140-6736(88)90741-6","article-title":"Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction","volume":"2","author":"Saikku","year":"1988","journal-title":"Lancet"},{"key":"10.1053\/pcad.2002.123782_bib7","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.CIR.87.4.1408","article-title":"Chlamydia in atherosclerosis","volume":"87","author":"Grayston","year":"1993","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0735-1097(98)00203-4","article-title":"Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction","volume":"32","author":"Anderson","year":"1998","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib9","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1161\/01.CIR.98.25.2796","article-title":"Prospective study of herpes simplex virus, cytomegalovirus, and the risk of future myocardial infarction and stroke","volume":"98","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1056\/NEJM198904063201407","article-title":"Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity","volume":"320","author":"Steinberg","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib11","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1172\/JCI116778","article-title":"Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells","volume":"92","author":"Marui","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1053\/pcad.2002.123782_bib12","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1161\/01.ATV.14.10.1665","article-title":"Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals","volume":"14","author":"Weber","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1053\/pcad.2002.123782_bib13","first-page":"49","article-title":"Mechanisms and mediators of leukocyte\/endothelium interaction during atherogenesis","volume":"25","author":"Lehr","year":"1993","journal-title":"Atheroscler Rev"},{"key":"10.1053\/pcad.2002.123782_bib14","first-page":"49","article-title":"Mechanisms and mediators of leukocyte\/endothelium interaction during atherogenesis","volume":"25","author":"Lehr","year":"1993","journal-title":"Atheroscler Rev"},{"key":"10.1053\/pcad.2002.123782_bib15","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1161\/01.ATV.19.10.2348","article-title":"Complement and atherosclerosis: Binding of CRP to degraded, nonoxidized LDL enhances complement activation","volume":"19","author":"Bhakdi","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/pcad.2002.123782_bib16","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/01.CIR.86.3.790","article-title":"Transient intermittent lymphocyte activation is responsible for the instability of angina","volume":"86","author":"Serneri","year":"1992","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib17","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1161\/01.CIR.99.16.2079","article-title":"Increasing levels of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events","volume":"99","author":"Biasucci","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib18","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00041433-199610000-00012","article-title":"Macrophages and atherosclerotic plaque stability","volume":"7","author":"Libby","year":"1996","journal-title":"Curr Opin Lipidol"},{"key":"10.1053\/pcad.2002.123782_bib19","first-page":"II-12","article-title":"Expression of the uncoupling protein UCP-2 in macrophages of unstable human atherosclerotic plaques","volume":"102","author":"Kockx","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib20","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1056\/NEJM198103193041201","article-title":"Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease","volume":"304","author":"Hirsh","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/01.CIR.80.1.198","article-title":"Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications","volume":"80","author":"Willerson","year":"1989","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(96)91684-0","article-title":"Thermal detection of cellular infiltrates in living atherosclerotic plaques: Possible implications for plaque rupture and thrombosis","volume":"347","author":"Casscells","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/pcad.2002.123782_bib23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1098\/rstb.1981.0101","article-title":"The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries","volume":"294","author":"Davies","year":"1981","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1053\/pcad.2002.123782_bib24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0735-1097(88)90356-7","article-title":"Angiographic progression of coronary artery disease and the development of myocardial infarction","volume":"12","author":"Ambrose","year":"1988","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib25","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.CIR.78.5.1157","article-title":"Can coronary angiography predict the site of a subsequent myocardial infarction in patients with mild-to-moderate coronary artery disease?","volume":"78","author":"Little","year":"1988","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1378\/chest.94.4.731","article-title":"Development of significant coronary artery lesions in areas of minimal disease. A common mechanism for coronary disease progression","volume":"94","author":"Haft","year":"1988","journal-title":"Chest"},{"key":"10.1053\/pcad.2002.123782_bib27","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1161\/01.CIR.79.4.733","article-title":"Circadian variation and triggers of onset of acute cardiovascular disease","volume":"79","author":"Muller","year":"1989","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0368-1319(66)80056-X","article-title":"Plaque fissuring in human coronary thrombosis","volume":"6","author":"Constantinides","year":"1966","journal-title":"J Atheroscle Res"},{"key":"10.1053\/pcad.2002.123782_bib29","first-page":"19","article-title":"The pathogenesis of a coronary thrombus","volume":"48","author":"Friedman","year":"1966","journal-title":"Am J Pathol"},{"key":"10.1053\/pcad.2002.123782_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1098\/rstb.1981.0101","article-title":"The pathological basis and microanatomy of occlusive thrombus formation in human coronary arteries","volume":"294","author":"Davies","year":"1981","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1053\/pcad.2002.123782_bib31","doi-asserted-by":"crossref","first-page":"114E","DOI":"10.1016\/0002-9149(89)90242-7","article-title":"Morphologic features of unstable atherothrombotic plaques underlying acute coronary syndromes","volume":"63","author":"Falk","year":"1989","journal-title":"Am J Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1136\/hrt.82.3.269","article-title":"Plaque erosion is a major substrate for coronary thrombosis in acute myocardial infarction","volume":"82","author":"Arbustini","year":"1999","journal-title":"Heart"},{"key":"10.1053\/pcad.2002.123782_bib33","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/hc3401.095074","article-title":"Incremental prognostic value of elevated baseline C-reactive protein among established markers of risk in percutaneous coronary intervention","volume":"104","author":"Chew","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib34","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM199408183310701","article-title":"The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina","volume":"331","author":"Liuzzo","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib35","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","article-title":"C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Monitoring trends and determinants in cardiovascular disease) Augsberg Cohort Study. 1984 to 1992","volume":"99","author":"Koenig","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib36","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1161\/01.ATV.17.6.1121","article-title":"Relationship of C-reactive protein to risk of cardiovascular disease in the elderly: Results from the Cardiovascular Health Study and the Rural Health Promotion Project","volume":"17","author":"Tracy","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/pcad.2002.123782_bib37","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.CIR.97.20.2007","article-title":"C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib38","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1056\/NEJM199704033361409","article-title":"Inflammation, atherosclerosis, and ischemic events: Exploring the hidden side of the moon","volume":"336","author":"Maseri","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(96)07591-5","article-title":"for the European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group. Production of C-Reactive protein and risk of coronary events in stable and unstable angina","volume":"349","author":"Haverkate","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/pcad.2002.123782_bib40","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0735-1097(99)00348-4","article-title":"Preprocedural serum levels of C-reactive protein predict early complications and late restenosis after coronary angioplasty","volume":"34","author":"Buffon","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib41","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","article-title":"Direct proinflammatory effect of C-reactive protein on human endothelial cells","volume":"102","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib42","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1161\/01.CIR.103.21.2531","article-title":"Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs","volume":"103","author":"Pasceri","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib43","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/01.CIR.104.9.974","article-title":"C-Reactive protein: Linking inflammation to cardiovascular complications. Editorial","volume":"104","author":"Yeh","year":"2001","journal-title":"Circulation"},{"issue":"20 suppl 4","key":"10.1053\/pcad.2002.123782_bib44","first-page":"IV2","article-title":"Acute coronary syndromes. Fifty years of progress","volume":"102","author":"Theroux","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib45","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/01.CIR.103.9.1194","article-title":"C-reactive protein-mediated low density lipoprotein uptake by macrophages. Implications for atherosclerosis","volume":"103","author":"Zwaka","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib46","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/S0735-1097(99)00348-4","article-title":"Preprocedural serum levels of C-reactive protein predict early complications and late restenosis after coronary angioplasty","volume":"34","author":"Buffon","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib47","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/01.CIR.101.15.1767","article-title":"Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men","volume":"101","author":"Ridker","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib48","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/S0735-1097(00)00581-7","article-title":"Predictive value of C-reactive protein and troponin T in patients with unstable angina: A comparative analysis: CAPTURE Investigators: Chimeric c7E3 Anti-Platelet Therapy in Unstable angina REfractory to standard treatment trial","volume":"35","author":"Heeschen","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib49","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1161\/hc3901.096721","article-title":"Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability","volume":"104","author":"Mallat","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib50","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0140-6736(96)91684-0","article-title":"Thermal detection of cellular infiltrates in living atherosclerotic plaques: Possible implications for plaque rupture and thrombosis","volume":"347","author":"Casscells","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/pcad.2002.123782_bib51","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1161\/01.CIR.99.15.1965","article-title":"Thermal heterogeneity with human atherosclerotic coronary arteries detected in vivo. A new method of detection by application of a special thermography catheter","volume":"99","author":"Stefanadis","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib52","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0735-1097(01)01137-8","article-title":"Increased local temperature in human coronary atherosclerotic plaques: An independent predictor of clinical outcome in patients undergoing a percutaneous coronary intervention","volume":"37","author":"Stefanadis","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/pcad.2002.123782_bib53","first-page":"1383","volume":"344","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/pcad.2002.123782_bib54","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM199511163332001","article-title":"Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia","volume":"333","author":"Shepherd","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib55","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1056\/NEJM199610033351401","article-title":"The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels","volume":"335","author":"Sacks","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib56","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/01.CIR.100.3.230","article-title":"Long-term effects of pravastatin on plasma concentration of C-reactive protein","volume":"100","author":"Ridker","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib57","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1161\/01.CIR.99.25.3227","article-title":"Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes: The RECIFE (reduction of cholesterol in ischemia and function of the endothelium) trial","volume":"99","author":"Dupuis","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib58","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/01.CIR.103.7.993","article-title":"Statins alter smooth muscle cell accumulation and collagen content in established atheroma of Wantanabe heritable hyperlipidemic rabbits","volume":"103","author":"Fukumoto","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib59","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/pcad.2002.123782_bib60","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1161\/01.CIR.99.12.1540","article-title":"Randomized secondary prevention trial of azithromycin in patients with coronary artery disease and serological evidence for Chlamydia pneumoniae infection. The Azithromycin in Coronary Artery Disease: Elimination of Myocardial Infection with Chlamydia (ACADEMIC) Study","volume":"99","author":"Anderson","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib61","doi-asserted-by":"crossref","unstructured":"Wakatsuki A, Okatani Y, Ikenoue N, et al: Effect of Medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen. Circulation (in press)","DOI":"10.1161\/hc1202.105945"},{"key":"10.1053\/pcad.2002.123782_bib62","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/01.CIR.100.7.713","article-title":"Hormone replacement therapy and increased plasma concentration of C-reactive protein","volume":"100","author":"Ridker","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib63","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.CIR.100.7.717","article-title":"Effects of postmenopausal hormones on inflammation sensitive proteins: The Postmenopausal Estrogen\/Progestin Interventions (PEPI) Study","volume":"100","author":"Cushman","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib64","doi-asserted-by":"crossref","unstructured":"Wakatsuki A, Okatani Y, Ikenoue N, et al: Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen. Circulation (in press)","DOI":"10.1161\/hc1202.105945"},{"key":"10.1053\/pcad.2002.123782_bib65","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1161\/01.CIR.97.1.75","article-title":"Inhibition of \u03b14 integrin and ICAM-1 markedly attenuate macrophage homing to atherosclerotic plaques in ApoE-deficient mice","volume":"97","author":"Patel","year":"1998","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib66","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1161\/01.CIR.101.3.235","article-title":"Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferator-activated receptor-\u03b3 activators","volume":"101","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib67","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1161\/01.CIR.99.24.3125","article-title":"PPAR\u03b1 activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells","volume":"99","author":"Marx","year":"1999","journal-title":"Circulation"},{"key":"10.1053\/pcad.2002.123782_bib68","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0002-9440(10)65540-X","article-title":"Macrophages in human atheroma contain PPAR\u03b3: Differentiation-dependent PPAR\u03b3 expression and reduction in MMP-9 activity through PPAR\u03b3 activation in mononuclear phagocytes","volume":"153","author":"Marx","year":"1998","journal-title":"Am J Pathol"}],"container-title":["Progress in Cardiovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033062002700200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0033062002700200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T20:22:15Z","timestamp":1554927735000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0033062002700200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0033062002700200"],"URL":"https:\/\/doi.org\/10.1053\/pcad.2002.123782","relation":{},"ISSN":["0033-0620"],"issn-type":[{"value":"0033-0620","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}