{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:23:18Z","timestamp":1792678998017,"version":"4.5.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2000,3]]},"DOI":"10.1053\/plac.1999.0522","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T10:55:08Z","timestamp":1032432908000},"page":"S25-S30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":311,"special_numbering":"SA","title":["Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia"],"prefix":"10.1016","volume":"21","author":[{"given":"I.","family":"Caniggia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Lye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/plac.1999.0522_RF1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1006\/dbio.1994.1223","article-title":"Human cytotrophoblast invasion is up-regulated by epidermal growth factor: evidence that paracrine factors modify this process","volume":"164","author":"Bass","year":"1994","journal-title":"Dev Biol"},{"key":"10.1053\/plac.1999.0522_RF2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0028-2243(93)90038-E","article-title":"Localization of alpha2, alpha5 and alpha6 integrin subunits in human endometrium, decidua and trophoblast","volume":"51","author":"Bischof","year":"1993","journal-title":"Eur J Obst Gynaecol Reprod Biol"},{"key":"10.1053\/plac.1999.0522_RF3","first-page":"10","article-title":"A simplified in situ hybridization protocol using non-radioactively labeled probes to detect abundant and rare mRNAs on tissue sections","volume":"1","author":"Braissant","year":"1998","journal-title":"Biochemica"},{"key":"10.1053\/plac.1999.0522_RF4","doi-asserted-by":"crossref","first-page":"3976","DOI":"10.1210\/endo.138.9.5403","article-title":"Activin is a local regulator of human cytotrophoblast cell differentiation","volume":"138","author":"Caniggia","year":"1997","journal-title":"Endocrinology"},{"key":"10.1053\/plac.1999.0522_RF5","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1210\/endo.138.11.5475","article-title":"Endoglin regulates trophoblast differentiation along the invasive pathway in human placental villous explants","volume":"138","author":"Caniggia","year":"1997","journal-title":"Endocrinology"},{"key":"10.1053\/plac.1999.0522_RF6","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI6380","article-title":"Inhibition of TGF\u03b23restores the invasive capability of extravillous trophoblast in preeclamptic pregnancies","volume":"103","author":"Caniggia","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1053\/plac.1999.0522_RF7","first-page":"5","article-title":"Oxygen and placental development in the first trimester: implications for the pathophysiology of preeclampsia","volume":"20","author":"Caniggia","year":"1999","journal-title":"Placenta"},{"key":"10.1053\/plac.1999.0522_RF8","doi-asserted-by":"crossref","unstructured":"Carmeliet, P, Dor, Y, Herbert, J-M, Fukumuras, D, Bruselsmans, K, Dewerchin, M, Neeman, M, Bono, F, Abramovitch, R, Maxwell, P, Koch, CJ, Ratcliffe, P, Moons, L, Jain, RK, Collen, D, Keshert, E, 1998, Role of HIF-1\u03b1 in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis, Nature, 394, 485, 490, Cross, JC, Werb, Z, Fisher, SJ, 1994, Implantation and the placenta: key pieces of the development puzzle, Science, 266, 1508, 1518","DOI":"10.1038\/28867"},{"key":"10.1053\/plac.1999.0522_RF9","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI115565","article-title":"Distribution patterns of extracellular matrix components differentiation along the invasive pathway, in vivo","volume":"89","author":"Damsky","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1053\/plac.1999.0522_RF10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0143-4004(92)90051-T","article-title":"Villous culture of first trimester human placenta\u2014Model to study extravillous trophoblast (EVT) differentiation","volume":"13","author":"Genbacev","year":"1992","journal-title":"Placenta"},{"key":"10.1053\/plac.1999.0522_RF11","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1172\/JCI118447","article-title":"Hypoxia alters early gestation human cytotrophoblast differentiation\/invasion in vitro and models the placental defects that occurs in preeclampsia","volume":"97","author":"Genbacev","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/plac.1999.0522_RF12","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"Genbacev","year":"1997","journal-title":"Science"},{"key":"10.1053\/plac.1999.0522_RF13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jcp.1041480207","article-title":"Mechanism of control of trophoblast invasion in situ","volume":"148","author":"Graham","year":"1991","journal-title":"J Cell Physiol"},{"key":"10.1053\/plac.1999.0522_RF14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/excr.1995.1105","article-title":"Functional role of cell surface integrins on human trophoblast cell migration: regulation by TGF-\u03b2, IGF-II and IGFBP-1","volume":"217","author":"Irving","year":"1995","journal-title":"Exp Cell Res"},{"key":"10.1053\/plac.1999.0522_RF15","series-title":"Role of locally produced growth factors in human placental growth and invasion with special reference to transforming growth factors","author":"Lala","year":"1994"},{"key":"10.1053\/plac.1999.0522_RF16","doi-asserted-by":"crossref","first-page":"17125","DOI":"10.1016\/S0021-9258(17)32529-2","article-title":"Interleukin-1\u03b2 regulates human cytotrophoblast metalloproteinase activity and invasion in vitro","volume":"269","author":"Librach","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.1999.0522_RF17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0143-4004(95)90110-8","article-title":"Localization of transforming growth factor \u03b2 and its natural inhibitor decorin in the human placenta and decidua throughout gestation","volume":"16","author":"Lysiak","year":"1995","journal-title":"Placenta"},{"key":"10.1053\/plac.1999.0522_RF18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/0046-8177(95)90162-0","article-title":"Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast","volume":"26","author":"Redline","year":"1995","journal-title":"Human Pathol"},{"key":"10.1053\/plac.1999.0522_RF19","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1073\/pnas.90.9.4304","article-title":"General involvement of hypoxia inducible factor1 in transcriptional response to hypoxia","volume":"90","author":"Wang","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/plac.1999.0522_RF20","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1172\/JCI119388","article-title":"Preeclampsia is associated with failure of human cytotrophoblast to mimic a vascular adhesion phenotype","volume":"99","author":"Zhou","year":"1997","journal-title":"J Clin Invest"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400499905222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400499905222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:46:03Z","timestamp":1758915963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400499905222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":20,"alternative-id":["S0143400499905222"],"URL":"https:\/\/doi.org\/10.1053\/plac.1999.0522","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2000,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/plac.1999.0522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Harcourt Publishers Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}