{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:06:43Z","timestamp":1790075203307,"version":"4.0.1"},"reference-count":126,"publisher":"Elsevier BV","issue":"5-6","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1053\/plac.2000.0535","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T10:55:08Z","timestamp":1032432908000},"page":"468-477","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Current Topic: The Uteroplacental Renin\u2013Angiotensin System"],"prefix":"10.1016","volume":"21","author":[{"given":"A.H.","family":"Nielsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.H.","family":"Schauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/plac.2000.0535_RF1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/0002-9378(61)90053-9","article-title":"Pressor response to angiotonin in pregnant and nonpregnant women","volume":"82","author":"Abdul-Karim","year":"1961","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1172\/JCI118131","article-title":"Localization of the angiotensin II and its receptor subtype expression in human endometrium and identification of a novel high-affinity angiotensin II binding site","volume":"96","author":"Ahmed","year":"1995","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF3","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/01.HYP.32.3.514","article-title":"Differences in tissue angiotensin II-forming pathways by species and organs in vitro","volume":"32","author":"Akasu","year":"1998","journal-title":"Hypertension"},{"key":"10.1053\/plac.2000.0535_RF4","first-page":"H266","article-title":"Uteroplacental renin in regulation of blood pressure in the pregnant rabbit","volume":"239","author":"Albertini","year":"1980","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF5","first-page":"s247","article-title":"Angiotensin I-converting enzyme in foetal membranes and chorionic cells in culture","volume":"2","author":"Alhenc-Gelas","year":"1984","journal-title":"J Hypertension"},{"key":"10.1053\/plac.2000.0535_RF6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1159\/000179189","article-title":"Angiotensin-II-induced angiogenesis in sponge implants in mice","volume":"16","author":"Andrade","year":"1996","journal-title":"Int J Microcirc"},{"key":"10.1053\/plac.2000.0535_RF7","first-page":"s30","article-title":"Angiotensin II receptors","volume":"10","author":"Ardaillou","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/plac.2000.0535_RF8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/cs0900499","article-title":"Angiotensin receptors in myometrium and myometrial vessels from uteri of women during the follicular and luteal phases of the menstrual cycle and in late pregnancy","volume":"90","author":"Bing","year":"1996","journal-title":"Clin Sci"},{"key":"10.1053\/plac.2000.0535_RF9","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1210\/endo.138.1.4879","article-title":"Pregnancy induces an increase in angiotensin II type-1 receptor expression in uterine but not systemic artery endothelium","volume":"138","author":"Bird","year":"1997","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2000.0535_RF10","first-page":"129","article-title":"Comparative placentation in laboratory animals; a review","volume":"4","author":"Bj\u00f6rkman","year":"1989","journal-title":"Scand J Lab Anim Sci"},{"key":"10.1053\/plac.2000.0535_RF11","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0002-9378(86)90148-1","article-title":"Uteroplacental unit as a source of elevated circulating prorenin levels in normal pregnancy","volume":"155","author":"Brar","year":"1986","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF12","doi-asserted-by":"crossref","first-page":"20636","DOI":"10.1074\/jbc.271.34.20636","article-title":"A protease processing site is essential for prorenin sorting to the regulated secretory pathway","volume":"271","author":"Brechler","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2000.0535_RF13","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of pre-eclampsia","volume":"1","author":"Brosens","year":"1972","journal-title":"Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF14","series-title":"The Renin-Angiotensin System","first-page":"51.1","article-title":"The fetal renin-angiotensin system","author":"Broughton Pipkin","year":"1993"},{"key":"10.1053\/plac.2000.0535_RF15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000396012","article-title":"The uteroplacental renin-angiotensin system in normal and hypertensive pregnancy","volume":"25","author":"Broughton Pipkin","year":"1981","journal-title":"Contributions to Nephrology"},{"key":"10.1053\/plac.2000.0535_RF16","first-page":"49","article-title":"Angiotensin II receptor characteristics and subtype expression in uterine arteries and myometrium during pregnancy","volume":"81","author":"Cox","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF17","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1172\/JCI116827","article-title":"Myometrial angiotensin II receptor subtypes change during ovine pregnancy","volume":"92","author":"Cox","year":"1993","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF18","first-page":"H212","article-title":"Tissue specific expression of vascular smooth muscle angiotensin II receptor subtypes during ovine pregnancy","volume":"271","author":"Cox","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF19","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0002-9378(83)90584-7","article-title":"Generation of angiotensin I by human chorion-decidua in vitro","volume":"145","author":"Craven","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF20","doi-asserted-by":"crossref","first-page":"s31","DOI":"10.1097\/00005344-199016004-00008","article-title":"Biochemical characterization of two angiotensin II receptor subtypes in the rat","volume":"16","author":"de Gasparo","year":"1990","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1053\/plac.2000.0535_RF21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0167-0115(94)90157-0","article-title":"Down regulation of the angiotensin II receptor subtype AT2in human myometrium during pregnancy","volume":"53","author":"de Gasparo","year":"1994","journal-title":"Regulatory Peptides"},{"key":"10.1053\/plac.2000.0535_RF22","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0003-2697(88)90521-0","article-title":"Measurement of immunoreactive angiotensin peptides in rat tissues: some pitfalls in angiotensin II analysis","volume":"174","author":"De Silva","year":"1988","journal-title":"Anal Biochem"},{"key":"10.1053\/plac.2000.0535_RF23","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1210\/jcem-65-2-349","article-title":"Source of plasma prorenin in early and late pregnancy: observations in a patient with primary ovarian failure","volume":"65","author":"Derkx","year":"1987","journal-title":"J Clin Endocrinol Metabolism"},{"key":"10.1053\/plac.2000.0535_RF24","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/01.CIR.89.1.493","article-title":"Editorial. Tissue angiotensin system in cardiovascular medicine. A paradigm shift?","volume":"89","author":"Dzau","year":"1994","journal-title":"Circulation"},{"key":"10.1053\/plac.2000.0535_RF25","first-page":"263","article-title":"Renin in different tissues, amniotic fluid and plasma of pregnant and non-pregnant rabbits","volume":"81","author":"Eskildsen","year":"1973","journal-title":"Acta Pathol Microbiol Scand A"},{"key":"10.1053\/plac.2000.0535_RF26","first-page":"141","article-title":"Neovascularization produced by angiotensin II","volume":"105","author":"Fernandez","year":"1985","journal-title":"J Lab Clin Med"},{"key":"10.1053\/plac.2000.0535_RF27","first-page":"s37","article-title":"Angiogenic action of angiotensin II is important for the glomerular growth of maturing kidneys","volume":"32","author":"Fogo","year":"1991","journal-title":"Kidney International"},{"key":"10.1053\/plac.2000.0535_RF28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0090-6980(74)80001-8","article-title":"The effect of angiotensin-II intravenous infusion on plasma renin activity and prostaglandins A, E, and F levels in the uterine vein of the pregnant monkey","volume":"6","author":"Franklin","year":"1974","journal-title":"Prostaglandins"},{"key":"10.1053\/plac.2000.0535_RF29","first-page":"122","article-title":"Preeclampsia: A review of the role of prostaglandins","volume":"71","author":"Friedman","year":"1988","journal-title":"Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF30","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI107462","article-title":"A study of angiotensin II pressor response throughout primigravid pregnancy","volume":"52","author":"Gant","year":"1973","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0002-9378(85)90309-6","article-title":"Prostaglandin production and stimulation by angiotensin II in the isolated perfused human placental cotyledon","volume":"151","author":"Glance","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF32","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1002\/elps.1150180929","article-title":"Angiotensinogen gene variation in a population case-control study of preeclampsia\/eclampsia in Australians and Chinese","volume":"18","author":"Guo","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1053\/plac.2000.0535_RF33","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0005-2744(78)90089-X","article-title":"Isorenin, pseudorenin, cathepsin D and renin. A comparative study of angiotensin-forming enzymes","volume":"522","author":"Hackenthal","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/plac.2000.0535_RF34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1055\/s-0029-1211289","article-title":"The uteroplacental renin-angiotensin system: a review","volume":"102","author":"Hagemann","year":"1994","journal-title":"Exp Clin Endocrinol"},{"key":"10.1053\/plac.2000.0535_RF35","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1440-1681.1993.tb01501.x","article-title":"Renin and prorenin in reproductive tissues during gestation in pigs and cattle","volume":"20","author":"Hagemann","year":"1993","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1053\/plac.2000.0535_RF36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1471-0528.1991.tb13361.x","article-title":"Angiotensin II levels in hypertensive and normotensive pregnancies","volume":"98","author":"Hanssens","year":"1991","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/plac.2000.0535_RF37","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0143-4004(05)80003-7","article-title":"Identification of \u2018renin\u2019-containing cells in the choriodecidua","volume":"16","author":"Hanssens","year":"1995","journal-title":"Placenta"},{"key":"10.1053\/plac.2000.0535_RF38","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1007\/s001090050277","article-title":"Genetic deletion and overexpression of angiotensin receptors","volume":"76","author":"Hein","year":"1998","journal-title":"J Mol Med"},{"key":"10.1053\/plac.2000.0535_RF39","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1507\/endocrj1954.34.887","article-title":"Expression of renin and angiotensinogen genes in the human placental tissues","volume":"34","author":"Ihara","year":"1987","journal-title":"Endocrinol Jpn"},{"key":"10.1053\/plac.2000.0535_RF40","first-page":"s2","article-title":"Molecular biology and signaling of angiotensin receptors: an overview","volume":"10","author":"Inagami","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/plac.2000.0535_RF41","first-page":"1273","article-title":"Human uterine decidual macrophages express renin","volume":"80","author":"Jikihara","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/0196-9781(84)90023-8","article-title":"Enzymes in placental microvilli: angiotensin I converting enzyme, angiotensinase A, carboxypeptidase, and neutral endopeptidase (\u2018enkephalinase\u2019)","volume":"5","author":"Johnson","year":"1984","journal-title":"Peptides"},{"key":"10.1053\/plac.2000.0535_RF43","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1471-0528.1980.tb04441.x","article-title":"Renin substrate, active and acid-activatable renin concentrations in human plasma and endometrium during menstrual cycles controlled by oral contraceptive preparations","volume":"87","author":"Johnson","year":"1980","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/plac.2000.0535_RF44","first-page":"585","article-title":"Distribution of the concentrations of angiotensin II, angiotensin II receptors, hPL, prolactin, and steroids in human placenta, amnion and chorion","volume":"86","author":"Kalenga","year":"1991","journal-title":"Revue Francaise Gyn\u00e9cologie et d'Obst\u00e9trique"},{"key":"10.1053\/plac.2000.0535_RF45","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1051\/rnd:19910307","article-title":"Angiotensin II receptors in the human placenta are type AT1","volume":"31","author":"Kalenga","year":"1991","journal-title":"Reproduction, Nutrition, D\u00e9velopement"},{"key":"10.1053\/plac.2000.0535_RF46","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0922-4106(94)90193-7","article-title":"Angiotensin II induces human placental lactogen and pregnancy-specific \u03b21-glucoprotein secretion via an angiotensin AT1receptor","volume":"268","author":"Kalenga","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/plac.2000.0535_RF47","first-page":"1233","article-title":"Angiotensin-II stimulates estradiol secretion from human placental explants through AT1receptor activation","volume":"80","author":"Kalenga","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0143-4004(96)80003-8","article-title":"Review article. Angiotensin II and its different receptor subtypes in placenta and foetal membranes","volume":"17","author":"Kalenga","year":"1996","journal-title":"Placenta"},{"key":"10.1053\/plac.2000.0535_RF49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2265.1996.703525.x","article-title":"Determination of renin, angiotensin converting enzyme and angiotensin II levels in human placenta, chorion and amnion from women with pregnancy induced hypertension","volume":"44","author":"Kalenga","year":"1996","journal-title":"Clin Endocrinol"},{"key":"10.1053\/plac.2000.0535_RF50","first-page":"998","article-title":"Down-regulation of angiotensin AT1receptor by progesterone in human placenta","volume":"81","author":"Kalenga","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF51","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-3565(25)23795-8","article-title":"Angiotensin II (AT1) vascular binding sites in human placentae from normal-term, preeclamptic and growth retarted pregnancies","volume":"271","author":"Knock","year":"1994","journal-title":"J Pharmacol Exp Therapeutics"},{"key":"10.1053\/plac.2000.0535_RF52","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/375146a0","article-title":"Male-female differences in fertility and blood pressure in ACE-deficient mice","volume":"375","author":"Krege","year":"1995","journal-title":"Nature"},{"key":"10.1053\/plac.2000.0535_RF53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/ki.1997.13","article-title":"Prorenin activation and prohormone convertases in the mouse As4.1 cell line","volume":"51","author":"Laframboise","year":"1997","journal-title":"Kidney International"},{"key":"10.1053\/plac.2000.0535_RF54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1055\/s-0029-1211275","article-title":"Placental structure, in a comparative aspect","volume":"102","author":"Leiser","year":"1994","journal-title":"Exp Clin Endocrinol"},{"key":"10.1053\/plac.2000.0535_RF55","first-page":"R460","article-title":"Evidence for a novel angiotensin II receptor involved in angiogenesis in chick embryo chorioallantoic membrane","volume":"264","author":"Le Noble","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF56","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0143-4004(05)80386-8","article-title":"Regional distribution of the angiotensinogens in human placentae","volume":"14","author":"Lenz","year":"1993","journal-title":"Placenta"},{"key":"10.1053\/plac.2000.0535_RF57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1210\/jcem-69-1-31","article-title":"Tissue levels of active and total renin, angiotensinogen, human chorionic gonadotropin, estradiol, and progesterone in human placentas from different methods of delivery","volume":"69","author":"Lenz","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF58","first-page":"E876","article-title":"Prorenin secretion from human placenta perfused in vitro","volume":"260","author":"Lenz","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF59","first-page":"137","article-title":"Expression of angiotensin II and its receptor subtypes in endometrial hyperplasia: a possible role in dysfunctional menstruation","volume":"75","author":"Li","year":"1996","journal-title":"Lab Investig"},{"key":"10.1053\/plac.2000.0535_RF60","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/humrep\/11.suppl_2.95","article-title":"Dual role of angiotensin II in the human endometrium","volume":"11","author":"Li","year":"1996","journal-title":"Human Reprod"},{"key":"10.1053\/plac.2000.0535_RF61","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1093\/humrep\/12.12.2804","article-title":"Compartmentalization and cyclic variation of immunoreactivity of renin and angiotensin converting enzyme in human endometrium throughout the menstrual cycle","volume":"12","author":"Li","year":"1997","journal-title":"Human Reprod"},{"key":"10.1053\/plac.2000.0535_RF62","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1172\/JCI119881","article-title":"Cellular localization of AT1receptor mRNA and protein in normal placenta and its reduced expression in intrauterine growth restriction","volume":"101","author":"Li","year":"1998","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF63","first-page":"711","article-title":"Angiotensin-converting enzyme activity in postmortem human tissues","volume":"48","author":"Lieberman","year":"1983","journal-title":"Lab Investig"},{"key":"10.1053\/plac.2000.0535_RF64","first-page":"105","article-title":"Uteroplacental blood flow in preeclampsia. Measurements with indium-113m and a computer-linked gamma camera","volume":"B1","author":"Lunell","year":"1982","journal-title":"Clin Exp Hypertension"},{"key":"10.1053\/plac.2000.0535_RF65","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/01.CIR.89.1.458","article-title":"Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence","volume":"89","author":"Lutterotti","year":"1994","journal-title":"Circulation"},{"key":"10.1053\/plac.2000.0535_RF66","doi-asserted-by":"crossref","first-page":"C92","DOI":"10.1152\/ajpcell.1990.258.1.C92","article-title":"Myosin light chain phosphorylation in human myometrial smooth muscle cells","volume":"258","author":"Mackenzie","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF67","first-page":"H188","article-title":"Uterine prostaglandin production in ovine pregnancy: effects of angiotensin II and indomethacin","volume":"263","author":"Magness","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1053\/plac.2000.0535_RF68","first-page":"1753","article-title":"Sex steroid modulation of AT2receptors in human myometrium","volume":"81","author":"Mancina","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF69","first-page":"4366","article-title":"Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy","volume":"81","author":"Matsumoto","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF70","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev.physiol.59.1.395","article-title":"Biological functions of angiotensin and its receptors","volume":"59","author":"Matsusaka","year":"1997","journal-title":"Ann Rev Physiol"},{"key":"10.1053\/plac.2000.0535_RF71","first-page":"113","article-title":"Localization of renin substrate in fetoplacental tissue","volume":"123","author":"Mets\u00e4rinne","year":"1990","journal-title":"Acta Endocrinologica (Copenhagen)"},{"key":"10.1053\/plac.2000.0535_RF72","first-page":"537","article-title":"Initiating enzymes of angiotensin II degradation in human placenta and pregnancy serum","volume":"22","author":"Mitzutani","year":"1994","journal-title":"Medical Science Research"},{"key":"10.1053\/plac.2000.0535_RF73","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0167-0115(95)00162-X","article-title":"Localization and quantitation of angiotensin AT1and AT2receptors in the pregnant and non-pregnant sheep uterus","volume":"61","author":"Moeller","year":"1996","journal-title":"Regulatory Peptides"},{"key":"10.1053\/plac.2000.0535_RF74","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0014-2999(76)90117-5","article-title":"A comparison of the effects of angiotensin II and heptapeptide on smooth muscle (vascular and uterine)","volume":"39","author":"Moore","year":"1976","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/plac.2000.0535_RF75","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/01.HYP.32.4.683","article-title":"Human spiral artery renin-angiotensin system","volume":"32","author":"Morgan","year":"1998","journal-title":"Hypertension"},{"key":"10.1053\/plac.2000.0535_RF76","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1471-0528.1995.tb11324.x","article-title":"Pre-eclampsia and the angiotensinogen gene","volume":"102","author":"Morgan","year":"1995","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/plac.2000.0535_RF77","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1136\/jmg.35.8.632","article-title":"Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in preeclampsia","volume":"35","author":"Morgan","year":"1998","journal-title":"J Med Gen"},{"key":"10.1053\/plac.2000.0535_RF78","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1172\/JCI119661","article-title":"Angiotensinogen T235 expression is elevated in decidual spiral arteries","volume":"100","author":"Morgan","year":"1997","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF79","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0002-9378(99)70156-0","article-title":"Angiotensinogen Thr245 variant is associated with abnormal physiologic change of the uterine spiral arteries in first-trimester decidua","volume":"180","author":"Morgan","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF80","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1172\/JCI110277","article-title":"Effect of angiotensin II on uterine and systemic vasculature in pregnant sheep","volume":"68","author":"Naden","year":"1981","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF81","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1210\/jcem-61-3-480","article-title":"Evidence for the existence of des-Asp1-angiotensin II in human uterine and adrenal tissues","volume":"61","author":"Naruse","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF82","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0143-4004(96)80008-7","article-title":"Histochemical evaluation of placental angiotensinase A in pre-eclampsia: enzyme activity in villous trophoblast indicates an enhanced likelihood of gestational proteinuric hypertension","volume":"17","author":"Neudeck","year":"1996","journal-title":"Placenta"},{"key":"10.1053\/plac.2000.0535_RF83","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/00004872-198812000-00001","article-title":"Editorial review. Is prorenin of physiological and clinical significance?","volume":"6","author":"Nielsen","year":"1988","journal-title":"J Hypertension"},{"key":"10.1053\/plac.2000.0535_RF84","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/978-1-4899-0952-7_15","article-title":"The tissue renin-angiotensin system in the female reproductive tissues: a review","volume":"377","author":"Nielsen","year":"1995","journal-title":"Adv Exp Med Biol"},{"key":"10.1053\/plac.2000.0535_RF85","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0143-4004(96)80007-5","article-title":"High densities of angiotensin II subtype 2 (AT2) receptors in the porcine placenta and fetal membranes","volume":"17","author":"Nielsen","year":"1996","journal-title":"Placenta"},{"key":"10.1053\/plac.2000.0535_RF86","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1440-1681.1997.tb01193.x","article-title":"Angiotensin II receptors and renin in the porcine uterus: myometrial AT2and endometrial AT1receptors are down-regulated during gestation","volume":"24","author":"Nielsen","year":"1997","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1053\/plac.2000.0535_RF87","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/j.1471-0528.1988.tb06550.x","article-title":"Studies on the effects of nitrendipine on oxytocin-, angiotensin II- and ergometrine-induced contraction of pregnant human myometrium in vitro","volume":"95","author":"Odum","year":"1988","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/plac.2000.0535_RF88","doi-asserted-by":"crossref","first-page":"13645","DOI":"10.1074\/jbc.270.23.13645","article-title":"Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma","volume":"270","author":"Oxvig","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2000.0535_RF89","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1172\/JCI116428","article-title":"Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction","volume":"91","author":"Paul","year":"1993","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF90","first-page":"316","article-title":"Expression of angiotensin II type-1 receptor and phospholipase C-linked Gaq\/11 protein in the human placenta","volume":"3","author":"Petit","year":"1996","journal-title":"J Soc Gynecol Investig"},{"key":"10.1053\/plac.2000.0535_RF91","first-page":"670","article-title":"A role for extracellular calcium in the regulation of placental lactogen release by angiotensin-II and dopamine in human term trophoblastic cells","volume":"77","author":"Petit","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF92","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1006\/frne.1998.0166","article-title":"The human placental renin-angiotensin system","volume":"19","author":"Poisner","year":"1998","journal-title":"Frontiers in Neuroendocrinology"},{"key":"10.1053\/plac.2000.0535_RF93","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1210\/endo-109-4-1150","article-title":"Localization of renin in trophoblasts in human chorion laeve at term pregnancy","volume":"109","author":"Poisner","year":"1981","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2000.0535_RF94","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3181\/00379727-169-41298","article-title":"Renin and inactive renin in human amnion at term pregnancy","volume":"169","author":"Poisner","year":"1982","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1053\/plac.2000.0535_RF95","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/expphysiol.1997.sp004033","article-title":"The control of blood flow to the placenta","volume":"82","author":"Poston","year":"1997","journal-title":"Exp Physiol"},{"key":"10.1053\/plac.2000.0535_RF96","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1016\/S0021-9258(18)69046-5","article-title":"Different secretory pathways of renin from mouse cells transfected with the human renin gene","volume":"263","author":"Pratt","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2000.0535_RF97","first-page":"345","article-title":"Immunohistochemical demonstration of renin in the endometrium","volume":"18","author":"Raju","year":"1989","journal-title":"Ann Acad Med, Singapore"},{"key":"10.1053\/plac.2000.0535_RF98","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1161\/01.RES.31.6.923","article-title":"Effects of angiotensin II and some analogues on vascular permeability in the rabbit","volume":"31","author":"Robertson","year":"1972","journal-title":"Circulation Research"},{"key":"10.1053\/plac.2000.0535_RF99","first-page":"s251","article-title":"Failure of angiotensin II to reduce plasma renin activity in hypertensive pregnant women","volume":"2","author":"Ruilope","year":"1984","journal-title":"J Hypertension"},{"key":"10.1053\/plac.2000.0535_RF100","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0021-9258(19)45491-4","article-title":"Multiple forms of cathepsin D from bovine uterus","volume":"247","author":"Sapolsky","year":"1972","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2000.0535_RF101","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/molehr\/2.9.659","article-title":"Type 1 angiotensin II receptors in human myometrium","volume":"2","author":"Saridogan","year":"1996","journal-title":"Mol Human Reprod"},{"key":"10.1053\/plac.2000.0535_RF102","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1095\/biolreprod59.3.684","article-title":"Autoradiographic localization and characterization of angiotensin II receptors in the bovine placenta and fetal membranes","volume":"59","author":"Schauser","year":"1998","journal-title":"Biol Reprod"},{"key":"10.1053\/plac.2000.0535_RF103","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1530\/jrf.0.1160403","article-title":"Dominance of type 1 angiotensin II receptor in the nonpregnant and pregnant bovine uterus","volume":"116","author":"Schauser","year":"1999","journal-title":"J Reprod Fert"},{"key":"10.1053\/plac.2000.0535_RF104","first-page":"2373","article-title":"Changes in active and inactive renin throughout normal pregnancy","volume":"A4","author":"Sealey","year":"1982","journal-title":"Clin Exp Hypertension"},{"key":"10.1053\/plac.2000.0535_RF105","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1172\/JCI114121","article-title":"Human decidua is a major source of renin","volume":"83","author":"Shaw","year":"1989","journal-title":"J Clin Investig"},{"key":"10.1053\/plac.2000.0535_RF106","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1440-1681.1984.tb00858.x","article-title":"Development of angiotensin converting enzyme in fetal lung and placenta of the rat and human","volume":"11","author":"Sim","year":"1984","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1053\/plac.2000.0535_RF107","series-title":"The Renin-Angiotensin System","first-page":"50.1","article-title":"The renin system in fertility and normal human pregnancy","author":"Skinner","year":"1993"},{"key":"10.1053\/plac.2000.0535_RF108","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0002-9378(68)90564-4","article-title":"Renin concentration in human fetal and maternal tissues","volume":"101","author":"Skinner","year":"1968","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF109","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1042\/cs0420479","article-title":"Analysis of changes in the renin-angiotensin system during pregnancy","volume":"42","author":"Skinner","year":"1972","journal-title":"Clin Sci"},{"key":"10.1053\/plac.2000.0535_RF110","first-page":"611","article-title":"The effect of angiotensin II and indomethacin on uterine artery blood flow in pregnant monkeys","volume":"50","author":"Speroff","year":"1977","journal-title":"Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF111","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1530\/jrf.0.0950791","article-title":"Evidence for a role for a uterine renin-angiotensin system in decidualization in rats","volume":"95","author":"Squires","year":"1992","journal-title":"J Reprod Fert"},{"key":"10.1053\/plac.2000.0535_RF112","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1699-0463.1960.tb01204.x","article-title":"A renin-like pressor substance found in the placenta of the cat","volume":"50","author":"Stakemann","year":"1960","journal-title":"Acta Pathologica et Microbiologica Scandinavica"},{"key":"10.1053\/plac.2000.0535_RF113","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/2171152a0","article-title":"Production of renin by in vitro cultures of human chorion and uterine muscle","volume":"217","author":"Symonds","year":"1968","journal-title":"Nature"},{"key":"10.1053\/plac.2000.0535_RF114","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1126\/science.274.5289.995","article-title":"Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen","volume":"274","author":"Takimoto","year":"1996","journal-title":"Science"},{"key":"10.1053\/plac.2000.0535_RF115","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0895-7061(96)00175-6","article-title":"Quantification of five forms of high molecular weight angiotensinogen from human placenta","volume":"9","author":"Tewksbury","year":"1996","journal-title":"Am J Hypertension"},{"key":"10.1053\/plac.2000.0535_RF116","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0031-6997(25)00446-6","article-title":"Angiotensin II receptors and angiotensin II receptor antagonists","volume":"45","author":"Timmermans","year":"1993","journal-title":"Pharmacol Rev"},{"key":"10.1053\/plac.2000.0535_RF117","first-page":"610","article-title":"Immunohistochemical profile of the human placenta. Studies on localization of prolactin, human chorionic gonadotropin, human placental lactogen, renin and oxytocin","volume":"34","author":"Unnikumar","year":"1988","journal-title":"Cell Mol Biol"},{"key":"10.1053\/plac.2000.0535_RF118","first-page":"s17","article-title":"Widespread tissue distribution of human chymase","volume":"12","author":"Urata","year":"1994","journal-title":"J Hypertension"},{"key":"10.1053\/plac.2000.0535_RF119","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1161\/01.HYP.30.6.1389","article-title":"Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells","volume":"30","author":"van Kesteren","year":"1997","journal-title":"Hypertension"},{"key":"10.1053\/plac.2000.0535_RF120","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/humrep\/12.4.651","article-title":"Review. Tissue renin-angiotensin system and reproduction","volume":"12","author":"Vinson","year":"1997","journal-title":"Human Reprod"},{"key":"10.1053\/plac.2000.0535_RF121","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/ng0593-59","article-title":"A molecular variant of angiotensinogen associated with preeclampsia","volume":"4","author":"Ward","year":"1993","journal-title":"Nature Gen"},{"key":"10.1053\/plac.2000.0535_RF122","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1471-0528.1982.tb04717.x","article-title":"Production of active and inactive renin by cultured explants from the human female genital tract","volume":"89","author":"Warren","year":"1982","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/plac.2000.0535_RF123","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1210\/jcem-40-1-108","article-title":"Relationship between plasma renin, renin-substrate, angiotensin II, aldosterone and electrolytes in normal pregnancy","volume":"40","author":"Weir","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2000.0535_RF124","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0006-291X(89)92133-5","article-title":"Preliminary biochemical characterization of two angiotensin II receptor subtypes","volume":"163","author":"Whitebread","year":"1989","journal-title":"Biochem Biophy Res Communications"},{"key":"10.1053\/plac.2000.0535_RF125","first-page":"453","article-title":"Expression of angiotensin-converting enzyme in human placenta and its physiologic role in the fetal circulation","volume":"84","author":"Yagami","year":"1994","journal-title":"Obstet Gynecol"},{"key":"10.1053\/plac.2000.0535_RF126","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1095\/biolreprod56.5.1189","article-title":"Expression of basic fibroblast growth factor, endothelial mitogenic activity, and angiotensin II type-1 receptors in the ovine placenta during the third trimester of pregnancy","volume":"56","author":"Zheng","year":"1997","journal-title":"Biol Reproduction"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400400905356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400400905356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:27:22Z","timestamp":1758907642000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400400905356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":126,"journal-issue":{"issue":"5-6","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0143400400905356"],"URL":"https:\/\/doi.org\/10.1053\/plac.2000.0535","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current Topic: The Uteroplacental Renin\u2013Angiotensin System","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/plac.2000.0535","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000  Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}