{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:31:20Z","timestamp":1762864280791,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1053\/plac.2000.0547","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T10:55:08Z","timestamp":1032432908000},"page":"646-653","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Human Term Placental Lipoxygenase-Mediated N-Demethylation of Phenothiazines and Insecticides in the Presence of Linoleic Acid"],"prefix":"10.1016","volume":"21","author":[{"given":"C.G.","family":"Hover","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Kulkarni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/plac.2000.0547_RF1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1176\/ajp.153.5.592","article-title":"Pharmacologic management of psychiatric illness during pregnancy: dilemmas and guidelines","volume":"153","author":"Altshuler","year":"1996","journal-title":"Am J Psychiatry"},{"key":"10.1053\/plac.2000.0547_RF2","first-page":"228","article-title":"Psychotropic medications in pregnant women: treatment dilemmas","volume":"169","author":"Austin","year":"1998","journal-title":"Med J Australia"},{"key":"10.1053\/plac.2000.0547_RF3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1053\/plac.2000.0547_RF4","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/0006-291X(89)92237-7","article-title":"Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol","volume":"159","author":"Byczkowski","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/plac.2000.0547_RF5","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/0006-2952(83)90392-1","article-title":"Teratogenic effects of cholinergic insecticides in chick embryos-IV","volume":"32","author":"Byrne","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF6","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1021\/bi00329a004","article-title":"Inhibition of soybean lipoxygenase 1 by N-alkylhydroxylamines","volume":"24","author":"Clapp","year":"1985","journal-title":"Biochemistry"},{"key":"10.1053\/plac.2000.0547_RF7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/tera.1420500406","article-title":"Oxidative metabolism of aflatoxin B1 by lipoxygenase purified from human term placenta and intrauterine conceptual tissues","volume":"50","author":"Datta","year":"1994","journal-title":"Teratology"},{"key":"10.1053\/plac.2000.0547_RF8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0306-3623(94)00164-I","article-title":"Peroxidative xenobiotic oxidation by partially purified peroxidase and lipoxygenase from human fetal tissues at 10 weeks of gestation","volume":"26","author":"Datta","year":"1995","journal-title":"Gen Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF9","first-page":"196","article-title":"Co-oxidative metabolism of 4-aminobiphenyl by lipoxygenase from soybean and human term placenta","volume":"25","author":"Datta","year":"1997","journal-title":"Drug Metab Dispos"},{"key":"10.1053\/plac.2000.0547_RF10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0009-2797(86)90050-5","article-title":"Irreversible binding with biological macromolecules and effects in bacterial mutagenicity tests of the radical cation of promethazine and photoactivated promethazine. Comparison with chlorpromazine","volume":"57","author":"De Mol","year":"1986","journal-title":"Chem Biol Interact"},{"key":"10.1053\/plac.2000.0547_RF11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0009-2797(84)90084-X","article-title":"Irreversible binding of the chlorpromazine radical cation and of photoactivated chlorpromazine to biological macromolecules","volume":"52","author":"De Mol","year":"1984","journal-title":"Chem Biol Interact"},{"key":"10.1053\/plac.2000.0547_RF12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0010-440X(84)90019-1","article-title":"Antipsychotic drug use and birth defects: an epidemiologic reassessment","volume":"25","author":"Edlund","year":"1984","journal-title":"Comparative Psychiatry"},{"key":"10.1053\/plac.2000.0547_RF13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10408449891344173","article-title":"Xenobiotic-metabolizing cytochrome P450 enzymes in the human feto-placental unit: Role in intrauterine toxicity","volume":"28","author":"Hakkola","year":"1998","journal-title":"Crit Rev Toxicol"},{"key":"10.1053\/plac.2000.0547_RF14","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/tera.1420260210","article-title":"Do organophosphate insecticides inhibit the conversion of tryotophan to NAD+in ovo ?","volume":"26","author":"Henderson","year":"1982","journal-title":"Teratology"},{"key":"10.1053\/plac.2000.0547_RF15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/pest.1998.2352","article-title":"Lipoxygenase-mediated demethylation of pesticides","volume":"61","author":"Hu","year":"1998","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"10.1053\/plac.2000.0547_RF16","first-page":"3","article-title":"Purification and partial characterization of lipoxygenase with dual catalytic activities from human term placenta","volume":"293","author":"Joseph","year":"1993","journal-title":"Biochem J"},{"key":"10.1053\/plac.2000.0547_RF17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/00498259409043261","article-title":"Xenobiotic oxidation during early pregnancy in man: peroxidase catalyzed chemical oxidation in conceptal tissues","volume":"24","author":"Joseph","year":"1994","journal-title":"Xenobiotica"},{"key":"10.1053\/plac.2000.0547_RF18","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0890-6238(94)90046-9","article-title":"Bioactivation of benzo(a)pyrene-7,8-dihydrodiol catalyzed by lipoxygenase purified from human term placenta and conceptal tissues","volume":"8","author":"Joseph","year":"1994","journal-title":"Reprod Toxicol"},{"key":"10.1053\/plac.2000.0547_RF19","series-title":"Placental Toxicology","first-page":"197","article-title":"Placental enzymes: Cytochrome P450s and their significance","author":"Juchau","year":"1995"},{"key":"10.1053\/plac.2000.0547_RF20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0003-9861(91)90301-X","article-title":"Oxidation of chlorpromazine by methemoglobin in the presence of hydrogen peroxide: formation of chlorpromazine radical cation and its covalent binding to methemoglobin","volume":"284","author":"Kelder","year":"1991","journal-title":"Arch Biochem Biophys"},{"key":"10.1053\/plac.2000.0547_RF21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0009-2797(91)90049-D","article-title":"Metabolic activation of chlorpromazine by stimulated human polymorphonuclear leukocytes: induction of covalent binding of chlorpromazine to nucleic acids and proteins","volume":"79","author":"Kelder","year":"1991","journal-title":"Chem Biol Interact"},{"key":"10.1053\/plac.2000.0547_RF22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0167-4838(94)90238-0","article-title":"Kinetic evaluation of the oxidation of phenothiazine derivatives by methemoglobin and horseradish peroxidase in the presence of hydrogen peroxide. Implications for the reaction mechanisms","volume":"1205","author":"Kelder","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/plac.2000.0547_RF23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/00039896.1968.10665156","article-title":"Effect of organic phosphorus compounds and alkylating agents on the rat fetus","volume":"16","author":"Kimbrough","year":"1968","journal-title":"Arch Environ Health"},{"key":"10.1053\/plac.2000.0547_RF24","series-title":"Handbook of Developmental Toxicology","first-page":"383","article-title":"Role of xenobiotic metabolism in developmental toxicity, Chapter 12","author":"Kulkarni","year":"1996"},{"key":"10.1053\/plac.2000.0547_RF25","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0006-291X(88)80606-5","article-title":"Hydroperoxidase activity of lipoxygenase: Hydrogen peroxide-dependent oxidation of xenobiotics","volume":"155","author":"Kulkarni","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/plac.2000.0547_RF26","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3109\/00498259509061895","article-title":"Xenobiotic metabolism in humans during early pregnancy: Peroxidase-mediated oxidation and bioactivation of 2-aminofluorene","volume":"25","author":"Kulkarni","year":"1995","journal-title":"Xenobiotica"},{"key":"10.1053\/plac.2000.0547_RF27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1021\/jm00279a006","article-title":"Stability of some phenothiazine radicals","volume":"15","author":"Levy","year":"1972","journal-title":"J Med Chem"},{"key":"10.1053\/plac.2000.0547_RF28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-291X(88)90599-2","article-title":"Soybean lipoxygenase-catalyzed oxidations by linoleic acid hydroperoxide: Different reducing substrates and dehydrogenation of phenidone and BW 755C","volume":"151","author":"Mansuy","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/plac.2000.0547_RF29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0002-9378(76)90601-3","article-title":"An evaluation of the teratogenicity of certain antinauseant drugs","volume":"125","author":"Milkovich","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0547_RF30","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1016\/0006-2952(77)90288-X","article-title":"Kynurenine formamidase inhibition as a possible mechanism for certain teratogenic effects of organophosphorus and methylcarbamate insecticides in chicken embryos","volume":"26","author":"Moscioni","year":"1977","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF31","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0048-3575(91)90069-X","article-title":"Role of lipoxygenase in xenobiotic oxidation: Parathion metabolism catalyzed by highly purified soybean lipoxygenase","volume":"40","author":"Naidu","year":"1991","journal-title":"Pesticide Biochemistry and Physiology"},{"key":"10.1053\/plac.2000.0547_RF32","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0090-9556(25)08892-0","article-title":"Aldrin epoxidation: Catalytic potential of lipoxygenase coupled with linoleic oxidation","volume":"19","author":"Naidu","year":"1991","journal-title":"Drug Metabol Dispos"},{"key":"10.1053\/plac.2000.0547_RF33","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1042\/bj0550416","article-title":"The colorimetric estimation of formaldehyde by means of the Hantzsch reaction","volume":"55","author":"Nash","year":"1953","journal-title":"Biochem J"},{"key":"10.1053\/plac.2000.0547_RF34","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1749-6632.1988.tb38579.x","article-title":"Leukotriene B4, 6-keto-prostaglandin F1\u03b1, thromboxane B2and free arachidonic acid levels in human placental tissues","volume":"524","author":"Ogburn","year":"1988","journal-title":"Ann NY Acad Sci"},{"key":"10.1053\/plac.2000.0547_RF35","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/0006-2952(94)90260-7","article-title":"Enzymatic oxidation of phenothiazines by lipoxygenase\/H2O2system","volume":"47","author":"Perez-Gilabert","year":"1994","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0005-2760(94)90045-0","article-title":"Lipoxygenase catalyzed oxidation of chlorpromazine by hydrogen peroxide at acidic pH","volume":"1214","author":"Perez-Gilabert","year":"1994","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/plac.2000.0547_RF37","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0891-5849(97)00118-4","article-title":"Oxidation of aminopyrine by the hydroperoxidase activity of lipoxygenase: a new proposed mechanism of N-demethylation","volume":"23","author":"Perez-Gilabert","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/plac.2000.0547_RF38","series-title":"Basic and Clinical Pharmacology","first-page":"464","article-title":"Antipsychotic agents and lithium","author":"Potter","year":"1998"},{"key":"10.1053\/plac.2000.0547_RF39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0006-2952(76)90142-8","article-title":"Chicken embryo NAD levels lowered by teratogenic organophosphorus and methylcarbamate insecticides","volume":"25","author":"Proctor","year":"1976","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1520-6866(1999)19:3<211::AID-TCM4>3.0.CO;2-M","article-title":"N-demthylation of phenothiazines by lipoxygenase from soybean and human term placenta in the presence of hydrogen peroxide","volume":"19","author":"Rajadhyaksha","year":"1999","journal-title":"Teratog, Carcinog Mutagen"},{"key":"10.1053\/plac.2000.0547_RF41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1159\/000243945","article-title":"Lipoxygenase activity in rat embryos and its potential for xenobiotic oxidation","volume":"63","author":"Roy","year":"1993","journal-title":"Biol Neonate"},{"key":"10.1053\/plac.2000.0547_RF42","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/0006-2952(78)90335-0","article-title":"Relation of yolk sac membrane kynurenine formamidase inhibition to certain teratogenic effects of organophosphorus insecticides and of carbaryl and eserine in chicken embryos","volume":"27","author":"Seifert","year":"1978","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF43","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/0002-9378(77)90029-1","article-title":"Antenatal exposure to the phenothiazines in relation to congenital malformations, perinatal mortality rate, birth weight and intelligence quotient score","volume":"128","author":"Slone","year":"1977","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2000.0547_RF44","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1001\/archpsyc.1960.03590120014002","article-title":"Fetal damage due to ECT, insulin coma, chlorpromazine, or reserpine","volume":"2","author":"Sobel","year":"1960","journal-title":"Arch Gen Psychiatry"},{"key":"10.1053\/plac.2000.0547_RF45","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(74)92749-4","article-title":"Species differences in experimental teratogenesis by tranquilizing agents","volume":"1","author":"Szabo","year":"1974","journal-title":"Lancet"},{"key":"10.1053\/plac.2000.0547_RF46","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1111\/j.2042-7158.1998.tb06915.x","article-title":"N-dealkylation of chlorimipramine and chlorpromazine by rat liver microsomal cytochrome P450 isozymes","volume":"50","author":"Valoti","year":"1998","journal-title":"J Pharm Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF47","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0006-2952(90)90478-4","article-title":"Activation of chlorpromazine by the myeloperoxidase system of the human neutrophil","volume":"40","author":"Van Zyl","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/plac.2000.0547_RF48","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0003-2697(92)90101-C","article-title":"Determination of the molar absorptivities of phenothiazine cation radicals generated by oxidation with hydrogen peroxide\/peroxidase","volume":"202","author":"Vazquez","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1053\/plac.2000.0547_RF49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/tera.1420100212","article-title":"Induction of cleft palate in mice by tranquilizers and barbituates","volume":"10","author":"Walker","year":"1974","journal-title":"Teratology"},{"key":"10.1053\/plac.2000.0547_RF50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/(SICI)1520-6866(1997)17:3<139::AID-TCM5>3.0.CO;2-I","article-title":"Oxidation of phenothiazines by human term placental peroxidase in non-smokers","volume":"17","author":"Yang","year":"1997","journal-title":"Teratog, Carcinog Mutagen"},{"key":"10.1053\/plac.2000.0547_RF51","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1099-0461(1998)12:3<175::AID-JBT6>3.0.CO;2-I","article-title":"N-dealkylation of aminopyrine catalyzed by soybean lipoxygenase in the presence of hydrogen peroxide","volume":"12","author":"Yang","year":"1998","journal-title":"J Biochem Mol Toxicol"},{"key":"10.1053\/plac.2000.0547_RF52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1995.1040","article-title":"Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice","volume":"131","author":"Yu","year":"1995","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400400905472?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400400905472?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:26:50Z","timestamp":1758907610000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400400905472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":52,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0143400400905472"],"URL":"https:\/\/doi.org\/10.1053\/plac.2000.0547","relation":{},"ISSN":["0143-4004"],"issn-type":[{"type":"print","value":"0143-4004"}],"subject":[],"published":{"date-parts":[[2000,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human Term Placental Lipoxygenase-Mediated N-Demethylation of Phenothiazines and Insecticides in the Presence of Linoleic Acid","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/plac.2000.0547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Harcourt Publishers Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}