{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:17:49Z","timestamp":1791328669897,"version":"4.3.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2002,4]]},"DOI":"10.1053\/plac.2002.0814","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:24:48Z","timestamp":1027668288000},"page":"S80-S86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"special_numbering":"SA","title":["Role of Leptin in Pregnancy\u2014A Review"],"prefix":"10.1016","volume":"23","author":[{"given":"N.","family":"Sagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kakui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Korita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Takemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Nuamah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Masuzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/plac.2002.0814_RF1","series-title":"Maternal-fetal medicine, 4th edn","first-page":"122","article-title":"Maternal nutrition","author":"Abrams","year":"1999"},{"key":"10.1053\/plac.2002.0814_RF2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.physiol.62.1.413","article-title":"Leptin","volume":"62","author":"Ahima","year":"2000","journal-title":"Annu Rev Physiol"},{"key":"10.1053\/plac.2002.0814_RF3","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1172\/JCI8341","article-title":"Pathophysiological role of leptin in obesity-related hypertension","volume":"105","author":"Aizawa-Abe","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1053\/plac.2002.0814_RF4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1530\/ror.0.0050018","article-title":"Placental leptin","volume":"5","author":"Ashworth","year":"2000","journal-title":"Rev Reprod"},{"key":"10.1053\/plac.2002.0814_RF5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/plac.1999.0431","article-title":"Leptin receptor in human term placenta: in situ hybridization and immunohistochemical localization","volume":"20","author":"Bodner","year":"1999","journal-title":"Placenta"},{"key":"10.1053\/plac.2002.0814_RF6","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"key":"10.1053\/plac.2002.0814_RF7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0140-6736(96)03173-X","article-title":"Decreased cerebrospinal-fluid\/serum leptin ratio in obesity: a possible mechanism for leptin resistance","volume":"348","author":"Caro","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/plac.2002.0814_RF8","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0396-318","article-title":"Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin","volume":"12","author":"Chehab","year":"1996","journal-title":"Nat Genet"},{"key":"10.1053\/plac.2002.0814_RF9","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nm0596-585","article-title":"Novel B219\/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction","volume":"2","author":"Cioffi","year":"1996","journal-title":"Nat Med"},{"key":"10.1053\/plac.2002.0814_RF10","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1073\/pnas.93.9.4096","article-title":"Identification of the promoter of the mouse obese gene","volume":"93","author":"De la Brousse","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0814_RF11","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1006\/bbrc.1997.7869","article-title":"Identification of the human leptin 5\u2032-flanking sequences involved in the trophoblast-specific translation","volume":"241","author":"Ebihara","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/plac.2002.0814_RF12","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.2337\/diabetes.50.6.1440","article-title":"Transgenic overexpression of leptin rescues insulin resistance and diabetes in a mouse model of lipoatrophic diabetes","volume":"50","author":"Ebihara","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0814_RF13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1046\/j.1464-5491.1999.00122.x","article-title":"Relative hypoleptinaemia in women with mild gestational diabetes mellitus","volume":"16","author":"Festa","year":"1999","journal-title":"Diabet Med"},{"key":"10.1053\/plac.2002.0814_RF14","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/35053251","article-title":"The missing link with obesity?","volume":"409","author":"Flier","year":"2001","journal-title":"Nature"},{"key":"10.1053\/plac.2002.0814_RF15","doi-asserted-by":"crossref","first-page":"30546","DOI":"10.1074\/jbc.272.48.30546","article-title":"Hyperleptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor","volume":"272","author":"Gavrilova","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0814_RF16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene","volume":"269","author":"Halaas","year":"1995","journal-title":"Science"},{"key":"10.1053\/plac.2002.0814_RF17","doi-asserted-by":"crossref","first-page":"28887","DOI":"10.1074\/jbc.270.48.28887","article-title":"The mouse obese gene: Genomic organization, promoter activity, and activation by CCAAT\/enhancer-binding protein \u03b1","volume":"270","author":"He","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0814_RF18","first-page":"1020","article-title":"Expression of placental leptin and leptin receptor transcripts in early pregnancy and at term","volume":"92","author":"Henson","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1053\/plac.2002.0814_RF19","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1095\/biolreprod63.5.1219","article-title":"Leptin in pregnancy","volume":"63","author":"Henson","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1053\/plac.2002.0814_RF20","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1073\/pnas.94.20.11073","article-title":"Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta","volume":"94","author":"Hoggard","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0814_RF21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/plac.2001.0628","article-title":"Leptin secretion to both the maternal and fetal circulation in the ex vivo perfused human term placenta","volume":"22","author":"Hoggard","year":"2001","journal-title":"Placenta"},{"key":"10.1053\/plac.2002.0814_RF22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(99)00126-4","article-title":"Current concepts concerning the role of leptin in reproductive function","volume":"157","author":"Holness","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/plac.2002.0814_RF23","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1073\/pnas.93.2.873","article-title":"Transcriptional activation of the mouse obese (ob) gene by CCAAT\/enhancer binding protein \u03b1","volume":"93","author":"Hwang","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0814_RF24","first-page":"4144","article-title":"Expression of functional leptin receptors in the human ovary","volume":"82","author":"Karlsson","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0814_RF25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-0115(00)00147-6","article-title":"Dynamic regulation of leptin entry into brain by the blood-brain barrier","volume":"92","author":"Kastin","year":"2000","journal-title":"Regul Pept"},{"key":"10.1053\/plac.2002.0814_RF26","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1210\/endo.141.7.7536","article-title":"In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: Overlapping but distinct pathways from insulin","volume":"141","author":"Kim","year":"2000","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2002.0814_RF27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/molehr\/6.8.763","article-title":"Placental leptin in normal, diabetic and fetal growth-retarded pregnancies","volume":"6","author":"Lea","year":"2000","journal-title":"Mol Hum Reprod"},{"key":"10.1053\/plac.2002.0814_RF28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2337\/diabetes.47.5.847","article-title":"Overexpression of placental leptin in diabetic pregnancy\u2014A critical role for insulin","volume":"47","author":"Lepercq","year":"1998","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0814_RF29","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1210\/jcem.86.6.7529","article-title":"Prenatal leptin production: evidence that fetal adipose tissue produces leptin","volume":"86","author":"Lepercq","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0814_RF30","first-page":"4298","article-title":"Leptin production and release in the dually in vitro perfused human placenta","volume":"85","author":"Linnemann","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0814_RF31","doi-asserted-by":"crossref","first-page":"9034","DOI":"10.1073\/pnas.92.20.9034","article-title":"Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes","volume":"92","author":"MacDougald","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0814_RF32","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nm0997-1029","article-title":"Nonadipose tissue production of leptin: Leptin as a novel placenta-derived hormone in humans","volume":"3","author":"Masuzaki","year":"1997","journal-title":"Nat Med"},{"key":"10.1053\/plac.2002.0814_RF33","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diabetes.48.8.1615","article-title":"Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation","volume":"48","author":"Masuzaki","year":"1999","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0814_RF34","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood.V89.5.1507","article-title":"Leptin stimulate fetal and adult erythroid and myeloid development","volume":"89","author":"Mikhail","year":"1997","journal-title":"Blood"},{"key":"10.1053\/plac.2002.0814_RF35","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.1073\/pnas.93.11.5507","article-title":"The adipocyte specific transcription factor C\/EBP\u03b1 modulates human ob gene expression","volume":"93","author":"Miller","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0814_RF36","first-page":"3225","article-title":"Augmented placental production of leptin in preeclampsia: possible involvement of placental hypoxia","volume":"83","author":"Mise","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0814_RF37","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.2337\/diabetes.48.9.1822","article-title":"Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin","volume":"48","author":"Ogawa","year":"1999","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0814_RF38","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1126\/science.7624776","article-title":"Effects of the obese gene product on body weight regulation in ob\/ob mice","volume":"269","author":"Pelleymounter","year":"1995","journal-title":"Science"},{"key":"10.1053\/plac.2002.0814_RF39","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1006\/bbrc.1998.9649","article-title":"PMA inhibits both spontaneous and glucocorticoid-mediated leptin secretion by human omental adipose tissue explants in vitro","volume":"252","author":"Pineiro","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/plac.2002.0814_RF40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1042\/bst0290068","article-title":"Leptin and its role in pregnancy and fetal development-an overview","volume":"29","author":"Reitman","year":"2001","journal-title":"Biochem Soc Trans"},{"key":"10.1053\/plac.2002.0814_RF41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0014-5793(95)01485-3","article-title":"Regulation of ob gene mRNA levels in cultured adipocytes","volume":"379","author":"Rentsch","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1053\/plac.2002.0814_RF42","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/S0140-6736(05)63940-2","article-title":"Leptin production by hydatidiform mole","volume":"350","author":"Sagawa","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/plac.2002.0814_RF43","article-title":"Placental protein and fetal growth","author":"Sagawa","year":"2001","journal-title":"Proceedings of 12th Fukuoka International Symposium on Perinatal Medicine, Fukuoka, Japan, 2001"},{"key":"10.1053\/plac.2002.0814_RF44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.HYP.31.1.409","article-title":"Chronic leptin infusion increases arterial pressure","volume":"31","author":"Shek","year":"1998","journal-title":"Hypertension"},{"key":"10.1053\/plac.2002.0814_RF45","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1126\/science.281.5383.1683","article-title":"Biological action of leptin as an angiogenic factor","volume":"281","author":"Sierra-Honigmann","year":"1998","journal-title":"Science"},{"key":"10.1053\/plac.2002.0814_RF46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"10.1053\/plac.2002.0814_RF47","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/0092-8674(95)90151-5","article-title":"Identification and expression cloning of a leptin receptor, OB-R","volume":"83","author":"Tartaglia","year":"1995","journal-title":"Cell"},{"key":"10.1053\/plac.2002.0814_RF48","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1210\/endo.142.7.8227","article-title":"Leptin administration prevents spontaneous gestational diabetes in heterozygous Leprdb\/+ mice: Effects on placental leptin and fetal growth","volume":"142","author":"Yamashita","year":"2001","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2002.0814_RF49","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0002-9378(98)70525-3","article-title":"A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth","volume":"178","author":"Yura","year":"1998","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/plac.2002.0814_RF50","first-page":"3609","article-title":"Augmentation of leptin synthesis and secretion through activation of protein kinases A and C in cultured human trophoblastic cells","volume":"83","author":"Yura","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0814_RF51","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1172\/JCI8353","article-title":"Accelarated puberty and late onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin","volume":"105","author":"Yura","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1053\/plac.2002.0814_RF52","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400402908143?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400402908143?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:27:49Z","timestamp":1758907669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400402908143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":52,"alternative-id":["S0143400402908143"],"URL":"https:\/\/doi.org\/10.1053\/plac.2002.0814","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of Leptin in Pregnancy\u2014A Review","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/plac.2002.0814","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}