{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T02:22:26Z","timestamp":1776133346726,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Placenta"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1053\/plac.2002.0905","type":"journal-article","created":{"date-parts":[[2003,3,25]],"date-time":"2003-03-25T21:15:53Z","timestamp":1048626953000},"page":"385-391","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Leptin Induces Mitogenic Effect on Human Choriocarcinoma Cell Line (JAr) via MAP Kinase Activation in a Glucose-dependent Fashion"],"prefix":"10.1016","volume":"24","author":[{"given":"G","family":"Bifulco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Trencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.A","family":"Tommaselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Miele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"di Carlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Beguinot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Nappi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/plac.2002.0905_RF1","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1210\/endo-107-6-2121","article-title":"Epidermal growth factor stimulates production of progesterone in cultured human choriocarcinoma cells","volume":"107","author":"Bahn","year":"1980","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2002.0905_RF2","doi-asserted-by":"crossref","first-page":"24306","DOI":"10.1074\/jbc.M202962200","article-title":"Glucose regulates insulin mitogenic effect by modulating SHP-2 activation and localization in JAr cells","volume":"277","author":"Bifulco","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF3","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1074\/jbc.M007439200","article-title":"Divergent roles of SHP-2 in ERK activation by leptin receptors","volume":"276","author":"Bj\u00f8rb\u00e6k","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF4","doi-asserted-by":"crossref","first-page":"32686","DOI":"10.1074\/jbc.272.51.32686","article-title":"Divergent signaling capacities of the long and short isoforms of the leptin receptor","volume":"272","author":"Bj\u00f8rb\u00e6k","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF5","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1210\/endo.142.9.8391","article-title":"Dissociation between insulin-mediated signaling pathways and biological effects in placental cells: role of protein kinase B and MAPK phosphorylation","volume":"142","author":"Boileau","year":"2001","journal-title":"Endocrinology"},{"key":"10.1053\/plac.2002.0905_RF6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/humrep\/12.suppl_1.26","article-title":"Obesity and reproduction","volume":"12","author":"Bray","year":"1997","journal-title":"Hum Reprod"},{"key":"10.1053\/plac.2002.0905_RF7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/plac.2002.0905_RF8","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.2337\/diabetes.48.12.2454","article-title":"Evidence that elevated glucose causes altered gene expression, apoptosis, and neural tube defects in a mouse model of diabetic pregnancy","volume":"48","author":"Fine","year":"1999","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0905_RF9","doi-asserted-by":"crossref","first-page":"11073","DOI":"10.1073\/pnas.94.20.11073","article-title":"Leptin and leptin receptor mRNA and protein expression in the murine fetus and placenta","volume":"30","author":"Hoggard","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0905_RF10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(99)00126-4","article-title":"Current concepts concerning the role of leptin in reproductive function","volume":"25","author":"Holness","year":"1999","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/plac.2002.0905_RF11","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M208284200","article-title":"U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells","author":"Hotokezaka","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/BF00400228","article-title":"Differential modulation of mitogenic and metabolic actions of insulin-like growth factor I in rat glomerular mesangial cells in high glucose culture","volume":"36","author":"Kikkawa","year":"1993","journal-title":"Diabetologia"},{"key":"10.1053\/plac.2002.0905_RF13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0143-4004(97)90097-7","article-title":"Placental weight to birthweight ratio is increased in mild gestational glucose intolerance","volume":"18","author":"Lao","year":"1997","journal-title":"Placenta"},{"key":"10.1053\/plac.2002.0905_RF14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/379632a0","article-title":"Abnormal splicing of the leptin receptor in diabetic mice","volume":"379","author":"Lee","year":"1996","journal-title":"Nature"},{"key":"10.1053\/plac.2002.0905_RF15","doi-asserted-by":"crossref","first-page":"C853","DOI":"10.1152\/ajpcell.00331.2001","article-title":"Proadipogenic effect of leptin on rat preadipocytes in vitro: activation of MAPK and STAT3 signaling pathways","volume":"282","author":"Machinal-Quelin","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1053\/plac.2002.0905_RF16","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/nm0997-1029","article-title":"Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans","volume":"3","author":"Masuzaki","year":"1997","journal-title":"Nat Med"},{"key":"10.1053\/plac.2002.0905_RF17","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1074\/jbc.274.5.3094","article-title":"Differential role of insulin receptor substrate IRS-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg 1152\u2192Gln insulin receptor","volume":"274","author":"Miele","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2337\/diabetes.49.6.981","article-title":"High glucose and glucosamine induce insulin resistance via different mechanisms in 3T3-L1 adipocytes","volume":"49","author":"Nelson","year":"2000","journal-title":"Diabetes"},{"key":"10.1053\/plac.2002.0905_RF19","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0002-9440(10)64069-2","article-title":"Hyperglycemia-induced vasculopathy in the murine conceptus is mediated via reductions of VEGF-A expression and VEGF receptor activation","volume":"158","author":"Pinter","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1053\/plac.2002.0905_RF20","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1210\/jcem.82.5.3935","article-title":"Levels of leptin in maternal serum, amniotic fluid, and arterial and venous cord blood: relation to neonatal and placental weight","volume":"82","author":"Schubring","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/plac.2002.0905_RF21","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1073\/pnas.95.4.1511","article-title":"A unique glucose-dependent apoptotic pathway induced by c-Myc","volume":"95","author":"Shim","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/plac.2002.0905_RF22","doi-asserted-by":"crossref","first-page":"12897","DOI":"10.1074\/jbc.272.20.12897","article-title":"Leptin induces mitogen-activated protein kinase-dependent proliferation of C3H10T1\/2 cells","volume":"272","author":"Takahashi","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000052884","article-title":"Maternal plasma leptin levels and their relationship to insulin and glucose in gestational-onset diabetes","volume":"51","author":"Vitoratos","year":"2001","journal-title":"Gynecol Obstet Invest"},{"key":"10.1053\/plac.2002.0905_RF24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s001250051601","article-title":"Hyperglycaemia in vitro alters the proliferation and mitochondrial activity of the choriocarcinoma cell lines BeWo, JAR and JEG-3 as models for human first-trimester trophoblast","volume":"44","author":"Weiss","year":"2001","journal-title":"Diabetologia"},{"key":"10.1053\/plac.2002.0905_RF25","doi-asserted-by":"crossref","first-page":"23703","DOI":"10.1074\/jbc.272.38.23703","article-title":"Glucose increases both the plasma membrane number and phosphorylation of insulin-like growth factor II\/mannose 6-phosphate receptors","volume":"272","author":"Zhang","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/plac.2002.0905_RF26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"}],"container-title":["Placenta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400402909057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143400402909057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:29:06Z","timestamp":1758907746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143400402909057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0143400402909057"],"URL":"https:\/\/doi.org\/10.1053\/plac.2002.0905","relation":{},"ISSN":["0143-4004"],"issn-type":[{"value":"0143-4004","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin Induces Mitogenic Effect on Human Choriocarcinoma Cell Line (JAr) via MAP Kinase Activation in a Glucose-dependent Fashion","name":"articletitle","label":"Article Title"},{"value":"Placenta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/plac.2002.0905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}