{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:57:09Z","timestamp":1791280629794,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":4216,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[2002,1]]},"DOI":"10.1053\/rmed.2001.1215","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T10:55:08Z","timestamp":1032432908000},"page":"52-58","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Eosinophilic airway inflammation as an underlying mechanism of undiagnosed prolonged cough in primary healthcare patients"],"prefix":"10.1053","volume":"96","author":[{"given":"P.","family":"RYTIL\u00c4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"METSO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"PET\u00c4YS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"SOHLMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"TY\u00d6LAHTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"KOHONEN-JALONEN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"KIVINIEMI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"HAAHTELA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/rmed.2001.1215_RF1","series-title":"NHLBI\/WHO Workshop Report","article-title":"Global Strategy for Asthma Management and Prevention","author":"Sheffer","year":"1995"},{"key":"10.1053\/rmed.2001.1215_RF2","first-page":"1","volume":"26","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/rmed.2001.1215_RF3","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/S0140-6736(89)92801-8","article-title":"Chronic cough: eosinophilic inflammation without asthma","volume":"i","author":"Gibson","year":"1989","journal-title":"Lancet"},{"key":"10.1053\/rmed.2001.1215_RF4","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1164\/ajrccm.156.1.9605044","article-title":"A systemic evaluation of mechanisms in chronic cough","volume":"156","author":"Carney","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/rmed.2001.1215_RF5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm.160.2.9810100","article-title":"Eosinophilic bronchitis is an important cause of chronic cough","volume":"160","author":"Brightling","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/rmed.2001.1215_RF6","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1183\/09031936.00.16582400","article-title":"Airway inflammation in patients with symptoms indicating asthma but with normal lung function","volume":"16","author":"Rytil\u00e4","year":"2000","journal-title":"Eur Resp J"},{"key":"10.1053\/rmed.2001.1215_RF7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0954-6111(95)90120-5","article-title":"The importance of inflammation in early asthma","volume":"89","author":"Haahtela","year":"1995","journal-title":"Respir Med"},{"key":"10.1053\/rmed.2001.1215_RF8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2222.2000.00740.x","article-title":"Eosinophilic bronchitis\u2014what is it and why is it important","volume":"30","author":"Brightling","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/rmed.2001.1215_RF9","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1056\/NEJM199409153311103","article-title":"Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma","volume":"331","author":"Haahtela","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1053\/rmed.2001.1215_RF10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/thx.52.2008.S1.5","volume":"52","year":"1997","journal-title":"Thorax"},{"key":"10.1053\/rmed.2001.1215_RF11","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1164\/ajrccm.158.5.9804028","article-title":"Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis","volume":"158","author":"Pizzichini","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/rmed.2001.1215_RF12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1365-2222.1995.tb01017.x","article-title":"Chronic cough with eosinophilic bronchitis: examination for variable airway obstruction and response to corticosteroids","volume":"25","author":"Gibson","year":"1995","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/rmed.2001.1215_RF13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0091-6749(97)70082-4","article-title":"Measuring airway inflammation in asthma: eosinophils and eosinophilic cationic protein in induced sputum compared with peripheral blood","volume":"99","author":"Pizzichini","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/rmed.2001.1215_RF14","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1164\/ajrccm.154.2.8756799","article-title":"Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid phase measurements","volume":"154","author":"Pizzichini","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/rmed.2001.1215_RF15","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1183\/09031936.96.09122441","article-title":"Repeatability of cellular and soluble markers of inflammation in induced sputum from patients with asthma","volume":"9","author":"i\u0144t Veen","year":"1996","journal-title":"Eur Resp J"},{"key":"10.1053\/rmed.2001.1215_RF16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1053\/rmed.2000.0970","article-title":"Granulocyte markers in induced sputum in patients with respiratory disorders and healthy persons obtained by two sputum processing methods","volume":"95","author":"Metso","year":"2001","journal-title":"Respir Med"},{"key":"10.1053\/rmed.2001.1215_RF17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1183\/09041950.005s1693","article-title":"Lung volumes and forced ventilatory flows. Report of the Working Party on Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society","volume":"6","author":"Quanjer","year":"1993","journal-title":"Eur Resp J"},{"key":"10.1053\/rmed.2001.1215_RF18","first-page":"1","article-title":"Skin tests used in type I-allergy testing. Position paper","volume":"44","author":"Dreborg","year":"1989","journal-title":"Allergy"},{"key":"10.1053\/rmed.2001.1215_RF19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1398-9995.1998.tb03904.x","article-title":"Respiratory symptoms, bronchial responsiveness, and cellular characteristics of induced sputum in elite swimmers","volume":"53","author":"Helenius","year":"1998","journal-title":"Allergy"},{"key":"10.1053\/rmed.2001.1215_RF20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000193861","article-title":"Sputum eosinophilia in chronic bronchitis and asthma","volume":"35","author":"O'Connell","year":"1978","journal-title":"Respiration"},{"key":"10.1053\/rmed.2001.1215_RF21","first-page":"1","article-title":"Reference values for spirometric, pulmonary diffusing capacity and body plethysmographic studies","volume":"42","author":"Viljanen","year":"1982","journal-title":"Scan J Clin Lab Invest"},{"key":"10.1053\/rmed.2001.1215_RF22","first-page":"S77","volume":"152","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1053\/rmed.2001.1215_RF23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1067\/mai.2000.108307","article-title":"Monitoring of patients with asthma: An evidence-based approach","volume":"106","author":"Gibson","year":"2000","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/rmed.2001.1215_RF24","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1046\/j.1365-2222.1997.890900.x","article-title":"Comparison of inflammatory cell counts in asthma: induced sputum versus bronchoalveolar lavage and bronchial biopsies","volume":"27","author":"Grootendorst","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/rmed.2001.1215_RF25","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/ajrccm\/141.3.640","article-title":"Chronic cough: the spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy","volume":"141","author":"Irwin","year":"1990","journal-title":"Am Rev Resp Dis"},{"key":"10.1053\/rmed.2001.1215_RF26","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1136\/bmj.316.7140.1286","article-title":"Identifying asthma and chronic obstructive pulmonary disease in patients with persistent cough presenting to general practitioners: descriptive study","volume":"316","author":"Thiadens","year":"1998","journal-title":"BMJ"},{"key":"10.1053\/rmed.2001.1215_RF27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2222.1996.tb00593.x","article-title":"Bronchial inflammation and the common cold: a comparison of atopic and non-atopic individuals","volume":"26","author":"Trigg","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1053\/rmed.2001.1215_RF28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1136\/thx.51.5.503","article-title":"Interrelationships between diagnosed asthma, asthma-like symptoms, and abnormal airway behaviour in adolescence: the Odense Schoolchild Study","volume":"51","author":"Siersted","year":"1996","journal-title":"Thorax"},{"key":"10.1053\/rmed.2001.1215_RF29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1398-9995.1996.tb04597.x","article-title":"Can early asthma be confirmed with laboratory tests?","volume":"51","author":"Metso","year":"1996","journal-title":"Allergy"},{"key":"10.1053\/rmed.2001.1215_RF30","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1016\/S0091-6749(98)70040-5","article-title":"Induced sputum and response to glucocorticoids","volume":"102","author":"Hargreave","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/rmed.2001.1215_RF31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1378\/chest.108.1.55","article-title":"Adverse effects of eosinophilia and smoking on the natural history of newly diagnosed chronic bronchitis","volume":"108","author":"Lebowitz","year":"1995","journal-title":"Chest"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611101912156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611101912156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T09:57:49Z","timestamp":1760608669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611101912156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,1]]}},"alternative-id":["S0954611101912156"],"URL":"https:\/\/doi.org\/10.1053\/rmed.2001.1215","relation":{},"ISSN":["0954-6111"],"issn-type":[{"value":"0954-6111","type":"print"}],"subject":[],"published":{"date-parts":[[2002,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eosinophilic airway inflammation as an underlying mechanism of undiagnosed prolonged cough in primary healthcare patients","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/rmed.2001.1215","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 Elsevier Science Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}