{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:38:08Z","timestamp":1777181888706,"version":"3.51.4"},"reference-count":241,"publisher":"Frontline Medical Communications, Inc.","issue":"3","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Cutaneous Medicine and Surgery"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1053\/sder.2001.28209","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T07:46:06Z","timestamp":1170488766000},"page":"166-183","source":"Crossref","is-referenced-by-count":43,"title":["Safety issues in isotretinoin therapy"],"prefix":"10.12788","volume":"20","author":[{"given":"Nathan","family":"Hanson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sancy","family":"Leachman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"5043","reference":[{"key":"10.1053\/sder.2001.28209_bib1","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/S0140-6736(80)92273-4","article-title":"13-CIS retinoic acid and acne","volume":"2","author":"Jones","year":"1980","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib2","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/S0140-6736(76)91685-8","article-title":"Treatment of lamellar ichthyosis and other keratinising dermatoses with an oral synthetic retinoid","volume":"2","author":"Peck","year":"1976","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJM197902153000701","article-title":"Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid","volume":"300","author":"Peck","year":"1979","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/S0190-9622(98)70049-0","article-title":"p54 where are you?","volume":"39","author":"Bernhard","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/S0899-9007(00)00436-6","article-title":"Recent advances in the use of vitamin A (retinoids) in the prevention and treatment of cancer","volume":"16","author":"Niles","year":"2000","journal-title":"Nutrition"},{"key":"10.1053\/sder.2001.28209_bib6","first-page":"3845","article-title":"Effect of 13-cis-retinoic acid on serum prostate-specific antigen levels in patients with recurrent prostate cancer after radical prostatectomy","volume":"6","author":"Shalev","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1053\/sder.2001.28209_bib7","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/S0190-9622(98)70451-7","article-title":"Retinoid chemoprevention in the high risk patient","volume":"39","author":"DiGiovanna","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib8","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM198806233182501","article-title":"Prevention of skin cancer in xeroderma pigmentosum with the use of oral isotretinoin","volume":"318","author":"Kraemer","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1346-8138.1992.tb03766.x","article-title":"Chemoprevention of skin cancer in xeroderma pigmentosum","volume":"19","author":"Kraemer","year":"1992","journal-title":"J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib10","doi-asserted-by":"crossref","first-page":"499","DOI":"10.7326\/0003-4819-107-4-499","article-title":"Treatment of advanced squamous cell carcinoma of the skin with isotretinoin","volume":"107","author":"Lippman","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1053\/sder.2001.28209_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/jnci\/84.4.235","article-title":"13-cis-retinoic acid and interferon alpha-2a: Effective combination therapy for advanced squamous cell carcinoma of the skin","volume":"84","author":"Lippman","year":"1992","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/sder.2001.28209_bib12","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/tera.1420330315","article-title":"Teratogen update: Vitamin A congeners","volume":"33","author":"Rosa","year":"1986","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib13","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1056\/NEJM198510033131401","article-title":"Retinoic acid embryopathy","volume":"313","author":"Lammer","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib14","first-page":"68A","article-title":"Risk for major malformation among human fetuses exposed to isotretinoin (13-cis-retinoic acid)","volume":"35","author":"Lammer","year":"1987","journal-title":"Tetratology"},{"key":"10.1053\/sder.2001.28209_bib15","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0190-9622(92)70088-W","article-title":"Epidemiology of isotretinoin exposure during pregnancy","volume":"26","author":"Dai","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib16","first-page":"43","article-title":"Teratogenicity of retinoids: A case and review of the literature","volume":"22","author":"Heckel","year":"1993","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"10.1053\/sder.2001.28209_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/tera.1420470108","article-title":"Importance of early exposure to 13-cis retinoic acid to induce teratogencity in the cynomolgus monkey","volume":"47","author":"Korte","year":"1993","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/tera.1420420310","article-title":"Induction of malformations in the cynomolgus monkey with 13-cis retinoic acid","volume":"42","author":"Hummler","year":"1990","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib19","unstructured":"Roche Laboratories Inc, data on file"},{"key":"10.1053\/sder.2001.28209_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJM199507133330206","article-title":"A pregnancy-prevention program in women of childbearing age receiving isotretinoin","volume":"333","author":"Mitchell","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib21","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0190-9622(82)70054-4","article-title":"Toxicology, carcinogenicity, and teratogenicity of some orally administered retinoids","volume":"6","author":"Kamm","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib22","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1001\/jama.1984.03340480049027","article-title":"The isotretinoin teratogen syndrome","volume":"251","author":"Benke","year":"1984","journal-title":"JAMA"},{"key":"10.1053\/sder.2001.28209_bib23","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0140-6736(84)92866-6","article-title":"Isotretinoin dysmorphic syndrome","volume":"1","author":"Braun","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib24","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0140-6736(84)91954-8","article-title":"Isotretinoin teratogenicity","volume":"1","author":"Hill","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0140-6736(83)90538-X","article-title":"Teratogenicity of isotretinoin","volume":"2","author":"Rosa","year":"1983","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib26","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0140-6736(85)90438-6","article-title":"Isotretinoin and reduction deformities","volume":"2","author":"McBride","year":"1985","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib27","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/tera.1420440602","article-title":"Limb reduction defects in humans associated with prenatal isotretinoin exposure","volume":"44","author":"Rizzo","year":"1991","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib28","first-page":"239","article-title":"A case of isotretinoin embryopathy with bilateral anotia and Taussig-Bing malformation","volume":"42","author":"Ceviz","year":"2000","journal-title":"Turk J Pediatr"},{"key":"10.1053\/sder.2001.28209_bib29","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1001\/archotol.125.12.1385","article-title":"Multiple temporal bone anomalies in isotretinoin syndrome: A temporal bone histopathologic case report","volume":"125","author":"Ishijima","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1053\/sder.2001.28209_bib30","first-page":"400","article-title":"Vestibular dysfunction in a child with embryonic exposure to accutane","volume":"15","author":"Westerman","year":"1994","journal-title":"Am J Otol"},{"key":"10.1053\/sder.2001.28209_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0890-6238(93)90273-A","article-title":"Neurobehavioral teratology of isotretinoin","volume":"7","author":"Adams","year":"1993","journal-title":"Reprod Toxicol"},{"key":"10.1053\/sder.2001.28209_bib32","first-page":"193","article-title":"Isotretinoin-induced craniofacial malformations in humans and hamsters","volume":"Suppl 2","author":"Willhite","year":"1986","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1053\/sder.2001.28209_bib33","first-page":"263","article-title":"Thymic hypoplasia associated with isotretinoin embryopathy","volume":"141","author":"Cohen","year":"1987","journal-title":"Am J Dis Child"},{"key":"10.1053\/sder.2001.28209_bib34","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1080\/107710496175435","article-title":"Retinoic acid embryopathy: Case report and review of literature","volume":"16","author":"Coberly","year":"1996","journal-title":"Pediatr Pathol Lab Med"},{"key":"10.1053\/sder.2001.28209_bib35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0091-3057(96)00284-5","article-title":"Similarities in genetic mental retardation and neurotenratogenic syndromes","volume":"55","author":"Adams","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1053\/sder.2001.28209_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0890-6238(98)00059-8","article-title":"Isotretinoin alters morphology, polarity, and motility of neural crest cells in culture","volume":"13","author":"Orris","year":"1999","journal-title":"Reprod Toxicol"},{"key":"10.1053\/sder.2001.28209_bib37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/tera.1420460602","article-title":"Avian model for 13-cis-retinoic acid embryopathy: Morphological characterization of ventricular septal defects","volume":"46","author":"Hart","year":"1992","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib38","first-page":"205","article-title":"Retinoic acid inhibits migration of cranial neural crest cells in the cultured mouse embryo","volume":"7","author":"Pratt","year":"1987","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1053\/sder.2001.28209_bib39","first-page":"13","article-title":"Altered gene expression in murine branchial arches following in utero exposure to retinoic acid","volume":"15","author":"Taylor","year":"1995","journal-title":"J Craniofac Genet Dev Biol"},{"key":"10.1053\/sder.2001.28209_bib40","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1002\/tera.1420370602","article-title":"Retinoic-acid-induced limb malformations resulting from apical ectodermal ridge cell death","volume":"37","author":"Sulik","year":"1988","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dev.103.Supplement.213","article-title":"Teratogens and craniofacial malformations: Relationships to cell death","volume":"103","author":"Sulik","year":"1988","journal-title":"Development"},{"key":"10.1053\/sder.2001.28209_bib42","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1600-0684.1998.tb00073.x","article-title":"Effects of 13-cis-retinoic acid on hindbrain and craniofacial morphogenesis in long-tailed macaques (Macaca fascicularis)","volume":"27","author":"Makori","year":"1998","journal-title":"J Med Primatol"},{"key":"10.1053\/sder.2001.28209_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(95)03681-4","article-title":"Differential teratogenic response of mouse embryos to receptor selective analogs of retinoic acid","volume":"100","author":"Kochhar","year":"1996","journal-title":"Chem Biol Interact"},{"key":"10.1053\/sder.2001.28209_bib44","first-page":"511","article-title":"Isotretinoin (RoAccutane) embryopathy: A case report","volume":"24","author":"Pilorget","year":"1995","journal-title":"J Gynecol Obstet Biol Reprod"},{"key":"10.1053\/sder.2001.28209_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tera.1420440102","article-title":"Recommendations for isotretinoin use in women of childbearing potential","volume":"44","author":"Anonymous","year":"1991","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib46","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/archderm.1989.01670150052005","article-title":"Safety of pregnancy after discontinuation of isotretinoin","volume":"125","author":"Dai","year":"1989","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib47","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0190-9622(98)70438-4","article-title":"Pharmacokinetics of oral isotretinoin","volume":"39","author":"Wiegand","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib48","article-title":"Contraceptive Technology","author":"Hatcher","year":"1997"},{"key":"10.1053\/sder.2001.28209_bib49","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/jama.279.14.1057","article-title":"Acne drug depression warnings highlight need for expert care","volume":"279","author":"Lamberg","year":"1998","journal-title":"JAMA"},{"key":"10.1053\/sder.2001.28209_bib50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1056\/NEJM200102083440616","article-title":"Depression and suicide in patients treated with isotretinoin","volume":"344","author":"Wysowski","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib51","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1046\/j.1365-2133.2000.03282.x","article-title":"Isotretinoin associated with craving for cigarettes","volume":"142","author":"Ling","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib52","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0033-3182(90)72206-2","article-title":"Isotretinoin and trichotillomania","volume":"31","author":"Mahr","year":"1990","journal-title":"Psychosomatics"},{"key":"10.1053\/sder.2001.28209_bib53","series-title":"Accutane (isotretinoin) capsules, in Physicians' Desk Reference","first-page":"2610","author":"Data courtesy of Roche Laboratories Inc","year":"2000"},{"key":"10.1053\/sder.2001.28209_bib54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0733-8635(05)70147-9","article-title":"Acne and rosacea: New and emerging therapies","volume":"18","author":"Thiboutot","year":"2000","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib55","series-title":"Pharmacoepidemiologic analysis of Accutane-associated psychiatric events: Presentation for Hoffman-LaRoche at the FDA's Dermatologic and Ophthalmic Drugs Advisory Committee Meeting","author":"Nelson","year":"2000"},{"key":"10.1053\/sder.2001.28209_bib56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1522-5720(05)70020-9","article-title":"Preventive services for the adolescent (13\u201320 years)","volume":"2","author":"Tenore","year":"2000","journal-title":"Clin in Fam Prac"},{"key":"10.1053\/sder.2001.28209_bib57","first-page":"1","article-title":"Deaths: Final data for 1997","volume":"47","author":"Hoyert","year":"1999","journal-title":"Natl Vital State Rep"},{"key":"10.1053\/sder.2001.28209_bib58","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1001\/archderm.136.10.1231","article-title":"Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide","volume":"136","author":"Jick","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib59","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1136\/bmj.316.7133.723a","article-title":"Acne drug is linked to severe depression","volume":"316","author":"Josefson","year":"1998","journal-title":"BMJ"},{"key":"10.1053\/sder.2001.28209_bib60","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1046\/j.1365-2133.1999.03188.x","article-title":"Isotretinoin treatment for acne vulgaris and its cutaneous and ocular side-effects","volume":"141","author":"Azurdia","year":"1999","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib61","first-page":"2810","article-title":"The Retinoids","volume":"vol 2","author":"Peck","year":"1999"},{"key":"10.1053\/sder.2001.28209_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2230.1993.tb00974.x","article-title":"Isotretinoin-associated pseudoporphyria","volume":"18","author":"Riordan","year":"1993","journal-title":"Clin Exp Dermatol"},{"key":"10.1053\/sder.2001.28209_bib63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0163-7258(89)90079-X","article-title":"Retinoid associated photoxicity and photosensitivity","volume":"40","author":"Ferguson","year":"1989","journal-title":"Pharmacol Ther"},{"key":"10.1053\/sder.2001.28209_bib64","first-page":"860","article-title":"Disseminated herpes triggered by isotretinoin in an atopic patient","volume":"117","author":"Joly","year":"1990","journal-title":"Ann Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib65","first-page":"369","article-title":"Acne fulminans triggered by isotretinoin therapy","volume":"118","author":"Joly","year":"1991","journal-title":"Ann Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000246812","article-title":"Itching in acne: An unusual complication of therapy","volume":"189","author":"Yee","year":"1994","journal-title":"Dermatology"},{"key":"10.1053\/sder.2001.28209_bib67","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1136\/oem.51.11.786-a","article-title":"Isotretinoin induced rubber glove dermatitis","volume":"51","author":"Williams","year":"1994","journal-title":"Occup Environ Med"},{"key":"10.1053\/sder.2001.28209_bib68","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0190-9622(09)80046-7","article-title":"Facial cellulitis during oral isotretinoin treatment for acne","volume":"31","author":"Boffa","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib69","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1001\/archderm.1986.01660190093024","article-title":"Isotretinoin and Staphylococcus aureus injection: A possible association","volume":"122","author":"Graham","year":"1986","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib70","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1001\/archderm.135.3.349","article-title":"Mucosal denudation of lips from isotretinoin therapy","volume":"135","author":"Graham","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib71","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2340\/0001555575413","article-title":"Isotretinoin-induced pemphigus","volume":"75","author":"Georgala","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib72","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1001\/archderm.1997.03890370123029","article-title":"Keloid formation with the 585-nm pulsed dye laser during isotretinoin treatment","volume":"133","author":"Bernestein","year":"1997","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib73","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1440-0960.1998.tb01483.x","article-title":"Pyogenic granuloma-like lesions in a patient using topical tretinoin","volume":"39","author":"MacKenzie-Wood","year":"1998","journal-title":"Australas J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib74","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000249356","article-title":"Paronychia and the formation of granulation tissue during isotretinoin therapy","volume":"172","author":"De Raeve","year":"1986","journal-title":"Dermatologica"},{"key":"10.1053\/sder.2001.28209_bib75","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000029843","article-title":"The effect of isotretinoin on biotinidase activity","volume":"12","author":"Schulpis","year":"1999","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"key":"10.1053\/sder.2001.28209_bib76","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0733-8635(05)70016-4","article-title":"Systemic retinoids: What's new?","volume":"16","author":"Saurat","year":"1998","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib77","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2133.1994.tb08524.x","article-title":"Long-term safety of isotretinoin as a treatment for acne vulgaris","volume":"131","author":"Goulden","year":"1994","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib78","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0733-8635(05)70418-6","article-title":"Acne: An overview of clinical research findings","volume":"15","author":"Thiboutot","year":"1997","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib79","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/S0190-9622(83)70184-2","article-title":"Retinoid therapy is associated with excess granulation tissue responses","volume":"9","author":"Campbell","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib80","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0733-8635(05)70252-7","article-title":"The use of retinoids in the pediatric patient","volume":"16","author":"Ruiz-Maldonado","year":"1998","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib81","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/S0190-9622(86)70167-9","article-title":"Atypical keloids after dermabrasion of patients taking isotretinoin","volume":"15","author":"Rubenstein","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib82","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1111\/j.1365-2133.1988.tb02574.x","article-title":"Delayed wound healing and keloid formation following argon laser treatment or dermabrasion during isotretinoin treatment","volume":"118","author":"Zachariae","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib83","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000211161","article-title":"Pharmacological effects of retinoids on skin cells","volume":"6","author":"Gendimenico","year":"1993","journal-title":"Skin Pharmacol"},{"key":"10.1053\/sder.2001.28209_bib84","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/00000372-198604000-00008","article-title":"Ultrastructural changes in sebaceous glands following treatment of cystic acne with isotretinoin","volume":"8","author":"Zelickson","year":"1986","journal-title":"Am J Dermatopathol"},{"key":"10.1053\/sder.2001.28209_bib85","doi-asserted-by":"crossref","first-page":"1538a","DOI":"10.1001\/archderm.1987.01660350142031","article-title":"The effect of 13-cis-retinoic acid on sebaceous glands","volume":"123","author":"Strauss","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib86","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000246581","article-title":"Retinoids and sebaceous gland activity","volume":"191","author":"Geiger","year":"1995","journal-title":"Dermatology"},{"key":"10.1053\/sder.2001.28209_bib87","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1523-1747.2000.00066.x","article-title":"13-cis retinoic acid exerts its specific activity on human sebocytes through selective intracellular isomerization to all-trans retinoic acid and binding to retinoid acid receptors","volume":"115","author":"Tsukada","year":"2000","journal-title":"J Invest Dermatol"},{"key":"10.1053\/sder.2001.28209_bib88","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0190-9622(86)70236-3","article-title":"Epidermal effects of retinoids: Supramolecular observations and clinical implications","volume":"15","author":"Elias","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib89","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/archderm.1981.01650100013019","article-title":"Nature of skin fragility in patients receiving retinoids for systemic effect","volume":"117","author":"Williams","year":"1981","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib90_1","first-page":"660","article-title":"Transient acute myopia resulting from isotretinoin (Accutane) therapy","volume":"16","author":"Palestine","year":"1984","journal-title":"Ann Ophthalmol"},{"key":"10.1053\/sder.2001.28209_bib90_2","first-page":"662","article-title":"Transient acute myopia resulting from isotretinoin (Accutane) therapy","volume":"16","author":"Palestine","year":"1984","journal-title":"Ann Ophthalmol"},{"key":"10.1053\/sder.2001.28209_bib91","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0733-8635(18)30320-6","article-title":"Retinoids and the eye","volume":"10","author":"Gross","year":"1992","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib92","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1067\/mjd.2000.110391","article-title":"Concomitant administration of vitamin E does not change the side effects of isotretinoin as used in acne vulgaris: A randomized trial","volume":"43","author":"Strauss","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib93","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1542\/peds.90.1.119","article-title":"Retinoid therapy for severe dermatological disorders","volume":"90","author":"American Academy of Pediatrics Committee on Drugs","year":"1992","journal-title":"Pediatrics"},{"key":"10.1053\/sder.2001.28209_bib94","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00003226-199107000-00002","article-title":"Meibomian gland morphology and tear osmolarity: Changes with Accutane therapy","volume":"10","author":"Mathers","year":"1991","journal-title":"Cornea"},{"key":"10.1053\/sder.2001.28209_bib95","first-page":"221","article-title":"Ocular side effects of isotretinoin therapy","volume":"59","author":"Caffery","year":"1988","journal-title":"J Am Optom Assoc"},{"key":"10.1053\/sder.2001.28209_bib96","first-page":"17","article-title":"Isotretinoin administration in treatment of acne vulgaris: A prospective study of the kind and extent of ocular complications","volume":"92","author":"Egger","year":"1995","journal-title":"Ophthalmologe"},{"key":"10.1053\/sder.2001.28209_bib97","first-page":"429","article-title":"Ocular side effects of accutane therapy","volume":"9","author":"Lerman","year":"1992","journal-title":"Lens Eye Toxic Res"},{"key":"10.1053\/sder.2001.28209_bib98","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00003226-200003000-00020","article-title":"Persistent corneal opacity after oral isotretinoin therapy for acne","volume":"19","author":"Ellies","year":"2000","journal-title":"Cornea"},{"key":"10.1053\/sder.2001.28209_bib99","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0002-9394(85)90676-2","article-title":"Adverse ocular reactions possibly associated with isotretinoin","volume":"100","author":"Fraunfelder","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"10.1053\/sder.2001.28209_bib100","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0002-9394(14)74237-0","article-title":"Anterior subcapsular cataracts as a possible adverse ocular reaction to isotretinoin","volume":"103","author":"Herman","year":"1987","journal-title":"Am J Ophthalmol"},{"key":"10.1053\/sder.2001.28209_bib101","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1046\/j.1440-0960.1999.00363.x","article-title":"Night blindness precipitated by isotretinoin in the setting of hypovitaminosis","volume":"40","author":"Welsh","year":"1999","journal-title":"A. Australas J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib102","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2230.1995.tb01297.x","article-title":"Abnormal night vision with isotretinoin therapy for acne","volume":"20","author":"Maclean","year":"1995","journal-title":"Clin Exp Dermatol"},{"key":"10.1053\/sder.2001.28209_bib103","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1016\/S0190-9622(98)70308-1","article-title":"Rational design of receptor-selective retinoids","volume":"39","author":"Chandraratna","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib104","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00075197-199807000-00005","article-title":"Vitamin A and regulation of gene expression","volume":"1","author":"Nagpal","year":"1998","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1053\/sder.2001.28209_bib105","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1046\/j.1440-1622.1999.01706.x","article-title":"Premature epiphyseal closure secondary to single-course vitamin A therapy","volume":"69","author":"Steele","year":"1999","journal-title":"Aust N Z J Surg"},{"key":"10.1053\/sder.2001.28209_bib106","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0161-4754(99)70088-6","article-title":"Extraspinal enthesopathy caused by isotretinoin therapy","volume":"22","author":"Brandt","year":"1999","journal-title":"J Manipulative Physiol Ther"},{"key":"10.1053\/sder.2001.28209_bib107","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/archderm.135.8.961","article-title":"Bone densities in patients receiving isotretinoin for cystic acne","volume":"135","author":"Leachman","year":"1999","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib108","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1001\/archderm.1996.03890310053007","article-title":"Effects of isotretinoin on bone mineralization during routine therapy with isotretinoin for acne vulgaris","volume":"132","author":"Margolis","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib109","first-page":"410","article-title":"Hypercal-cemia: A dose-limiting toxicity associated with 13-cis-retinoic acid","volume":"15","author":"Villablanca","year":"1993","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1053\/sder.2001.28209_bib110","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0140-6736(92)91825-S","article-title":"Isotretinoin and the axial skeleton","volume":"340","author":"Tangrea","year":"1992","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib111","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1001\/archderm.1992.01680170053004","article-title":"Skeletal hyperostosis in patients receiving chronic, very-low-dose isotretinoin","volume":"128","author":"Tangrea","year":"1992","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib112","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2133.1988.tb03471.x","article-title":"Skeletal toxicity with isotretinoin therapy: A clinico-radiological evaluationtion","volume":"119","author":"Carey","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib113","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1056\/NEJM198611063151901","article-title":"Extraspinal tendon and ligament calcification associated with long-term therapy with etretinate","volume":"315","author":"DiGiovanna","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib114","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/0002-9343(84)90376-0","article-title":"Bilateral nasal bone osteophytosis associated with short-term oral isotretinoin therapy for cystic acne vulgaris","volume":"77","author":"Novick","year":"1984","journal-title":"Am J Med"},{"key":"10.1053\/sder.2001.28209_bib115","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2214\/ajr.151.5.967","article-title":"Evolution of skeletal hyperostoses caused by 13-cis-retinoic acid therapy","volume":"151","author":"Pennes","year":"1988","journal-title":"Am J Roentgenol"},{"key":"10.1053\/sder.2001.28209_bib116","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/S0190-9622(84)80329-1","article-title":"Isotretinoin therapy is associated with early skeletal radiographic changes","volume":"10","author":"Ellis","year":"1984","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib117","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0190-9622(88)70131-0","article-title":"Long-term radiographic follow-up after isotretinoin therapy","volume":"18","author":"Ellis","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib118","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2214\/ajr.142.5.979","article-title":"Early skeletal hyperostoses secondary to 13-cis-retinoic acid","volume":"142","author":"Pennes","year":"1984","journal-title":"Am J Roentgenol"},{"key":"10.1053\/sder.2001.28209_bib119","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0190-9622(82)70148-3","article-title":"Premature epiphyseal closure in a child receiving oral 13-cis-retinoic acid","volume":"7","author":"Milstone","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib120","first-page":"316","article-title":"Dense metaphyseal bands and growth arrest associated with isotretinoin therapy","volume":"142","author":"Marini","year":"1988","journal-title":"Am J Dis Child"},{"key":"10.1053\/sder.2001.28209_bib121","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00004424-198601000-00007","article-title":"Minimal spinal hyperostosis with low-dose isotretinoin therapy","volume":"21","author":"Kilcoyne","year":"1986","journal-title":"Invest Radiol"},{"key":"10.1053\/sder.2001.28209_bib122","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0190-9622(98)70011-8","article-title":"Uses of vitamins A, C, and E and related compounds in dermatology: A review","volume":"39","author":"Keller","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib123","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-2230.1992.tb02159.x","article-title":"Acute Achilles tendonitis following oral isotretinoin therapy for acne vulgaris","volume":"17","author":"Bottomley","year":"1992","journal-title":"Clin Exp Dermatol"},{"key":"10.1053\/sder.2001.28209_bib124","first-page":"2009","article-title":"Achilles and suprapatellar tendinitis due to isotretinoin","volume":"22","author":"Hernandez Rodriguez","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1053\/sder.2001.28209_bib125","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1001\/archderm.1996.03890360115029","article-title":"Severe acute myopathy induced by isotretinoin","volume":"132","author":"Fiallo","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib126","first-page":"2","article-title":"Isotretinoin induced rhabdomyolysis: A case report","volume":"5","author":"Trauner","year":"1999","journal-title":"Dermatol Online J"},{"key":"10.1053\/sder.2001.28209_bib127","first-page":"94","article-title":"Muscular damage during isotretinoin treatment","volume":"125","author":"Heudes","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib128","doi-asserted-by":"crossref","first-page":"352","DOI":"10.2340\/0001555572352354","article-title":"Comparison of muscle-derived serum carbonic anhydrase III and myoglobin in dermatological patients: Effects of isotretinoin treatment","volume":"72","author":"Oikarinen","year":"1992","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib129","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1440-1746.1990.tb01635.x","article-title":"Hepatic toxicity of vitamin A and synthetic retinoids","volume":"5","author":"Fallon","year":"1990","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/sder.2001.28209_bib130","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2133.1991.tb00638.x","article-title":"Fatty liver following isotretinoin therapy","volume":"124","author":"Taylor","year":"1991","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib131","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0190-9622(88)70165-6","article-title":"Liver toxicity of retinoid therapy","volume":"19","author":"Roenigk","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib132","series-title":"Comprehensive Dermatologic Drug Therapy","first-page":"269","article-title":"Systemic Retinoids","author":"Nguyen","year":"2001"},{"key":"10.1053\/sder.2001.28209_bib133","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2133.1985.tb02293.x","article-title":"A sequential comparison of etretinate (Tigason) and isotretinoin (Roaccutane) with special regard to their effects on serum lipoproteins","volume":"112","author":"Vahlquist","year":"1985","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib134","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI1581","article-title":"Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor: Contribution to the hypertriglyceridemic action of retinoids","volume":"102","author":"Vu-Dac","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1053\/sder.2001.28209_bib135","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1006\/faat.1996.0164","article-title":"Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors","volume":"33","author":"Standeven","year":"1996","journal-title":"Fundam Appl Toxicol"},{"key":"10.1053\/sder.2001.28209_bib136","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJM198510173131604","article-title":"Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne","volume":"313","author":"Bershad","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib137","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1111\/j.1365-2133.1990.tb14730.x","article-title":"Serum lipid elevation during isotretinoin therapy for acne in the west of Scotland","volume":"122","author":"Walker","year":"1990","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib138","first-page":"1855","article-title":"Marked hyperlipidemia and pancreatitis associated with isotretinoin therapy","volume":"87","author":"McCarter","year":"1992","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/sder.2001.28209_bib139","doi-asserted-by":"crossref","first-page":"63","DOI":"10.7326\/0003-4819-107-1-63","article-title":"Pancreatitis associated with isotretinoin-induced hypertriglyceridemia","volume":"107","author":"Flynn","year":"1987","journal-title":"Ann Intern Med"},{"key":"10.1053\/sder.2001.28209_bib140","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2340\/0001555566144148","article-title":"Changes in laboratory variables induced by isotretinoin treatment of acne","volume":"66","author":"Michaelsson","year":"1986","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib141","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1526-4610.1989.hed2907441.x","article-title":"Drug-related headache","volume":"29","author":"Askmark","year":"1989","journal-title":"Headache"},{"key":"10.1053\/sder.2001.28209_bib142","first-page":"165","article-title":"Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne","volume":"55","author":"Lee","year":"1995","journal-title":"Cutis"},{"key":"10.1053\/sder.2001.28209_bib143","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000246786","article-title":"Effects of oral isotretinoin on human auditory brainstem response","volume":"189","author":"Nikiforidis","year":"1994","journal-title":"Dermatology"},{"key":"10.1053\/sder.2001.28209_bib144","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/106002809302700626","article-title":"Isotretinoin: Possible cause of acute seizure and confusion","volume":"27","author":"Marroni","year":"1993","journal-title":"Ann Pharmacother"},{"key":"10.1053\/sder.2001.28209_bib145","doi-asserted-by":"crossref","first-page":"A5","DOI":"10.1093\/milmed\/156.8.A5","article-title":"Pseudo-tumor cerebri and acne","volume":"156","author":"Gottfried","year":"1991","journal-title":"Mil Med"},{"key":"10.1053\/sder.2001.28209_bib146","first-page":"399","article-title":"Pseudotumor cerebri caused by isotretinoin","volume":"42","author":"Roytman","year":"1988","journal-title":"Cutis"},{"key":"10.1053\/sder.2001.28209_bib147","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1212\/WNL.34.11.1509","article-title":"Pseudotumor cerebri caused by a synthetic vitamin A preparation","volume":"34","author":"Spector","year":"1984","journal-title":"Neurology"},{"key":"10.1053\/sder.2001.28209_bib148","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/bjo.73.4.286","article-title":"Visual toxicity of synthetic retinoids","volume":"73","author":"Brown","year":"1989","journal-title":"Br J Ophthalmol"},{"key":"10.1053\/sder.2001.28209_bib149","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000053721","article-title":"Effects of retinoids on in vitro and in vivo IgE production","volume":"124","author":"Worm","year":"2001","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1053\/sder.2001.28209_bib150","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1182\/blood.V92.5.1713","article-title":"Retinoic acid inhibits CD40+ interleukin-4-mediated IgE production in vitro","volume":"92","author":"Worm","year":"1998","journal-title":"Blood"},{"key":"10.1053\/sder.2001.28209_bib151","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3168\/jds.S0022-0302(95)76617-6","article-title":"Administration of 13-cis-retinoic acid to dairy cattle. 2: Phenotype of blood leukocytes and production of immunoglobulin","volume":"78","author":"Franklin","year":"1995","journal-title":"J Dairy Sci"},{"issue":"suppl 25","key":"10.1053\/sder.2001.28209_bib152","first-page":"55","article-title":"Evidence for anti-inflammatory activities of oral synthetic retinoids: Experimental findings and clinical experience","volume":"109","author":"Orfanos","year":"1983","journal-title":"Br J Dermat"},{"key":"10.1053\/sder.2001.28209_bib153","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0162-3109(97)00048-9","article-title":"Immunosuppressive activity of 13-cis-retinoic acid in rats: Aspects of pharmacokinetics and pharmacodynamics","volume":"37","author":"Vergelli","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1053\/sder.2001.28209_bib154","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2340\/0001555567481490","article-title":"Neutrophil function in psoriasis: Effects of retinoids","volume":"67","author":"Coble","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib155","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/BF00455175","article-title":"Effect of retinoids on natural killer cell activity","volume":"278","author":"Pigatto","year":"1986","journal-title":"Arch Dermatol Res"},{"key":"10.1053\/sder.2001.28209_bib156","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/096032718500400402","article-title":"Effects of retinoids on human lymphocyte functions in vitro","volume":"4","author":"Moriguchi","year":"1985","journal-title":"Hum Toxicol"},{"key":"10.1053\/sder.2001.28209_bib157","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0190-9622(86)80321-8","article-title":"Acute arthritis during isotretinoin therapy for acne","volume":"15","author":"Camisa","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib158","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1001\/archinte.1984.00350210200037","article-title":"Acute arthritis during isotretinoin treatment for acne","volume":"144","author":"Matsuoka","year":"1984","journal-title":"Arch Intern Med"},{"key":"10.1053\/sder.2001.28209_bib159","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0140-6736(90)90657-Q","article-title":"Post-isotretinoin vasculitis","volume":"335","author":"Aractingi","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib160","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0140-6736(89)91820-5","article-title":"Delayed onset of vasculitis following isotretinoin","volume":"2","author":"Reynolds","year":"1989","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib161","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/S0140-6736(89)92099-0","article-title":"Vasculitis and retinoids","volume":"2","author":"Dwyer","year":"1989","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib162","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1001\/archderm.1987.01660330030005","article-title":"Severe vasculitis during isotretinoin therapy","volume":"123","author":"Epstein","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib163","first-page":"1241","article-title":"Arthritis precipitated by isotretinoin treatment for acne vulgaris","volume":"20","author":"Hughes","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1053\/sder.2001.28209_bib164","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000018162","article-title":"Acute arthritis after isotretinoin","volume":"198","author":"Lehucher Ceyrac","year":"1999","journal-title":"Dermatology"},{"key":"10.1053\/sder.2001.28209_bib165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0950-3579(05)80297-3","article-title":"Rheumatological symptoms due to retinoids","volume":"5","author":"Kaplan","year":"1991","journal-title":"Baillieres Clin Rheumatol"},{"key":"10.1053\/sder.2001.28209_bib166","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1111\/j.1572-0241.1999.02568.x","article-title":"Isotretinoin: Possible component cause of inflammatory bowel disease","volume":"94","author":"Prokop","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/sder.2001.28209_bib167","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1365-2133.1990.tb01483.x","article-title":"Treatment of severe acne with isotretinoin in patients with inflammatory bowel disease","volume":"123","author":"Godfrey","year":"1990","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib168","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0733-8635(05)70237-0","article-title":"Systemic retinoid therapy","volume":"19","author":"DiGiovanna","year":"2001","journal-title":"Dermatol Clin"},{"key":"10.1053\/sder.2001.28209_bib169","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1468-3083.2000.00061-10.x","article-title":"Acute appendicitis and isotretinoin: A coincidence?","volume":"14","author":"Azon-Masoliver","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib170","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1365-4362.1996.tb01675.x","article-title":"Acute esophagitis caused by isotretinoin","volume":"35","author":"Amichai","year":"1996","journal-title":"Int J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib171","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0248-8663(96)80763-6","article-title":"Transient dysfibrinogenemia and thrombocytopenia associated with recurrent acute pancreatitis in the course of isotretinoin therapy","volume":"16","author":"Aurousseau","year":"1995","journal-title":"Rev Med Interne"},{"key":"10.1053\/sder.2001.28209_bib172","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0016-5085(87)90925-5","article-title":"Isotretinoin-associated proctosigmoiditis","volume":"93","author":"Martin","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1053\/sder.2001.28209_bib173","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0190-9622(85)80374-1","article-title":"Exercise-induced bronchoconstriction related to isotretinoin therapy","volume":"13","author":"Fisher","year":"1985","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib174","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1365-2133.2000.03324.x","article-title":"Exacerbation of asthma by isotretinoin","volume":"142","author":"Kapur","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib175","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1378\/chest.110.4.1128","article-title":"Isotretinoin-related eosinophilic pleural effusion","volume":"110","author":"Milleron","year":"1996","journal-title":"Chest"},{"key":"10.1053\/sder.2001.28209_bib176","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/bmj.312.7035.886","article-title":"Bronchospasm induced by isotretinoin","volume":"312","author":"Sabroe","year":"1996","journal-title":"Bmj"},{"key":"10.1053\/sder.2001.28209_bib177","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2340\/0001555575290292","article-title":"Retinoids and fibrinolysis","volume":"75","author":"Back","year":"1995","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib178","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1749-6632.1992.tb51614.x","article-title":"Enhancement of tissue-type plasminogen activator levels by retinoids in rat tissues in vivo","volume":"667","author":"Kooistra","year":"1992","journal-title":"Ann NY Acad Sci"},{"key":"10.1053\/sder.2001.28209_bib179","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2133.1992.tb08056.x","article-title":"Exacerbation of bleeding tendency in a patient with haemophilia A during treatment with isotretinoin","volume":"127","author":"Dootson","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib180","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2133.1995.tb02494.x","article-title":"The influence of isotretinoin upon fibrinolysis in patients with acne","volume":"133","author":"Dootson","year":"1995","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib181","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1093\/ndt\/12.6.1299a","article-title":"Renal impairment induced by isotretinoin","volume":"12","author":"Pavese","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/sder.2001.28209_bib182","doi-asserted-by":"crossref","first-page":"330","DOI":"10.2340\/0001555577330","article-title":"Urethritis associated with isotretinoin therapy","volume":"77","author":"Edwards","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib183","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1258\/0956462961917357","article-title":"Nonspecific urethritis\u2014Possible association with isotretinoin therapy","volume":"7","author":"Kellock","year":"1996","journal-title":"Int J STD AIDS"},{"key":"10.1053\/sder.2001.28209_bib184","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/ndt\/15.6.923","article-title":"Nephrotic syndrome associated with isotretinoin","volume":"15","author":"van Oers","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/sder.2001.28209_bib185","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0190-9622(86)80152-9","article-title":"Thyrotoxicosis developing while on isotretinoin","volume":"15","author":"Minuk","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib186","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/clinchem\/32.5.913","article-title":"Lack of effect of isotretinoin on thyroid-function tests","volume":"32","author":"O'Leary","year":"1986","journal-title":"Clin Chem"},{"key":"10.1053\/sder.2001.28209_bib187","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/oxfordjournals.ndt.a027388","article-title":"The development of insulin-dependent diabetes mellitus in renal transplant patient receiving oral isotretinoin","volume":"11","author":"Timperley","year":"1996","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/sder.2001.28209_bib188","first-page":"191","article-title":"Vitamin A in the treatment of menorrhagia","volume":"51","author":"Lithgow","year":"1977","journal-title":"S Afr Med J"},{"key":"10.1053\/sder.2001.28209_bib189","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0190-9622(88)80289-5","article-title":"Roaccutane and menorrhagia","volume":"18","author":"Christmas","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib190","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/jrf.0.1050153","article-title":"Menstrual cycle related differences in the proliferative responses of cultured human endometrial stromal cells to retinoic acid","volume":"105","author":"Loughney","year":"1995","journal-title":"J Reprod Fertil"},{"key":"10.1053\/sder.2001.28209_bib191","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/oxfordjournals.humrep.a136137","article-title":"Variation in the expression of cellular retinoid binding proteins in human endometrium throughout the menstrual cycle","volume":"10","author":"Loughney","year":"1995","journal-title":"Hum Reprod"},{"key":"10.1053\/sder.2001.28209_bib192","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1365-2133.1988.tb02609.x","article-title":"Amenorrhoea during treatment with isotretinoin","volume":"118","author":"Cox","year":"1988","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib193","doi-asserted-by":"crossref","first-page":"394","DOI":"10.2340\/0001555577394396","article-title":"Isotretinoin, tetracycline and circulating hormones in acne","volume":"77","author":"Palatsi","year":"1997","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/sder.2001.28209_bib194","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1210\/jc.80.4.1158","article-title":"Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients","volume":"80","author":"Boudou","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/sder.2001.28209_bib195","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0140-6736(94)92803-7","article-title":"Effects of isotretinoin on male reproductive system","volume":"344","author":"Coleman","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib196","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1001\/archderm.1988.01670040042019","article-title":"Effect of isotretinoin on serum levels of precursor and peripherally derived androgens in patients with acne","volume":"124","author":"Lookingbill","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib197","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/j.1439-0272.1987.tb01915.x","article-title":"Spermatological investigations in patients treated with etretinate and isotretinoin","volume":"19","author":"Torok","year":"1987","journal-title":"Andrologia"},{"key":"10.1053\/sder.2001.28209_bib198","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1056\/NEJM198304283081710","article-title":"Hormones, retinoids, and acne","volume":"308","author":"Pochi","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1053\/sder.2001.28209_bib199","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0300-483X(80)90015-3","article-title":"Atrophy induced in the tubules of the testes of Syrian hamsters by two retinoids","volume":"17","author":"Stinson","year":"1980","journal-title":"Toxicology"},{"key":"10.1053\/sder.2001.28209_bib200","doi-asserted-by":"crossref","first-page":"123","DOI":"10.26719\/1999.5.1.123","article-title":"Long-term administration of vitamin A and the process of spermatogenesis","volume":"5","author":"Sadek","year":"1999","journal-title":"East Mediterr Health J"},{"key":"10.1053\/sder.2001.28209_bib201","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(05)64845-3","article-title":"Isotretinoin and azathioprine: A synergy that makes hair curl?","volume":"348","author":"van der Pijl","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/sder.2001.28209_bib202","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/BF00179013","article-title":"Taste and olfactory disturbances after treatment for acne with isotretinoin, a 13-cis-isomer of retinoic acid","volume":"247","author":"Heise","year":"1990","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.1053\/sder.2001.28209_bib203","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2230.1990.tb02053.x","article-title":"Isotretinoin and curly hair","volume":"15","author":"Bunker","year":"1990","journal-title":"Clin Exp Dermatol"},{"key":"10.1053\/sder.2001.28209_bib204","first-page":"1370","article-title":"A case from practice (256): 1. Right-sided gynecomastia possibly drug-induced (Roaccutan). 2. Status following excision and covering of a B-cell non-Hodgkin lymphoma of the skull. 3. Lumbar irritation syndrome of unclear origin","volume":"81","author":"Fluckiger","year":"1992","journal-title":"Schweiz Rundsch Med Prax"},{"key":"10.1053\/sder.2001.28209_bib205","first-page":"466","article-title":"Acquired pili torti in two patients treated with synthetic retinoids","volume":"35","author":"Hays","year":"1985","journal-title":"Cutis"},{"key":"10.1053\/sder.2001.28209_bib206","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1001\/archderm.1985.01660040024005","article-title":"Iatrogenic breast discharge with isotretinoin","volume":"121","author":"Larsen","year":"1985","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib207","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000247785","article-title":"Decreased isotretinoin efficacy during acute alcohol intake","volume":"182","author":"Soria","year":"1991","journal-title":"Dermatologica"},{"key":"10.1053\/sder.2001.28209_bib208","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1600-0773.1988.tb01897.x","article-title":"Haloperidol and metabolite concentrations in the rat after concurrent isotretinoin administration: A preliminary report","volume":"62","author":"Straw","year":"1988","journal-title":"Pharmacol Toxicol"},{"key":"10.1053\/sder.2001.28209_bib209","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/BF00370735","article-title":"Influence of oral isotretinoin on hepatic and cutaneous P-450-dependent isozyme activities","volume":"286","author":"Goerz","year":"1994","journal-title":"Arch Dermatol Res"},{"key":"10.1053\/sder.2001.28209_bib210","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/S0190-9622(98)70484-0","article-title":"Systemic antifungal agents used to treat onychomycosis","volume":"38","author":"Katz","year":"1998","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib211","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/jn\/128.7.1239","article-title":"Zinc pretreatment inhibits isotretinoin teratogenicity and induces embryonic metallothionein in CD-1 mice","volume":"128","author":"Blain","year":"1998","journal-title":"J Nutr"},{"key":"10.1053\/sder.2001.28209_bib212","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3181\/00379727-209-43887","article-title":"Protection of mice from teratogeninduced cleft palate by exogenous methionine","volume":"209","author":"Lau","year":"1995","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1053\/sder.2001.28209_bib213","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/tera.1420450105","article-title":"Inhibition of isotretinoin teratogenicity by acetylsalicylic acid pretreatment in mice","volume":"45","author":"Kubow","year":"1992","journal-title":"Teratology"},{"key":"10.1053\/sder.2001.28209_bib214","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1207\/S15327914NC3602_9","article-title":"Use of arginine to reduce the severity of retinoid-induced hypertriglyceridemia","volume":"36","author":"Radcliffe","year":"2000","journal-title":"Nutr Cancer"},{"key":"10.1053\/sder.2001.28209_bib215","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1046\/j.1525-1500.1998.00056.x","article-title":"The use of soy protein isolate to reduce the severity of 13-cis retinoic acidinduced hypertriglyceridemia","volume":"22","author":"Radcliffe","year":"1998","journal-title":"Cancer Detect Prev"},{"key":"10.1053\/sder.2001.28209_bib216","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1008092906465","article-title":"Partial replacement of dietary casein with soy protein isolate can reduce the severity of retinoid-induced hypertriglyceridemia","volume":"52","author":"Radcliffe","year":"1998","journal-title":"Plant Foods Hum Nutr"},{"key":"10.1053\/sder.2001.28209_bib217","first-page":"401","article-title":"Dietary cottonseed protein can reduce the severity of retinoid-induced hypertriglyceridemia","volume":"18","author":"Radcliffe","year":"1994","journal-title":"Cancer Detect Prev"},{"key":"10.1053\/sder.2001.28209_bib218","first-page":"48","article-title":"Treatment of severe forms of acne by combined administration of Roaccutan and vitamin E","volume":"1","author":"Kunin","year":"1988","journal-title":"Vestn Dermatol Venerol"},{"key":"10.1053\/sder.2001.28209_bib219","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1177\/096032718700600308","article-title":"Effect of dietary fish oil on hyperlipidaemia due to isotretinoin and etretinate","volume":"6","author":"Marsden","year":"1987","journal-title":"Hum Toxicol"},{"key":"10.1053\/sder.2001.28209_bib220","first-page":"205","article-title":"L-carnitine supplementation in patients with cystic acne on isotretinoin therapy","volume":"13","author":"Georgala","year":"1999","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib221","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S0190-9622(99)70058-7","article-title":"Clinical pearl: Vitamin E (alpha-tocopherol), 800 IU daily, may reduce retinoid toxicity","volume":"41","author":"Salasche","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib222","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1008209525671","article-title":"Phase I trial of alpha-tocopherol effects on 13-cis-retinoic acid toxicity","volume":"8","author":"Dimery","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1053\/sder.2001.28209_bib223","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0145-2126(98)00057-5","article-title":"A pilot trial of 13-cis-retinoic acid and alpha-tocopherol with recombinant human erythropoietin in myelodysplastic syndrome patients with progressive or transfusion-dependent anemias. The Central Pennsylvania Oncology Group","volume":"22","author":"Besa","year":"1998","journal-title":"Leuk Res"},{"key":"10.1053\/sder.2001.28209_bib224","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0002-9343(90)90215-Y","article-title":"Treatment with 13-cis-retinoic acid in transfusion-dependent patients with myelodysplastic syndrome and decreased toxicity with addition of alpha-tocopherol","volume":"89","author":"Besa","year":"1990","journal-title":"Am J Med"},{"key":"10.1053\/sder.2001.28209_bib225","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1468-3083.1998.tb00763.x","article-title":"Medium dose isotretinoin for the treatment of acne","volume":"11","author":"Hermes","year":"1998","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1053\/sder.2001.28209_bib226","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2133.1993.tb11850.x","article-title":"Isotretinoin for the treatment of acne vulgaris: Which factors may predict the need for more than one course?","volume":"129","author":"Stainforth","year":"1993","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib227","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1001\/archderm.134.7.884","article-title":"Efficacy of low-dose isotretinoin in patients with treatment-resistant rosacea","volume":"134","author":"Erdogan","year":"1998","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib228","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1001\/archderm.1994.01690030051008","article-title":"A comparison of the efficacy of topical tretinoin and low-dose oral isotretinoin in rosacea","volume":"130","author":"Ertl","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib229","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0190-9622(82)70067-2","article-title":"Action of isotretinoin in acne rosacea and gram-negative folliculitis","volume":"6","author":"Plewig","year":"1982","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib230","series-title":"Therapy of Moderate to Severe Psoriasis","first-page":"94","article-title":"Systemic Retinoid Therapy","author":"Lowe","year":"1993"},{"key":"10.1053\/sder.2001.28209_bib231","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/j.1365-2133.1997.tb03680.x","article-title":"Isotretinoin-PUVA in women with psoriasis","volume":"136","author":"Anstey","year":"1997","journal-title":"Br J Dermatol"},{"key":"10.1053\/sder.2001.28209_bib232","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0190-9622(08)80253-8","article-title":"Retinoids in psoriasis and disorders of keratinization","volume":"27","author":"Fritsch","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib233","first-page":"1985","article-title":"Cisplatin, vindesine, mitomycin-C and 13-cis retinoic acid in the treatment of advanced non small cell lung cancer: A phase II pilot study","volume":"20","author":"Recchia","year":"2000","journal-title":"Anticancer Res"},{"key":"10.1053\/sder.2001.28209_bib234","first-page":"269","article-title":"Carboplatin, vindesine, 5-fluorouracil-leucovorin and 13-cis retinoic acid in the treatment of advanced non-small cell lung cancer: A phase II study","volume":"150","author":"Recchia","year":"1999","journal-title":"Clin Ter"},{"key":"10.1053\/sder.2001.28209_bib235","first-page":"3015","article-title":"Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A\/J mice at low doses: A pilot study","volume":"6","author":"Dahl","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1053\/sder.2001.28209_bib236","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0190-9622(88)70162-0","article-title":"Treatment and prevention of basal cell carcinoma with oral isotretinoin","volume":"19","author":"Peck","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/sder.2001.28209_bib237","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1001\/archderm.1996.03890250108025","article-title":"Failure of interferon alfa and isotretinoin combination therapy in the nevoid basal cell carcinoma syndrome","volume":"132","author":"Sollitto","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1053\/sder.2001.28209_bib238","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1159\/000018399","article-title":"Muir-Torre syndrome: Treatment with isotretinoin and interferon alpha-2a can prevent tumour development","volume":"200","author":"Graefe","year":"2000","journal-title":"Dermatology"},{"key":"10.1053\/sder.2001.28209_bib239","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1200\/JCO.1995.13.8.1950","article-title":"Interferon alfa-2a and 13-cis-retinoic acid in renal cell carcinoma: Antitumor activity in a phase II trial and interactions in vitro","volume":"13","author":"Motzer","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1053\/sder.2001.28209_bib240","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1200\/JCO.2000.18.16.2972","article-title":"Phase III trial of interferon alfa-2a with or without 13-cis-retinoic acid for patients with advanced renal cell carcinoma","volume":"18","author":"Motzer","year":"2000","journal-title":"J Clin Oncol"}],"container-title":["Seminars in Cutaneous Medicine and Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1085562901800250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1085562901800250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scmsjournal.com\/wp-content\/uploads\/2016\/08\/v20i3-Hanson.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T17:10:10Z","timestamp":1707585010000},"score":1,"resource":{"primary":{"URL":"http:\/\/scmsjournal.com\/article\/buy_now\/?id=619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":241,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S1085562901800250"],"URL":"https:\/\/doi.org\/10.1053\/sder.2001.28209","relation":{},"ISSN":["1085-5629"],"issn-type":[{"value":"1085-5629","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}