{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:12:42Z","timestamp":1768522362369,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4855,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1053\/seiz.2000.0381","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T17:49:59Z","timestamp":1027878599000},"page":"224-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study"],"prefix":"10.1053","volume":"9","author":[{"given":"J.","family":"Bruni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Guberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Vachon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Desforges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"THE CANADIAN VIGABATRIN STUDY GROUP","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/seiz.2000.0381_RF1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1471-4159.1977.tb10721.x","article-title":"Gamma-vinyl GABA (4-amino-hex-5-enoic acid), as new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice","volume":"29","author":"Jung","year":"1977","journal-title":"Journal of Neurochemistry"},{"key":"10.1053\/seiz.2000.0381_RF2","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/0006-2952(79)90529-X","article-title":"Inhibitors of GABA metabolism","volume":"28","author":"Metcalf","year":"1979","journal-title":"Biochemical Pharmacology"},{"key":"10.1053\/seiz.2000.0381_RF3","first-page":"S7","article-title":"Pharmacology and clinical pharmacology of vigabatrin","volume":"2","author":"Richens","year":"1991","journal-title":"Journal of Child Neurology"},{"key":"10.1053\/seiz.2000.0381_RF4","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1111\/j.1528-1157.1995.tb05996.x","article-title":"Antiepileptic drug mechanisms of action","volume":"36","author":"MacDonald","year":"1995","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF5","series-title":"Antiepileptic Drugs. 4th edition","first-page":"903","article-title":"Vigabatrin: mechanisms of action","author":"Jung","year":"1995"},{"key":"10.1053\/seiz.2000.0381_RF6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1528-1157.1986.tb03512.x","article-title":"Double-blind, placebo-controlled study of vigabatrin (gamma-vinyl GABA) in drug resistant epilepsy","volume":"27","author":"Loiseau","year":"1986","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1528-1157.1986.tb03600.x","article-title":"Vigabatrin in the treatment of epilepsy: a double-blind, placebo controlled study","volume":"27","author":"Tartara","year":"1986","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1212\/WNL.37.2.184","article-title":"Vigabatrin for refractory complex partial seizures: multicentre single-blind study with long-term follow-up","volume":"37","author":"Browne","year":"1987","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0381_RF9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1136\/jnnp.52.4.467","article-title":"Vigabatrin in the treatment of epilepsy. A long-term follow-up","volume":"52","author":"Tartara","year":"1989","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1053\/seiz.2000.0381_RF10","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1212\/WNL.41.4.562","article-title":"Vigabatrin in drug-resistant partial epilepsy: a 5-year follow-up study","volume":"41","author":"Sivenius","year":"1991","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0381_RF11","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.1528-1157.1991.tb04688.x","article-title":"Open double-blind and long term study of vigabatrin in chronic epilepsy","volume":"32","author":"Reynolds","year":"1991","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1212\/WNL.41.3.363","article-title":"Multicentre long-term safety and efficacy study of vigabatrin for refractory complex partial seizures. An update","volume":"41","author":"Browne","year":"1991","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0381_RF13","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1001\/archneur.1993.00540010020012","article-title":"Long-term antiepileptic efficacy of vigabatrin in drug-refractory epilepsy in mentally retarded patients. A 5-year follow-up study","volume":"50","author":"Pitkanen","year":"1993","journal-title":"Archives of Neurology"},{"key":"10.1053\/seiz.2000.0381_RF14","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1177\/0883073891006002071","article-title":"Vigabatrin in childhood epilepsy","volume":"6","author":"Dulac","year":"1991","journal-title":"Journal of Child Neurology"},{"key":"10.1053\/seiz.2000.0381_RF15","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1177\/0883073891006002091","article-title":"Dose\u2013response study of vigabatrin in children with refractory epilepsy","volume":"6","author":"Herranz","year":"1991","journal-title":"Journal of Child Neurology"},{"key":"10.1053\/seiz.2000.0381_RF16","first-page":"S30","article-title":"Gamma-vinyl GABA (vigabatrin): clinical experience in adult and adolescent patients with intractable epilepsy","volume":"33","author":"Reynolds","year":"1992","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF17","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1136\/jnnp.57.9.1057","article-title":"Effects of vigabatrin on partial seizures and cognitive function","volume":"57","author":"Grunewald","year":"1994","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"key":"10.1053\/seiz.2000.0381_RF18","first-page":"S26","article-title":"Treatment of pediatric epilepsies with gamma-vinyl GABA (vigabatrin)","volume":"33","author":"Gram","year":"1992","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF19","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1177\/0883073891006002101","article-title":"Therapeutic trial of vigabatrin in refractory infantile spasms","volume":"6","author":"Chiron","year":"1991","journal-title":"Journal of Child Neurology"},{"key":"10.1053\/seiz.2000.0381_RF20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1212\/WNL.46.1.54","article-title":"A double-blind, placebo-controlled study of vigabatrin three g\/day in patients with uncontrolled complex partial seizures","volume":"46","author":"French","year":"1996","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0381_RF21","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1212\/WNL.43.12.2501","article-title":"Evaluation of the effects of vigabatrin on cognitive abilities and quality of life in epilepsy","volume":"43","author":"Dodrill","year":"1993","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0381_RF22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1528-1157.1995.tb00976.x","article-title":"Effects of differing dosages of vigabatrin (Sabril) on cognitive abilities and quality of life in epilepsy","volume":"36","author":"Dodrill","year":"1995","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF23","first-page":"S60","article-title":"Randomized controlled pilot study of vigabatrin versus carbamazepine monotherapy in newly diagnosed patients with epilepsy. Interim report","volume":"2","author":"Kalviainen","year":"1991","journal-title":"Journal of Child Neurology"},{"key":"10.1053\/seiz.2000.0381_RF24","first-page":"S104","article-title":"Vigabatrin versus carbamazepine in newly diagnosed epileptic patients. A randomized response conditional cross-over study [abstract]","volume":"36","author":"Tanganelli","year":"1995","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0381_RF25","first-page":"512","article-title":"Treatment with antiepileptic drugs. Possible neuroprotective effects","volume":"47 (Suppl. 1)","author":"Pitkanen","year":"1996","journal-title":"Neurology"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131100903819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131100903819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:26:01Z","timestamp":1761009961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131100903819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S1059131100903819"],"URL":"https:\/\/doi.org\/10.1053\/seiz.2000.0381","relation":{},"ISSN":["1059-1311"],"issn-type":[{"value":"1059-1311","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vigabatrin as add-on therapy for adult complex partial seizures: a double-blind, placebo-controlled multicentre study","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/seiz.2000.0381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 BEA Trading, Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}