{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:10:54Z","timestamp":1761091854715,"version":"build-2065373602"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,3,1]],"date-time":"2001-03-01T00:00:00Z","timestamp":983404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":4521,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","seizure-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seizure"],"published-print":{"date-parts":[[2001,3]]},"DOI":"10.1053\/seiz.2000.0467","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T10:55:08Z","timestamp":1032432908000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood"],"prefix":"10.1053","volume":"10","author":[{"given":"Matthias","family":"Sigler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Michael","family":"Strassburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Erich","family":"Boenigk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/seiz.2000.0467_RF1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0022-3565(25)07651-7","article-title":"The anticonvulsant activity of a-phenyl succinimides","volume":"103","author":"Chen","year":"1951","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1053\/seiz.2000.0467_RF2","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1021\/ja01154a126","article-title":"Anticonvulsants. I. An investigation of N-R-a-R1-a-phenylsuccimides","volume":"73","author":"Miller","year":"1951","journal-title":"Journal of the American Chemical Society"},{"key":"10.1053\/seiz.2000.0467_RF3","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1021\/ja01156a033","article-title":"Anticonvulsants. II. A study of N-R-a, b-substituted succimides","volume":"73","author":"Miller","year":"1951","journal-title":"Journal of the American Chemical Society"},{"key":"10.1053\/seiz.2000.0467_RF4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/archneurpsyc.1951.02320080040003","article-title":"Use of methylphenylsuccimide in treatment if petit mal epilepsy","volume":"66","author":"Zimmerman","year":"1951","journal-title":"Archives of Neurology and Psychiatry"},{"key":"10.1053\/seiz.2000.0467_RF5","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.24.3.250","article-title":"Plasma levels of methsuximide and N-desmethylmethsuximide during methsuximide therapy","volume":"24","author":"Strong","year":"1974","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0467_RF6","series-title":"Antiepileptic Drugs","first-page":"707","article-title":"Other succinimides\u2014Methsuximide","author":"Browne","year":"1999"},{"key":"10.1053\/seiz.2000.0467_RF7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1528-1157.1979.tb04787.x","article-title":"Pharmacological interactions of mesuximide with phenobarbital and phenytoin in hospitalized epileptic patients","volume":"20","author":"Rambeck","year":"1979","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0467_RF8","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1212\/WNL.33.4.414","article-title":"Methsuximide for complex partial seizures: efficacy, toxicity, clinical pharmacology, and drug interactions","volume":"33","author":"Browne","year":"1983","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0467_RF9","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1542\/peds.19.4.614","article-title":"Celontin (PM-396) in the treatment of epilepsy","volume":"19","author":"Livingston","year":"1956","journal-title":"Pediatrics"},{"key":"10.1053\/seiz.2000.0467_RF10","first-page":"383","article-title":"N-Methyl-a,a-Methyl- phenylsuccinimide in psychomotor epilepsy","volume":"17","author":"Cordoba","year":"1956","journal-title":"Diseases of the Nervous System"},{"key":"10.1053\/seiz.2000.0467_RF11","first-page":"377","article-title":"[Methsuximide in the treatment of epilepsies]","volume":"48","author":"Stenzel","year":"1977","journal-title":"Nervenarzt"},{"key":"10.1053\/seiz.2000.0467_RF12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1059-1311(96)80062-8","article-title":"Methsuximide therapy of juvenile myoclonic epilepsy","volume":"5","author":"Hurst","year":"1996","journal-title":"Seizure"},{"key":"10.1053\/seiz.2000.0467_RF13","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1001\/jama.1973.03220130015004","article-title":"Methsuximide overdose. Delayed onset of profound coma","volume":"223","author":"Karch","year":"1973","journal-title":"Journal of the American Medical Association"},{"key":"10.1053\/seiz.2000.0467_RF14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1542\/peds.87.2.186","article-title":"Methsuximide for intractable childhood seizures","volume":"87","author":"Tennison","year":"1991","journal-title":"Pediatrics"},{"key":"10.1053\/seiz.2000.0467_RF15","first-page":"S29","article-title":"Use of new antiepileptic drugs in the treatment of childhood epilepsy","volume":"40 (Suppl. 6)","author":"Pellock","year":"1999","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0467_RF16","first-page":"489","article-title":"Epileptic encephalopathy of children with diffuse slow spikes and waves (alias \u2018petit mal variant\u2019) or Lennox syndrome","volume":"13","author":"Gastaut","year":"1966","journal-title":"Annals of Pediatrics Paris"},{"key":"10.1053\/seiz.2000.0467_RF17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0021-9673(01)94635-7","article-title":"Simultaneous determination of Zonisamide and nine other anti-epileptic drugs and metabolites in serum. A comparison of microbore and conventional high-performance liquid chromatography","volume":"385","author":"Juergens","year":"1987","journal-title":"Journal of Chromatography"},{"key":"10.1053\/seiz.2000.0467_RF18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1212\/WNL.31.6.741","article-title":"Methsuximide for refractory complex partial seizures","volume":"31","author":"Wilder","year":"1981","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0467_RF19","first-page":"801","article-title":"Preliminary experience with the succinimide \u2018Celontin\u2019 in epilepsy therapy","volume":"16","author":"Dreyer","year":"1959","journal-title":"Die Medizinische"},{"key":"10.1053\/seiz.2000.0467_RF20","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1001\/archneurpsyc.1954.02330060056008","article-title":"Use of N-Methyl-a,a-Methylphenylsuccinimide in treatment of petit mal epilepsy","volume":"72","author":"Zimmerman","year":"1954","journal-title":"Archives of Neurology and Psychiatry"},{"key":"10.1053\/seiz.2000.0467_RF21","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archneurpsyc.1956.02330250067009","article-title":"N-Methyl-a,a-Methylsuccinimide in psychomotor epilepsy therapy","volume":"76","author":"Zimmerman","year":"1956","journal-title":"Archives of Neurology and Psychiatry"},{"key":"10.1053\/seiz.2000.0467_RF22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1212\/WNL.7.7.483","article-title":"Use of Celontin in the treatment of mixed epilepsies","volume":"7","author":"Carter","year":"1957","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0467_RF23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1212\/WNL.8.3.201","article-title":"Celontin in patients with refractory epilepsy","volume":"8","author":"Dow","year":"1958","journal-title":"Neurology"},{"key":"10.1053\/seiz.2000.0467_RF24","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1056\/NEJM195805012581807","article-title":"Methsuximide in psychomotor and petit-mal seizures","volume":"258","author":"French","year":"1958","journal-title":"New England Journal of Medicine"},{"key":"10.1053\/seiz.2000.0467_RF25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1528-1157.1959.tb04252.x","article-title":"Celontin\u2014a new anticonvulsant","volume":"1","author":"Scholl","year":"1959","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0467_RF26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1528-1157.1959.tb04291.x","article-title":"Treatment of petit mal epilepsy with new succinimides: PM 680 and Celontin","volume":"1","author":"Trolle","year":"1959","journal-title":"Epilepsia"},{"key":"10.1053\/seiz.2000.0467_RF27","first-page":"306","article-title":"Celontin (Petinutin)\u2014contribution to a differentiated epilepsy therapy","volume":"31","author":"Rabe","year":"1960","journal-title":"Nervenarzt"},{"key":"10.1053\/seiz.2000.0467_RF28","first-page":"355","article-title":"Methsuximide (Celontin) for complex partial seizures: Efficacy, toxicity, clinical pharmacology, and drug interactions","volume":"30","author":"Browne","year":"1980","journal-title":"Neurology"}],"container-title":["Seizure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131100904679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1059131100904679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T01:26:45Z","timestamp":1761010005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1059131100904679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["S1059131100904679"],"URL":"https:\/\/doi.org\/10.1053\/seiz.2000.0467","relation":{},"ISSN":["1059-1311"],"issn-type":[{"type":"print","value":"1059-1311"}],"subject":[],"published":{"date-parts":[[2001,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood","name":"articletitle","label":"Article Title"},{"value":"Seizure","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/seiz.2000.0467","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 BEA Trading, Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}