{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:05:40Z","timestamp":1761987940145,"version":"build-2065373602"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2003,5,25]],"date-time":"2003-05-25T00:00:00Z","timestamp":1053820800000},"content-version":"vor","delay-in-days":1209,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["sfnmjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Neonatology"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1053\/siny.1999.0116","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T17:49:59Z","timestamp":1027878599000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Novel treatments after experimental brain injury"],"prefix":"10.1053","volume":"5","author":[{"given":"Michael V.","family":"Johnston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William H.","family":"Trescher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wako","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/siny.1999.0116_RF1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3101(24)00110-5","article-title":"Hypoxic and ischemic central nervous system disorders in infants and children","volume":"42","author":"Johnston","year":"1995","journal-title":"Adv Pediatr"},{"key":"10.1053\/siny.1999.0116_RF2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0165-0173(90)90011-C","article-title":"Physiological and pathophysiological roles of excitatory amino acids during central nervous system development","volume":"15","author":"McDonald","year":"1990","journal-title":"Brain Res Rev"},{"key":"10.1053\/siny.1999.0116_RF3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00004424-199904000-00001","article-title":"Unilateral hypoxic-ischemic injury in the neonatal rat brain evaluated by in vivo MRI","volume":"34","author":"Albensi","year":"1999","journal-title":"Invest Radiol"},{"key":"10.1053\/siny.1999.0116_RF4","first-page":"427","article-title":"Perinatal asphyxia: MR findings in the first 10 days","volume":"16","author":"Barkovich","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"10.1053\/siny.1999.0116_RF5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1203\/00006450-199611000-00014","article-title":"A piglet survival model of posthypoxic encephalopathy","volume":"40","author":"Thoresen","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0165-3806(91)90214-4","article-title":"Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxia-ischemia","volume":"64","author":"Andine","year":"1991","journal-title":"Dev Brain Res"},{"key":"10.1053\/siny.1999.0116_RF7","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0304-3940(87)90379-X","article-title":"Extracellular overflow of glutamate, aspartate, GABA and taurine in the cortex and basal ganglia of fetal lambs during hypoxia-ischemia","volume":"78","author":"Hagberg","year":"1987","journal-title":"Neurosci Lett"},{"key":"10.1053\/siny.1999.0116_RF8","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1651-2227.1993.tb12601.x","article-title":"Excitatory amino acids in the cerebral spinal fluid of asphyxiated infants: relationship to hypoxic-ischemic encephalopathy","volume":"82","author":"Hagberg","year":"1993","journal-title":"Acta Paediatr"},{"key":"10.1053\/siny.1999.0116_RF9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1126\/science.283.5401.496","article-title":"Energy on demand","volume":"283","author":"Magistretti","year":"1999","journal-title":"Science"},{"key":"10.1053\/siny.1999.0116_RF10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.410420310","article-title":"Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum","volume":"42","author":"Martin","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.1999.0116_RF11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0887-8994(92)90050-9","article-title":"Excitatory amino acids in cerebrospinal fluid in neonatal asphyxia","volume":"8","author":"Riikonen","year":"1992","journal-title":"Pediatr Neurol"},{"key":"10.1053\/siny.1999.0116_RF12","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/j.1471-4159.1986.tb00803.x","article-title":"Perinatal hypoxia-ischemia disrupts striatal high affinity3H-glutamate uptake into synaptosomes","volume":"47","author":"Silverstein","year":"1986","journal-title":"J Neurochem"},{"key":"10.1053\/siny.1999.0116_RF13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1203\/00006450-199112000-00021","article-title":"Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: an in vivo microdialysis study","volume":"30","author":"Silverstein","year":"1991","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF14","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/S0022-3476(98)70525-6","article-title":"Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention","volume":"132","author":"Delivoria-Papadopoulos","year":"1998","journal-title":"J Pediatr"},{"key":"10.1053\/siny.1999.0116_RF15","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1523\/JNEUROSCI.17-09-03064.1997","article-title":"Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis","volume":"17","author":"Pang","year":"1997","journal-title":"J Neurosci"},{"key":"10.1053\/siny.1999.0116_RF16","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1523\/JNEUROSCI.09-08-02809.1989","article-title":"Sensitivity of the developing rat brain to hypobaric\/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity","volume":"9","author":"Ikonomidou","year":"1989","journal-title":"J Neurosci"},{"key":"10.1053\/siny.1999.0116_RF17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0014-2999(87)90295-0","article-title":"MK-801 protects the neonatal brain from hypoxic-ischemic damage","volume":"140","author":"McDonald","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/siny.1999.0116_RF18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1469-8749.1995.tb12035.x","article-title":"Prevention by magnesium of excitotoxic neuronal death in the developing brain: an animal model for clinical intervention studies","volume":"37","author":"Marret","year":"1995","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.1999.0116_RF19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1203\/00006450-199307000-00006","article-title":"Scavengers of free oxygen radicals in combination with magnesium sulphate ameliorate perinatal hypoxia-ischemic brain injury in the rat","volume":"34","author":"Thordstein","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0006-8993(88)90306-X","article-title":"Neurotoxicity of N-methyl-D-asparate is markedly enhanced in developing rat central nervous system","volume":"459","author":"McDonald","year":"1988","journal-title":"Brain Res"},{"key":"10.1053\/siny.1999.0116_RF21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000244109","article-title":"Hypoxia-ischemia in the neonatal rat brain: histopathology after post-treatment with NMDA and non-NMDA receptor antagonists","volume":"66","author":"Hagberg","year":"1994","journal-title":"Biol Neonate"},{"key":"10.1053\/siny.1999.0116_RF22","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1212\/WNL.39.5.713","article-title":"Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat","volume":"39","author":"Hattori","year":"1989","journal-title":"Neurology"},{"key":"10.1053\/siny.1999.0116_RF23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1615\/CritRevNeurobiol.v12.i3.40","article-title":"Nitric oxide in cerebral ischemic neurodegeneration and excitotoxicity","volume":"12","author":"Strijbos","year":"1998","journal-title":"Crit Rev Neurobiol"},{"key":"10.1053\/siny.1999.0116_RF24","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0896-6273(95)90186-8","article-title":"Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function","volume":"15","author":"Ankarcrona","year":"1995","journal-title":"Neuron"},{"key":"10.1053\/siny.1999.0116_RF25","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1523\/JNEUROSCI.16-16-05004.1996","article-title":"Viscous cycle involving Na+channels, glutamate release, and NMDA receptors mediates delayed neurodegeneration through nitric oxide formation","volume":"16","author":"Strijbos","year":"1996","journal-title":"J Neurosci"},{"doi-asserted-by":"crossref","unstructured":"Tseng, EE, Brock, MV, Lange, MS, Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest, Ann Thorac Surg, 64, 1639, 1647","key":"10.1053\/siny.1999.0116_RF26","DOI":"10.1016\/S0003-4975(97)01110-7"},{"key":"10.1053\/siny.1999.0116_RF27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nm1097-1089","article-title":"Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia","volume":"3","author":"Eliasson","year":"1997","journal-title":"Nat Med"},{"key":"10.1053\/siny.1999.0116_RF28","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1161\/01.STR.26.8.1478","article-title":"Ischemic delayed neuronal death, a mitochondrial hypothesis","volume":"26","author":"Abe","year":"1995","journal-title":"Stroke"},{"key":"10.1053\/siny.1999.0116_RF29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1203\/00006450-199809000-00007","article-title":"Persistent increases in cerebral lactate concentration after birth asphyxia","volume":"44","author":"Hanrahan","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00004647-199803000-00008","article-title":"Mitochondrial function and energy metabolism after hypoxia-ischemia inthe immature rat brain: involvement of NMDA receptors","volume":"18","author":"Gilland","year":"1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0006-8993(98)00064-X","article-title":"Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion","volume":"790","author":"Almeida","year":"1998","journal-title":"Brain Res"},{"key":"10.1053\/siny.1999.0116_RF32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/S0006-8993(98)01240-2","article-title":"Nitric oxide mediates glutamate-induced mitochondrial depolarization in rat cortical neurons","volume":"816","author":"Almeida","year":"1999","journal-title":"Brain Res"},{"key":"10.1053\/siny.1999.0116_RF33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/excr.1997.4026","article-title":"Apoptosis, excitotoxicity and neuropathology","volume":"239","author":"Leist","year":"1998","journal-title":"Exp Cell Res"},{"key":"10.1053\/siny.1999.0116_RF34","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/ana.410360610","article-title":"Evidence for hypoxia-induced, programmed cell death of cultured neurons","volume":"36","author":"Rosenbaum","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.1999.0116_RF35","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1365-2990.1996.tb01122.x","article-title":"Apoptosis in perinatal hypoxic-ischemic cerebral damage","volume":"22","author":"Edwards","year":"1996","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1053\/siny.1999.0116_RF36","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1203\/00006450-199711000-00022","article-title":"Apoptosis in the brains of infants suffering intrauterine cerebral injury","volume":"42","author":"Edwards","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF37","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/1531-8249(199904)45:4<421::AID-ANA2>3.0.CO;2-Q","article-title":"Caspases as treatment targets in stroke and neurodegenerative diseases","volume":"45","author":"Schulz","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.1999.0116_RF38","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1038\/jcbfm.1995.122","article-title":"Effect of delayed MK-801 (dizocilpine) treatment with or without immediate postischemic hypothermia on chronic neuronal survival after global forebrain ischemia in rats","volume":"15","author":"Dietrich","year":"1995","journal-title":"J Cerebr Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF39","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0092-8674(00)80430-4","article-title":"Caspases: intracellular signaling by proteolysis","volume":"91","author":"Salvesen","year":"1997","journal-title":"Cell"},{"key":"10.1053\/siny.1999.0116_RF40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(94)00217-3","article-title":"Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss","volume":"29","author":"Beilharz","year":"1995","journal-title":"Brain Res Mol Brain Res"},{"key":"10.1053\/siny.1999.0116_RF41","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1097\/00001756-199401120-00031","article-title":"DNA damage consistent with apoptosis in transient focal ischemic neocortex","volume":"5","author":"MacManus","year":"1994","journal-title":"Neuroreport"},{"key":"10.1053\/siny.1999.0116_RF42","article-title":"Apoptosis in an neonatal rat model of cerebral hypoxia-ischemia","author":"Nakajima","year":"1999","journal-title":"Soc Neurosci Abstr"},{"key":"10.1053\/siny.1999.0116_RF43","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1161\/01.STR.29.12.2622","article-title":"Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia","volume":"29","author":"Pulera","year":"1998","journal-title":"Stroke"},{"key":"10.1053\/siny.1999.0116_RF44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1365-2990.1997.tb01181.x","article-title":"Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia","volume":"23","author":"Yue","year":"1997","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.1053\/siny.1999.0116_RF45","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1097\/00004647-199709000-00006","article-title":"DNA fragmentation follows delayed neuronal death in CA1 neurons exposed to transient global ischemia in the rat","volume":"17","author":"Petito","year":"1997","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF46","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","article-title":"Interventions for perinatal hypoxic-ischemic encephalopathy","volume":"100","author":"Vannucci","year":"1997","journal-title":"Pediatrics"},{"key":"10.1053\/siny.1999.0116_RF47","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1006\/nbdi.1996.0006","article-title":"Neonatal mice lacking neuronal nitric oxide synthase are less vulnerable to hypoxic-ischemic injury","volume":"3","author":"Ferriero","year":"1996","journal-title":"Neurobiol Dis"},{"key":"10.1053\/siny.1999.0116_RF48","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.7522345","article-title":"Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase","volume":"265","author":"Huang","year":"1994","journal-title":"Science"},{"key":"10.1053\/siny.1999.0116_RF49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0014-2999(92)90168-4","article-title":"Neuroprotective effects of N-nitro-arginine in focal stroke in the 7-day old rat","volume":"218","author":"Trifiletti","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/siny.1999.0116_RF50","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1203\/00006450-199511000-00004","article-title":"L-name reduces infarct volume in a filament model of transient middle cerebral artery occlusion in the rat pup","volume":"38","author":"Ashwal","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1203\/00006450-199401000-00003","article-title":"Inhibitor of nitric oxide synthesis reduces hypoxic-ischemic brain damage in the neonatal rat","volume":"35","author":"Hamada","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF52","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/jcbfm.1992.102","article-title":"Inhibition of nitric oxide synthesis increases focal ischemic infarction in the rat","volume":"12","author":"Yamamoto","year":"1992","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF53","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/jcbfm.1995.76","article-title":"Basic fibroblast growth factor protects against excitoxicity and chemical hypoxia in both neonatal and adult rats","volume":"15","author":"Kirschner","year":"1995","journal-title":"J Cerebr Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF54","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/jcbfm.1993.27","article-title":"Basic fibroblast growth factor protects against hypoxia-ischemia and NMDA neurotoxicity in neonatal rats","volume":"13","author":"Nozaki","year":"1993","journal-title":"J Cerebr Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF55","first-page":"2490","article-title":"Human FGF-1 gene delivery protects against quinolinate-induced striatal and hippocampal injury in neonatal rats","volume":"10","author":"Hossain","year":"1998","journal-title":"Eur J Neurosci"},{"key":"10.1053\/siny.1999.0116_RF56","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI118416","article-title":"Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lamb","volume":"97","author":"Johnston","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/siny.1999.0116_RF57","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1203\/00006450-199903000-00005","article-title":"Possible protective role of growth hormone in hypoxia-ischemia","volume":"45","author":"Gustafson","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.1999.0116_RF58","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/ana.410390117","article-title":"Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury","volume":"39","author":"Holtzman","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.1999.0116_RF59","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1073\/pnas.94.21.11657","article-title":"Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule cells","volume":"94","author":"Du","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/siny.1999.0116_RF60","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0165-6147(94)90090-6","article-title":"Calpain inhibition: an overview of its therapeutic potential","volume":"15","author":"Wang","year":"1994","journal-title":"Trends Pharmacol Sci"},{"key":"10.1053\/siny.1999.0116_RF61","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0006-8993(95)00399-B","article-title":"Fodrin degradation and subcellular distribution of calpains after neonatal rat cerebral hypoxic-ischemia","volume":"684","author":"Blomgren","year":"1995","journal-title":"Brain Res"},{"key":"10.1053\/siny.1999.0116_RF62","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1172\/JCI2169","article-title":"Caspase inhibitor affords neuroprotection after delayed administration in a rat model of neonatal hypoxic-ischemic brain injury","volume":"101","author":"Cheng","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1053\/siny.1999.0116_RF63","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.94.5.2007","article-title":"Inhibition of interleukin 1-beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage","volume":"94","author":"Hara","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/siny.1999.0116_RF64","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0306-4522(96)00225-4","article-title":"Adenovirus-mediated over-expression ov interleukin-1 receptor antagonist reduces susceptibility to excitotoxic brain injury in perinatal rats","volume":"75","author":"Hagan","year":"1996","journal-title":"Neurosciences"},{"key":"10.1053\/siny.1999.0116_RF65","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0197-0186(96)00072-1","article-title":"Cytokines and perinatal brain injury","volume":"30","author":"Silverstein","year":"1997","journal-title":"Neurochem Int"},{"key":"10.1053\/siny.1999.0116_RF66","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1097\/00004647-199810000-00003","article-title":"Prolonged therapeutic window for ischemic brain damage caused bydelayed caspase activation","volume":"18","author":"Zhu","year":"1998","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.1999.0116_RF67","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/sj.bjp.0701871","article-title":"Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischemia in mice","volume":"124","author":"Ma","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1053\/siny.1999.0116_RF68","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0387-7604(97)00027-2","article-title":"Brief post-hypoxic-ischemic hypothermia markedly delays neonatal brain injury","volume":"19","author":"Trescher","year":"1997","journal-title":"Brain Dev"}],"container-title":["Seminars in Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084275699901161?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084275699901161?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:12:17Z","timestamp":1761059537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084275699901161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S1084275699901161"],"URL":"https:\/\/doi.org\/10.1053\/siny.1999.0116","relation":{},"ISSN":["1084-2756"],"issn-type":[{"type":"print","value":"1084-2756"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel treatments after experimental brain injury","name":"articletitle","label":"Article Title"},{"value":"Seminars in Neonatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/siny.1999.0116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Harcourt Publishers Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}