{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:36:48Z","timestamp":1788514608214,"version":"build-2803163510"},"reference-count":138,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Neonatology"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1053\/siny.2001.0042","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T14:55:08Z","timestamp":1032447308000},"page":"109-120","source":"Crossref","is-referenced-by-count":41,"title":["Hypoxic-ischemic brain injury in the newborn: pathophysiology and potential strategies for intervention"],"prefix":"10.1053","volume":"6","author":[{"given":"Peter D.","family":"Gluckman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine S.","family":"Pinal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair J.","family":"Gunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/siny.2001.0042_RF1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1055\/s-2000-9293","article-title":"Hypoxic-ischemic encephalopathy","volume":"17","author":"Vannucci","year":"2000","journal-title":"Am J Perinatol"},{"key":"10.1053\/siny.2001.0042_RF2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0887-8994(99)00020-X","article-title":"The use of hypothermia: a role in the treatment of neonatal asphyxia?","volume":"21","author":"Wagner","year":"1999","journal-title":"Pediatr Neurol"},{"key":"10.1053\/siny.2001.0042_RF3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1203\/00006450-198905000-00004","article-title":"Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy","volume":"25","author":"Azzopardi","year":"1989","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1203\/00006450-199205000-00016","article-title":"Cerebral histological and electrophysiological changes after asphyxia in fetal sheep","volume":"31","author":"Gunn","year":"1992","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9378(97)80004-X","article-title":"Fetal heart rate changes during brief repeated umbilical cord occlusion do not reflect cardiovascular deterioration in fetal lambs","volume":"176","author":"de Haan","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1203\/00006450-199006000-00004","article-title":"Delayed seizures occurring with hypoxic-ischemic encephalopathy in the fetal sheep","volume":"27","author":"Williams","year":"1990","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/01.STR.22.4.516","article-title":"Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep","volume":"22","author":"Williams","year":"1991","journal-title":"Stroke"},{"key":"10.1053\/siny.2001.0042_RF8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/ana.410310104","article-title":"Outcome after ischemia in the developing sheep brain: An electroencephalographic and histological study","volume":"31","author":"Williams","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.2001.0042_RF9","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1111\/j.1469-8749.1992.tb11407.x","article-title":"When and why do brain cells die?","volume":"34","author":"Gluckman","year":"1992","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.2001.0042_RF10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0169-328X(94)00217-3","article-title":"Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss","volume":"29","author":"Beilharz","year":"1995","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1203\/00006450-199605000-00008","article-title":"Accumulation of cytotoxins during the development of seizures and edema after hypoxic-ischemic injury in late gestation fetal sheep","volume":"39","author":"Tan","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1203\/00006450-199601000-00007","article-title":"Delayed vasodilation and altered oxygenation following cerebral ischemia in fetal sheep","volume":"39","author":"Marks","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF13","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/01.STR.30.12.2735","article-title":"Role of the cerebrovascular and metabolic responses in the delayed phases of injury after transient cerebral ischemia in fetal sheep","volume":"30","author":"Abi Raad","year":"1999","journal-title":"Stroke"},{"key":"10.1053\/siny.2001.0042_RF14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0006-291X(92)91774-K","article-title":"A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury","volume":"182","author":"Gluckman","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/siny.2001.0042_RF15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0303-7207(98)00035-5","article-title":"Asphyxial brain injury\u2014the role of the IGF system","volume":"140","author":"Gluckman","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/siny.2001.0042_RF16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0169-328X(92)90048-G","article-title":"Hypoxia-ischemia induces transforming growth factor beta 1 mRNA in the infant rat brain","volume":"13","author":"Klempt","year":"1992","journal-title":"Mol Brain Res"},{"key":"10.1053\/siny.2001.0042_RF17","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00001756-199404000-00012","article-title":"Neuronal rescue with transforming growth factor-beta(1) after hypoxic-ischaemic brain injury","volume":"5","author":"McNeill","year":"1994","journal-title":"Neuroreport"},{"key":"10.1053\/siny.2001.0042_RF18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00004647-199603000-00007","article-title":"Coordinate IGF-I and IGFBP5 gene expression in perinatal rat brain after hypoxia-ischemia","volume":"16","author":"Lee","year":"1996","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.2001.0042_RF19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI119153","article-title":"Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal sheep","volume":"99","author":"Gunn","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1053\/siny.2001.0042_RF20","doi-asserted-by":"crossref","first-page":"F200","DOI":"10.1136\/fn.74.3.F200","article-title":"Effect of radiant heat on head temperature gradient in term infants","volume":"74","author":"Gunn","year":"1996","journal-title":"Arch Dis Child Fetal Neonat Ed"},{"key":"10.1053\/siny.2001.0042_RF21","first-page":"147","article-title":"Electrophysiological responses of the fetus to hypoxia and asphyxia","volume":"16","author":"Gunn","year":"1991","journal-title":"J Dev Physiol"},{"key":"10.1053\/siny.2001.0042_RF22","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic-ischemic brain damage in the rat","volume":"9","author":"Rice","year":"1981","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.2001.0042_RF23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0165-0270(94)90034-5","article-title":"Two models for determining the mechanisms of damage and repair after hypoxic-ischemic injury in the developing rat brain","volume":"55","author":"Sirimanne","year":"1994","journal-title":"J Neurosci Methods"},{"key":"10.1053\/siny.2001.0042_RF24","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1203\/00006450-199412000-00003","article-title":"Delayed (\u2018secondary\u2019) cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy","volume":"36","author":"Lorek","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1161\/01.STR.22.10.1270","article-title":"MK-801 does not protect against hypoxic-ischemic brain injury in piglets","volume":"22","author":"LeBlanc","year":"1991","journal-title":"Stroke"},{"key":"10.1053\/siny.2001.0042_RF26","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1203\/00006450-199506000-00006","article-title":"Repeated episodes of umbilical cord occlusion in fetal sheep lead to preferential damage to the striatum and sensitise the heart to further insults","volume":"37","author":"Mallard","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF27","series-title":"Acquired Damage in the Developing Brain: its Timing and Causation","article-title":"Asphyxia","author":"Gunn","year":"2001"},{"key":"10.1053\/siny.2001.0042_RF28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0028-2243(95)02297-6","article-title":"The brain of the asphyxiated fetus\u2014basic research","volume":"65","author":"Jensen","year":"1996","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1053\/siny.2001.0042_RF29","first-page":"16","article-title":"Experiments in perinatal brain injury: What have we learnt?","volume":"1","author":"de Haan","year":"1996","journal-title":"Prenat Neonat Med"},{"key":"10.1053\/siny.2001.0042_RF30","first-page":"11","article-title":"The fetal circulation and its response to stress","volume":"6","author":"Rudolph","year":"1984","journal-title":"J Dev Physiol"},{"key":"10.1053\/siny.2001.0042_RF31","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0095-5108(18)30395-6","article-title":"Pathophysiology of perinatal asphyxia","volume":"20","author":"Williams","year":"1993","journal-title":"Clin Perinatol"},{"key":"10.1053\/siny.2001.0042_RF32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1203\/00006450-199205000-00016","article-title":"Cerebral histologic and electrocorticographic changes after asphyxia in fetal sheep","volume":"31","author":"Gunn","year":"1992","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF33","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0002-9378(11)91728-1","article-title":"Transient umbilical cord occlusion causes hippocampal damage in the fetal sheep","volume":"167","author":"Mallard","year":"1992","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-4886(83)90019-5","article-title":"Hypoxic-ischemic cerebral necrosis in midgestational sheep fetuses: physiopathologic correlations","volume":"80","author":"Ting","year":"1983","journal-title":"Exp Neurol"},{"key":"10.1053\/siny.2001.0042_RF35","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0002-9378(89)90269-X","article-title":"Acid-base status at birth and neurodevelopmental outcome at four and one-half years","volume":"161","author":"Dennis","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF36","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1471-0528.1986.tb07896.x","article-title":"Apgar score, meconium and acidaemia at birth in relation to neonatal neurological morbidity","volume":"93","author":"Dijxhoorn","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1053\/siny.2001.0042_RF37","first-page":"120","article-title":"Does the Apgar score have diagnostic value?","volume":"72","author":"Marrin","year":"1988","journal-title":"Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF38","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0095-5108(18)30050-2","article-title":"Long-term neurodevelopmental outcome of asphyxiated newborns","volume":"26","author":"Simon","year":"1999","journal-title":"Clin Perinatol"},{"key":"10.1053\/siny.2001.0042_RF39","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1542\/peds.100.6.1004","article-title":"Interventions for perinatal hypoxic-ischemic encephalopathy","volume":"100","author":"Vannucci","year":"1997","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.STR.15.2.221","article-title":"The pathogenesis of watershed infarcts in the brain","volume":"15","author":"Torvik","year":"1984","journal-title":"Stroke"},{"key":"10.1053\/siny.2001.0042_RF41","series-title":"Neurology of the Newborn","first-page":"279","article-title":"Hypoxic-ischemic encephalopathy: Neuropathology and pathogenesis","author":"Volpe","year":"1995"},{"key":"10.1053\/siny.2001.0042_RF42","series-title":"Cell Death in Biology and Pathology","first-page":"9","article-title":"Cell death: a new classification separating apoptosis from necrosis","author":"Wyllie","year":"1981"},{"key":"10.1053\/siny.2001.0042_RF43","first-page":"18","article-title":"Patterns of cell death","volume":"13","author":"Walker","year":"1988","journal-title":"Methods Achiev Exp Pathol"},{"key":"10.1053\/siny.2001.0042_RF44","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0301-0082(00)00011-3","article-title":"Mechanisms underlying hypoxia-induced neuronal apoptosis","volume":"62","author":"Banasiak","year":"2000","journal-title":"Prog Neurobiol"},{"key":"10.1053\/siny.2001.0042_RF45","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/284555a0","article-title":"Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation","volume":"284","author":"Wyllie","year":"1980","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF46","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/356397a0","article-title":"Social controls on cell survival and cell death","volume":"356","author":"Raff","year":"1992","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF47","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0166-2236(99)01435-6","article-title":"Neuronal apoptosis in acute necrotic insults: why is this subject such a mess?","volume":"22","author":"Roy","year":"1999","journal-title":"Trends Neurosci"},{"key":"10.1053\/siny.2001.0042_RF48","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/35037739","article-title":"Apoptosis in the nervous system","volume":"407","author":"Yuan","year":"2000","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF49","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF50","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/35037747","article-title":"From bench to clinic with apoptosis-based therapeutic agents","volume":"407","author":"Nicholson","year":"2000","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF51","doi-asserted-by":"crossref","first-page":"7994","DOI":"10.1523\/JNEUROSCI.20-21-07994.2000","article-title":"Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat","volume":"20","author":"Nakajima","year":"2000","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF52","series-title":"Fetal and Neonatal Neurology and Neurosurgery","article-title":"Pathophysiology of asphyxia","author":"Bennet","year":"2001"},{"key":"10.1053\/siny.2001.0042_RF53","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0022-3476(80)80574-9","article-title":"Neonatal asphyxia. I. Relationship of obstetric and neonatal complications to neonatal mortality in 38,405 consecutive deliveries","volume":"96","author":"MacDonald","year":"1980","journal-title":"J Pediatr"},{"key":"10.1053\/siny.2001.0042_RF54","doi-asserted-by":"crossref","first-page":"7424","DOI":"10.1523\/JNEUROSCI.20-19-07424.2000","article-title":"Effect of dexamethasone treatment on maturational changes in the NMDA receptor in sheep brain","volume":"20","author":"Mcgowan","year":"2000","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF55","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0165-3806(99)00131-5","article-title":"The ontogeny of glutamate receptors and D-aspartate binding sites in the ovine CNS","volume":"118","author":"Anderson","year":"1999","journal-title":"Dev Brain Res"},{"key":"10.1053\/siny.2001.0042_RF56","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0887-8994(95)00192-1","article-title":"Immunohistochemical study of myelination and oligodendrocyte in infants with periventricular leukomalacia","volume":"13","author":"Iida","year":"1995","journal-title":"Pediatr Neurol"},{"key":"10.1053\/siny.2001.0042_RF57","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/(SICI)1098-2779(1997)3:1<96::AID-MRDD12>3.0.CO;2-M","article-title":"Cellular and molecular pathogenesis of periventricular white matter injury","volume":"3","author":"Back","year":"1997","journal-title":"Mental Retard Develop Disabil Res Rev"},{"key":"10.1053\/siny.2001.0042_RF58","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1203\/00006450-199805000-00017","article-title":"Maturational change in the cortical response to hypoperfusion injury in the fetal sheep","volume":"43","author":"Reddy","year":"1998","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF59","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0002-9378(97)70539-8","article-title":"Absence of neuronal damage after umbilical cord occlusion of 10, 15, and 20 minutes in midgestation fetal sheep","volume":"176","author":"Keunen","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF60","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1469-7793.1999.0247z.x","article-title":"The cardiovascular and cerebrovascular responses of the immature fetal sheep to acute umbilical cord occlusion","volume":"517","author":"Bennet","year":"1999","journal-title":"J Physiol"},{"key":"10.1053\/siny.2001.0042_RF61","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/oxfordjournals.bmb.a069888","article-title":"Glycogen reserves and their changes at birth and in anoxia","volume":"17","author":"Shelley","year":"1961","journal-title":"Br Med Bull"},{"key":"10.1053\/siny.2001.0042_RF62","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0002-9378(94)70409-0","article-title":"Increased vulnerability to neuronal damage after umbilical cord occlusion in fetal sheep with advancing gestation","volume":"170","author":"Mallard","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF63","series-title":"Intrauterine asphyxia and the developing fetal brain","first-page":"37","article-title":"Experimental models of perinatal brain damage: Relevance to human pathology","author":"Myers","year":"1977"},{"key":"10.1053\/siny.2001.0042_RF64","first-page":"1837","article-title":"Profound asphyxia in the premature infant: Imaging findings","volume":"16","author":"Barkovich","year":"1995","journal-title":"Am J Neuroradiol"},{"key":"10.1053\/siny.2001.0042_RF65","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0306-4522(94)00504-X","article-title":"Repeated asphyxia causes loss of striatal projection neurons in the fetal sheep brain","volume":"65","author":"Mallard","year":"1995","journal-title":"Neuroscience"},{"key":"10.1053\/siny.2001.0042_RF66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199707000-00001","article-title":"Maternal intrauterine infection, cytokines, and brain damage in the preterm newborn","volume":"42","author":"Dammann","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF67","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1469-8749.1993.tb11687.x","article-title":"Infectious diseases in pregnancy, cytokines and neurological impairment: an hypothesis","volume":"35","author":"Adinolfi","year":"1993","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.2001.0042_RF68","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1001\/jama.1997.03550030047032","article-title":"Maternal infection and cerebral palsy in infants of normal birth weight","volume":"278","author":"Grether","year":"1997","journal-title":"JAMA"},{"key":"10.1053\/siny.2001.0042_RF69","first-page":"288","article-title":"Fever","volume":"24","author":"Dinarello","year":"1997","journal-title":"Sem Oncol"},{"key":"10.1053\/siny.2001.0042_RF70","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0022-3476(00)90004-0","article-title":"Brain damage in preterm newborns: biological response modification as a strategy to reduce disabilities","volume":"136","author":"Dammann","year":"2000","journal-title":"J Pediatr"},{"key":"10.1053\/siny.2001.0042_RF71","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1469-8749.1985.tb04581.x","article-title":"The development of the human blood-CSF-brain barrier","volume":"27","author":"Adinolfi","year":"1985","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.2001.0042_RF72","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1469-8749.1993.tb11688.x","article-title":"Preterm birth and cerebral palsy: is tumor necrosis factor the missing link?","volume":"35","author":"Leviton","year":"1993","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.2001.0042_RF73","first-page":"177","article-title":"Brain damage and temperature: cellular and molecular mechanisms","volume":"71","author":"Dietrich","year":"1996","journal-title":"Adv Neurol"},{"key":"10.1053\/siny.2001.0042_RF74","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0140-6736(96)90008-2","article-title":"Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome","volume":"347","author":"Reith","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/siny.2001.0042_RF75","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1542\/peds.105.1.8","article-title":"Intrapartum maternal fever and neonatal outcome","volume":"105","author":"Lieberman","year":"2000","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF76","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0303-7207(98)00039-2","article-title":"Fetal growth and placental function","volume":"140","author":"Bauer","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/siny.2001.0042_RF77","first-page":"402","article-title":"Insulin resistance in short children with intrauterine growth retardation","volume":"82","author":"Hofman","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/siny.2001.0042_RF78","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1136\/adc.73.4.287","article-title":"Size at birth and plasma insulin-like growth factor-1 concentrations","volume":"73","author":"Fall","year":"1995","journal-title":"Arch Dis Child Fetal Neonat Ed"},{"key":"10.1053\/siny.2001.0042_RF79","first-page":"697","article-title":"Restricted cardiovascular and cerebral performance of intra-uterine growth retarded newbornpiglets during severe hypoxia","volume":"48","author":"Bauer","year":"1989","journal-title":"Biomed Biochem Acta"},{"key":"10.1053\/siny.2001.0042_RF80","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1203\/00006450-198811000-00019","article-title":"Cerebral tolerance of hypoxia in growth-retarded and appropriately grown newborn guinea pigs","volume":"24","author":"Thordstein","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF81","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1095-6433(98)01001-0","article-title":"Fetal brain injury following prolonged hypoxemia and placental insufficiency: a review","volume":"119","author":"Rees","year":"1998","journal-title":"Comp Biochem Physiol"},{"key":"10.1053\/siny.2001.0042_RF82","first-page":"211","article-title":"Structure of the fetal sheep brain in experimental growth retardation","volume":"10","author":"Rees","year":"1988","journal-title":"J Dev Physiol"},{"key":"10.1053\/siny.2001.0042_RF83","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0736-5748(88)90051-2","article-title":"The effects of intrauterine growth retardation on synaptogenesis and mitochondrial formation in the cerebral and cerebellar cortices of fetal sheep","volume":"6","author":"Bisignano","year":"1988","journal-title":"Int J Dev Neurosci"},{"key":"10.1053\/siny.2001.0042_RF84","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1203\/00006450-198811000-00012","article-title":"Precocial neural function in the growth retarded fetal lamb","volume":"24","author":"Cook","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF85","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1159\/000241398","article-title":"Influence of intrauterine growth retardation on brain development alteration of myelination","volume":"39","author":"Bourre","year":"1981","journal-title":"Biol Neonate"},{"key":"10.1053\/siny.2001.0042_RF86","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0736-5748(90)90003-K","article-title":"The effects of intrauterine growth retardation on the structural development of cranial nerves (optic, trochlear) in fetal sheep","volume":"8","author":"Rees","year":"1990","journal-title":"Int J Dev Neurosci"},{"key":"10.1053\/siny.2001.0042_RF87","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1542\/peds.86.5.707","article-title":"Impact of intrauterine growth retardation and body proportionality on fetal and neonatal outcome","volume":"86","author":"Kramer","year":"1990","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF88","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1748-1716.1986.tb07862.x","article-title":"Evidence indicating trophic importance of IGF-1 in regenerating peripheral nerves","volume":"126","author":"Hansson","year":"1986","journal-title":"Acta Physiol Scand"},{"key":"10.1053\/siny.2001.0042_RF89","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0006-8993(89)90531-3","article-title":"Insulin-like growth factor 1 (IGF-1) stimulates regeneration of the rat sciatic nerve","volume":"486","author":"Kanje","year":"1989","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF90","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1523\/JNEUROSCI.10-02-00558.1990","article-title":"Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors 1 and 2","volume":"10","author":"Knusel","year":"1990","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF91","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0006-291X(05)80172-X","article-title":"Insulin-like growth factor 1 supports embryonic nerve cell survival","volume":"172","author":"Svrzic","year":"1990","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1053\/siny.2001.0042_RF92","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1073\/pnas.85.1.265","article-title":"Differential expression of insulin-like growth factor genes in rat central nervous system","volume":"85","author":"Rotwein","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1053\/siny.2001.0042_RF93","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0169-328X(98)00122-3","article-title":"Co-ordinated and cellular specific induction of the components of the IGF\/IGFBP axis in the rat brain following hypoxic-ischemic injury","volume":"59","author":"Beilharz","year":"1998","journal-title":"Mol Brain Res"},{"key":"10.1053\/siny.2001.0042_RF94","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/jcbfm.1993.79","article-title":"The effects of IGF-1 treatment after hypoxic-ischemic brain injury in adult rats","volume":"13","author":"Guan","year":"1993","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.2001.0042_RF95","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1172\/JCI118416","article-title":"Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs","volume":"97","author":"Johnston","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/siny.2001.0042_RF96","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00004647-200003000-00010","article-title":"The window of opportunity for neuronal rescue with insulin-like growth factor-1 after hypoxia-ischemia in rats is critically modulated by cerebral temperature during recovery","volume":"20","author":"Guan","year":"2000","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/siny.2001.0042_RF97","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0169-328X(92)90151-Z","article-title":"Expression of insulin-like growth factor binding protein-2 (IGFBP-2) following transient hypoxia-ischemia in the infant rat brain","volume":"15","author":"Klempt","year":"1992","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF98","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0169-328X(93)90021-G","article-title":"Hypoxia and hypoxia\/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain","volume":"17","author":"Klempt","year":"1993","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF99","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0169-328X(93)90191-Q","article-title":"Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury","volume":"18","author":"Beilharz","year":"1993","journal-title":"Mol Brain Res"},{"key":"10.1053\/siny.2001.0042_RF100","doi-asserted-by":"crossref","unstructured":"Guan, J, Bennet, L, Wu, D, George, S, Waldvogel, HJ, Faull, RLM, Insulin-like growth factor-1 reduces white matter damage following ischemic brain injury in fetal sheep, J Cereb Blood Flow Metab, 2001","DOI":"10.1097\/00004647-200105000-00003"},{"key":"10.1053\/siny.2001.0042_RF101","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1523\/JNEUROSCI.14-12-07629.1994","article-title":"Cell death of spinal motoneurons in the chick embryo following deafferentation: rescue effects of tissue extracts, soluble proteins, and neurotrophic agents","volume":"14","author":"Yin","year":"1994","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF102","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1523\/JNEUROSCI.15-02-01172.1995","article-title":"Apoptosis in cerebellar granule cells is blocked by high KCl, forskolin, and IGF-1 through distinct mechanisms of action: The involvement of intracellular calcium and RNA synthesis","volume":"15","author":"Galli","year":"1995","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF103","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1074\/jbc.272.1.154","article-title":"Insulin-like growth factor 1 inhibits apoptosis using the phosphatidylinositol 3'-kinase and mitogen-activated protein kinase pathways","volume":"272","author":"Parrizas","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/siny.2001.0042_RF104","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1523\/JNEUROSCI.17-05-01548.1997","article-title":"Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways\u2014possible involvement of PI 3-kinase in IGF-1 signaling","volume":"17","author":"Dmello","year":"1997","journal-title":"J Neurosci"},{"key":"10.1053\/siny.2001.0042_RF105","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1128\/MCB.17.3.1595","article-title":"Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and AKT","volume":"17","author":"Kulik","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1053\/siny.2001.0042_RF106","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1210\/endo.135.6.7988428","article-title":"Generation of des-(1-3) insulin-like growth factor-I in serum by an acid protease","volume":"135","author":"Yamamoto","year":"1994","journal-title":"Endocrinology"},{"key":"10.1053\/siny.2001.0042_RF107","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1677\/joe.0.1460141","article-title":"Enzymatic conversion of IGF-I to des(1-3)IGF-I in rat serum and tissues: A further potential site of growth hormone regulation of IGF-I action","volume":"146","author":"Yamamoto","year":"1995","journal-title":"J Endocrinol"},{"key":"10.1053\/siny.2001.0042_RF108","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1210\/endo.137.3.8603600","article-title":"The effects of insulin-like growth factor (IGF)-1, IGF-2, and Des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats\u2014evidence for a role for IGF binding proteins","volume":"137","author":"Guan","year":"1996","journal-title":"Endocrinology"},{"key":"10.1053\/siny.2001.0042_RF109","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001756-199901180-00031","article-title":"Neuroprotective effects of Gly-Pro-Glu, the N-terminal tripeptide of IGF-1, in the hippocampus in vitro","volume":"10","author":"Saura","year":"1999","journal-title":"Neuroreport"},{"key":"10.1053\/siny.2001.0042_RF110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0306-4522(98)00338-8","article-title":"The effects of the N-terminal tripeptide of insulin-like growth factor-1, glycine-proline-glutamate in different regions following hypoxic-ischemic brain injury in adult rats","volume":"89","author":"Guan","year":"1999","journal-title":"Neuroscience"},{"key":"10.1053\/siny.2001.0042_RF111","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(88)90931-6","article-title":"Localization of binding sites for insulin-like growth factor-1 (IGF-1) in the rat brain by quantitative autoradiography","volume":"444","author":"Bohannon","year":"1988","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF112","series-title":"Clinical applications of TGF-beta. 1st ed","author":"Amento","year":"1991"},{"key":"10.1053\/siny.2001.0042_RF113","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/334260a0","article-title":"Deactivation of macrophages by transforming growth factor-beta","volume":"334","author":"Tsunawaki","year":"1988","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF114","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.4049\/jimmunol.151.4.2150","article-title":"Transforming growth factor-\u03b21 suppresses activation and proliferation of microglia in vitro","volume":"151","author":"Suzumura","year":"1993","journal-title":"J Immunol"},{"key":"10.1053\/siny.2001.0042_RF115","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/344868a0","article-title":"Activin is a nerve cell survival molecule","volume":"344","author":"Schubert","year":"1990","journal-title":"Nature"},{"key":"10.1053\/siny.2001.0042_RF116","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0006-8993(97)00275-8","article-title":"Activin exerts a neurotrophic effect on cultured hippocampal neurons","volume":"760","author":"Iwahori","year":"1997","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF117","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/j.1460-2075.1995.tb07052.x","article-title":"TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity","volume":"14","author":"Krieglstein","year":"1995","journal-title":"EMBO J"},{"key":"10.1053\/siny.2001.0042_RF118","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/0306-4522(95)00413-0","article-title":"Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain","volume":"70","author":"Lai","year":"1996","journal-title":"Neuroscience"},{"key":"10.1053\/siny.2001.0042_RF119","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0006-8993(99)01638-8","article-title":"Expression of the activin axis and neuronal rescue effects of recombinant activin A following hypoxic-ischemic brain injury in the infant rat","volume":"835","author":"Wu","year":"1999","journal-title":"Brain Res"},{"key":"10.1053\/siny.2001.0042_RF120","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/00006450-199505000-00019","article-title":"Mild hypothermia after severe transient hypoxia-ischemia ameliorates delayed cerebral energy failure in the newborn piglet","volume":"37","author":"Thoresen","year":"1995","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF121","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1469-8749.1992.tb11432.x","article-title":"Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year","volume":"34","author":"Roth","year":"1992","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/siny.2001.0042_RF122","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1542\/peds.102.5.1098","article-title":"Neuroprotection with prolonged head cooling started before post-ischemic seizures in fetal sheep","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF123","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1203\/00006450-199604000-00005","article-title":"The effect of prolonged modification of cerebral temperature on outcome after hypoxic-ischemic brain injury in the infant rat","volume":"39","author":"Sirimanne","year":"1996","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF124","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1203\/00006450-199909000-00005","article-title":"Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep","volume":"46","author":"Gunn","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF125","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1542\/peds.102.4.885","article-title":"Selective head cooling in newborn infants after perinatal asphyxia: a safety study","volume":"102","author":"Gunn","year":"1998","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF126","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1542\/peds.106.4.684","article-title":"Pilot study of treatment with whole body hypothermia for neonatal encephalopathy","volume":"106","author":"Azzopardi","year":"2000","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF127","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1006\/bbrc.1995.2895","article-title":"Specific inhibition of apoptosis after cerebral hypoxia- ischaemia by moderate post-insult hypothermia","volume":"217","author":"Edwards","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/siny.2001.0042_RF128","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.410320511","article-title":"Suppression of postischemic epileptiform activity with MK-801 improves neural outcome in fetal sheep","volume":"32","author":"Tan","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.2001.0042_RF129","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0304-3940(90)90569-U","article-title":"Magnesium reduces N-methyl-D-aspartate (NMDA)-mediated brain injury in perinatal rats","volume":"109","author":"McDonald","year":"1990","journal-title":"Neurosci Lett"},{"key":"10.1053\/siny.2001.0042_RF130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1542\/peds.95.2.263","article-title":"Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?","volume":"95","author":"Nelson","year":"1995","journal-title":"Pediatrics"},{"key":"10.1053\/siny.2001.0042_RF131","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1056\/NEJM199507273330401","article-title":"A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia","volume":"333","author":"Lucas","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/siny.2001.0042_RF132","first-page":"155","article-title":"Magnesium sulfate therapy is not neuroprotective after moderate hypoxia-ischemia in the immature rat","volume":"1","author":"Gunn","year":"1996","journal-title":"Prenat Neonat Med"},{"key":"10.1053\/siny.2001.0042_RF133","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9378(97)80005-1","article-title":"Magnesium sulfate therapy during asphyxia in near-term fetal lambs does not compromise the fetus but does not reduce cerebral injury","volume":"176","author":"de Haan","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1053\/siny.2001.0042_RF134","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/00006450-199703000-00024","article-title":"Magnesium sulfate after transient hypoxia-ischemia fails to prevent delayed cerebral energy failure in the newborn piglet","volume":"41","author":"Penrice","year":"1997","journal-title":"Pediatr Res"},{"key":"10.1053\/siny.2001.0042_RF135","doi-asserted-by":"crossref","DOI":"10.1016\/S0306-4522(01)00145-2","article-title":"Insulin-like growth factor-1 improves somatosensory function and reduces the extent of cortical infarction and ongoing neuronal loss after hypoxia-ischemia in rats","author":"Guan","year":"2001","journal-title":"Neuroscience"},{"key":"10.1053\/siny.2001.0042_RF136","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1002\/1531-8249(199911)46:5<755::AID-ANA11>3.0.CO;2-0","article-title":"Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term","volume":"46","author":"Inder","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1053\/siny.2001.0042_RF137","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-3782(99)00010-9","article-title":"Prediction of neurological outcome after birth asphyxia from early continuous two-channel electroencephalography","volume":"55","author":"Azzopardi","year":"1999","journal-title":"Early Hum Dev"},{"key":"10.1053\/siny.2001.0042_RF138","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1542\/peds.103.6.1263","article-title":"Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography","volume":"103","author":"al Naqeeb","year":"1999","journal-title":"Pediatrics"}],"container-title":["Seminars in Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084275601900429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084275601900429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T04:42:38Z","timestamp":1682138558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084275601900429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":138,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S1084275601900429"],"URL":"https:\/\/doi.org\/10.1053\/siny.2001.0042","relation":{},"ISSN":["1084-2756"],"issn-type":[{"value":"1084-2756","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}