{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:57:19Z","timestamp":1761893839105},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1053\/sonc.2003.50068","type":"journal-article","created":{"date-parts":[[2003,4,28]],"date-time":"2003-04-28T19:53:00Z","timestamp":1051559580000},"page":"172-177","source":"Crossref","is-referenced-by-count":17,"title":["Predictive variables for malignant transformation in 452 patients with asymptomatic IgM monoclonal gammopathy"],"prefix":"10.1053","volume":"30","author":[{"given":"Enrica","family":"Morra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Varettoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Cavanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Canesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Tresoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Barbarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/sonc.2003.50068_bib1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0025-7125(16)30734-9","article-title":"Differential diagnosis of monoclonal gammopathy","volume":"72","author":"Gandara","year":"1988","journal-title":"Med Clin North Am"},{"key":"10.1053\/sonc.2003.50068_bib2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0025-6196(12)65225-2","article-title":"The spectrum of IgM monoclonal gammopathy in 430 cases","volume":"62","author":"Kyle","year":"1987","journal-title":"Mayo Clin Proc"},{"key":"10.1053\/sonc.2003.50068_bib3","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1200\/JCO.2000.18.1.214","article-title":"Waldenstr\u00f6m's macroglobulinemia: Clinical features, complications, and management","volume":"18","author":"Dimopoulos","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1053\/sonc.2003.50068_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1182\/blood.V98.1.41","article-title":"Prognostic factors and response to fludarabine therapy in patients with Waldenstr\u00f6m macroglobulinemia: Results of United States intergroup trial (Southwest Oncology Group S9003)","volume":"98","author":"Dhodapkar","year":"2001","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib5","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1365-2141.2001.03144.x","article-title":"Waldenstr\u00f6m macroglobulinemia: Presenting features and outcome in a series with 217 cases","volume":"115","author":"Garc\u00eda-Sanz","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1053\/sonc.2003.50068_bib6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1200\/JCO.1993.11.8.1553","article-title":"Prognostic factors in Waldenstr\u00f6m's macroglobulinemia: A report of 167 cases","volume":"11","author":"Facon","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1053\/sonc.2003.50068_bib7","first-page":"852","article-title":"Prognostic factors in Waldenstr\u00f6m macroglobulinemia: A report on 232 patients with the description of a new scoring system and its validation on 253 other patients","volume":"96","author":"Morel","year":"2000","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1634\/theoncologist.5-1-63","article-title":"Waldenstr\u00f6m's macroglobulinemia","volume":"5","author":"Gertz","year":"2000","journal-title":"Oncologist"},{"key":"10.1053\/sonc.2003.50068_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/1099-1069(200006)18:2<41::AID-HON654>3.0.CO;2-W","article-title":"Waldenstr\u00f6m's macroglobulinemia: Laboratory diagnosis and treatment","volume":"18","author":"Owen","year":"2000","journal-title":"Hematol Oncol"},{"key":"10.1053\/sonc.2003.50068_bib10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1309\/4LCN-JMPG-5U71-UWQB","article-title":"Waldenstr\u00f6m macroglobulinemia. Development of diagnostic criteria and identification of prognostic factors","volume":"116","author":"Owen","year":"2001","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/sonc.2003.50068_bib11","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1200\/JCO.20.6.1625","article-title":"Prognostic factors for malignant transformation in monoclonal gammopathy of undetermined significance and smoldering multiple myeloma","volume":"20","author":"Cesana","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.1053\/sonc.2003.50068_bib12","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1182\/blood.V87.3.912.bloodjournal873912","article-title":"Role of different hematologic variables in defining the risk of malignant transformation in monoclonal gammopathy","volume":"87","author":"Baldini","year":"1996","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib13","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJMoa01133202","article-title":"A long-term study on prognosis in monoclonal gammopathy of undetermined significance","volume":"346","author":"Kyle","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/sonc.2003.50068_bib14","first-page":"123","article-title":"Gammapatia monoclonale idiopatica. Studio a lungo termine di 313 casi","volume":"80","author":"Paladini","year":"1989","journal-title":"Recenti Prog Med"},{"key":"10.1053\/sonc.2003.50068_bib15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2141.1992.tb08245.x","article-title":"Malignant transformation and life expectancy in monoclonal gammopathy of undetermined significance","volume":"81","author":"Blade","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1053\/sonc.2003.50068_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0025-6196(12)60015-9","article-title":"\u201cBenign\u201d monoclonal gammopathy after 20 to 35 years of follow-up","volume":"68","author":"Kyle","year":"1993","journal-title":"Mayo Clin Proc"},{"key":"10.1053\/sonc.2003.50068_bib17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2141.1995.tb05256.x","article-title":"Malignant transformation of monoclonal gammopathy of undetermined significance among out-patients of a community hospital of Southeastern Netherlands","volume":"91","author":"Van de Poel","year":"1995","journal-title":"Br J Haemathol"},{"key":"10.1053\/sonc.2003.50068_bib18","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1182\/blood.V83.6.1452.1452","article-title":"Waldenstr\u00f6m's macroglobulinaemia","volume":"83","author":"Dimopoulos","year":"1994","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib19","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1182\/blood.V83.10.2939.2939","article-title":"Study of prognosis in Waldenstr\u00f6m's macroglobulinemia: A proposal for a simple binary classification with clinical and investigational utility","volume":"83","author":"Gobbi","year":"1994","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib20","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jcp.42.6.567","article-title":"Proposals for the classification of chronic (mature) B and T lymphoid leukaemias. French-American-British (FAB) Cooperative Group","volume":"42","author":"Bennett","year":"1989","journal-title":"J Clin Pathol"},{"key":"10.1053\/sonc.2003.50068_bib21","doi-asserted-by":"crossref","first-page":"15051506","DOI":"10.1182\/blood.V100.4.1505.h81602001505_1505_1507","article-title":"Typical Waldenstr\u00f6m macroglobulinemia is derived from a B-cell arrested after cessation of somatic mutation but prior to isotype switch events","volume":"100","author":"Sahota","year":"2002","journal-title":"Blood"},{"key":"10.1053\/sonc.2003.50068_bib22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s00277-001-0385-8","article-title":"Waldenstr\u00f6m's macroglobulinemia: Clinical course and prognostic factors in 60 patients","volume":"80","author":"Kyrtsonis","year":"2001","journal-title":"Ann Hematol"},{"key":"10.1053\/sonc.2003.50068_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1600-0609.1983.tb00664.x","article-title":"Bone marrow histology in Waldenstr\u00f6m's macroglobulinaemia. Clinical relevance of subtype recognition","volume":"31","author":"Bartl","year":"1983","journal-title":"Scand J Haematol"},{"key":"10.1053\/sonc.2003.50068_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V","article-title":"A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis","volume":"48","author":"Binet","year":"1981","journal-title":"Cancer"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775403700724?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775403700724?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T16:06:03Z","timestamp":1584633963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775403700724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0093775403700724"],"URL":"https:\/\/doi.org\/10.1053\/sonc.2003.50068","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}