{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:17:16Z","timestamp":1792016236698,"version":"4.4.0"},"reference-count":82,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Radiation Oncology"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1053\/srao.2002.35250","type":"journal-article","created":{"date-parts":[[2002,10,15]],"date-time":"2002-10-15T15:45:27Z","timestamp":1034696727000},"page":"296-304","source":"Crossref","is-referenced-by-count":47,"title":["The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer"],"prefix":"10.1053","volume":"12","author":[{"given":"Fen","family":"Xia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon N.","family":"Powell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/srao.2002.35250_bib1","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1126\/science.2270482","article-title":"Linkage of early-onset familial breast cancer to chromosome 17q21","volume":"250","author":"Hall","year":"1990","journal-title":"Science"},{"key":"10.1053\/srao.2002.35250_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCAI","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1053\/srao.2002.35250_bib3","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1098-2388(200006)18:4<287::AID-SSU3>3.0.CO;2-5","article-title":"Clinico-pathological characteristics of BRCA1-and BRCA2-related breast cancer","volume":"18","author":"Chappuis","year":"2000","journal-title":"Semin Surg Oncol"},{"key":"10.1053\/srao.2002.35250_bib4","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/1521-1878(200008)22:8<728::AID-BIES6>3.0.CO;2-B","article-title":"Roles of BRCA1 and its interacting proteins","volume":"22","author":"Deng","year":"2000","journal-title":"Bioessays"},{"key":"10.1053\/srao.2002.35250_bib5","first-page":"5952","article-title":"BRCA1 at a branch point","volume":"98","author":"Parvin","year":"2001"},{"key":"10.1053\/srao.2002.35250_bib6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1097-2765(00)80466-9","article-title":"Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells","volume":"3","author":"Xu","year":"1999","journal-title":"Mol Cell"},{"key":"10.1053\/srao.2002.35250_bib7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1097-2765(00)80238-5","article-title":"Genetic analysis of BRCA1 function in a defined tumor cell line","volume":"4","author":"Scully","year":"1999","journal-title":"Mol Cell"},{"key":"10.1053\/srao.2002.35250_bib8","first-page":"270","article-title":"Non homologous endjoining of ionizing radiation-induced DNA double strand breaks in human tumor cells deficient in BRCA1 or BRCA2","volume":"61","author":"Wang","year":"2001","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1097-2765(01)00174-5","article-title":"Brca2 is required for homology-directed repair of chromosomal breaks","volume":"7","author":"Moynahan","year":"2001","journal-title":"Mol Cell"},{"key":"10.1053\/srao.2002.35250_bib10","doi-asserted-by":"crossref","first-page":"6386","DOI":"10.1128\/MCB.17.11.6386","article-title":"Chromosomal double-strand breaks induce gene conversion at high frequency in mammalian cells","volume":"17","author":"Taghian","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1053\/srao.2002.35250_bib11","first-page":"1245","article-title":"DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus","volume":"60","author":"DiBiase","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib12","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1128\/MCB.21.10.3445-3450.2001","article-title":"Involvement of Brcal in S-phase and G(2)-phase checkpoints after ionizing irradiation","volume":"21","author":"Xu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1053\/srao.2002.35250_bib13","first-page":"639","article-title":"A derivative of an ataxia-tanlangiectasia (A-T) cell line withnormal radiosensitivity but A-T-like inhibition of DNA synthesis","volume":"49","author":"Lehmann","year":"1986","journal-title":"Int J Radiat Biol"},{"key":"10.1053\/srao.2002.35250_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1126\/science.281.5379.1009","article-title":"BRCA1 required for transcription-coupled repair of oxidative DNA damage","volume":"281","author":"Gowen","year":"1998","journal-title":"Science"},{"key":"10.1053\/srao.2002.35250_bib15","first-page":"4842","article-title":"Homology-directed DNA repair, mitomycin-C resistance, and chromosome stability is restored with correction of a Brcal mutation","volume":"61","author":"Moynahan","year":"2001","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib16","doi-asserted-by":"crossref","first-page":"33487","DOI":"10.1074\/jbc.M005824200","article-title":"BRCA1 facilitates stress-induced apoptosis in breast and ovarian cancer cell lines","volume":"275","author":"Thangaraju","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/srao.2002.35250_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1146\/annurev.genet.32.1.95","article-title":"The genetics of breast cancer susceptibility","volume":"32","author":"Rahman","year":"1998","journal-title":"Annu Rev Genet"},{"key":"10.1053\/srao.2002.35250_bib18","first-page":"8644","article-title":"Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining","volume":"98","author":"Xia","year":"2001"},{"key":"10.1053\/srao.2002.35250_bib19","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1101\/gad.14.11.1400","article-title":"Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation","volume":"14","author":"Yu","year":"2000","journal-title":"Gene Dev"},{"key":"10.1053\/srao.2002.35250_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(00)80276-2","article-title":"Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells","volume":"2","author":"Chen","year":"1998","journal-title":"Mol Cell"},{"key":"10.1053\/srao.2002.35250_bib21","first-page":"5287","article-title":"The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment","volume":"95","author":"Chen","year":"1998"},{"key":"10.1053\/srao.2002.35250_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1097-2765(01)00175-7","article-title":"Role of BRCA2 in control of the RAD51 recombination and DNA repair protein","volume":"7","author":"Davies","year":"2001","journal-title":"Mol Cell"},{"key":"10.1053\/srao.2002.35250_bib23","doi-asserted-by":"crossref","first-page":"32931","DOI":"10.1074\/jbc.274.46.32931","article-title":"Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)\/M checkpoint control","volume":"274","author":"Chen","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/srao.2002.35250_bib24","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1080\/02841860152619089","article-title":"ATM\u2014a key determinant of multiple cellular responses to irradiation","volume":"40","author":"Kastan","year":"2001","journal-title":"Acta Oncologica"},{"key":"10.1053\/srao.2002.35250_bib25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1383-5742(00)00034-X","article-title":"The ATM gene and breast cancer: Is it really a risk factor?","volume":"462","author":"Angele","year":"2000","journal-title":"Mutat Res"},{"key":"10.1053\/srao.2002.35250_bib26","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1056\/NEJM198705213162101","article-title":"Breast and other cancers in families with ataxia-telangiectasia","volume":"316","author":"Swift","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1053\/srao.2002.35250_bib27","first-page":"573","article-title":"The incidence and gene frequency of ataxia-telangiectasia in the United States","volume":"39","author":"Swift","year":"1986","journal-title":"Am J Hum Genet"},{"key":"10.1053\/srao.2002.35250_bib28","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0959-8049(00)00378-6","article-title":"Germline mutations associated with breast cancer susceptibility","volume":"37","author":"Iau","year":"2001","journal-title":"Eur J Cancer"},{"key":"10.1053\/srao.2002.35250_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/S0959-8049(98)00414-6","article-title":"Cellular responses to radiation and risk of breast cancer","volume":"35","author":"Jongmans","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1053\/srao.2002.35250_bib30","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/jnci\/92.10.795","article-title":"Cancer risk and the ATM gene: A continuing debate","volume":"92","author":"Khanna","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/srao.2002.35250_bib31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2307\/3579232","article-title":"Induction and rejoining of DNA double-strand breaks and interphase chromosome breaks after exposure to x-ray in one normal and two hypersensitive human fibroblast cell lines","volume":"144","author":"Badie","year":"1995","journal-title":"Radiat Res"},{"key":"10.1053\/srao.2002.35250_bib32","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/095530097143202","article-title":"G2 chromosomal sensitivity in fibroblast of ataxia-telangiectasia heterozygotes and Li-Fraumeni syndrome patient with radioresistant cells","volume":"72","author":"Mitchell","year":"1997","journal-title":"Intl J Radiat Biol"},{"key":"10.1053\/srao.2002.35250_bib33","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1590\/S0036-36341999000800008","article-title":"The epidemiology of Her-2\/neu and P53 in breast cancer","volume":"41","author":"Bernstein","year":"1999","journal-title":"Salud Publica de Mexico"},{"key":"10.1053\/srao.2002.35250_bib34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1677\/erc.0.0060051","article-title":"Clinical studies of p53 in treatment and benefit of breast cancer patients","volume":"6","author":"Bergh","year":"1999","journal-title":"Endocr-Relat Cancer"},{"key":"10.1053\/srao.2002.35250_bib35","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/clon.1999.9032","article-title":"The role of the p53 tumour suppressor gene in human breast cancer","volume":"11","author":"Phillips","year":"1999","journal-title":"Clin Oncol UK"},{"key":"10.1053\/srao.2002.35250_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/scbi.1999.0124","article-title":"Molecular genetics of breast cancer progression","volume":"9","author":"Ingvarsson","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1053\/srao.2002.35250_bib37","first-page":"698","article-title":"Prognostic importance of p53 and c-erbB-2 oncoproteins overex-pression in patients with breast cancer","volume":"81","author":"Chariyalertsak","year":"1998","journal-title":"J Med Assoc Thailand"},{"key":"10.1053\/srao.2002.35250_bib38","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/(SICI)1520-6823(1999)7:2<55::AID-ROI1>3.0.CO;2-#","article-title":"Tumor suppressor genes and breast cancer","volume":"7","author":"Buchholz","year":"1999","journal-title":"Radiat Oncol Investig"},{"key":"10.1053\/srao.2002.35250_bib39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0140-6736(05)63327-2","article-title":"p53 mutations in BRCA1-associated familial breast cancer","volume":"350","author":"Crook","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/srao.2002.35250_bib40","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1038\/sj.onc.1202106","article-title":"p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1-and BRCA2-associated breast tumours","volume":"17","author":"Crook","year":"1998","journal-title":"Oncogene"},{"key":"10.1053\/srao.2002.35250_bib41","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0140-6736(05)70461-X","article-title":"p53 involvement in BRCA1-associated breast cancer","volume":"350","author":"Eisinger","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/srao.2002.35250_bib42","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/scbi.1999.0124","article-title":"Molecular genetics of breast cancer progression","volume":"9","author":"Ingvarsson","year":"1999","journal-title":"Semin Cancer Biol"},{"key":"10.1053\/srao.2002.35250_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1515\/BC.1999.019","article-title":"The functions of breast cancer susceptibility gene 1 (BRCA1) product and its associated proteins","volume":"380","author":"Irminger-Finger","year":"1999","journal-title":"Biol Chem"},{"key":"10.1053\/srao.2002.35250_bib44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/1097-0215(20000820)90:4<175::AID-IJC1>3.0.CO;2-W","article-title":"Survival of colorectal cancer cell lines treated with paclitaxel, radiation, and 5-FU: Effect of TP53 or hMLH1 deficiency","volume":"90","author":"Kennedy","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1053\/srao.2002.35250_bib45","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/00000421-200110000-00014","article-title":"Effects of p53 mutations on cellular sensitivity to ionizing radiation","volume":"24","author":"Matsui","year":"2001","journal-title":"Am J Clin Oncol"},{"key":"10.1053\/srao.2002.35250_bib46","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/mutage\/16.1.7","article-title":"p53 deficiency alters the yield and spectrum of radiation-induced lacZ mutants in the brain of transgenic mice","volume":"16","author":"Chang","year":"2001","journal-title":"Mutagenesis"},{"key":"10.1053\/srao.2002.35250_bib47","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1038\/sj.onc.1203935","article-title":"Adenovirus-mediated pl6INK4a gene expression radiosensitizes non-small cell lung cancer cells in a p53-dependent manner","volume":"19","author":"Kawabe","year":"2000","journal-title":"Oncogene"},{"key":"10.1053\/srao.2002.35250_bib48","first-page":"4859","article-title":"CDC25B and p53 are independently implicated in radiation sensitivity for human esophageal cancers","volume":"6","author":"Miyata","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib49_1","first-page":"741","article-title":"Biological basis of radiation sensitivity: Part 2. Cellular and molecular determinants of radiosensitivity","volume":"14","author":"Rosen","year":"2000","journal-title":"Oncology (Huntington)"},{"key":"10.1053\/srao.2002.35250_bib49_2","first-page":"757","article-title":"Biological basis of radiation sensitivity: Part 2. Cellular and molecular determinants of radiosensitivity","volume":"14","author":"Rosen","year":"2000","journal-title":"Oncology (Huntington)"},{"key":"10.1053\/srao.2002.35250_bib50","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1080\/09553000050111505","article-title":"Evidence for the expression of radiation-induced potentially lethal damage being a p53-dependent process","volume":"76","author":"Schwartz","year":"2000","journal-title":"Intl J Radiat Biol"},{"key":"10.1053\/srao.2002.35250_bib51","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1667\/0033-7587(2000)154[0140:LOEOTS]2.0.CO;2","article-title":"Lack of effect of TP53 status on fluorodeoxyuridine-mediated radiosensitization","volume":"154","author":"Lawrence","year":"2000","journal-title":"Radiat Res"},{"key":"10.1053\/srao.2002.35250_bib52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s002800051004","article-title":"The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization","volume":"45","author":"Chen","year":"2000","journal-title":"Cancer Chemoth Pharm"},{"key":"10.1053\/srao.2002.35250_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1097-0215(20000320)89:2<187::AID-IJC14>3.0.CO;2-V","article-title":"Clinical significance of p53 functional loss in squamous cell carcinoma of the oropharynx","volume":"89","author":"Obata","year":"2000","journal-title":"Intl J Cancer"},{"key":"10.1053\/srao.2002.35250_bib54","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.1038\/sj.onc.1203053","article-title":"A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy","volume":"18","author":"Wouters","year":"1999","journal-title":"Oncogene"},{"key":"10.1053\/srao.2002.35250_bib55","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2307\/3580145","article-title":"Sensitizing human cervical cancer cells in vitro to ionizing radiation with interferon beta or gamma","volume":"152","author":"Gruninger","year":"1999","journal-title":"Radiat Res"},{"key":"10.1053\/srao.2002.35250_bib56","first-page":"1827","article-title":"G2\/M checkpoint is p53-dependent and independent after irradiation in five human sarcoma cell lines","volume":"19","author":"Bache","year":"1999","journal-title":"Anticancer Res"},{"key":"10.1053\/srao.2002.35250_bib57","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/095530099140465","article-title":"Functional inactivation of p53 by HPV-E6 transformation is associated with a reduced expression of radiation-induced potentially lethal damage","volume":"75","author":"Schwartz","year":"1999","journal-title":"Intl J Radiat Biol"},{"key":"10.1053\/srao.2002.35250_bib58","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/(SICI)1097-0215(19980911)77:6<913::AID-IJC19>3.0.CO;2-1","article-title":"Characterisation of the p53 status, BCL-2 expression and radiation and platinum drug sensitivity of a panel of human ovarian cancer cell lines","volume":"77","author":"Pestell","year":"1998","journal-title":"Intl J Cancer"},{"key":"10.1053\/srao.2002.35250_bib59","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.onc.1203142","article-title":"Dissociation of p53-mediated suppression of homologous recombination from G1\/S cell cycle checkpoint control","volume":"19","author":"Willers","year":"2000","journal-title":"Oncogene"},{"key":"10.1053\/srao.2002.35250_bib60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0027-5107(96)00193-5","article-title":"The tumor suppressor p53 modifies mutational processes in a human lymphoblastoid cell line","volume":"373","author":"Xia","year":"1997","journal-title":"Mutat Res"},{"key":"10.1053\/srao.2002.35250_bib61","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/6029","article-title":"Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas","volume":"21","author":"Wilson","year":"1999","journal-title":"Nat Genet"},{"key":"10.1053\/srao.2002.35250_bib62","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJM200102223440801","article-title":"Gene-expression profiles in hereditary breast cancer","volume":"344","author":"Hedenfalk","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/srao.2002.35250_bib63","first-page":"1752s","article-title":"BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway","volume":"59","author":"Chen","year":"1999","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib64","first-page":"328","article-title":"Differential toxicity of anticacer agents among DNA repair and check-point mutants of Saccharomyces cerevisiae","volume":"60","author":"Simon","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib65","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/20014091084191","article-title":"HER2: The neu prognostic marker for breast cancer","volume":"38","author":"Tsongalis","year":"2001","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1053\/srao.2002.35250_bib66","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-1-4757-3147-7_4","article-title":"The molecular and cellular biology of HER2\/neu gene amplification\/overex-pression and the clinical development of Herceptin (trastuzumab) therapy for breast cancer","volume":"103","author":"Pegram","year":"2000","journal-title":"Cancer Treat Res"},{"key":"10.1053\/srao.2002.35250_bib67","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0093-7754(01)90289-1","article-title":"HER2 overexpression and cancer targeting","volume":"28","author":"Wang","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1053\/srao.2002.35250_bib68","first-page":"41","article-title":"An overview of monoclonal antibody therapy of cancer","volume":"26","author":"Weiner","year":"1999","journal-title":"Semin Oncol"},{"key":"10.1053\/srao.2002.35250_bib69","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/cbr.1999.14.5","article-title":"Perceptions of Herceptin: A monoclonal antibody for the treatment of breast cancer","volume":"14","author":"Dillman","year":"1999","journal-title":"Cancer Biother Radiopharm"},{"key":"10.1053\/srao.2002.35250_bib70","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1056\/NEJM199405053301802","article-title":"c-erbB-2 expression and response to adjuvant therapy in woman with nodepositive early breast cancer","volume":"330","author":"Muss","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1053\/srao.2002.35250_bib71","first-page":"1347","article-title":"Monoclonal antibody to HER-2\/neureceptor modulates repair of radiation-induced DNA damage and enhances radiosensitivity of human breast cancer cell overexpressing this oncogene","volume":"59","author":"Pietras","year":"1999","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib72","first-page":"3206","article-title":"Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation","volume":"7","author":"Tezuka","year":"2001","journal-title":"Clin Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib73","first-page":"1676","article-title":"ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response","volume":"98","author":"Peretz","year":"2001"},{"key":"10.1053\/srao.2002.35250_bib74","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1053\/srao.2001.26027","article-title":"Radiation response modification following molecular inhibition of epidermal growth factor receptor signaling","volume":"11","author":"Harari","year":"2001","journal-title":"Semin Radiat Oncol"},{"key":"10.1053\/srao.2002.35250_bib75","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/bcr277","article-title":"The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer","volume":"3","author":"Chiarle","year":"2001","journal-title":"Breast Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib76","first-page":"S6","article-title":"Cell cycle and breast cancer","volume":"20","author":"Puisieux","year":"2000","journal-title":"Annales de Pathologie"},{"key":"10.1053\/srao.2002.35250_bib77","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0304-3835(00)00657-1","article-title":"Cyclin D1 in breast premalignancy and early breast cancer: Implications for prevention and treatment","volume":"162","author":"Zhou","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1053\/srao.2002.35250_bib78","first-page":"2","article-title":"Translational research offers individually tailored treatments for cancer patients","volume":"6","author":"Bartelink","year":"2000","journal-title":"Cancer J Sci Am"},{"key":"10.1053\/srao.2002.35250_bib79","first-page":"2611","article-title":"Radiation and the Apo2L\/TRAIL apoptotic pathway preferentially inhibit the colonization of premalignant human breast cells overexpressing cyclin D1","volume":"60","author":"Zhou","year":"2000","journal-title":"Cancer Res"},{"key":"10.1053\/srao.2002.35250_bib80","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/S0360-3016(00)00525-3","article-title":"Cyclin D1 expression and early breast cancer recurrence following lumpectomy and radiation","volume":"47","author":"Turner","year":"2000","journal-title":"Intl J Radiat Oncol Biol Phys"},{"key":"10.1053\/srao.2002.35250_bib81","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/(SICI)1097-0215(20000220)90:1<22::AID-IJC3>3.0.CO;2-T","article-title":"Prognostic significance of cyclin D1 protein levels in early-stage larynx cancer treated with primary radiation","volume":"90","author":"Yoo","year":"2000","journal-title":"Intl J Cancer"}],"container-title":["Seminars in Radiation Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429602800315?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053429602800315?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T22:07:09Z","timestamp":1682374029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053429602800315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S1053429602800315"],"URL":"https:\/\/doi.org\/10.1053\/srao.2002.35250","relation":{},"ISSN":["1053-4296"],"issn-type":[{"value":"1053-4296","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}