{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:13:18Z","timestamp":1761930798737,"version":"build-2065373602"},"reference-count":141,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine Reviews"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1053\/tmrv.2003.50006","type":"journal-article","created":{"date-parts":[[2003,5,5]],"date-time":"2003-05-05T12:41:25Z","timestamp":1052138485000},"page":"95-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Islet transplantation, stem cells, and transfusion medicine"],"prefix":"10.1053","volume":"17","author":[{"given":"Lennart","family":"L\u00f6gdberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Sgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian P.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher D.","family":"Hillyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/tmrv.2003.50006_bib1","first-page":"827","article-title":"Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy","volume":"61","author":"Kelly","year":"1967","journal-title":"Surgery"},{"key":"10.1053\/tmrv.2003.50006_bib2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/ndt\/16.5.893","article-title":"Islet transplantation: A field on the move","volume":"16","author":"Reach","year":"2001","journal-title":"Nephrol Dial Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1046\/j.1464-5491.2001.00465.x","article-title":"Human islet cell transplantation\u2014Future prospects","volume":"18","author":"White","year":"2001","journal-title":"Diabet Med"},{"key":"10.1053\/tmrv.2003.50006_bib4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s005340050171","article-title":"Islet transplantation","volume":"7","author":"Inoue","year":"2000","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1053\/tmrv.2003.50006_bib5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.2337\/diacare.21.2.296","article-title":"Economic consequences of diabetes mellitus in the U.S. in 1997","volume":"21","author":"American Diabetes Association","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1053\/tmrv.2003.50006_bib6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0140-6736(01)05415-0","article-title":"Type 1 diabetes: New perspectives on disease pathogenesis and treatment","volume":"358","author":"Atkinson","year":"2001","journal-title":"Lancet"},{"issue":"suppl","key":"10.1053\/tmrv.2003.50006_bib7","doi-asserted-by":"crossref","first-page":"C11","DOI":"10.2337\/diacare.21.3.C11","article-title":"Diabetes in America: Epidemiology and scope of the problem","volume":"21","author":"Harris","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1053\/tmrv.2003.50006_bib8","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.2337\/diacare.23.9.1278","article-title":"Diabetes trends in the U.S.: 1990-1998","volume":"23","author":"Mokdad","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1053\/tmrv.2003.50006_bib9","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s001250100580","article-title":"The role of impaired early insulin secretion in the pathogenesis of Type II diabetes mellitus","volume":"44","author":"Pratley","year":"2001","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.2337\/diabetes.50.2007.S1","article-title":"The islet in type 2 diabetes: Back to center stage","volume":"50","author":"Cerasi","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"The Diabetes Control and Complications Trial Research Group","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1056\/NEJM200002103420603","article-title":"Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy","volume":"342","author":"The Diabetes Control and Complications Trial\/Epidemiology of Diabetes Interventions and Complications Research Group","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00007890-199903150-00001","article-title":"Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation","volume":"67","author":"Tyden","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199807093390202","article-title":"Reversal of lesions of diabetic nephropathy after pancreas transplantation","volume":"339","author":"Fioretto","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2337\/diabetes.50.1.47","article-title":"Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis","volume":"50","author":"Robertson","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/diabetes.50.4.710","article-title":"Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol","volume":"50","author":"Ryan","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib20","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJM199702063360607","article-title":"Procurement and allocation of solid organs for transplantation","volume":"336","author":"Hauptman","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/00007890-199604150-00010","article-title":"Variables in organ donors that affect the recovery of human islets of Langerhans","volume":"61","author":"Lakey","year":"1996","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib22","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1097\/00007890-200005270-00021","article-title":"Non-heart-beating organ donors: A potential source of islets for transplantation?","volume":"69","author":"Clayton","year":"2000","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2337\/diab.37.4.413","article-title":"Automated method for isolation of human pancreatic islets","volume":"37","author":"Ricordi","year":"1988","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib24","first-page":"3276","article-title":"Safety testing of Liberase, a purified enzyme blend for human islet isolation","volume":"27","author":"Gill","year":"1995","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib25","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0041-1345(97)01419-X","article-title":"Evaluation of a purified enzyme blend for the recovery and in vitro function of isolated canine islets","volume":"30","author":"Lakey","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib26","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2337\/diab.46.7.1120","article-title":"Improved human islet isolation using a new enzyme blend, Liberase","volume":"46","author":"Linetsky","year":"1997","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/00007890-200108270-00003","article-title":"Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia","volume":"72","author":"Lakey","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib28","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/S0002-9610(05)81149-3","article-title":"Pancreatic islet transplantation: Is purification necessary?","volume":"166","author":"Gores","year":"1993","journal-title":"Am J Surg"},{"key":"10.1053\/tmrv.2003.50006_bib29","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0041-1345(97)01309-2","article-title":"Monitoring of insulin content during human islet isolation","volume":"30","author":"Brandhorst","year":"1998","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00572864","article-title":"The use of continuous density gradients for the assessment of islet and exocrine tissue densities and islet purification","volume":"30","author":"Robertson","year":"1993","journal-title":"Acta Diabetol"},{"key":"10.1053\/tmrv.2003.50006_bib31","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2337\/diab.38.1.S143","article-title":"Large-scale purification of human islets utilizing discontinuous albumin gradient on IBM 2991 cell separator","volume":"38","author":"Lake","year":"1989","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2337\/diab.39.4.401","article-title":"Islet mass and function in diabetes and transplantation","volume":"39","author":"Weir","year":"1990","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1620\/tjem.124.177","article-title":"Morphometrical analysis on topographical difference in size distribution, number and volume of islets in the human pancreas","volume":"124","author":"Saito","year":"1978","journal-title":"Tohoku J Exp Med"},{"key":"10.1053\/tmrv.2003.50006_bib34","first-page":"974","article-title":"The bioburden of 590 consecutive human pancreata for islet transplant research","volume":"24","author":"Scharp","year":"1992","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/BF00404026","article-title":"Normoglycaemia after transplantation of freshly isolated and cryopreserved pancreatic islets in type 1 (insulin-dependent) diabetes mellitus","volume":"34","author":"Warnock","year":"1991","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00400857","article-title":"Long-term follow-up after transplantation of insulin-producing pancreatic islets into patients with type 1 (insulin-dependent) diabetes mellitus","volume":"35","author":"Warnock","year":"1992","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib37","first-page":"3471","article-title":"Cryopreservation purifies canine pancreatic microfragments","volume":"19","author":"Evans","year":"1987","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00007890-199301000-00029","article-title":"The effect of cryopreservation on the survival and MHC antigen expression of murine islet allografts","volume":"55","author":"Cattral","year":"1993","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib39","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/096368979800700405","article-title":"Effect of cryopreservation on the survival and function of murine islet isografts and allografts","volume":"7","author":"Cattral","year":"1998","journal-title":"Cell Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib40","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF01655133","article-title":"Cryopreservation of insulin-producing tissue in rats and dogs","volume":"8","author":"Rajotte","year":"1984","journal-title":"World J Surg"},{"key":"10.1053\/tmrv.2003.50006_bib41","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00007890-198707000-00017","article-title":"Survival of cryopreserved isolated adult human pancreatic islets of Langerhans","volume":"44","author":"Warnock","year":"1987","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib42","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2337\/diab.38.3.386","article-title":"Long-term cryogenic storage of purified adult human islets of Langerhans","volume":"38","author":"Kneteman","year":"1989","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib43","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00007890-199909150-00011","article-title":"Effects of cryopreservation on in vitro and in vivo long-term function of human islets","volume":"68","author":"Piemonti","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib44","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0011-2240(84)90079-8","article-title":"Vitrification as an approach to cryopreservation","volume":"21","author":"Fahy","year":"1984","journal-title":"Cryobiology"},{"key":"10.1053\/tmrv.2003.50006_bib45","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s001090050330","article-title":"Viability and recovery of frozen-thawed human islets and in vivo quality control by xenotransplantation","volume":"77","author":"Langer","year":"1999","journal-title":"J Mol Med"},{"key":"10.1053\/tmrv.2003.50006_bib46","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3727\/000000001783986576","article-title":"Development of a cryopreservation procedure employing a freezer bag for pancreatic islets using a newly developed cryoprotectant","volume":"10","author":"Miyamoto","year":"2001","journal-title":"Cell Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib47","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/00007890-200109270-00005","article-title":"Novel approaches to cryopreservation of human pancreatic islets","volume":"72","author":"Lakey","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib48","doi-asserted-by":"crossref","first-page":"583","DOI":"10.3727\/000000001783986369","article-title":"Islet cryopreservation using intracellular preservation solutions","volume":"10","author":"Lakey","year":"2001","journal-title":"Cell Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib49","first-page":"1029","article-title":"Human islet preparations and the expression of MHC antigens","volume":"24","author":"Swift","year":"1992","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib50","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/00007890-199110000-00023","article-title":"Evidence for direct and indirect pathways in the generation of the alloimmune response against pancreatic islets","volume":"52","author":"Stock","year":"1991","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib51","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1097\/00007890-199506000-00018","article-title":"Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell","volume":"59","author":"Tamura","year":"1995","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1172\/JCI12335","article-title":"Reversal of established autoimmune diabetes by restoration of endogenous beta cell function","volume":"108","author":"Ryu","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/tmrv.2003.50006_bib53","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s001250051658","article-title":"Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: Its relevance for treatment in established diabetes and islet transplantation","volume":"44","author":"Chatenoud","year":"2001","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib54","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0167-5699(99)01554-6","article-title":"Pancreatic islet xenotransplantation: The potential for tolerance induction","volume":"21","author":"Smith","year":"2000","journal-title":"Immunol Today"},{"key":"10.1053\/tmrv.2003.50006_bib55","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.2337\/diabetes.50.2007.S20","article-title":"Beta-cell turnover: Its assessment and implications","volume":"50","author":"Bonner-Weir","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib56","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1530\/eje.0.1410644","article-title":"Expression of Reg and cytokeratin 20 during ductal cell differentiation and proliferation in a mouse model of autoimmune diabetes","volume":"141","author":"Anastasi","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"10.1053\/tmrv.2003.50006_bib57","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s005340050115","article-title":"The Reg gene family and Reg proteins: With special attention to the regeneration of pancreatic beta-cells","volume":"6","author":"Okamoto","year":"1999","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1053\/tmrv.2003.50006_bib58","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1677\/joe.0.1620189","article-title":"Effect of partial pancreatectomy on diabetic status in BALB\/c mice","volume":"162","author":"Hardikar","year":"1999","journal-title":"J Endocrinol"},{"key":"10.1053\/tmrv.2003.50006_bib59","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0303-7207(00)00234-3","article-title":"Transcription factor expression during pancreatic islet regeneration","volume":"164","author":"Kritzik","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"10.1053\/tmrv.2003.50006_bib60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/00006676-200007000-00053","article-title":"Neogenesis of pancreatic endocrine cells in copper-deprived rat models","volume":"21","author":"Al-Abdullah","year":"2000","journal-title":"Pancreas"},{"key":"10.1053\/tmrv.2003.50006_bib61","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1677\/joe.0.1650725","article-title":"Possible relationship between changes in islet neogenesis and islet neogenesis-associated protein-positive cell mass induced by sucrose administration to normal hamsters","volume":"165","author":"Del Zotto","year":"2000","journal-title":"J Endocrinol"},{"key":"10.1053\/tmrv.2003.50006_bib62","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s001250100623","article-title":"Factors controlling pancreatic cell differentiation and function","volume":"44","author":"Edlund","year":"2001","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib63","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s001250100628","article-title":"Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function","volume":"44","author":"McKinnon","year":"2001","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib64","doi-asserted-by":"crossref","first-page":"5379","DOI":"10.1210\/endo.142.12.8520","article-title":"Promotion of beta-cell regeneration by betacellulin in ninety percent- pancreatectomized rats","volume":"142","author":"Li","year":"2001","journal-title":"Endocrinology"},{"key":"10.1053\/tmrv.2003.50006_bib65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s005340170052","article-title":"Hepatocyte growth factor: Clinical implications in hepatobiliary pancreatic surgery","volume":"8","author":"Kaido","year":"2001","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"10.1053\/tmrv.2003.50006_bib66","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib67","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/73128","article-title":"Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells","volume":"6","author":"Ramiya","year":"2000","journal-title":"Nat Med"},{"key":"10.1053\/tmrv.2003.50006_bib68","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3727\/000000001783987016","article-title":"Human pancreatic ductal cells: Large-scale isolation and expansion","volume":"10","author":"Gmyr","year":"2001","journal-title":"Cell Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib69","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2337\/diabetes.50.3.521","article-title":"Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes","volume":"50","author":"Zulewski","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib70","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2337\/diabetes.50.8.1691","article-title":"Insulin production by human embryonic stem cells","volume":"50","author":"Assady","year":"2001","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib71","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib72","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2337\/diabetes.49.2.157","article-title":"Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice","volume":"49","author":"Soria","year":"2000","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib73","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/86439","article-title":"Can stem cells cross lineage boundaries?","volume":"7","author":"Anderson","year":"2001","journal-title":"Nat Med"},{"key":"10.1053\/tmrv.2003.50006_bib74","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/sj.leu.2402445","article-title":"Toward a new paradigm of cell plasticity","volume":"16","author":"Theise","year":"2002","journal-title":"Leukemia"},{"key":"10.1053\/tmrv.2003.50006_bib75","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/S0301-472X(01)00752-4","article-title":"Somatic stem cell plasticity: Current evidence and emerging concepts","volume":"29","author":"Wulf","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1053\/tmrv.2003.50006_bib76","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1468-0734.2001.00027.x","article-title":"Adult stem cell plasticity and methods of detection","volume":"5","author":"Almeida-Porada","year":"2001","journal-title":"Rev Clin Exp Hematol"},{"key":"10.1053\/tmrv.2003.50006_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcb.10045","article-title":"Stem cells: A minireview","volume":"38","author":"Jackson","year":"2002","journal-title":"J Cell Biochem Suppl"},{"key":"10.1053\/tmrv.2003.50006_bib78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1634\/stemcells.20-3-195","article-title":"Somatic stem cell plasticity: to be or not to be","volume":"20","author":"Hawley","year":"2002","journal-title":"Stem Cells"},{"key":"10.1053\/tmrv.2003.50006_bib79","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.284.5417.1168","article-title":"Bone marrow as a potential source of hepatic oval cells","volume":"284","author":"Petersen","year":"1999","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib80","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/hep.510310135","article-title":"Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation","volume":"31","author":"Theise","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/tmrv.2003.50006_bib81","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/jhep.2000.9124","article-title":"Liver from bone marrow in humans","volume":"32","author":"Theise","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/tmrv.2003.50006_bib82","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1038\/81326","article-title":"Purified hematopoietic stem cells can differentiate into hepatocytes in vivo","volume":"6","author":"Lagasse","year":"2000","journal-title":"Nat Med"},{"key":"10.1053\/tmrv.2003.50006_bib83","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/35018642","article-title":"Hepatocytes from non-hepatic adult stem cells","volume":"406","author":"Alison","year":"2000","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib84","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJMoa3461002","article-title":"Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells","volume":"346","author":"Korbling","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib85","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1126\/science.279.5356.1528","article-title":"Muscle regeneration by bone marrow-derived myogenic progenitors","volume":"279","author":"Ferrari","year":"1998","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib86","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/43919","article-title":"Dystrophin expression in the mdx mouse restored by stem cell transplantation","volume":"401","author":"Gussoni","year":"1999","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib87","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s004290050237","article-title":"Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice","volume":"199","author":"Bittner","year":"1999","journal-title":"Anat Embryol (Berl)"},{"key":"10.1053\/tmrv.2003.50006_bib88","doi-asserted-by":"crossref","first-page":"14482","DOI":"10.1073\/pnas.96.25.14482","article-title":"Hematopoietic potential of stem cells isolated from murine skeletal muscle","volume":"96","author":"Jackson","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib89","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI12150","article-title":"Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells","volume":"107","author":"Jackson","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/tmrv.2003.50006_bib90","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/35070587","article-title":"Bone marrow cells regenerate infarcted myocardium","volume":"410","author":"Orlic","year":"2001","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib91","doi-asserted-by":"crossref","first-page":"10344","DOI":"10.1073\/pnas.181177898","article-title":"Mobilized bone marrow cells repair the infarcted heart, improving function and survival","volume":"98","author":"Orlic","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib92","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1161\/01.RES.85.3.221","article-title":"Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization","volume":"85","author":"Asahara","year":"1999","journal-title":"Circ Res"},{"key":"10.1053\/tmrv.2003.50006_bib93","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/86498","article-title":"Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function","volume":"7","author":"Kocher","year":"2001","journal-title":"Nat Med"},{"key":"10.1053\/tmrv.2003.50006_bib94","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0092-8674(01)00328-2","article-title":"Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell","volume":"105","author":"Krause","year":"2001","journal-title":"Cell"},{"key":"10.1053\/tmrv.2003.50006_bib95","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1126\/science.290.5497.1775","article-title":"From marrow to brain: Expression of neuronal phenotypes in adult mice","volume":"290","author":"Brazelton","year":"2000","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib96","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1126\/science.290.5497.1779","article-title":"Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow","volume":"290","author":"Mezey","year":"2000","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib97","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C","article-title":"Adult rat and human bone marrow stromal cells differentiate into neurons","volume":"61","author":"Woodbury","year":"2000","journal-title":"J Neurosci Res"},{"key":"10.1053\/tmrv.2003.50006_bib98","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/path.976","article-title":"Bone marrow contributes to renal parenchymal turnover and regeneration","volume":"195","author":"Poulsom","year":"2001","journal-title":"J Pathol"},{"key":"10.1053\/tmrv.2003.50006_bib99","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1056\/NEJMoa012081","article-title":"Chimerism of the transplanted heart","volume":"346","author":"Quaini","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/tmrv.2003.50006_bib100","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1161\/01.RES.0000014822.62629.EB","article-title":"Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts","volume":"90","author":"Laflamme","year":"2002","journal-title":"Circ Res"},{"key":"10.1053\/tmrv.2003.50006_bib101","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature00870","article-title":"Pluripotency of mesenchymal stem cells derived from adult marrow","volume":"418","author":"Jiang","year":"2002","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib102","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1073\/pnas.032438799","article-title":"Muscle-derived hematopoietic stem cells are hematopoietic in origin","volume":"99","author":"McKinney-Freeman","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib103","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.128.6.871","article-title":"A bipotential precursor population for pancreas and liver within the embryonic endoderm","volume":"128","author":"Deutsch","year":"2001","journal-title":"Development"},{"key":"10.1053\/tmrv.2003.50006_bib104","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0002-9440(10)63999-5","article-title":"Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells","volume":"158","author":"Wang","year":"2001","journal-title":"Am J Pathol"},{"key":"10.1053\/tmrv.2003.50006_bib105","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib106","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1357-4310(98)01425-7","article-title":"Towards gene therapy of diabetes mellitus","volume":"5","author":"Levine","year":"1999","journal-title":"Mol Med Today"},{"key":"10.1053\/tmrv.2003.50006_bib107","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s001250051085","article-title":"Prospects for gene therapy of insulin-dependent diabetes mellitus","volume":"41","author":"Efrat","year":"1998","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib108","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/35044106","article-title":"Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue","volume":"408","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib109","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/sj.gt.3301297","article-title":"Regulated hepatic insulin gene therapy of STZ-diabetic rats","volume":"7","author":"Thule","year":"2000","journal-title":"Gene Ther"},{"key":"10.1053\/tmrv.2003.50006_bib110","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/sj.gt.3301076","article-title":"Glucose regulated production of human insulin in rat hepatocytes","volume":"7","author":"Thule","year":"2000","journal-title":"Gene Ther"},{"key":"10.1053\/tmrv.2003.50006_bib111","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s002680020341","article-title":"Human islet transplantation: update","volume":"25","author":"Boker","year":"2001","journal-title":"World J Surg"},{"key":"10.1053\/tmrv.2003.50006_bib112","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.1994.tb00870.x","article-title":"Endothelial cell activation and thromboregulation during xenograft rejection","volume":"141","author":"Bach","year":"1994","journal-title":"Immunol Rev"},{"key":"10.1053\/tmrv.2003.50006_bib113","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00007890-199908150-00006","article-title":"Significant progress in porcine islet mass isolation utilizing liberase HI for enzymatic low-temperature pancreas digestion","volume":"68","author":"Brandhorst","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib114","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007890-200101150-00021","article-title":"A human CD46 transgenic pig model system for the study of discordant xenotransplantation","volume":"71","author":"Diamond","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib115","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0140-6736(94)90570-3","article-title":"Transplantation of porcine fetal pancreas to diabetic patients","volume":"344","author":"Groth","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/tmrv.2003.50006_bib116","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2337\/diabetes.51.1.79","article-title":"A distinct Th1 immune response precedes the described Th2 response in islet xenograft rejection","volume":"51","author":"Krook","year":"2002","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib117","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00007890-199201000-00039","article-title":"Evidence that multiple defects in cell-surface molecule interactions across species differences are responsible for diminished xenogeneic T cell responses","volume":"53","author":"Moses","year":"1992","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib118","first-page":"128","article-title":"Impact of culture and cryopreservation on MHC class II antigen expression in canine and porcine islets","volume":"25","author":"Bretzel","year":"1990","journal-title":"Horm Metab Res Suppl"},{"key":"10.1053\/tmrv.2003.50006_bib119","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00007890-198008000-00012","article-title":"Cellular changes in cultured mouse thyroid glands and islets of Langerhans","volume":"30","author":"Parr","year":"1980","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib120","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/34766","article-title":"Call for moratorium on xenotransplants","volume":"391","author":"Bach","year":"1998","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib121","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0140-6736(98)07145-1","article-title":"No evidence of infection with porcine endogenous retrovirus in recipients of porcine islet-cell xenografts","volume":"352","author":"Heneine","year":"1998","journal-title":"Lancet"},{"key":"10.1053\/tmrv.2003.50006_bib122","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1126\/science.285.5431.1236","article-title":"Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group","volume":"285","author":"Paradis","year":"1999","journal-title":"Science"},{"key":"10.1053\/tmrv.2003.50006_bib123","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/15209150050194314","article-title":"Future trends in islet cell transplantation","volume":"2","author":"Shapiro","year":"2002","journal-title":"Diabetes Technol Ther"},{"key":"10.1053\/tmrv.2003.50006_bib124","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.96.14.8132","article-title":"Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154","volume":"96","author":"Kenyon","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/tmrv.2003.50006_bib125","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.2337\/diabetes.48.7.1473","article-title":"Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154","volume":"48","author":"Kenyon","year":"1999","journal-title":"Diabetes"},{"key":"10.1053\/tmrv.2003.50006_bib126","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/307168a0","article-title":"Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts","volume":"307","author":"Ildstad","year":"1984","journal-title":"Nature"},{"key":"10.1053\/tmrv.2003.50006_bib127","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02786391","article-title":"Mixed hematopoietic chimerism and transplantation tolerance","volume":"16","author":"Nikolic","year":"1997","journal-title":"Immunol Res"},{"key":"10.1053\/tmrv.2003.50006_bib128","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1097\/00007890-199908270-00001","article-title":"Mixed chimerism as an approach for the induction of transplantation tolerance","volume":"68","author":"Wekerle","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib129","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0797-783","article-title":"Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning","volume":"3","author":"Sykes","year":"1997","journal-title":"Nat Med"},{"key":"10.1053\/tmrv.2003.50006_bib130","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/00007890-199911150-00022","article-title":"Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance","volume":"68","author":"Wekerle","year":"1999","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib131","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00007890-200107270-00036","article-title":"Long-term islet allograft function in the absence of chronic immunosuppression: A case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor","volume":"72","author":"Kawai","year":"2001","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib132","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00125-001-0729-x","article-title":"Considerations for successful transplantation of encapsulated pancreatic islets","volume":"45","author":"de Vos","year":"2002","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib133","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00007890-200201150-00023","article-title":"Reversal of diabetes in mice by xenotransplantation of a bioartificial pancreas in a prevascularized subcutaneous site","volume":"73","author":"Wang","year":"2002","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib134","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI118929","article-title":"Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression","volume":"98","author":"Sun","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/tmrv.2003.50006_bib135","first-page":"3308","article-title":"Encapsulated islet iso-, allo-, and xenografts in diabetic NOD mice","volume":"27","author":"Weber","year":"1995","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib136","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0167-5699(97)01008-6","article-title":"Immunoisolation: at a turning point","volume":"18","author":"Lanza","year":"1997","journal-title":"Immunol Today"},{"key":"10.1053\/tmrv.2003.50006_bib137","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00007890-199002000-00034","article-title":"The role of CD4+ helper T cells in the destruction of microencapsulated islet xenografts in nod mice","volume":"49","author":"Weber","year":"1990","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib138","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1177\/096368979700600405","article-title":"Alginate polylysine microcapsules as immune barrier: Permeability of cytokines and immunoglobulins over the capsule membrane","volume":"6","author":"Kulseng","year":"1997","journal-title":"Cell Transplant"},{"key":"10.1053\/tmrv.2003.50006_bib139","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s001250050673","article-title":"Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets","volume":"40","author":"De Vos","year":"1997","journal-title":"Diabetologia"},{"key":"10.1053\/tmrv.2003.50006_bib140","first-page":"1183","article-title":"Activation of intraislet lymphoid cells causes destruction of islet cells","volume":"138","author":"Lacy","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1053\/tmrv.2003.50006_bib141","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1097\/00007890-199002000-00003","article-title":"Interstitial class II-positive cell depletion by donor pretreatment with gamma irradiation. Evidence of differential immunogenicity between vascularized cardiac allografts and islets","volume":"49","author":"Stegall","year":"1990","journal-title":"Transplantation"},{"key":"10.1053\/tmrv.2003.50006_bib142","first-page":"2725","article-title":"Long-term survival of rat islet allografts after pretreatment with low dose gamma irradiation","volume":"21","author":"James","year":"1989","journal-title":"Transplant Proc"},{"key":"10.1053\/tmrv.2003.50006_bib143","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S1074-7613(02)00273-X","article-title":"Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells","volume":"16","author":"Hugues","year":"2002","journal-title":"Immunity"}],"container-title":["Transfusion Medicine Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796303900010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887796303900010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:17:28Z","timestamp":1760138248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887796303900010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":141,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0887796303900010"],"URL":"https:\/\/doi.org\/10.1053\/tmrv.2003.50006","relation":{},"ISSN":["0887-7963"],"issn-type":[{"type":"print","value":"0887-7963"}],"subject":[],"published":{"date-parts":[[2003,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Islet transplantation, stem cells, and transfusion medicine","name":"articletitle","label":"Article Title"},{"value":"Transfusion Medicine Reviews","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/tmrv.2003.50006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}