{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:41:55Z","timestamp":1761057715520},"reference-count":62,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"published-print":{"date-parts":[[2003,2]]},"DOI":"10.1053\/ybeog.2003.0348","type":"journal-article","created":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T20:14:53Z","timestamp":1053375293000},"page":"131-148","source":"Crossref","is-referenced-by-count":8,"title":["Acne and hirsuties in teenagers"],"prefix":"10.1053","volume":"17","author":[{"given":"Julian H.","family":"Barth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/ybeog.2003.0348_RF1","doi-asserted-by":"crossref","unstructured":"Thomas, PK, Ferriman, DG, Variation in facial and pubic hair growth in white women, American Journal of Physical Anthropology, 1957;, 15, 171, \u2013 180","DOI":"10.1002\/ajpa.1330150208"},{"key":"10.1053\/ybeog.2003.0348_RF2","series-title":"Acne","author":"Cunliffe","year":"1989"},{"key":"10.1053\/ybeog.2003.0348_RF3","doi-asserted-by":"crossref","unstructured":"Aktan, S, Ozmen, E, Sanli, B, Anxiety, depression and nature of acne vulgaris in adolescents, International Journal of Dermatology, 2000;, 39, 354, \u2013 357","DOI":"10.1046\/j.1365-4362.2000.00907.x"},{"key":"10.1053\/ybeog.2003.0348_RF4","doi-asserted-by":"crossref","unstructured":"Smithard, A, Glazebrook, C, Williams, HC, Acne prevalence, knowledge about acne and psychological morbidity: a community-based study, British Journal of Dermatology, 2001;, 145, 274, \u2013 279","DOI":"10.1046\/j.1365-2133.2001.04346.x"},{"key":"10.1053\/ybeog.2003.0348_RF5","doi-asserted-by":"crossref","unstructured":"Lim, CC, Tan, TC, Personality, disability and acne in college students, Clinical & Experimental Dermatology, 1991;, 16, 371, \u2013 373","DOI":"10.1111\/j.1365-2230.1991.tb00404.x"},{"key":"10.1053\/ybeog.2003.0348_RF6","unstructured":"Downing, DT, Stewart, ME, Wertz, PW, Strauss, JS, The effect of sebum on epidermal lipid composition. In, Marks, R, Plewig, G, editors, Acne and related disorders, London, Martin Dunitz;, 1989"},{"key":"10.1053\/ybeog.2003.0348_RF7","doi-asserted-by":"crossref","unstructured":"Cunliffe, WJ, Holland, DB, Clark, SM, Stables, GI, Comedogenesis: some new aetiological, clinical and therapeutic strategies, British Journal of Dermatology, 2000;, 142, 1084, \u2013 1091","DOI":"10.1046\/j.1365-2133.2000.03531.x"},{"key":"10.1053\/ybeog.2003.0348_RF8","doi-asserted-by":"crossref","unstructured":"Ingham, E, Gowland, G, Ward, RM, et al, Antibodies to P. acnes and P. acnes exocellular enzymes in the normal population at various ages and in patients with acne vulgaris, British Journal of Dermatology, 1987;, 116, 805, \u2013 812","DOI":"10.1111\/j.1365-2133.1987.tb04899.x"},{"key":"10.1053\/ybeog.2003.0348_RF9","doi-asserted-by":"crossref","unstructured":"Leyden, JJ, McGinley, KJ, Cavalieri, S, et al, Propionibacterium acnes resistance to antibiotics in acne patients, Journal of the American Academy of Dermatology, 1983;, 8, 41, \u2013 45","DOI":"10.1016\/S0190-9622(83)70005-8"},{"key":"10.1053\/ybeog.2003.0348_RF10","doi-asserted-by":"crossref","unstructured":"Karvonen, SL, Rasanen, L, Cunliffe, WJ, et al, Increased hypersensitivity to Propionibacterium acnes in patients with severe nodular acne and acne fulminans, Dermatology, 1994;, 189, 344, \u2013 349","DOI":"10.1159\/000246876"},{"key":"10.1053\/ybeog.2003.0348_RF11","unstructured":"Tanner, JM, Growth and endocrinology of the adolescent. In, Gardner, LI, editor, Endocrine and genetic diseases of childhood and adolescence, Philadelphia, WB Saunders;, 1975"},{"key":"10.1053\/ybeog.2003.0348_RF12","doi-asserted-by":"crossref","unstructured":"Shah, PN, Human body hair\u2014a quantitative study, American Journal of Obstetrics & Gynecology, 1957;, 73, 1255, \u2013 1265","DOI":"10.1016\/0002-9378(57)90268-5"},{"key":"10.1053\/ybeog.2003.0348_RF13","doi-asserted-by":"crossref","unstructured":"Reynolds, EL, The appearance of adult patterns of body hair in man, Annals of the New York Academy of Sciences, 1951;, 53, 576, \u2013 584","DOI":"10.1111\/j.1749-6632.1951.tb31959.x"},{"key":"10.1053\/ybeog.2003.0348_RF14","doi-asserted-by":"crossref","unstructured":"Bottomley, WW, Cunliffe, WJ, Severe flares of acne following isotretinoin: large closed comedones (Macrocomedones) are a risk factor, Acta Dermato-Venereologica, 1993;, 7, 74","DOI":"10.2340\/000155557374"},{"key":"10.1053\/ybeog.2003.0348_RF15","doi-asserted-by":"crossref","unstructured":"Barth, JH, How hairy are hirsute women?, Clinical Endocrinology, 1997;, 47, 255, \u2013 260","DOI":"10.1046\/j.1365-2265.1997.2481062.x"},{"key":"10.1053\/ybeog.2003.0348_RF16","doi-asserted-by":"crossref","unstructured":"Lunde, O, Grottum, P, Body hair growth in women: normal or hirsute, American Journal of Physical Anthropology, 1984;, 64, 307, \u2013 313","DOI":"10.1002\/ajpa.1330640313"},{"key":"10.1053\/ybeog.2003.0348_RF17","doi-asserted-by":"crossref","unstructured":"Cotterill, JA, Cunliffe, WJ, Suicide in dermatological patients, British Journal of Dermatology, 1997;, 137, 246, \u2013 250","DOI":"10.1046\/j.1365-2133.1997.18131897.x"},{"key":"10.1053\/ybeog.2003.0348_RF18","doi-asserted-by":"crossref","unstructured":"Barth, JH, Catalan, J, Cherry, CA, Day, AE, Psychological morbidity in women referred for treatment of hirsutism, Journal of Psychosomatic Research, 1993;, 37, 615, \u2013 619","DOI":"10.1016\/0022-3999(93)90056-L"},{"key":"10.1053\/ybeog.2003.0348_RF19","doi-asserted-by":"crossref","unstructured":"Rosner, W, Hryb, DJ, Khan, MS, et al, Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane, Journal of Steroid Biochemistry & Molecular Biology, 1999;, 69, 481, \u2013 485","DOI":"10.1016\/S0960-0760(99)00070-9"},{"key":"10.1053\/ybeog.2003.0348_RF20","doi-asserted-by":"crossref","unstructured":"Dijkstra, AC, Goos, CMAA, Cunliffe, WJ, et al, Is increased 5\u03b1-reductase activity a primary phenomenon in androgen-dependent skin disorders?, Journal of Investigative Dermatology, 1987;, 89, 87, \u2013 92","DOI":"10.1111\/1523-1747.ep12580432"},{"key":"10.1053\/ybeog.2003.0348_RF21","doi-asserted-by":"crossref","unstructured":"Imperato-McGinley, J, Gautier, T, Cai, L-Q, et al, The androgen control of sebum production. Studies of subjects with dihydrotestosterone deficiency and complete androgen insensitivity, Journal of Clinical Endocrinology & Metabolism, 1993;, 76, 524, \u2013 528","DOI":"10.1210\/jcem.76.2.8381804"},{"key":"10.1053\/ybeog.2003.0348_RF22","doi-asserted-by":"crossref","unstructured":"Wilson, JD, Griffin, JE, Russell, DW, Steroid 5\u03b1-reductase 2 deficiency, Endocrine Reviews, 1993;, 14, 577, \u2013 593","DOI":"10.1210\/edrv-14-5-577"},{"key":"10.1053\/ybeog.2003.0348_RF23","doi-asserted-by":"crossref","unstructured":"Adashi, EY, Hsueh, AJW, Yen, SSC, Insulin enhancement of luteinizing hormone and follicle-stimulating hormone release by cultured pituitary cells, Endocrinology, 1981;, 108, 885, \u2013 901","DOI":"10.1210\/endo-108-4-1441"},{"key":"10.1053\/ybeog.2003.0348_RF24","doi-asserted-by":"crossref","unstructured":"Cara, JF, Rosenfeld, RL, Insulin-like growth factor 1 and insulin potentiate luteinizing hormone-induced androgen synthesis by rat ovarian thecal-interstitial cells, Endocrinology, 1988;, 123, 733, \u2013 739","DOI":"10.1210\/endo-123-2-733"},{"key":"10.1053\/ybeog.2003.0348_RF25","doi-asserted-by":"crossref","unstructured":"Plymate, SR, Matej, LA, Jones, RE, Friedl, KF, Inhibition of sex hormone-binding globulin production in the human hepatoma (Hep G2) cell line by insulin and prolactin, Journal of Clinical Endocrinology & Metabolism, 1988;, 67, 460, \u2013 464","DOI":"10.1210\/jcem-67-3-460"},{"key":"10.1053\/ybeog.2003.0348_RF26","doi-asserted-by":"crossref","unstructured":"Philpott, MP, Sanders, DA, Kealey, T, Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-1 at physiologic concentrations is an important regulator of hair follicle growth in vitro, Journal of Investigative Dermatology, 1994;, 102, 857, \u2013 861","DOI":"10.1111\/1523-1747.ep12382494"},{"key":"10.1053\/ybeog.2003.0348_RF27","doi-asserted-by":"crossref","unstructured":"Amiel, SA, Caprio, S, Sherwin, RS, et al, Insulin resistance of puberty: a defect restricted to peripheral glucose metabolism, Journal of Clinical Endocrinology & Metabolism, 1991;, 72, 277, \u2013 282","DOI":"10.1210\/jcem-72-2-277"},{"key":"10.1053\/ybeog.2003.0348_RF28","doi-asserted-by":"crossref","unstructured":"Motley, RJ, Finlay, AY, Practical use of a disability index in the routine management of acne, Clinical & Experimental Dermatology, 1992;, 17, 1, \u2013 3","DOI":"10.1111\/j.1365-2230.1992.tb02521.x"},{"key":"10.1053\/ybeog.2003.0348_RF29","unstructured":"Layton, AM, Psychological assessment of skin disease, Interfaces in Dermatology, 1994;, i, 9, \u2013 11"},{"key":"10.1053\/ybeog.2003.0348_RF30","doi-asserted-by":"crossref","unstructured":"Finlay, AY, Quality of life measurement in dermatology: a practical guide, British Journal of Dermatology, 1997;, 136, 305, \u2013 314","DOI":"10.1046\/j.1365-2133.1997.5541510.x"},{"key":"10.1053\/ybeog.2003.0348_RF31","doi-asserted-by":"crossref","unstructured":"Ferriman, D, Gallwey, JD, Clinical assessment of body hair growth in women, Journal of Clinical Endocrinology, 1961;, 21, 1440, \u2013 1447","DOI":"10.1210\/jcem-21-11-1440"},{"key":"10.1053\/ybeog.2003.0348_RF32","doi-asserted-by":"crossref","unstructured":"Levell, MJ, Cawood, ML, Burke, B, Cunliffe, WJ, Acne is not associated with abnormal plasma androgens, British Journal of Dermatology, 1989;, 120, 649, \u2013 654","DOI":"10.1111\/j.1365-2133.1989.tb01351.x"},{"key":"10.1053\/ybeog.2003.0348_RF33","doi-asserted-by":"crossref","unstructured":"Aizawa, H, Nakada, Y, Niimura, M, Androgen status in adolescent women with acne vulgaris, Journal of Dermatology, 1995;, 22, 530, \u2013 532","DOI":"10.1111\/j.1346-8138.1995.tb03440.x"},{"key":"10.1053\/ybeog.2003.0348_RF34","doi-asserted-by":"crossref","unstructured":"Bunker, CB, Newton, JA, Kilborn, J, et al, Most women with acne have polycystic ovaries, British Journal of Dermatology, 1989;, 121, 675, \u2013 680","DOI":"10.1111\/j.1365-2133.1989.tb08208.x"},{"key":"10.1053\/ybeog.2003.0348_RF35","doi-asserted-by":"crossref","unstructured":"Bunker, CB, Newton, JA, Conway, GS, et al, The hormonal profile of women with acne and polycystic ovaries, Clinical & Experimental Dermatology, 1991;, 16, 420, \u2013 423","DOI":"10.1111\/j.1365-2230.1991.tb01226.x"},{"key":"10.1053\/ybeog.2003.0348_RF36","doi-asserted-by":"crossref","unstructured":"Michelmore, KF, Balen, AH, Dunger, DB, Vessey, MP, Polycystic ovaries and associated clinical and biochemical features in young women, Clinical Endocrinology, 1999;, 51, 779, \u2013 786","DOI":"10.1046\/j.1365-2265.1999.00886.x"},{"key":"10.1053\/ybeog.2003.0348_RF37","doi-asserted-by":"crossref","unstructured":"van Hooff, MHA, Voorhorst, FJ, Kaptein, MBH, et al, Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens and insulin, Fertility & Sterility, 2000;, 74, 49, \u2013 58","DOI":"10.1016\/S0015-0282(00)00584-7"},{"key":"10.1053\/ybeog.2003.0348_RF38","doi-asserted-by":"crossref","unstructured":"Avivi, I, Pollack, S, Gideoni, O, et al, Overdiagnosis of 21-hydroxylase late onset congenital adrenal hyperplasia: correlation of corticotropin test and human leukocyte antigen typing, Fertility & Sterility, 1996;, 66, 557, \u2013 563","DOI":"10.1016\/S0015-0282(16)58567-7"},{"key":"10.1053\/ybeog.2003.0348_RF39","doi-asserted-by":"crossref","unstructured":"Spritzer, P, Billaud, L, Thalabard, J-C, et al, Cyproterone acetate versus hydrocortisone treatment in late-onset adrenal hyperplasia, Journal of Clinical Endocrinology & Metabolism, 1990;, 70, 642, \u2013 646","DOI":"10.1097\/00006254-199008000-00018"},{"key":"10.1053\/ybeog.2003.0348_RF40","doi-asserted-by":"crossref","unstructured":"Palmert, MR, Gordon, CM, Kartashov, AI, et al, Screening for abnormal glucose tolerance in adolescents with polycystic ovary syndrome, Journal of Clinical Endocrinology & Metabolism, 2002;, 87, 1017, \u2013 1023","DOI":"10.1210\/jcem.87.3.8305"},{"key":"10.1053\/ybeog.2003.0348_RF41","doi-asserted-by":"crossref","unstructured":"Miller, JA, Wojnarowska, FT, Dowd, PM, et al, Anti-androgen treatment in women with acne: a controlled trial, British Journal of Dermatology, 1986;, 114, 605, \u2013 716","DOI":"10.1111\/j.1365-2133.1986.tb04880.x"},{"key":"10.1053\/ybeog.2003.0348_RF42","doi-asserted-by":"crossref","unstructured":"Farrell, LN, Strauss, AM, The treatment of severe cystic acne with 13-cis-retioic acid, Journal of the American Academy of Dermatology, 1980;, 3, 602, \u2013 611","DOI":"10.1016\/S0190-9622(80)80074-0"},{"key":"10.1053\/ybeog.2003.0348_RF43","doi-asserted-by":"crossref","unstructured":"Jones, DH, Blanc, D, Cunliffe, WJ, 13-cis-retinoic acid and acne, Lancet, 1980;, ii, 1048, \u2013 1049","DOI":"10.1016\/S0140-6736(80)92273-4"},{"key":"10.1053\/ybeog.2003.0348_RF44","doi-asserted-by":"crossref","unstructured":"Layton, AM, Stainforth, JM, Cunliffe, WJ, Ten years experience of oral isotretinoin for the treatment of acne vulgaris, Journal of Dermatological Treatment, 1993;, 4, S2, \u2013 S5","DOI":"10.3109\/09546639309082157"},{"key":"10.1053\/ybeog.2003.0348_RF45","doi-asserted-by":"crossref","unstructured":"Barth, JH, Macdonald-Hull, SP, Mark, J, et al, Isotretinoin therapy for acne vulgaris: a re-evaluation of the need for measurements of plasma lipids and liver function tests, British Journal of Dermatology, 1993;, 129, 704, \u2013 707","DOI":"10.1111\/j.1365-2133.1993.tb03336.x"},{"key":"10.1053\/ybeog.2003.0348_RF46","doi-asserted-by":"crossref","unstructured":"Kobayashi, T, Electrosurgery using insulated needles: epilation, Journal of Dermatological Surgery & Oncology, 1985;, 11, 993, \u2013 1000","DOI":"10.1111\/j.1524-4725.1985.tb01383.x"},{"key":"10.1053\/ybeog.2003.0348_RF47","doi-asserted-by":"crossref","unstructured":"Peereboom-Wynia, JDR, The effect of various methods of epilation of density of hair growth in women with idiopathic hirsutism, Archiv fur Dermatologische Forschung, 1972;, 243, 164, \u2013 176","DOI":"10.1007\/BF00595493"},{"key":"10.1053\/ybeog.2003.0348_RF48","doi-asserted-by":"crossref","unstructured":"Barth, JH, Cherry, CA, Wojnarowska, F, Dawber, RPR, Spironolactone is an effective and well tolerated systemic anti-androgen therapy for hirsute women, Journal of Clinical Endocrinology & Metabolism, 1989;, 68, 966, \u2013 970","DOI":"10.1210\/jcem-68-5-966"},{"key":"10.1053\/ybeog.2003.0348_RF49","doi-asserted-by":"crossref","unstructured":"Barth, JH, Cherry, CA, Wojnarowska, F, Dawber, RPR, Cyproterone acetate for severe hirsutism: results of a double-blind dose-ranging study, Clinical Endocrinology, 1991;, 35, 5, \u2013 10","DOI":"10.1111\/j.1365-2265.1991.tb03489.x"},{"key":"10.1053\/ybeog.2003.0348_RF50","unstructured":"Garcia Cortes, M, Andrade, RJ, Lucena, MI, Flutamide-induced hepatotoxicity: report of a case series, Revista Espanola de Enfermedades Digestivas, 2001;, 93, 423, \u2013 432"},{"key":"10.1053\/ybeog.2003.0348_RF51","doi-asserted-by":"crossref","unstructured":"Kelly, CJG, Gordon, D, The effect of metformin on hirsuitism in polycystic ovary syndrome, European Journal of Endocrinology, 2002;, 147, 217, \u2013 221","DOI":"10.1530\/eje.0.1470217"},{"key":"10.1053\/ybeog.2003.0348_RF52","doi-asserted-by":"crossref","unstructured":"Balfour, JA, McClellan, K, Topical eflornithine, American Journal of Clinical Dermatology, 2001;, ii, 197, \u2013 201","DOI":"10.2165\/00128071-200102030-00009"},{"key":"10.1053\/ybeog.2003.0348_RF53","doi-asserted-by":"crossref","unstructured":"Jansen, T, Plewig, G, Acne fulminans, International Journal of Dermatology, 1998;, 37, 254, \u2013 257","DOI":"10.1046\/j.1365-4362.1998.00443.x"},{"key":"10.1053\/ybeog.2003.0348_RF54","unstructured":"Chivot, M, Acne flare-up and deterioration with oral isotretinoin, Annales de Dermatologie et de Venereologie, 2001;, 128, 224, \u2013 228"},{"key":"10.1053\/ybeog.2003.0348_RF55","doi-asserted-by":"crossref","unstructured":"Karvonen, SL, Acne fulminans: report of clinical findings and treatment of twenty four patients, Journal of the American Academy of Dermatology, 1993;, 28, 572, \u2013 579","DOI":"10.1016\/0190-9622(93)70076-6"},{"key":"10.1053\/ybeog.2003.0348_RF56","doi-asserted-by":"crossref","unstructured":"Seukeran, DC, Cunliffe, WJ, The treatment of acne fulminans: a review of 25 cases, British Journal of Dermatology, 1999;, 141, 307, \u2013 309","DOI":"10.1046\/j.1365-2133.1999.02982.x"},{"key":"10.1053\/ybeog.2003.0348_RF57","doi-asserted-by":"crossref","unstructured":"MacDonald Hull, S, Cunliffe, WJ, Hughes, BR, Treatment of the depressed and dysmorphophobic acne patient, Clinical & Experimental Dermatology, 1991;, 16, 210, \u2013 211","DOI":"10.1111\/j.1365-2230.1991.tb00350.x"},{"key":"10.1053\/ybeog.2003.0348_RF58","doi-asserted-by":"crossref","unstructured":"Arnold, LM, Auchenback, MB, McElroy, SL, Psychogenic excoriation. Clinical features, proposed diagnostic criteria, epidemiology and approaches to treatment, CNS Drugs, 2001;, 15, 351, \u2013 359","DOI":"10.2165\/00023210-200115050-00002"},{"key":"10.1053\/ybeog.2003.0348_RF59","doi-asserted-by":"crossref","unstructured":"Gupta, MA, Gupta, AK, Olanzepine may be an effective adjunctive therapy in the management of acne excoriee: a case report, Journal of Cutaneous Medicine and Surgery, 2001;, 5, 25, \u2013 27","DOI":"10.1177\/120347540100500106"},{"key":"10.1053\/ybeog.2003.0348_RF60","doi-asserted-by":"crossref","unstructured":"Shenefelt, PD, Hypnosis in dermatology, Archives of Dermatology, 2000;, 136, 393, \u2013 399","DOI":"10.1001\/archderm.136.3.393"},{"key":"10.1053\/ybeog.2003.0348_RF61","doi-asserted-by":"crossref","unstructured":"Kent, A, Drummond, LM, Acne excoriee\u2014a case report of treatment using habit reversal, Clinical & Experimental Dermatology, 1989;, 14, 163, \u2013 164","DOI":"10.1111\/j.1365-2230.1989.tb00918.x"},{"key":"10.1053\/ybeog.2003.0348_RF62","doi-asserted-by":"crossref","unstructured":"Cotterill, JA, Cunliffe, WJ, Suicide in dermatological patients, British Journal of Dermatology, 1997;, 137, 246, \u2013 250","DOI":"10.1046\/j.1365-2133.1997.18131897.x"}],"container-title":["Best Practice &amp; Research Clinical Obstetrics &amp; Gynaecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693402001268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521693402001268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T21:57:00Z","timestamp":1704837420000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521693402001268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["S1521693402001268"],"URL":"https:\/\/doi.org\/10.1053\/ybeog.2003.0348","relation":{},"ISSN":["1521-6934"],"issn-type":[{"value":"1521-6934","type":"print"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}