{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:32:50Z","timestamp":1774438370877,"version":"3.50.1"},"reference-count":116,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2000,9]]},"DOI":"10.1054\/blre.2000.0133","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T14:55:24Z","timestamp":1032447324000},"page":"157-171","source":"Crossref","is-referenced-by-count":15,"title":["Aplastic anaemia: Management"],"prefix":"10.1054","volume":"14","author":[{"given":"S.B.","family":"Killick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.W.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/blre.2000.0133_RF1","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1182\/blood.V70.6.1718.1718","volume":"70","year":"1987","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0037-1963(00)90026-X","article-title":"Haemopoietic cell destruction by immune mechanisms in acquired aplastic anemia","volume":"37","author":"Young","year":"2000","journal-title":"Sem Haematol"},{"key":"10.1054\/blre.2000.0133_RF3","series-title":"Aplastic anaemia. Pathophysiology and treatment","first-page":"3","article-title":"Stem cell defect in aplastic anaemia","author":"Marsh","year":"2000"},{"key":"10.1054\/blre.2000.0133_RF4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1182\/blood.V48.1.63.63","article-title":"Severe aplastic anaemia: a prospective study of the effect of early marrow transplantation on acute mortality","volume":"48","author":"Camitta","year":"1976","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2141.1988.tb02460.x","article-title":"Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party","volume":"70","author":"Bacigalupo","year":"1988","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0037-1963(00)90031-3","article-title":"Treatment of acquired aplastic anaemia: bone marrow transplantation compared with immunosuppressive therapy. The European Group for Blood and Marrow Transplant experience","volume":"37","author":"Bacigalupo","year":"2000","journal-title":"Sem Haematol"},{"key":"10.1054\/blre.2000.0133_RF7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0609.1996.tb01639.x","article-title":"When should the clinician suspect a drug-induced blood dyscrasia, and how should he proceed?","volume":"60","author":"Heimpel","year":"1996","journal-title":"Eur J Haematol (suppl 1)"},{"key":"10.1054\/blre.2000.0133_RF8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S0140-6736(95)91273-8","article-title":"Aplastic anaemia","volume":"346","author":"Young","year":"1995","journal-title":"Lancet"},{"key":"10.1054\/blre.2000.0133_RF9","first-page":"81","article-title":"A pathogenetic link between aplastic anemia and paroxysmal nocturnal hemoglobinuria is suggested by a high frequency of aplastic anemia patients with a deficiency of phosphatidylinositol glycan anchored proteins","volume":"23","author":"Schrezenmeier","year":"1995","journal-title":"Exp Haematol"},{"key":"10.1054\/blre.2000.0133_RF10","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1182\/blood.V83.8.2323.2323","article-title":"Development of the glycosylphosphatitylinositol-anchoring defect characteristic for paroxysmal nocturnal hemoglobinuria in patients with aplastic anemia","volume":"83","author":"Schubert","year":"1994","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF11","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1182\/blood.V85.5.1354.bloodjournal8551354","article-title":"Aplastic anemia and paroxysmal nocturnal hemoglobinuria: search for a pathogenetic link","volume":"85","author":"Griscelli-Bennaceur","year":"1995","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF12","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1056\/NEJM199310143291603","article-title":"Malignant tumors occurring after treatment of aplastic anemia. European Bone Marrow Transplantation-Severe Aplastic Anaemia Working Party","volume":"329","author":"Socie","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF13","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2141.1989.tb00230.x","article-title":"Long-term follow-up of severe aplastic anaemia patients treated with antithymocyte globulin. Severe Aplastic Anaemia Working Party of the European Cooperative Group for Bone Marrow Transplantation (EBMT)","volume":"73","author":"De Planque","year":"1989","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1182\/blood.V80.2.337.337","article-title":"Morphology in patients with severe aplastic anemia treated with antilymphocyte globulin","volume":"80","author":"Tichelli","year":"1992","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0950-3536(11)80028-4","article-title":"Epidemiology of aplastic anaemia","volume":"5","author":"Gordon-Smith","year":"1992","journal-title":"Baillieres Clinical Haematology"},{"key":"10.1054\/blre.2000.0133_RF16","series-title":"The drug aetiology of agranulocytosis and aplastic anaemia","author":"Kaufman","year":"1991"},{"key":"10.1054\/blre.2000.0133_RF17","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1182\/blood.V77.10.2166.2166","article-title":"Incidence of aplastic anemia in Bangkok. The Aplastic Anemia Study Group","volume":"77","author":"Issaragrisil","year":"1991","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2141.1995.tb05248.x","article-title":"An association of aplastic anaemia in Thailand with low socioeconomic status. Aplastic Anemia Study Group","volume":"91","author":"Issaragrisil","year":"1995","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF19","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1056\/NEJM199704103361504","article-title":"Hepatitis-associated aplastic anemia","volume":"336","author":"Brown","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF20","unstructured":"Young, N. S.Alter, B. P. Aplastic anaemia; acquired and inherited. WB Saunders, 1994"},{"key":"10.1054\/blre.2000.0133_RF21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/0140-6736(93)92230-Q","article-title":"Aplastic anaemia and remoxipride","volume":"342","author":"Philpott","year":"1993","journal-title":"Lancet"},{"key":"10.1054\/blre.2000.0133_RF22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2141.1994.tb05019.x","article-title":"Aplastic anaemia following exposure to 3,4-methylenedioxymethamphetamine (\u2018Ecstasy\u2019)","volume":"88","author":"Marsh","year":"1994","journal-title":"Br J Haematol."},{"key":"10.1054\/blre.2000.0133_RF23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/bmj.311.7002.451a","article-title":"Is it time to stop using chloramphenicol on the eye? Prospective study of aplastic anaemia should give definitive answer","volume":"311","author":"Gordon-Smith","year":"1995","journal-title":"Br Med J"},{"key":"10.1054\/blre.2000.0133_RF24","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1097\/00043764-199311000-00013","article-title":"Aplastic anemia and pesticides. An etiologic association?","volume":"35","author":"Fleming","year":"1993","journal-title":"J Occup Med"},{"key":"10.1054\/blre.2000.0133_RF25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/10428199409049654","article-title":"Hematopoietic malignancies and related disorders among benzene-exposed workers in China","volume":"14","author":"Travis","year":"1994","journal-title":"Leuk Lymphoma"},{"key":"10.1054\/blre.2000.0133_RF26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2141.1989.tb00294.x","article-title":"Pregnancy associated aplastic anaemia: a report of five cases and review of current management","volume":"73","author":"Aitchison","year":"1989","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF27","first-page":"234","article-title":"Haematological and immunological abnormalities in eating disorders","volume":"48","author":"Howard","year":"1992","journal-title":"Br J Hosp Med"},{"key":"10.1054\/blre.2000.0133_RF28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/rheumatology\/30.4.301","article-title":"Aplastic anaemia in systemic lupus erythematosus: a cellular immune mechanism?","volume":"30","author":"Roffe","year":"1991","journal-title":"Br J Rheumatol"},{"key":"10.1054\/blre.2000.0133_RF29","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJM199002013220507","article-title":"Transfusion-associated graft-versus-host disease","volume":"323","author":"Anderson","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2141.1981.tb07241.x","article-title":"The aplastic presentation of childhood leukaemia \u2013 a feature of common ALL","volume":"49","author":"Breatnach","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1182\/blood.V80.2.337.337","article-title":"Morphology in patients with severe aplastic anaemia treated with antilymphocyte globulin","volume":"80","author":"Tichelli","year":"1992","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0037-1963(00)90027-1","article-title":"Myelodysplastic syndrome and aplastic anaemia: distinct entities or diseases with a common pathophysiology","volume":"37","author":"Barrett","year":"2000","journal-title":"Sem Haematol"},{"key":"10.1054\/blre.2000.0133_RF33","first-page":"1134","article-title":"Clonal cytogenetic abnormalities in patients with otherwise typical aplastic anaemia","volume":"15","author":"Appelbaum","year":"1989","journal-title":"Exp Haematol"},{"key":"10.1054\/blre.2000.0133_RF34","first-page":"268a","article-title":"Cytogenetic abnormalities in aplastic anaemia","volume":"7 (suppl 1)","author":"Tichelli","year":"1996","journal-title":"Bone Marrow Transpl"},{"key":"10.1054\/blre.2000.0133_RF35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2141.1999.01187.x","article-title":"Abnormal cytogenetic clones in patients with aplastic anaemia: response to immunosuppressive therapy","volume":"104","author":"Geary","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF36","first-page":"418","article-title":"Cytogenetic abnormalities in patients with aplastic anaemia","volume":"81","author":"Mikhailova","year":"1986","journal-title":"Haematologica"},{"key":"10.1054\/blre.2000.0133_RF37","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1046\/j.1365-2141.1997.812721.x","article-title":"Pilot study of HLA alloimmunization after transfusion with pre-storage leucodepleted blood products in aplastic anaemia","volume":"97","author":"Killick","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-73-1-1","article-title":"Long-term platelet support of patients with aplastic anemia. Effect of splenectomy and steroid therapy","volume":"73","author":"Grumet","year":"1970","journal-title":"Ann Int Med"},{"key":"10.1054\/blre.2000.0133_RF39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2141.1987.00011.x-i1","article-title":"Refractoriness to random donor platelet transfusions in patients with aplastic anaemia: a multivariate analysis of data from 264 cases","volume":"66","author":"Klingemann","year":"1987","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1365-2141.1990.tb06375.x","article-title":"Pretransfused patients with severe aplastic anaemia exhibit high numbers of cytotoxic T lymphocyte precursors probably directed at non-HLA antigens","volume":"76","author":"Kaminski","year":"1990","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0037-1963(00)90032-5","article-title":"Haematopoietic growth factors in the pathogenesis and for the treatment of aplastic anaemia","volume":"37","author":"Marsh","year":"2000","journal-title":"Sem Haematol"},{"key":"10.1054\/blre.2000.0133_RF42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0140-6736(94)92763-4","article-title":"Haemopoietic growth factors in aplastic anaemia: a cautionary note. European Bone Marrow Transplant Working Party for Severe Aplastic Anaemia","volume":"344","author":"Marsh","year":"1994","journal-title":"Lancet"},{"key":"10.1054\/blre.2000.0133_RF43","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1182\/blood.V84.3.941.941","article-title":"Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anaemia","volume":"84","author":"Storb","year":"1994","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF44","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1182\/blood.V89.10.3890","article-title":"Long term follow up of allogeneic marrow transplants in patients with aplastic anaemia conditioned with cyclophosphamide with antithymocyte globulin","volume":"89","author":"Storb","year":"1997","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF45","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood.V89.8.3048","article-title":"Stable mixed haemopoietic chimerism in DLA identical littermate dogs given sublethal total body irradiation before and after pharmacological immunosuppression after marrow transplantation","volume":"89","author":"Storb","year":"1997","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM197701132960201","article-title":"Marrow transplanted for treatment of aplastic anaemia. An analysis of factors associated with graft rejection","volume":"296","author":"Storb","year":"1977","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF47","series-title":"Aplastic anaemia. Pathophysiology and treatment","first-page":"230","article-title":"HLA identical sibling bone marrow transplantation to treat severe aplastic anaemia","author":"McCann","year":"2000"},{"key":"10.1054\/blre.2000.0133_RF48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1182\/blood.V59.2.236.236","article-title":"Marrow transplantation with or without donor buffy coat cells for 65 transfused aplastic anaemia patients","volume":"59","author":"Storb","year":"1982","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF49","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1182\/blood.V90.12.4705","article-title":"Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft versus host disease","volume":"90","author":"Storek","year":"1997","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF50","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/sj.bmt.1701500","article-title":"Chronic graft versus host disease after allogeneic peripheral blood progenitor cell or bone marrow transplant from matched related donors: a case control study","volume":"22","author":"Solano","year":"1998","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF51","first-page":"858","article-title":"Bone marrow transplantation for severe aplastic anemia: has outcome improved?","volume":"90","author":"Passweg","year":"1997","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF52","first-page":"233","article-title":"Graft rejection and second bone marrow transplants for acquired aplastic anaemia: a report from the Aplastic Anaemia Working Party of the European Bone Marrow Transplant Group","volume":"13","author":"McCann","year":"1994","journal-title":"Bone Marrow Transplantation"},{"key":"10.1054\/blre.2000.0133_RF53","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1182\/blood.V91.6.1833","article-title":"Malignancies after haemopoietic stem cell transplantation: many questions, some answers","volume":"91","author":"Deeg","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF54","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1182\/blood.V91.10.3637","article-title":"Long term outcome after marrow transplantation for severe aplastic anaemia","volume":"91","author":"Deeg","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF55","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1182\/blood.V87.7.3045.bloodjournal8773045","article-title":"Pregnancies following high dose cyclophosphamide with or without high dose busulphan or total body irradiation and bone marrow transplantation","volume":"87","author":"Sanders","year":"1996","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF56","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1542\/peds.77.2.179","article-title":"Bone marrow transplant experience for children with aplastic anaemia","volume":"77","author":"Sanders","year":"1986","journal-title":"Paediatrics"},{"key":"10.1054\/blre.2000.0133_RF57","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1182\/blood.V78.9.2451.2451","article-title":"Bone marrow transplantation in 107 patients with severe aplastic anaemia using cyclophosphamide and thoracoabdominal irradiation for conditioning: long term follow up","volume":"78","author":"Gluckman","year":"1991","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF58","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1182\/blood.V87.1.386.386","article-title":"Malignancies after marrow transplantation for aplastic anaemia and Fanconi anaemia: a joint Seattle and Paris analysis of results in 700 patients","volume":"87","author":"Deeg","year":"1996","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF59","first-page":"531","article-title":"Bone marrow transplantation from donors other than HLA identical siblings: a report of the EBMT Working Party","volume":"3","author":"Bacigalupo","year":"1988","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF60","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/00007890-199601150-00012","article-title":"Bone marrow transplantation for severe aplastic anaemia from genotypically HLA non identical relatives","volume":"61","author":"Wagner","year":"1996","journal-title":"Transplantation."},{"key":"10.1054\/blre.2000.0133_RF61","series-title":"Aplastic anaemia. Pathophysiology and treatment","first-page":"258","article-title":"Alternative donor bone marrow transplantation for severe acquired aplastic anaemia","author":"Hows","year":"2000"},{"key":"10.1054\/blre.2000.0133_RF62","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/00007890-198804000-00010","article-title":"Probability of finding HLA matched unrelated donors","volume":"45","author":"Beatty","year":"1986","journal-title":"Transplantation"},{"key":"10.1054\/blre.2000.0133_RF63","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1182\/blood.V68.6.1322.1322","article-title":"Histocompatible unrelated volunteer donors compared with HLA non-identical family donors in marrow transplantation for aplastic anaemia and leukaemia","volume":"68","author":"Hows","year":"1986","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF64","first-page":"45","article-title":"Changing trends in marrow transplantation for aplastic anaemia","volume":"10","author":"Storb","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF65","doi-asserted-by":"crossref","first-page":"116","DOI":"10.7326\/0003-4819-126-2-199701150-00004","article-title":"Results of transplantating bone marrow from genetically identical twins into patients with aplastic anaemia","volume":"126","author":"Hinterberger","year":"1997","journal-title":"Ann Intern Med"},{"key":"10.1054\/blre.2000.0133_RF66","first-page":"579a","article-title":"Fate of patients undergoing unrelated donor searches in the UK","volume":"17","author":"Hows","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF67","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1056\/NEJM199303043280901","article-title":"Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program","volume":"328","author":"Kernan","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF68","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1046\/j.1365-2141.1996.d01-1772.x","article-title":"Unrelated donor bone marrow transplantation to treat severe aplastic anaemia in children and young adults","volume":"94","author":"Margolis","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF69","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/sj.bmt.1702027","article-title":"Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukaemia and aplastic anaemia","volume":"24","author":"Kodera","year":"1999","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF70","series-title":"Aplastic anaemia. Pathophysiology.","first-page":"308","article-title":"Guidelines for treating aplastic anaemia","author":"Schrezenmeier","year":"2000"},{"key":"10.1054\/blre.2000.0133_RF71","first-page":"3147a","article-title":"Marrow transplantation from unrelated donors for patients with aplastic anaemia (AA) \u2013 optimisation of a conditioning regimen","volume":"94, suppl 1 (part 1 of 2)","author":"Deeg","year":"1999","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF72","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/bbmt.1999.v5.pm10465104","article-title":"Marrow transplantation from unrelated donors for patients with severe aplastic anaemia who have failed immunosuppressive therapy","volume":"5","author":"Deeg","year":"1999","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF73","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1136\/bmj.2.5702.131","article-title":"Bone marrow graft in man after conditioning by antilymphocytic serum","volume":"2","author":"Mathe","year":"1970","journal-title":"Br Med J"},{"key":"10.1054\/blre.2000.0133_RF74","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(77)91537-9","article-title":"Treatment of aplastic anaemia by antilymphocyte globulin with and without allogeneic bone-marrow infusions","volume":"2","author":"Speck","year":"1977","journal-title":"Lancet"},{"key":"10.1054\/blre.2000.0133_RF75","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/00007890-199403150-00010","article-title":"A comprehensive definition of the major antibody specificites in polyclonal rabbit antithymocyte globulin","volume":"57","author":"Rebellato","year":"1994","journal-title":"Transplantation"},{"key":"10.1054\/blre.2000.0133_RF76","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1097\/00007890-199103000-00024","article-title":"Antibodies against functional leukocyte surface molecules in polyclonal antilymphocyte and antithymocyte globulins","volume":"51","author":"Bonnefoy-Berard","year":"1991","journal-title":"Transplantation."},{"key":"10.1054\/blre.2000.0133_RF77","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1182\/blood.V65.2.407.407","article-title":"Lymphokine abnormalities in aplastic anaemia: implications for the mechanism of action of antithymocyte globulin","volume":"65","author":"Gascon","year":"1985","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF78","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1182\/blood.V78.1.163.163","article-title":"In vitro production of granulocyte-macrophage colony stimulating factor in aplastic anaemia: possible mechanisms of action of antithymocyte globulin","volume":"78","author":"Nimer","year":"1991","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF79","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2141.1989.tb00295.x","article-title":"Effect of antilymphocyte globulin (ALG) on bone marrow T\/non-T cells for aplastic anaemia patients and normal controls","volume":"73","author":"Tong","year":"1989","journal-title":"Br. J Haematol"},{"key":"10.1054\/blre.2000.0133_RF80","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1182\/blood.V91.7.2360","article-title":"Induction of Fas (Apo-1, CD95) \u2013 mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins","volume":"91","author":"Genestier","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF81","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1073\/pnas.82.14.4823","article-title":"Differenetiation of normal marrow and HL60 cells induced by antithymocyte globulin","volume":"82","author":"Hunter","year":"1985","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1054\/blre.2000.0133_RF82","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2141.1994.tb05091.x","article-title":"The role of CD45RO in antithymocyte globulin\u2019s stimulation of primitive haemopoietic cells","volume":"88","author":"Huang","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF83","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1046\/j.1365-2141.2000.01853.x","article-title":"Effect of antithymocyte globulin on bone marrow CD34+ cells in aplastic anaemia and myelodysplasia","volume":"108","author":"Killick","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF84","series-title":"Aplastic anaemia: Current perspectives on the pathogenesis and treatment","first-page":"154","article-title":"Therapy of aplastic anaemia: is a consensus possible?","author":"Heimpel","year":"1993"},{"key":"10.1054\/blre.2000.0133_RF85","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0308-2261(21)00042-4","article-title":"Classification and aetiology of the aplastic anaemias","volume":"7","author":"Alter","year":"1978","journal-title":"Clin Haematol"},{"key":"10.1054\/blre.2000.0133_RF86","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/pgmj.56.655.322","article-title":"Aplastic anaemia: an analysis of 174 patients","volume":"56","author":"Mir","year":"1980","journal-title":"Postgrad Med J"},{"key":"10.1054\/blre.2000.0133_RF87","first-page":"240","article-title":"Transient pancytopenia. A report from the International Agranulocytosis and Aplastic Study","volume":"61","author":"Keisu","year":"1990","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF88","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1159\/000040999","article-title":"What is the definition of cure of aplastic anaemia?","volume":"103","author":"Camitta","year":"2000","journal-title":"Acta Haematologica"},{"key":"10.1054\/blre.2000.0133_RF89","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1056\/NEJM198301203080301","article-title":"Antithymocyte globulin treatment in patients with aplastic anemia: a prospective randomized trial","volume":"308","author":"Champlin","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF90","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2141.1981.tb02810.x","article-title":"Severe aplastic anaemia: correlation of in vitro tests with clinical response to immunosuppression in 20 patients","volume":"47","author":"Bacigalupo","year":"1981","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF91","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2141.1982.tb02817.x","article-title":"Results of immunosuppression in 170 cases of severe aplastic anaemia. Report of the European Group of Bone Marrow Transplantation (EGBMT)","volume":"51","author":"Gluckman","year":"1982","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF92","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1365-2141.1993.tb03153.x","article-title":"Avascular necrosis after treatment of aplastic anaemia with antilymphocyte globulin and high dose methyl prednisolone","volume":"84","author":"Marsh","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF93","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000041001","article-title":"Results of immunosuppression in aplastic anaemia","volume":"103","author":"Marsh","year":"2000","journal-title":"Acta Haematologica"},{"key":"10.1054\/blre.2000.0133_RF94","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood.V66.1.184.184","article-title":"Do abdrogens enhance the response to antithymocyte globulin in patients with aplastic anaemia? A prospective randomised trial","volume":"66","author":"Champlin","year":"1985","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF95","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1365-2141.1993.tb04645.x","article-title":"Treatment of aplastic anaemia (AA) with antilymphocyte globulin (ALG) and methylprednisolone (MPred) with or without androgens: a randomized trial from the EBMT SAA working party","volume":"83","author":"Bacigalupo","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF96","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1365-2141.1989.tb07695.x","article-title":"Cyclosporine therapy of aplastic anaemia, congenital and acquired red cell aplasia","volume":"72","author":"Leonard","year":"1989","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF97","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-0609.1989.tb00269.x","article-title":"Oral cyclosporin-A is effective treatment for untreated and also for previously immunosuppressed patients with severe bone marrow failure","volume":"43","author":"Hinterberger-Fischer","year":"1989","journal-title":"Eur J Haematol"},{"key":"10.1054\/blre.2000.0133_RF98","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1056\/NEJM199105093241901","article-title":"Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. The German Aplastic Anemia Study Group","volume":"324","author":"Frickhofen","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF99","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0037-1963(00)90030-1","article-title":"Immunosuppressive therapy of aplastic anaemia with antithymocyte globulin and cyclosporine","volume":"37","author":"Frickhofen","year":"2000","journal-title":"Semin. Haematol"},{"key":"10.1054\/blre.2000.0133_RF100","doi-asserted-by":"crossref","first-page":"3058","DOI":"10.1182\/blood.V85.11.3058.bloodjournal85113058","article-title":"Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia","volume":"85","author":"Rosenfeld","year":"1995","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF101","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1182\/blood.V79.10.2540.bloodjournal79102540","article-title":"Multicenter randomized study comparing cyclosporine-A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia","volume":"79","author":"Gluckman","year":"1992","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF102","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1182\/blood.V93.7.2191","volume":"93","author":"Marsh","year":"1999","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF103","article-title":"Results of a randomised study of glycosylated rHuG-CSF Lenograstim in severe aplastic anaemia","volume":"92","author":"Gluckman","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF104","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1182\/blood.V90.3.1009","article-title":"Myelodysplastic syndrome and acute myeloid leukaemia as late complications in children with acquired aplastic anaemia","volume":"90","author":"Ohara","year":"1997","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF105","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1046\/j.1365-2141.1998.01014.x","article-title":"Long term administration of G-CSF for aplastic anaemia is closely related to the early evolution of monosomy 7 in adults","volume":"103","author":"Kaito","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF106","series-title":"Aplastic anaemia. Pathophysiology and treatment","first-page":"275","article-title":"Treatment of children with acquired aplastic anaemia","author":"Locascuilli","year":"2000"},{"key":"10.1054\/blre.2000.0133_RF107","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7326\/0003-4819-130-3-199902020-00004","article-title":"Effectiveness of immunosuppressive therapy in older patients with aplastic anaemia","volume":"130","author":"Tichelli","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1054\/blre.2000.0133_RF108","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V76.9.1748.1748","article-title":"The haemnatopoietic defect in aplastic anaemia assessed by long term marrow culture","volume":"76","author":"Marsh","year":"1990","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF109","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1182\/blood.V91.6.1959","article-title":"The assessment of the haemopoietic reservoir after immunosuppressive therapy or bone marrow transplantation in severe aplastic anaemia","volume":"91","author":"Podesta","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2000.0133_RF110","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1365-2141.1993.tb03181.x","article-title":"Relapse of aplastic anaemia after immunosuppressive treatment: a report from the European Bone Marrow Transplantation Group SAA Working Party","volume":"85","author":"Schrezenmeier","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF111","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-2141.1998.00578.x","article-title":"Repeated treatment with horse antilymphocyte globulin for severe aplastic anaemia","volume":"100","author":"Tichelli","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF112","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.1365-2141.1991.tb08608.x","article-title":"Is aplastic anaemia a pre-leukaemic disorder?","volume":"77","author":"Marsh","year":"1991","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2000.0133_RF113","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0037-1963(00)90033-7","article-title":"Late clonal diseases of treated aplastic anaemia","volume":"37","author":"Socie","year":"2000","journal-title":"Sem Haematol"},{"key":"10.1054\/blre.2000.0133_RF114","first-page":"819","article-title":"Campath-1G in vivo confers a low incidence of graft versus host disease associated with a high incidence of mixed chimerism after bone marrow transplantation for severe aplastic anaemia using HLA identical sibling donors","volume":"17","author":"Hamblin","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"10.1054\/blre.2000.0133_RF115","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1056\/NEJM197612302952708","article-title":"Recovery from aplastic anaemia after treatment with cyclophosphamide","volume":"295","author":"Baran","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1054\/blre.2000.0133_RF116","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1182\/blood.V87.2.491.bloodjournal872491","article-title":"Complete remission in severe aplastic anaemia after high dose cyclophosphamide without bone marrow transplantation","volume":"87","author":"Brodsky","year":"1996","journal-title":"Blood"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X00901334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X00901334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T22:24:10Z","timestamp":1704320650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X00901334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,9]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,9]]}},"alternative-id":["S0268960X00901334"],"URL":"https:\/\/doi.org\/10.1054\/blre.2000.0133","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,9]]}}}