{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:44:07Z","timestamp":1770741847065,"version":"3.49.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Reviews"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1054\/blre.2001.0184","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:33:30Z","timestamp":1027668810000},"page":"57-59","source":"Crossref","is-referenced-by-count":15,"title":["The potential role of thrombopoietin in idiopathic thrombocytopenic purpura"],"prefix":"10.1054","volume":"16","author":[{"given":"A.","family":"von dem Borne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Folman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"van den Oudenrijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Linthorst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"de Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/blre.2001.0184_RF1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1055\/s-0037-1615024","article-title":"Evaluation of thrombopoiesis in thrombocytopenic disorders by simultaneous measurement of reticulated platelets of whole blood and serum thrombopoietin concentrations","volume":"79","author":"Koike","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1054\/blre.2001.0184_RF2","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1007\/s002800051043","article-title":"Cloning of thrombopoietin and its therapeutic potential","volume":"38","author":"Miyazaki","year":"1996","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1054\/blre.2001.0184_RF3","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/369568a0","article-title":"Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin","volume":"369","author":"Kaushansky","year":"1994","journal-title":"Nature"},{"key":"10.1054\/blre.2001.0184_RF4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/369565a0","article-title":"Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo","volume":"369","author":"Lok","year":"1994","journal-title":"Nature"},{"key":"10.1054\/blre.2001.0184_RF5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/369571a0","article-title":"cMpl ligand is a humoral regulator of megakaryocytopoiesis","volume":"369","author":"Wendling","year":"1994","journal-title":"Nature"},{"key":"10.1054\/blre.2001.0184_RF6","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1182\/blood.V87.10.4068.bloodjournal87104068","article-title":"Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction","volume":"87","author":"Emmons","year":"1996","journal-title":"Blood"},{"key":"10.1054\/blre.2001.0184_RF7","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1055\/s-0037-1615023","article-title":"The diagnostic value of thrombopoietin level measurements in thrombocytopenia","volume":"79","author":"Porcelijn","year":"1998","journal-title":"Thromb Haemost"},{"key":"10.1054\/blre.2001.0184_RF8","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s002770050538","article-title":"Serum levels of thrombopoietin, IL-11, and IL-6 in pediatric thrombocytopenias","volume":"78","author":"Cremer","year":"1999","journal-title":"Ann Hematol"},{"key":"10.1054\/blre.2001.0184_RF9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1046\/j.1365-2141.1998.00747.x","article-title":"Plasma thrombopoietin levels in thrombocytopenic states: implication for a regulatory role of bone marrow megakaryocytes","volume":"101","author":"Hou","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2001.0184_RF10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00001721-199709000-00004","article-title":"Increased serum levels of thrombopoietin in patients with thrombotic thrombocytopenic purpura, idiopathic thrombocytopenic purpura, or disseminated intravascular coagulation","volume":"8","author":"Hiyoyama","year":"1997","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1054\/blre.2001.0184_RF11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00001721-200011020-00002","article-title":"The effect of steroid and intravenous immunoglobulin on thrombopoietin levels in pediatric patients with immune thrombocytopenic purpura","volume":"11","author":"Kocak","year":"2000","journal-title":"Blood Coagul Fibrinolysis"},{"key":"10.1054\/blre.2001.0184_RF12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1055\/s-0038-1650641","article-title":"Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura","volume":"76","author":"Mukai","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1054\/blre.2001.0184_RF13","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1182\/blood.V92.1.46.413k44_46_52","article-title":"Concentrations of thrombopoietin in bone marrow in normal subjects and in patients with idiopathic thrombocytopenic purpura, aplastic anemia, and essential thrombocythemia correlate with its mRNA expression of bone marrow stromal cells","volume":"92","author":"Hirayama","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2001.0184_RF14","first-page":"261","article-title":"Recombinant human thrombopoietin: clinical experience and in vivo biology","volume":"35","author":"Vadhan-Raj","year":"1998","journal-title":"Semin Hematol"},{"key":"10.1054\/blre.2001.0184_RF15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0037-1963(00)90052-0","article-title":"Future directions with platelet growth factors","volume":"37","author":"Kuter","year":"2000","journal-title":"Semin Hematol"},{"key":"10.1054\/blre.2001.0184_RF16","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1046\/j.1365-2141.1998.00683.x","article-title":"Serum thrombopoietin level is mainly regulated by megakaryocyte mass rather than platelet mass in human subjects","volume":"101","author":"Nagasawa","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/blre.2001.0184_RF17","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood.V88.9.3354.bloodjournal8893354","article-title":"Differential mechanisms in the regulation of endogenous levels of thrombopoietin and interleukin-11 during thrombocytopenia: insight into the regulation of platelet production","volume":"88","author":"Chang","year":"1996","journal-title":"Blood"},{"key":"10.1054\/blre.2001.0184_RF18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1055\/s-0038-1650545","article-title":"Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenic purpura","volume":"76","author":"Ichikawa","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1054\/blre.2001.0184_RF19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood.V88.2.511.bloodjournal882511","article-title":"Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates","volume":"88","author":"Harker","year":"1996","journal-title":"Blood"},{"key":"10.1054\/blre.2001.0184_RF20","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1182\/blood.V91.12.4427","article-title":"Treatment of thrombocytopenia in chimpanzees infected with human immunodeficiency virus by pegylated recombinant human megakaryocyte growth and development factor","volume":"91","author":"Harker","year":"1998","journal-title":"Blood"},{"key":"10.1054\/blre.2001.0184_RF21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/stem.5530160714","article-title":"Effects of Mpl ligands on platelet production and function in nonhuman primates","volume":"16","author":"Harker","year":"1998","journal-title":"Stem Cells"},{"key":"10.1054\/blre.2001.0184_RF22","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1182\/blood.V95.8.2514","article-title":"Effects of megakaryocyte growth and development factor on platelet production, platelet life span, and platelet function in healthy human volunteers","volume":"95","author":"Harker","year":"2000","journal-title":"Blood"}],"container-title":["Blood Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X01901845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0268960X01901845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T17:31:00Z","timestamp":1581010260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0268960X01901845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S0268960X01901845"],"URL":"https:\/\/doi.org\/10.1054\/blre.2001.0184","relation":{},"ISSN":["0268-960X"],"issn-type":[{"value":"0268-960X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}