{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:23:28Z","timestamp":1791105808532,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Calcium"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1054\/ceca.1999.0099","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:33:30Z","timestamp":1027668810000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism"],"prefix":"10.1016","volume":"27","author":[{"given":"J.","family":"Doutheil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Althausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Treiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Paschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1054\/ceca.1999.0099_RF1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0166-2236(96)10074-6","article-title":"Bright and dark sides of nitric oxide in ischemic brain injury","volume":"20","author":"Iadecola","year":"1997","journal-title":"Trends Neurosci"},{"key":"10.1054\/ceca.1999.0099_RF2","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1161\/01.STR.28.6.1283","article-title":"Nitric oxide synthase in models of focal ischemia","volume":"28","author":"Samdani","year":"1997","journal-title":"Stroke"},{"key":"10.1054\/ceca.1999.0099_RF3","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1161\/01.STR.29.3.705","article-title":"Calcium in ischemic cell death","volume":"29","author":"Kristian","year":"1998","journal-title":"Stroke"},{"key":"10.1054\/ceca.1999.0099_RF4","first-page":"165","article-title":"Pulmonary microsomes contain a Ca2+-transport system sensitive to oxidative stress","volume":"1228","author":"Menshikova","year":"1995","journal-title":"Biochem Biophys Acta"},{"key":"10.1054\/ceca.1999.0099_RF5","first-page":"569","article-title":"Rabbit brain endoplasmic reticulum membranes as target for free radicals. Changes in Ca2+-transport and protection by stobadine","volume":"36","author":"Racay","year":"1995","journal-title":"Biochem Mol Biol Int"},{"key":"10.1054\/ceca.1999.0099_RF6","doi-asserted-by":"crossref","first-page":"H929","DOI":"10.1152\/ajpheart.1988.255.4.H929","article-title":"Cellular compartmentation in ischemic myocardium: indirect analysis by electron probe","volume":"24","author":"Walsh","year":"1988","journal-title":"Heart Circ Physiol"},{"key":"10.1054\/ceca.1999.0099_RF7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1161\/01.RES.65.2.526","article-title":"Alterations in cardiac sarcoplasmic reticulum calcium transport in the postischemic \u2018stunned\u2019 myocardium","volume":"65","author":"Krause","year":"1989","journal-title":"Circ Res"},{"key":"10.1054\/ceca.1999.0099_RF8","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1006\/jmcc.1996.0159","article-title":"Sarcoplasmic reticulum calcium uptake in human myocardium subjected to ischemia and reperfusion during cardiac surgery","volume":"28","author":"Zucchi","year":"1996","journal-title":"J Mol Cell Cardiol"},{"key":"10.1054\/ceca.1999.0099_RF9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004647-199901000-00001","article-title":"Disturbances of the functioning of endoplasmic reticulum: a key mechanism underlying neuronal cell injury?","volume":"19","author":"Paschen","year":"1999","journal-title":"J Cereb Blood Flow Metabol"},{"key":"10.1054\/ceca.1999.0099_RF10","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1046\/j.1471-4159.1996.67041735.x","article-title":"Depletion of neuronal endoplasmic reticulum calcium stores by thapsigargin: effect on protein synthesis","volume":"67","author":"Paschen","year":"1996","journal-title":"J Neurochem"},{"key":"10.1054\/ceca.1999.0099_RF11","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1523\/JNEUROSCI.19-01-00147.1999","article-title":"Nitric oxide acutely inhibits neuronal energy production","volume":"19","author":"Brorson","year":"1999","journal-title":"J Neurosci"},{"key":"10.1054\/ceca.1999.0099_RF12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3940(97)00961-0","article-title":"Nitric oxide induces death in a catechiolaminergic cell line derived from the central nervous system","volume":"241","author":"Smith","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1054\/ceca.1999.0099_RF13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0022-3565(25)22859-2","article-title":"Blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation of rabbit aorta by certain ferrous hemoproteins","volume":"233","author":"Martin","year":"1985","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1054\/ceca.1999.0099_RF14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0006-8993(97)00899-8","article-title":"Relation of neuronal endoplasmic reticulum calcium homeostasis to ribosomal aggregation and protein synthesis: implications for stress-induced suppression of protein synthesis","volume":"775","author":"Doutheil","year":"1997","journal-title":"Brain Res"},{"key":"10.1054\/ceca.1999.0099_RF15","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+indicators with greatly improved fluorescence properties","volume":"260","author":"Grynkiewicz","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1054\/ceca.1999.0099_RF16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0165-6147(98)01184-5","article-title":"A tool coming of age \u2013 thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases","volume":"19","author":"Treiman","year":"1998","journal-title":"Trends Pharmacol Sci"},{"key":"10.1054\/ceca.1999.0099_RF17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0014-5793(95)01304-0","article-title":"Thapsigargin discriminates strongly between Ca2+-ATPase phosphorylated intermediates with different subcellular distributions in bovine adrenal chromaffin cells","volume":"377","author":"Caspersen","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1054\/ceca.1999.0099_RF18","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0020-711X(93)90348-I","article-title":"Isolation of chromaffin cell thapsigargin-sensitive Ca2+store in light microsomes from bovine adrenal medulla","volume":"25","author":"Mathiasen","year":"1993","journal-title":"Int J Biochem"},{"key":"10.1054\/ceca.1999.0099_RF19","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1046\/j.1471-4159.1995.65041692.x","article-title":"Comparison of in vitro ischemia-induced disturbances in energy metabolism and protein synthesis in the hippocampus of rats and gerbils","volume":"65","author":"Paschen","year":"1995","journal-title":"J Neurochem"},{"key":"10.1054\/ceca.1999.0099_RF20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1054\/ceca.1999.0099_RF21","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1021\/bi00851a033","article-title":"The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers","volume":"7","author":"Atkinson","year":"1968","journal-title":"Biochemistry"},{"key":"10.1054\/ceca.1999.0099_RF22","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1128\/MCB.16.8.4273","article-title":"Signals from the stressed endoplasmic reticulum induce C\/EBP-homologous protein (CHOP\/GADD153)","volume":"16","author":"Wang","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1054\/ceca.1999.0099_RF23","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1046\/j.1471-4159.1997.69062538.x","article-title":"Temporal analysis of changes in neuronal c-fos mRNA levels induced by depletion of endoplasmic reticulum calcium stores: effect of clamping cytoplasmic calcium activity at resting levels","volume":"69","author":"Gissel","year":"1997","journal-title":"J Neurochem"},{"key":"10.1054\/ceca.1999.0099_RF24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acidic guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1054\/ceca.1999.0099_RF25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0304-3940(97)13459-0","article-title":"Neuroprotective nitric oxide synthase inhibitor reduces intracellular calcium accumulation following transient global ischemia in the gerbil","volume":"224","author":"Kohno","year":"1997","journal-title":"Neurosci Lett"},{"key":"10.1054\/ceca.1999.0099_RF26","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1016\/S0021-9258(19)50615-9","article-title":"Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol","volume":"265","author":"Kuznetsov","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1054\/ceca.1999.0099_RF27","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev.ph.52.030190.003045","article-title":"Calcium dependent regulation of protein synthesis in intact mammalian cells","volume":"52","author":"Brostrom","year":"1990","journal-title":"Ann Rev Physiol"},{"key":"10.1054\/ceca.1999.0099_RF28","doi-asserted-by":"crossref","first-page":"16619","DOI":"10.1074\/jbc.270.28.16619","article-title":"Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis","volume":"270","author":"Srivastava","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1054\/ceca.1999.0099_RF29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"10.1054\/ceca.1999.0099_RF30","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1046\/j.1471-4159.1996.67052005.x","article-title":"Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translational initiation","volume":"67","author":"Degracia","year":"1996","journal-title":"J Neurochem"},{"key":"10.1054\/ceca.1999.0099_RF31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/neur.1996.0024","article-title":"Decrease inositol (1,4,5)-triphosphate receptor levels in Alzheimer\u2019s disease cerebral cortex: selectivity of changes and possible correlation to pathological severity","volume":"5","author":"Haug","year":"1996","journal-title":"Neurodegeneration"},{"key":"10.1054\/ceca.1999.0099_RF32","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1073\/pnas.89.7.2590","volume":"89","author":"Frandsen","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/ceca.1999.0099_RF33","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1046\/j.1471-4159.1997.69041703.x","article-title":"Calcium mobilization by ryanodine promotes the phosphorylation of initiation factor 2\u03b1 subunit and inhibition of protein synthesis in cultured neurons","volume":"69","author":"Alc\u00e1zar","year":"1997","journal-title":"J Neurochem"},{"key":"10.1054\/ceca.1999.0099_RF34","doi-asserted-by":"crossref","first-page":"20539","DOI":"10.1016\/S0021-9258(17)30536-7","article-title":"Accommodation of protein synthesis to chronic deprivation of intracellular sequestered calcium","volume":"265","author":"Brostrom","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1054\/ceca.1999.0099_RF35","first-page":"3446","article-title":"Competetive inhibition of a set of endoplasmic reticulum proteins (grp78, grp94 and erp72) retards cell growth arrest and lowers viability after ionophore treatment","volume":"11","author":"Li","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1054\/ceca.1999.0099_RF36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(98)00278-X","article-title":"Role of calcium in the activation of erp72 and heme oxygenase-1 expression on depletion of endoplasmic reticulum calcium stores in rat neuronal cell culture","volume":"247","author":"Linden","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1054\/ceca.1999.0099_RF37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1020631029168","article-title":"Erp72 expression activated by transient cerebral ischemia or disturbances of neuronal endoplasmic reticulum calcium stores","volume":"13","author":"Paschen","year":"1998","journal-title":"Metabol Brain Dis"},{"key":"10.1054\/ceca.1999.0099_RF38","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0169-328X(98)00180-6","article-title":"Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction","volume":"60","author":"Paschen","year":"1998","journal-title":"Mol Brain Res"},{"key":"10.1054\/ceca.1999.0099_RF39","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/j.1460-2075.1996.tb00386.x","article-title":"NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression","volume":"15","author":"Belsham","year":"1996","journal-title":"EMBO J"},{"key":"10.1054\/ceca.1999.0099_RF40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0169-328X(98)00031-X","article-title":"The modulatory role of nitric oxide in the regulation of proenkephalin and prodynorphin gene expression induced by kainic acid in rat hippocampus","volume":"56","author":"Won","year":"1998","journal-title":"Mol Brain Res"},{"key":"10.1054\/ceca.1999.0099_RF41","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/BF01273359","article-title":"Ultrastructural distribution of NADPH-Diaphorase in the normal hippocampus and after long-term potentiation","volume":"103","author":"Faberzuschratter","year":"1996","journal-title":"J Neural Transmission"},{"key":"10.1054\/ceca.1999.0099_RF42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0014-5793(95)00848-4","article-title":"Nitric oxide induces intracellular calcium mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic \u03b2-cells","volume":"371","author":"Willmott","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1054\/ceca.1999.0099_RF43","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1006\/bbrc.1996.0821","article-title":"Nitric oxide inhibits ATP-dependent Ca2+uptake into platelet membrane vesicles","volume":"222","author":"Pernollet","year":"1996","journal-title":"Biochem Biophys Res Comm"},{"key":"10.1054\/ceca.1999.0099_RF44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF03401915","article-title":"Inhibition of protein synthesis by nitric oxide correlates with cytostatic activity: nitric oxide induces phosphorylation of initiation factor eIF-2\u03b1","volume":"4","author":"Kim","year":"1998","journal-title":"Mol Med"},{"key":"10.1054\/ceca.1999.0099_RF45","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0022-3565(25)32738-2","article-title":"Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates","volume":"218","author":"Ignarro","year":"1981","journal-title":"J Pharmacol Exp Therap"},{"key":"10.1054\/ceca.1999.0099_RF46","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1096\/fasebj.3.9.2545495","article-title":"Endothelium-derived relaxing and contracting factors","volume":"3","author":"Furchgott","year":"1989","journal-title":"FASEB J"}],"container-title":["Cell Calcium"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416099900994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143416099900994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T19:57:07Z","timestamp":1758916627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143416099900994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0143416099900994"],"URL":"https:\/\/doi.org\/10.1054\/ceca.1999.0099","relation":{},"ISSN":["0143-4160"],"issn-type":[{"value":"0143-4160","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of nitric oxide on endoplasmic reticulum calcium homeostasis, protein synthesis and energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Cell Calcium","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1054\/ceca.1999.0099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Harcourt Publishers Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}