{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T03:22:45Z","timestamp":1649215365384},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Homeopath J"],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an outbreak of epidemic neuropathy (EN) in Cuba (1992\u20131993), most patients were improved by vitamin therapy. In subjects with residual symptoms, alternative treatments including homeopathy were suggested to ameliorate optic and peripheral signs of the disease. An open clinical pilot trial was conducted on 31 patients with long standing symptoms of optic (OPTI group, n=15) or peripheral EN (PERI group, n=16). During the trial, OPTI and PERI patients continued the same treatment that they received before. Carboneum sulphuratum and Tabacum in homeopathic dilutions were administered for 30 days. These medicines are specific to optic EN, but not closely linked with peripheral EN. Clinical status was evaluated by neurological and ophthalmologic tests at diagnosis (Ddiag), 7 days before homeopathic treatment (D0) and 90 days after (D90). From D0 to D90, the percentages of improvement were 73.3% for the OPTI form and 12.5% for the PERI form. The percentage of improved OPTI patients was significantly higher after the homeopathic treatment vs the period between Ddiag and D0 for optical EN (P&lt;0.01), but not for PERI subjects (P&gt;0.05). In the OPTI group, colour vision, visual acuity and visual field improved after homeopathic treatment (P&lt;0.001), these parameters did not change between Ddiag and D90 (P&gt;0.05). Carboneum sulphuratum and Tabacum showed a reasonable effectiveness in optical EN, but were not effective in PERI EN.<\/jats:p>","DOI":"10.1054\/homp.1999.0481","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T14:55:42Z","timestamp":1032447342000},"page":"154-157","source":"Crossref","is-referenced-by-count":1,"title":["Homeopathy in Cuban epidemic neuropathy: an open clinical trial"],"prefix":"10.1055","volume":"90","author":[{"given":"J","family":"Cairo","sequence":"first","affiliation":[{"name":"Instituto Finlay, Avenida 27, La Lisa, Ciudad Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BE","family":"Elliot","sequence":"first","affiliation":[{"name":"Hospital Abel Santamaria, Pinar del R\u0131\u0301o, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Barnouin","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche EPI-A, INRA, 63122 Saint Gen\u00e8s Champanelle, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Fleites","sequence":"first","affiliation":[{"name":"Centro Nacional de Toxicolog\u0131\u0301a, Marianao, Ciudad Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Araoz","sequence":"first","affiliation":[{"name":"Hospital Abel Santamaria, Pinar del R\u0131\u0301o, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Morales","sequence":"first","affiliation":[{"name":"Centro Provincial de Higiene y Epidemiolog\u0131\u0301a, Pinar del R\u0131\u0301o, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Verdura","sequence":"first","affiliation":[{"name":"Instituto Finlay, Avenida 27, La Lisa, Ciudad Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sanchez","sequence":"first","affiliation":[{"name":"Hospital Abel Santamaria, Pinar del R\u0131\u0301o, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Serrano","sequence":"first","affiliation":[{"name":"Direcci\u00f3n Nacional de Epidemiolog\u0131\u0301a, Ministerio de Salud P\u00fablica, Ciudad Habana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JL","family":"Alvarez","sequence":"first","affiliation":[{"name":"Hospital Abel Santamaria, Pinar del R\u0131\u0301o, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J-J","family":"Veillard","sequence":"first","affiliation":[{"name":"Homeopathic physician, 63400 Chamali\u00e8res, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"10.1054\/homp.1999.0481_R1","first-page":"183","volume":"43","year":"1994","journal-title":"Morb Mortal Wkly Rep"},{"key":"10.1054\/homp.1999.0481_R2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1001\/archopht.1994.01090170139037","article-title":"Epidemic optic neuropathy in Cuba: eye findings","volume":"112","author":"Sadun","year":"1994","journal-title":"Arch Ophtalmol"},{"key":"10.1054\/homp.1999.0481_R3","unstructured":"Mas Bermejo, P, Rodriguez, R, Barcelo C et al, Neuropat\u0131\u0301a epid\u00e9mica en Cuba: un an\u00e1lisis epidemiol\u00f3gico, La Habana, Ministerio de Salud P\u00fablica, 1993, 1\u201314"},{"key":"10.1054\/homp.1999.0481_R4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0022-510X(94)90130-9","article-title":"An epidemic in Cuba of optic neuropathy, sensorineural deafness, peripheral sensory neuropathy and dorsolateral myeloneuropathy","volume":"127","author":"Roman","year":"1994","journal-title":"J Neurol Sci"},{"key":"10.1054\/homp.1999.0481_R5","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1212\/WNL.44.10.1784","article-title":"Epidemic neuropathy in Cuba: a plea to end the United States economic embargo on a humanitarian basis","volume":"44","author":"Roman","year":"1994","journal-title":"Neurology"},{"key":"10.1054\/homp.1999.0481_R6","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1056\/NEJM199511023331803","article-title":"Epidemic optic neuropathy in Cuba-clinical characterization and risk factors","volume":"333","author":"The Cuba Neuropathy Field Investigation Team","year":"1995","journal-title":"New Engl J Med"},{"key":"10.1054\/homp.1999.0481_R7","first-page":"12","author":"P\u00e9rez Cristi\u00e1","year":"1994","journal-title":"Toxic-Nutritional Factors in the Epidemic Neuropathy"},{"key":"10.1054\/homp.1999.0481_R8","first-page":"87","article-title":"Risques toxico-nutritionnels, neuropathie p\u00e9riph\u00e9rique et s\u00e9curit\u00e9 alimentaire \u00e0 Cuba. 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