{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:58:17Z","timestamp":1777852697853,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hand Surgery"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p>Dupuytren\u2019s contracture shares certain properties with malignant tumours, characterized by proliferation and lack of apoptosis, which may be induced by the c- myc oncogene. Because of these similarities, the relationship between the c- myc oncogene expression, bcl-2 oncogene (antiapoptotic gene) and proliferation was investigated in Dupuytren\u2019s disease. Proliferation was assessed by immunohistochemical staining of the mib-1 antibody. Results were compared with those from fibrosarcoma specimens, representing a related malignant tumour. Non-diseased fascia from Dupuytren patients and flexor retinaculum from patients undergoing carpal tunnel release without Dupuytren\u2019s disease were used as controls. Expression of c- myc was elevated in primary Dupuytren\u2019s disease and fibrosarcoma specimens, whilst recurrent Dupuytren\u2019s disease, non-diseased Dupuytren fascia and flexor retinaculum exhibited significantly lower levels. Neither bcl-2 nor mib-1 were detected in Dupuytren\u2019s disease, non-diseased fascia or flexor retinaculum, in contrast to fibrosarcoma. The imbalance between proliferation and apoptosis, producing malignant growth was thus confirmed for fibrosarcoma, but not for Dupuytren\u2019s disease.<\/jats:p>","DOI":"10.1054\/jhsb.1999.0251","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T11:33:28Z","timestamp":1032435208000},"page":"511-514","source":"Crossref","is-referenced-by-count":20,"title":["Is Dupuytren\u2019s Disease Caused by an Imbalance between Proliferation and Cell Death?"],"prefix":"10.1177","volume":"24","author":[{"given":"B.","family":"JEMEC","sequence":"first","affiliation":[{"name":"From the CRC Gray Laboratory and the Department of Plastic Surgery, Mount Vernon Hospital, Northwood, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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