{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T23:59:17Z","timestamp":1777852757539,"version":"3.51.4"},"reference-count":49,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hand Surgery"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:p>We have examined biopsies of Dupuytren\u2019s contracture palmar fascia, overlying subcutis and skin, and have correlated the distribution of gross macroscopic changes in the hand, mapped pre- and intraoperatively, with light microscopic immunohistochemical findings. We report increased numbers of S100 positive Langerhans cells (an epidermal cell of dendritic lineage) and CD45 positive cells, both in \u201cnodules\u201d and at dermo-epidermal junctions, in the biopsied tissues. This suggests that Langerhans cells migrate from the epidermis into Dupuytren\u2019s contracture tissue, possibly in response to local changes in levels of inflammatory cytokines within the tissue. Our findings, together with other reports of increased numbers of dermal dendrocytes and inflammatory cells in Dupuytren\u2019s contracture tissue, lend circumstantial support to the \u201cextrinsic theory\u201d of the pathogenesis of Dupuytren\u2019s contracture. However, the earliest stages of the disease process have not been defined, and therefore the events which ultimately produce fibrosis in the palmar fascial complex in susceptible individuals could begin in the skin and\/or within deeper tissues, especially where there is dysregulation of the immune system.<\/jats:p>","DOI":"10.1054\/jhsb.2000.0518","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T11:33:28Z","timestamp":1032435208000},"page":"362-367","source":"Crossref","is-referenced-by-count":17,"title":["Langerhans Cells in Dupuytren\u2019s Contracture"],"prefix":"10.1177","volume":"26","author":[{"given":"F. 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