{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:47:59Z","timestamp":1791910079090,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":7892,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jpain.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Pain"],"published-print":{"date-parts":[[2002,2]]},"DOI":"10.1054\/jpai.2002.27001","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T07:34:15Z","timestamp":1027668855000},"page":"3-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia"],"prefix":"10.1054","volume":"3","author":[{"given":"Prisca","family":"Honor\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth H.","family":"Kamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D.","family":"Rogers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.F.","family":"Gebhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick W.","family":"Mantyh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1054\/jpai.2002.27001_bib1","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.1523\/JNEUROSCI.17-20-08049.1997","article-title":"Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation","volume":"17","author":"Abbadie","year":"1997","journal-title":"J Neurosci"},{"key":"10.1054\/jpai.2002.27001_bib2","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1152\/jn.2000.83.4.2239","article-title":"Physiological properties of the lamina I spinoparabrachial neurons in the rat","volume":"83","author":"Bester","year":"2000","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib3","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1523\/JNEUROSCI.12-12-04878.1992","article-title":"Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat","volume":"12","author":"Birder","year":"1992","journal-title":"J Neurosci"},{"key":"10.1054\/jpai.2002.27001_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0006-8993(99)01546-2","article-title":"Increased c-fos expression in spinal lumbosacral projection neurons and preganglionic neurons after irritation of the lower urinary tract in the rat","volume":"834","author":"Birder","year":"1999","journal-title":"Brain Res"},{"key":"10.1054\/jpai.2002.27001_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/cne.903560302","article-title":"Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis","volume":"356","author":"Brown","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1054\/jpai.2002.27001_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1152\/physrev.1994.74.1.95","article-title":"Sensory innervation of the viscera: Peripheral basis of visceral pain","volume":"74","author":"Cervero","year":"1994","journal-title":"Physiol Rev"},{"key":"10.1054\/jpai.2002.27001_bib7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0006-8993(96)00661-0","article-title":"Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors","volume":"736","author":"Coutinho","year":"1996","journal-title":"Brain Res"},{"key":"10.1054\/jpai.2002.27001_bib8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF01945358","article-title":"Neuropeptides in pelvic afferent pathways","volume":"43","author":"de Groat","year":"1987","journal-title":"Experientia"},{"key":"10.1054\/jpai.2002.27001_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0006-8993(95)00022-I","article-title":"Spinoparabrachial tract neurons showing substance P receptor-like immunoreactivity in the lumbar spinal cord of the rat","volume":"674","author":"Ding","year":"1995","journal-title":"Brain Res"},{"key":"10.1054\/jpai.2002.27001_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0306-4522(98)00276-0","article-title":"Substance P receptor (neurokinin-1)-expressing neurons in lamina I of the spinal cord encode for the intensity of noxious stimulation: A c-Fos study in rat","volume":"89","author":"Doyle","year":"1999","journal-title":"Neuroscience"},{"key":"10.1054\/jpai.2002.27001_bib11","doi-asserted-by":"crossref","first-page":"10208","DOI":"10.1073\/pnas.88.22.10208","article-title":"Pharmacological properties of a potent and selective nonpeptide substance P antagonist","volume":"88","author":"Garret","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/jpai.2002.27001_bib12","first-page":"24","article-title":"Visceral nociception: Consequences, modulation and the future","volume":"10","author":"Gebhart","year":"1995","journal-title":"Eur J Anaesthesiol Suppl"},{"key":"10.1054\/jpai.2002.27001_bib13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0079-6123(08)61083-3","article-title":"Visceral polymodal receptors","volume":"113","author":"Gebhart","year":"1996","journal-title":"Prog Brain Res"},{"issue":"suppl A","key":"10.1054\/jpai.2002.27001_bib14","first-page":"37A","article-title":"Peripheral contributions to visceral hyperalgesia","volume":"13","author":"Gebhart","year":"1999","journal-title":"Can J Gastroenterol"},{"key":"10.1054\/jpai.2002.27001_bib15","doi-asserted-by":"crossref","first-page":"G834","DOI":"10.1152\/ajpgi.2000.278.6.G834","article-title":"Pathobiology of visceral pain: Molecular mechanisms and therapeutic implications IV. Visceral afferent contributions to the pathobiology of visceral pain","volume":"278","author":"Gebhart","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1054\/jpai.2002.27001_bib16","doi-asserted-by":"crossref","first-page":"7670","DOI":"10.1523\/JNEUROSCI.19-17-07670.1999","article-title":"Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states","volume":"19","author":"Honore","year":"1999","journal-title":"J Neurosci"},{"key":"10.1054\/jpai.2002.27001_bib17","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/0016-5085(94)90065-5","article-title":"Involvement of neurokinin 1 and 2 receptors in viscerosensitive response to rectal distension in rats","volume":"107","author":"Julia","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1054\/jpai.2002.27001_bib18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3565(24)29307-1","article-title":"Combinations of neurokinin receptor antagonists reduce visceral hyperalgesia","volume":"299","author":"Kamp","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1054\/jpai.2002.27001_bib19","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1152\/jn.1996.75.6.2606","article-title":"Spinothalamic and spinohypothalamic tract neurons in the sacral spinal cord of rats. II. Responses to cutaneous and visceral stimuli","volume":"75","author":"Katter","year":"1996","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/cne.903190411","article-title":"Segmental distribution and peptide content of primary afferent neurons innervating the urogenital organs and colon of male rats","volume":"319","author":"Keast","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1054\/jpai.2002.27001_bib21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cne.902310402","article-title":"Primary afferent projections of the major splanchnic nerve to the spinal cord and gracile nucleus of the cat","volume":"231","author":"Kuo","year":"1985","journal-title":"J Comp Neurol"},{"key":"10.1054\/jpai.2002.27001_bib22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0306-4522(00)00148-2","article-title":"Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene","volume":"98","author":"Laird","year":"2000","journal-title":"Neuroscience"},{"key":"10.1054\/jpai.2002.27001_bib23","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0306-4522(95)00558-7","article-title":"Neurokinin-1 receptors on lumbar spinothalamic neurons in the rat","volume":"72","author":"Marshall","year":"1996","journal-title":"Neuroscience"},{"key":"10.1054\/jpai.2002.27001_bib24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1523\/JNEUROSCI.14-02-00712.1994","article-title":"NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception","volume":"14","author":"McCarson","year":"1994","journal-title":"J Neurosci"},{"key":"10.1054\/jpai.2002.27001_bib25","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/S0026-895X(25)09547-1","article-title":"The neurokinin-1 receptor antagonist LY306,740 blocks nociception-induced increases in dorsal horn neurokinin-1 receptor gene expression","volume":"50","author":"McCarson","year":"1996","journal-title":"Mol Pharmacol"},{"key":"10.1054\/jpai.2002.27001_bib26","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0014-2999(98)00040-5","article-title":"Effects of tachykinin receptor antagonists on the rat jejunal distension pain response","volume":"345","author":"McLean","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1054\/jpai.2002.27001_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gut.42.6.814","article-title":"Symptoms and visceral perception in severe functional and organic dyspepsia","volume":"42","author":"Mertz","year":"1998","journal-title":"Gut"},{"key":"10.1054\/jpai.2002.27001_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3940(87)90047-4","article-title":"Substance P-, somatostatin- and calcitonin gene-related peptide-like immunoreactivity and fluoride resistant acid phosphatase-activity in relation to retrogradely labeled cutaneous, muscular and visceral primary sensory neurons in the rat","volume":"74","author":"Molander","year":"1987","journal-title":"Neurosci Lett"},{"key":"10.1054\/jpai.2002.27001_bib29","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1152\/jn.1987.57.6.1867","article-title":"Characterization of neuronal responses to noxious visceral and somatic stimuli in the medial lumbosacral spinal cord of the rat","volume":"57","author":"Ness","year":"1987","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib30","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1152\/jn.1988.60.4.1419","article-title":"Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat","volume":"60","author":"Ness","year":"1988","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib31","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0006-8993(88)91555-7","article-title":"Colorectal distension as a noxious visceral stimulus: Physiologic and pharmacologic characterization of pseudoaffective reflexes in the rat","volume":"450","author":"Ness","year":"1988","journal-title":"Brain Res"},{"key":"10.1054\/jpai.2002.27001_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-8993(89)90516-7","article-title":"Characterization of superficial T13-L2 dorsal horn neurons encoding for colorectal distension in the rat: Comparison with neurons in deep laminae","volume":"486","author":"Ness","year":"1989","journal-title":"Brain Res"},{"key":"10.1054\/jpai.2002.27001_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0304-3940(00)00832-6","article-title":"Acute inflammation differentially alters the activity of two classes of rat spinal visceral nociceptive neurons","volume":"281","author":"Ness","year":"2000","journal-title":"Neurosci Lett"},{"key":"10.1054\/jpai.2002.27001_bib34","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1126\/science.286.5444.1558","article-title":"Transmission of chronic nociception by spinal neurons expressing the substance P receptor","volume":"286","author":"Nichols","year":"1999","journal-title":"Science"},{"issue":"pt 2","key":"10.1054\/jpai.2002.27001_bib35","first-page":"H526","article-title":"Role of spinal NK1 receptors in cardiovascular responses to chemical stimulation of the gallbladder","volume":"268","author":"Pan","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1054\/jpai.2002.27001_bib36","first-page":"350","article-title":"Pathophysiology of pain","author":"Ruch","year":"1961"},{"key":"10.1054\/jpai.2002.27001_bib37","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0304-3959(94)00194-J","article-title":"Antinociceptive profiles of non-peptidergic neurokinin 1 and neurokinin 2 receptor antagonists: A comparison to other classes of antinociceptive agent","volume":"61","author":"Seguin","year":"1995","journal-title":"Pain"},{"key":"10.1054\/jpai.2002.27001_bib38","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1152\/jn.1994.71.6.2046","article-title":"Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat","volume":"71","author":"Sengupta","year":"1994","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib39","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0014-2999(94)90809-5","article-title":"Non-specific effects of the tachykinin NK1 receptor antagonist, CP-99,994, in antinociceptive tests in rat, mouse and gerbil","volume":"271","author":"Smith","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1054\/jpai.2002.27001_bib40","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1152\/jn.1998.80.5.2632","article-title":"Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character","volume":"80","author":"Su","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1054\/jpai.2002.27001_bib41","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0140-6736(80)91885-1","article-title":"Site of pain from the irritable bowel","volume":"2","author":"Swarbrick","year":"1980","journal-title":"Lancet"},{"key":"10.1054\/jpai.2002.27001_bib42","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0016-5085(91)90717-Y","article-title":"Epidemiology of colonic symptoms and the irritable bowel syndrome","volume":"101","author":"Talley","year":"1991","journal-title":"Gastroenterology"},{"issue":"suppl 2","key":"10.1054\/jpai.2002.27001_bib43","first-page":"1143","article-title":"Functional bowel disorders and functional abdominal pain","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"10.1054\/jpai.2002.27001_bib44","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1460-9568.2000.00950.x","article-title":"Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem","volume":"12","author":"Todd","year":"2000","journal-title":"Eur J Neurosci"},{"key":"10.1054\/jpai.2002.27001_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0304-3959(92)90247-9","article-title":"Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat","volume":"49","author":"Traub","year":"1992","journal-title":"Pain"},{"key":"10.1054\/jpai.2002.27001_bib46","first-page":"47","article-title":"Sensory mechanisms of the spinal cord","author":"Willis","year":"1991"}],"container-title":["The Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590002037744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1526590002037744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T19:37:56Z","timestamp":1761507476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1526590002037744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,2]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,2]]}},"alternative-id":["S1526590002037744"],"URL":"https:\/\/doi.org\/10.1054\/jpai.2002.27001","relation":{},"ISSN":["1526-5900"],"issn-type":[{"value":"1526-5900","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Pain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1054\/jpai.2002.27001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2002 American Pain Society. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}