{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:01:39Z","timestamp":1704326499166},"reference-count":52,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1054\/mehy.1999.0024","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T11:34:15Z","timestamp":1027683255000},"page":"216-220","source":"Crossref","is-referenced-by-count":2,"title":["Oral vaccine in otosclerosis"],"prefix":"10.1054","volume":"54","author":[{"given":"M.A.","family":"Lopez-Gonzalez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/mehy.1999.0024_RF1","article-title":"Otosclerosis. A genetic and clinical study","author":"Larson","year":"1960","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF2","first-page":"99","article-title":"Etiology of otospongiotic sensorineural hearing losses","volume":"10","author":"Causse","year":"1989","journal-title":"Am J Otol"},{"key":"10.1054\/mehy.1999.0024_RF3","first-page":"1","article-title":"The inner ear in genetically determined deafness","volume":"187","author":"Altman","year":"1963","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF4","first-page":"202","article-title":"Genetic factors in otosclerosis","volume":"41","author":"Morrison","year":"1967","journal-title":"Ann R Coll Surg Eng"},{"key":"10.1054\/mehy.1999.0024_RF5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/00016488909138366","article-title":"Immunochemistry of otosclerosis","volume":"470","author":"Arnold","year":"1990","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF6","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3109\/00016489509139314","article-title":"Otosclerosis: a measles virus associated inflammatory disease","volume":"115","author":"Niedermeyer","year":"1995","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF7","first-page":"26","article-title":"Human leukocyte antigen and otosclerosis","volume":"47","author":"Gamir","year":"1996","journal-title":"Acta Otorrinolaring Esp"},{"key":"10.1054\/mehy.1999.0024_RF8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1159\/000275725","article-title":"Secretory immunoglobulin A in the human endolymphatic sac","volume":"46","author":"Arnold","year":"1984","journal-title":"ORL"},{"key":"10.1054\/mehy.1999.0024_RF9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/000348948409300211","article-title":"Immunology of the inner ear. Evidence of local antibody production","volume":"93","author":"Harris","year":"1984","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1054\/mehy.1999.0024_RF10","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1288\/00005537-198606000-00018","article-title":"The endolymphatic sac. Its importance in inner ear immune response","volume":"96","author":"Tomiyama","year":"1986","journal-title":"Laryngoscope"},{"key":"10.1054\/mehy.1999.0024_RF11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0196-0709(87)80047-9","article-title":"Morphologic and immunohistochemical observations of otosclerotic stapes","volume":"8","author":"Lim","year":"1987","journal-title":"Am J Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000276115","article-title":"The epithelium of the human endolymphatic sac. Immunochemical characterization","volume":"52","author":"Altermatt","year":"1990","journal-title":"ORL"},{"key":"10.1054\/mehy.1999.0024_RF13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3109\/00016489109100755","article-title":"Homing of lymphocytes to the inner ear","volume":"111","author":"Gloddek","year":"1991","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF14","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/000348948409300107","article-title":"Etiopathogenesis of otosclerosis: a hypothesis","volume":"93","author":"Yoo","year":"1984","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1054\/mehy.1999.0024_RF15","first-page":"211","article-title":"Otospongiosis as a genetic disease. Early detection, medical management, and prevention","volume":"5","author":"Causse","year":"1984","journal-title":"Am J Otol"},{"key":"10.1054\/mehy.1999.0024_RF16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1177\/019459989310900312","article-title":"The effects of etidronate disodium on progressive hearing loss from otosclerosis","volume":"109","author":"Kennedy","year":"1993","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1054\/mehy.1999.0024_RF17","first-page":"47","article-title":"Early detection of otosclerosis by impedance audiometry screening","volume":"17","author":"Causse","year":"1983","journal-title":"Scand Audiol"},{"key":"10.1054\/mehy.1999.0024_RF18","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archotol.1952.00710010550003","article-title":"Threshold of reflex contractions of muscles of the middle ear recruitment of loudness","volume":"55","author":"Metz","year":"1952","journal-title":"Arch Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF19","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3109\/00016487009131567","article-title":"Early diagnosis of VIII nerve tumors by acoustic reflex tests","volume":"263","author":"Anderson","year":"1970","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1001\/archotol.1972.00770090791004","article-title":"Studies in impedance audiometry. I. Normal and sensorineural ears","volume":"96","author":"Jerger","year":"1972","journal-title":"Arch Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF21","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1001\/archotol.1973.00780020160003","article-title":"Acoustic middle ear muscle reflexes in patients with otosclerosis","volume":"98","author":"Terkildsen","year":"1973","journal-title":"Arch Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/archotol.1974.00780030173003","article-title":"Studies in impedance audiometry. III. Middle ear disorders","volume":"99","author":"Jerger","year":"1973","journal-title":"Arch Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF23","first-page":"491","article-title":"Essai d\u2019explication de l\u2019effect on-off dans I\u2019otospongiose","volume":"91","author":"Causse","year":"1974","journal-title":"Ann Otol"},{"key":"10.1054\/mehy.1999.0024_RF24","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.7112122","article-title":"Type II collagen autoimmunity in otosclerosis and M\u00e9ni\u00e8re\u2019s disease","volume":"217","author":"Yoo","year":"1982","journal-title":"Science"},{"key":"10.1054\/mehy.1999.0024_RF25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/000348948309200201","article-title":"Type II collagen-induced autoimmune otospongiosis, A preliminary report","volume":"92","author":"Yoo","year":"1983","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1054\/mehy.1999.0024_RF26","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0196-0709(86)80048-5","article-title":"Type II collagen-induced otospongiosis-like lesions in rats","volume":"7","author":"Huang","year":"1986","journal-title":"Am J Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF27","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1177\/019459989010300619","article-title":"Effects of indomethacin and calcitonin on bone absorption in type II-collagen-induced otosclerosis-like lesions in rats","volume":"103","author":"Huang","year":"1991","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1054\/mehy.1999.0024_RF28","series-title":"The Molecular Pathology of Autoimmune Diseases.","first-page":"715","article-title":"Immunologic aspects of otologic disease","author":"Schiff","year":"1993"},{"key":"10.1054\/mehy.1999.0024_RF29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/00016488809097004","article-title":"The role of type II collagen autoimmunity in otosclerosis revisited","volume":"105","author":"Sorensen","year":"1988","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF30","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0140-6736(91)91165-Q","article-title":"Correlation between antibodies to type II collagen and treatment outcome in bilateral progressive sensorineural hearing loss","volume":"337","author":"Helfgott","year":"1991","journal-title":"Lancet"},{"key":"10.1054\/mehy.1999.0024_RF31","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1177\/000348949210101207","article-title":"Antibodies against a 30 kilodaltons cochlear protein and type II and IX collagens in the serum of patients with inner ear diseases","volume":"101","author":"Joliat","year":"1992","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1054\/mehy.1999.0024_RF32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/0140-6736(92)90386-H","article-title":"Type II collagen antibodies in patients with sensorineural hearing loss","volume":"339","author":"Sutjita","year":"1992","journal-title":"Lancet"},{"key":"10.1054\/mehy.1999.0024_RF33","first-page":"277","article-title":"Presence of autoantibodies against specific cartilage collagens of otosclerotic patients","volume":"44","author":"Bujia","year":"1993","journal-title":"Acta Otorrinolaring Esp"},{"key":"10.1054\/mehy.1999.0024_RF34","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1084\/jem.180.2.745","article-title":"T cell recognition of carbohydrates on type II collagen","volume":"180","author":"Michaelsson","year":"1994","journal-title":"J Exp Med"},{"key":"10.1054\/mehy.1999.0024_RF35","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1288\/00005537-198605000-00006","article-title":"Predictive value of laboratory tests in \u2018autoimmune\u2019 inner ear disease: preliminary report","volume":"96","author":"Hughes","year":"1986","journal-title":"Laryngoscope"},{"key":"10.1054\/mehy.1999.0024_RF36","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/00016489.1992.11665399","article-title":"New immunobiological tests in the investigation of M\u00e9ni\u00e8re disease and sensorineural hearing loss","volume":"112","author":"Lejeune","year":"1992","journal-title":"Acta Otolaryngol"},{"key":"10.1054\/mehy.1999.0024_RF37","first-page":"171","article-title":"Apport des tests de transformation lymphoblastique et d\u2019immunofluorescence indirecte au diagnostic des surdit\u00e9s auto-immunes chez I\u2019homme","volume":"115","author":"Charachon","year":"1994","journal-title":"Revue Laryngologie"},{"key":"10.1054\/mehy.1999.0024_RF38","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1288\/00005537-199108000-00015","article-title":"The lymphocyte transformation test with type II collagen as a diagnostic tool of autoimmune sensorineural hearing loss","volume":"101","author":"Berger","year":"1991","journal-title":"Laryngoscope"},{"key":"10.1054\/mehy.1999.0024_RF39","doi-asserted-by":"crossref","first-page":"7443","DOI":"10.1073\/pnas.83.19.7443","article-title":"Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen","volume":"83","author":"Nagler-Anderson","year":"1986","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/mehy.1999.0024_RF40","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.4049\/jimmunol.145.8.2489","article-title":"Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen","volume":"154","author":"Zhang","year":"1990","journal-title":"J Immunol"},{"key":"10.1054\/mehy.1999.0024_RF41","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1126\/science.8378772","article-title":"Effects of oral administration of type II collagen on rheumatoid arthritis","volume":"261","author":"Trentham","year":"1993","journal-title":"Science"},{"key":"10.1054\/mehy.1999.0024_RF42","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0008-8749(88)90305-X","article-title":"Suppression of experimental encephalomyelitis by the oral administration of myelin basic protein","volume":"112","author":"Bitar","year":"1988","journal-title":"Cel Immunol"},{"key":"10.1054\/mehy.1999.0024_RF43","doi-asserted-by":"crossref","first-page":"440","DOI":"10.4049\/jimmunol.140.2.440","article-title":"Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments","volume":"140","author":"Higgins","year":"1988","journal-title":"J Immunol"},{"key":"10.1054\/mehy.1999.0024_RF44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1084\/jem.174.4.791","article-title":"Antigen-driven bystander suppression after oral administration of antigens","volume":"174","author":"Miller","year":"1991","journal-title":"J Exp Med"},{"key":"10.1054\/mehy.1999.0024_RF45","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.4049\/jimmunol.147.7.2155","article-title":"Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy","volume":"147","author":"Whitacre","year":"1991","journal-title":"J Immunol"},{"key":"10.1054\/mehy.1999.0024_RF46","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.4049\/jimmunol.144.5.1689","article-title":"Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-Antigen","volume":"144","author":"Nussenblatt","year":"1990","journal-title":"J Immunol"},{"key":"10.1054\/mehy.1999.0024_RF47","doi-asserted-by":"crossref","first-page":"10252","DOI":"10.1073\/pnas.88.22.10252","article-title":"Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin","volume":"88","author":"Zhang","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/mehy.1999.0024_RF48","doi-asserted-by":"crossref","first-page":"7762","DOI":"10.1073\/pnas.89.16.7762","article-title":"Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat","volume":"89","author":"Sayegh","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/mehy.1999.0024_RF49","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00007890-199201000-00033","article-title":"Down-regulation of the immune response to histocompatibility antigen and prevention of sensitization by skin allografts by orally administered alloantigen","volume":"53","author":"Sayegh","year":"1992","journal-title":"Transplantation"},{"key":"10.1054\/mehy.1999.0024_RF50","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.7680493","article-title":"Doubled-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis","volume":"259","author":"Weiner","year":"1993","journal-title":"Science"},{"key":"10.1054\/mehy.1999.0024_RF51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0165-5728(93)90045-Z","article-title":"Suppression of experimental autoimmune myasthenia gravis by oral administration of acetylcholine receptor","volume":"44","author":"Wang","year":"1993","journal-title":"J Neuroimmunol"},{"key":"10.1054\/mehy.1999.0024_RF52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1073\/pnas.89.1.421","article-title":"Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor B after antigen-specific triggering","volume":"89","author":"Miller","year":"1992","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987799900245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987799900245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T22:40:08Z","timestamp":1704321608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987799900245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0306987799900245"],"URL":"https:\/\/doi.org\/10.1054\/mehy.1999.0024","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}