{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T22:11:50Z","timestamp":1649196710934},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1054\/mehy.2000.1108","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T15:33:28Z","timestamp":1032449608000},"page":"52-57","source":"Crossref","is-referenced-by-count":2,"title":["Cell darwinism, apoptosis, free radicals and haematological malignancies"],"prefix":"10.1054","volume":"56","author":[{"given":"A.","family":"Cucuianu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/mehy.2000.1108_RF1","first-page":"61","article-title":"Universal acid","author":"Dennet","year":"1995","journal-title":"Darwin\u2019s Dangerous Idea"},{"key":"10.1054\/mehy.2000.1108_RF2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/00008571-199212000-00014","article-title":"Evolutionary aspects of human cancer","volume":"2","author":"Ramel","year":"1992","journal-title":"Pharmacogenetics"},{"key":"10.1054\/mehy.2000.1108_RF3","first-page":"229","article-title":"Cellular adaptation and cancerogenesis","volume":"89","author":"La Torre","year":"1998","journal-title":"Minerva Med"},{"key":"10.1054\/mehy.2000.1108_RF4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00062752-199502010-00003","article-title":"Mechanisms of cell commitment in myeloid cell differentiation","volume":"2","author":"Bedi","year":"1995","journal-title":"Curr Opin Hematol"},{"key":"10.1054\/mehy.2000.1108_RF5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00048062","article-title":"Apoptosis in the development of the immune system: growth factors, clonal selection and bcl-2","volume":"11","author":"McCarthy","year":"1992","journal-title":"Cancer Metastasis Rev"},{"key":"10.1054\/mehy.2000.1108_RF6","first-page":"220","article-title":"B lymphocyte physiology: the beginning and the end","volume":"204","author":"Nossal","year":"1997","journal-title":"Ciba Found Symp"},{"key":"10.1054\/mehy.2000.1108_RF7","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/nm0898-882","article-title":"Self-organization, complexity and chaos: the new biology for medicine","volume":"4","author":"Coffey","year":"1998","journal-title":"Nature Medicine"},{"key":"10.1054\/mehy.2000.1108_RF8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF01698481","article-title":"Programmed cell death \u2013 many questions still to be answered","volume":"69","author":"Binder","year":"1994","journal-title":"Ann Hematol"},{"key":"10.1054\/mehy.2000.1108_RF9","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/S0140-6736(95)90015-2","article-title":"Tumour suppressor genes in disease and therapy","volume":"345","author":"Skuse","year":"1995","journal-title":"Lancet"},{"key":"10.1054\/mehy.2000.1108_RF10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","article-title":"p53, guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"key":"10.1054\/mehy.2000.1108_RF11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0952-7915(98)80222-7","article-title":"Mechanisms of CD95 (APO-1\/Fas)- mediated apoptosis","volume":"10","author":"Peter","year":"1998","journal-title":"Curr Opin Immunol"},{"key":"10.1054\/mehy.2000.1108_RF12","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/21697","article-title":"Interaction of c-Abl and p73\u00e1 and their collaboration to induce apoptosis","volume":"399","author":"Agami","year":"1999","journal-title":"Nature"},{"key":"10.1054\/mehy.2000.1108_RF13","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1126\/science.281.5381.1322","article-title":"The Bcl-2 protein family: arbiters of cell survival","volume":"281","author":"Adams","year":"1998","journal-title":"Science"},{"key":"10.1054\/mehy.2000.1108_RF14","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0733-8619(05)70091-8","article-title":"Aging and apoptosis control","volume":"16","author":"Tomei","year":"1998","journal-title":"Neurol Clin"},{"key":"10.1054\/mehy.2000.1108_RF15","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1532-5415.1997.tb05981.x","article-title":"What does cell death have to do with aging?","volume":"45","author":"Warner","year":"1997","journal-title":"J Am Geriatr Soc"},{"key":"10.1054\/mehy.2000.1108_RF16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/1097-0142(19950101)75:1+<370::AID-CNCR2820751319>3.0.CO;2-Q","article-title":"Non-Hodgkin\u2019s lymphoma","volume":"75","author":"Greiner","year":"1995","journal-title":"Cancer"},{"key":"10.1054\/mehy.2000.1108_RF17","first-page":"21","article-title":"Regulators of apoptosis in B-cell neoplasms","volume":"Suppl 3","author":"Reed","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1054\/mehy.2000.1108_RF18","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1182\/blood.V84.8.2412.2412","article-title":"p53 in hematologic malignancies","volume":"8","author":"Imamura","year":"1994","journal-title":"Blood"},{"key":"10.1054\/mehy.2000.1108_RF19","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1182\/blood.V83.5.1179.1179","article-title":"BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic death","volume":"83","author":"McGahon","year":"1994","journal-title":"Blood"},{"key":"10.1054\/mehy.2000.1108_RF20","first-page":"S45","article-title":"Very low level of major BCR-ABL expression in blood of some healthy individuals","volume":"17","author":"Biernaux","year":"1996","journal-title":"Bone Marrow Transplantation"},{"key":"10.1054\/mehy.2000.1108_RF21","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1182\/blood.V92.9.3362","article-title":"The presence of typical and atypical BCR-ABL fusion genes in leucocytes of normal individuals: biologic significance and implications for the assessment of minimal residual disease","volume":"92","author":"Bose","year":"1998","journal-title":"Blood"},{"key":"10.1054\/mehy.2000.1108_RF22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0145-2126(91)90137-I","article-title":"Relationship between clonality and transformation in acute leukemia","volume":"1","author":"Butturini","year":"1991","journal-title":"Leukemia Research"},{"key":"10.1054\/mehy.2000.1108_RF23","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1046\/j.1365-2141.1997.1933010.x","article-title":"Clonal hematopoiesis in normal elderly women: implications for the myeloproliferative disorders and myelodysplastic syndromes","volume":"97","author":"Champion","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1365-2141.1992.tb08245.x","article-title":"Malignant transformation and life expectancy in monoclonal gammopathy of undetermined significance","volume":"81","author":"Blade","year":"1992","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1046\/j.1365-2141.1998.00708.x","article-title":"Ineffective haemopoiesis and apoptosis in myelodysplastic syndromes","volume":"101","author":"Parker","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF26","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1182\/blood.V78.12.3209.3209","article-title":"Clonal hematopoiesis in patients with acquired aplastic anemia","volume":"78","author":"van Kamp","year":"1991","journal-title":"Blood"},{"key":"10.1054\/mehy.2000.1108_RF27","first-page":"201","article-title":"Paroxysmal nocturnal hemoglobinuria","volume":"36","author":"Rotoli","year":"1989","journal-title":"Sem Hematol"},{"key":"10.1054\/mehy.2000.1108_RF28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","article-title":"Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria","volume":"73","author":"Takeda","year":"1993","journal-title":"Cell"},{"key":"10.1054\/mehy.2000.1108_RF29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1365-2559.1992.tb01007.x","article-title":"Post-transplant lymphoproliferative disorders: a morphologic, phenotypic and genotypic spectrum of disease","volume":"20","author":"Sverdlow","year":"1992","journal-title":"Histopathology"},{"key":"10.1054\/mehy.2000.1108_RF30","first-page":"1068","article-title":"Epidemiology and pathogenesis of AIDS-related lymphomas","volume":"12","author":"Aboulafia","year":"1998","journal-title":"Oncology"},{"key":"10.1054\/mehy.2000.1108_RF31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/bies.950181214","article-title":"Werner syndrome: entering the helicase era","volume":"18","author":"Epstein","year":"1996","journal-title":"Bioessays"},{"key":"10.1054\/mehy.2000.1108_RF32","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/00062752-199903000-00005","article-title":"The molecular and cellular biology of Fanconi anemia","volume":"6","author":"Garcia-Higuera","year":"1999","journal-title":"Curr Opin Hematol"},{"key":"10.1054\/mehy.2000.1108_RF33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1046\/j.1365-2141.1999.01201.x","article-title":"Normal primitive haematopoietic progenitors are more frequent than their leukaemic counterpart in newly diagnosed patients with chronic myeloid leukaemia but rapidly decline with time","volume":"104","author":"Frassoni","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF34","first-page":"193","article-title":"Oxidative stress and apoptosis","volume":"54","author":"Mathieu","year":"1996","journal-title":"Ann Pharm Fr"},{"key":"10.1054\/mehy.2000.1108_RF35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0005-2728(98)00120-0","article-title":"Role of mitochondria in oxidative stress and ageing","volume":"1366","author":"Lenaz","year":"1998","journal-title":"Biochim Biophys Acta"},{"key":"10.1054\/mehy.2000.1108_RF36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1027387301845","article-title":"Reactive oxygen and nitrogen species regulate mitochondrial Ca2+ homeostasis and respiration","volume":"17","author":"Richter","year":"1997","journal-title":"Biosci Rep"},{"key":"10.1054\/mehy.2000.1108_RF37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1749-6632.1998.tb09913.x","article-title":"Redox regulation of caspases during apoptosis","volume":"854","author":"Hampton","year":"1998","journal-title":"Ann NY Acad Sci"},{"key":"10.1054\/mehy.2000.1108_RF38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1023\/A:1006873518427","article-title":"Reactive oxygen species, mitochondria and aging","volume":"174","author":"Papa","year":"1997","journal-title":"Mol Cell Biochem"},{"key":"10.1054\/mehy.2000.1108_RF39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1056\/NEJM199509073331007","article-title":"Mitochondrial DNA and disease","volume":"333","author":"Johns","year":"1993","journal-title":"N Eng J Med"},{"key":"10.1054\/mehy.2000.1108_RF40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0925-4439(95)00011-R","article-title":"Reactive oxygen species and the regulation of cell death by the Bcl-2 family","volume":"1271","author":"Korsmeyer","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1054\/mehy.2000.1108_RF41","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1182\/blood.V91.5.1700","article-title":"Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome c and activation of caspase-3","volume":"91","author":"Amarante-Mendes","year":"1998","journal-title":"Blood"},{"key":"10.1054\/mehy.2000.1108_RF42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2141.1999.01303.x","article-title":"An association between mitochondrial function and all-trans retinoic acid-induced apoptosis in acute myeloblastic leukemia cells","volume":"105","author":"Zheng","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF43","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1152\/ajpcell.1992.262.6.C1384","article-title":"Differential sensitivity of AS-30D rat hepatoma cells and normal hepatocytes to anoxic cell damage","volume":"262","author":"Kobryn","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1054\/mehy.2000.1108_RF44","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3109\/02841869509094003","article-title":"Modification of tumor glucose metabolism for therapeutic benefit","volume":"34","author":"Hamilton","year":"1995","journal-title":"Acta Oncol"},{"key":"10.1054\/mehy.2000.1108_RF45","first-page":"2537","article-title":"Changes in the zonation of lactate dehydrogenase activity in lobules of rat liver after experimentally induced colon carcinoma metastases","volume":"14","author":"Griffini","year":"1994","journal-title":"Anticancer Res"},{"key":"10.1054\/mehy.2000.1108_RF46","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-2141.1998.00551.x","article-title":"Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anemias without hypoplastic bone marrow","volume":"100","author":"Jonasova","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF47","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1365-2141.1994.tb06746.x","article-title":"Unexpected remission of acute myeloid leukemia after GM-CSF","volume":"87","author":"Bassan","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1054\/mehy.2000.1108_RF48","first-page":"151","article-title":"Gastrointestinal lymphomas of T and B-cell type","volume":"12","author":"Isaacson","year":"1999","journal-title":"Mod Pathol"},{"key":"10.1054\/mehy.2000.1108_RF49","first-page":"1021","article-title":"Helicobacter pylori induces apoptosis in mucosal lymphocytes in patients with gastritis","volume":"36","author":"Reinacher-Schick","year":"1998","journal-title":"Z Gastroenterol"},{"key":"10.1054\/mehy.2000.1108_RF50","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/bmj.317.7173.1636","article-title":"Diet and the prevention of cancer","volume":"317","author":"Cummings","year":"1998","journal-title":"BMJ"},{"key":"10.1054\/mehy.2000.1108_RF51","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00008469-199904000-00002","article-title":"Energy balance and cancers","volume":"8","author":"Gerber","year":"1999","journal-title":"Eur J Canc Prevent"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987700911083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987700911083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T22:10:28Z","timestamp":1581027028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987700911083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0306987700911083"],"URL":"https:\/\/doi.org\/10.1054\/mehy.2000.1108","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}