{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:44:29Z","timestamp":1774125869657,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1054\/npep.1999.0786","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T15:33:28Z","timestamp":1032449608000},"page":"45-50","source":"Crossref","is-referenced-by-count":8,"title":["Tachykinin activation of human monocytes from patients with interstitial lung disease, healthy smokers or healthy volunteers"],"prefix":"10.1054","volume":"34","author":[{"given":"S.","family":"Brunelleschi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nicali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lavagno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Viano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Gagliardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ghio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Albera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1054\/npep.1999.0786_RF1","first-page":"551","article-title":"Receptors and antagonists for substance P and related peptides","volume":"46","author":"Regoli","year":"1994","journal-title":"Pharmacol Rev"},{"key":"10.1054\/npep.1999.0786_RF2","first-page":"515","article-title":"Inflammatory mediators of asthma: an update","volume":"50","author":"Barnes","year":"1998","journal-title":"Pharmacol Rev"},{"key":"10.1054\/npep.1999.0786_RF3","first-page":"1","article-title":"The tachykinin NK1 receptor","volume":"32","author":"Quartara","year":"1998","journal-title":"Part II: Distribution and pathophysiological roles. Neuropeptides"},{"key":"10.1054\/npep.1999.0786_RF4","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1016\/S0021-9258(18)67021-8","article-title":"Binding characteristics and affinity labelling of protein constituents of the human IM-9 lymphoblast receptor for substance P","volume":"261","author":"Payan","year":"1986","journal-title":"J Biol Chem"},{"key":"10.1054\/npep.1999.0786_RF5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000053571","article-title":"Human skin mast cells produce TNF-alpha by substance P","volume":"117(suppl. 1)","author":"Okayama","year":"1998","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1054\/npep.1999.0786_RF6","doi-asserted-by":"crossref","first-page":"PL1","DOI":"10.1016\/0024-3205(91)90416-9","article-title":"Priming effects of mammalian tachykinins on human neutrophils","volume":"48","author":"Brunelleschi","year":"1991","journal-title":"Life Sci"},{"key":"10.1054\/npep.1999.0786_RF7","first-page":"629","article-title":"Activation of human neutrophils by tachykinins: effect on formyl-methionyl-leucyl-phenylalanine- and platelet-activating factor-stimulated superoxide anion production and antibody-dependent cell-mediated cytotoxicity","volume":"78","author":"Wozniak","year":"1993","journal-title":"Immunology"},{"key":"10.1054\/npep.1999.0786_RF8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF00169165","article-title":"The tachykinin NK-1 receptor mediates the migration-promoting effect of substance P on human skin fibroblast in culture","volume":"353","author":"Parenti","year":"1996","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.bjp.0700923","article-title":"The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1","volume":"120","author":"Nakamura","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF10","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.4049\/jimmunol.136.10.3856","article-title":"Substance P: binding properties and studies on cellular responses in guinea pig macrophages","volume":"136","author":"Hartung","year":"1986","journal-title":"J Immunol"},{"key":"10.1054\/npep.1999.0786_RF11","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1476-5381.1990.tb15821.x","article-title":"Tachykinins activate guinea-pig alveolar macrophages: involvement of NK1 and NK2 receptors","volume":"100","author":"Brunelleschi","year":"1990","journal-title":"Br J Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0143-4179(96)90010-4","article-title":"Tachykinin activation of human alveolar macrophages in tobacco smoke and sarcoidosis: a phenotypical and functional study","volume":"30","author":"Brunelleschi","year":"1996","journal-title":"Neuropeptides"},{"key":"10.1054\/npep.1999.0786_RF13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-0115(97)00029-3","article-title":"The effects of tachykinins on inflammatory and immune cells","volume":"70","author":"Maggi","year":"1997","journal-title":"Regul Pept"},{"key":"10.1054\/npep.1999.0786_RF14","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1126\/science.2457950","article-title":"Effect of neuropeptides on production of inflammatory cytokines by human monocytes","volume":"241","author":"Lotz","year":"1988","journal-title":"Science"},{"key":"10.1054\/npep.1999.0786_RF15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1128\/CDLI.1.3.330-335.1994","article-title":"Characterization of substance P binding to human monocyte\/macrophages","volume":"1","author":"Lucey","year":"1994","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1054\/npep.1999.0786_RF16","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.4049\/jimmunol.153.8.3691","article-title":"Activation of human monocytes via a non-neurokinin substance P receptor that is coupled to Gi protein, calcium, phospholipase D, MAP kinase, and IL-6 production","volume":"153","author":"Kavelaars","year":"1994","journal-title":"J Immunol"},{"key":"10.1054\/npep.1999.0786_RF17","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.4049\/jimmunol.159.11.5654","article-title":"Human monocytes and macrophages express substance P and neurokinin-1 receptor","volume":"59","author":"Ho","year":"1997","journal-title":"J Immunol"},{"key":"10.1054\/npep.1999.0786_RF18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0165-5728(98)00170-2","article-title":"Identification of delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes","volume":"91","author":"Lai","year":"1998","journal-title":"J Neuroimmunol"},{"key":"10.1054\/npep.1999.0786_RF19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0165-5728(97)00201-4","article-title":"Detection of substance P immunoreactivity in human peripheral leukocytes","volume":"82","author":"De Giorgio","year":"1998","journal-title":"J Neuroimmunol"},{"key":"10.1054\/npep.1999.0786_RF20","first-page":"L1073","article-title":"Rat alveolar macrophages express preprotachykinin gene-1 mRNA-encoding tachykinins","volume":"273","author":"Killingsworth","year":"1997","journal-title":"Am J Pathol"},{"key":"10.1054\/npep.1999.0786_RF21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0143-4179(98)90040-3","article-title":"Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis","volume":"32","author":"Brunelleschi","year":"1998","journal-title":"Neuropeptides"},{"key":"10.1054\/npep.1999.0786_RF22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0014-2999(93)90113-V","article-title":"NK1 receptors mediate the increase in mucociliary activity produced by tachykinins","volume":"231","author":"Linderg","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF23","first-page":"L309","article-title":"Substance P (NK-1) and neurokinin A (NK-2)-receptor gene expression in inflammatory airway disease","volume":"269","author":"Bai","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1054\/npep.1999.0786_RF24","first-page":"33","article-title":"Substance P-like immunoreactive substance in bronchoalveolar lavage fluids from patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis","volume":"13","author":"Takeyama","year":"1996","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"10.1054\/npep.1999.0786_RF25","first-page":"L339","article-title":"Tachykinin regulation of airway smooth muscle cell proliferation","volume":"269","author":"Neveral","year":"1995","journal-title":"Am J Pathol"},{"key":"10.1054\/npep.1999.0786_RF26","first-page":"L278","article-title":"Effects of neuropeptides on human lung fibroblast proliferation and chemotaxis","volume":"268","author":"Harrison","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1054\/npep.1999.0786_RF27","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJM199704243361706","article-title":"Sarcoidosis","volume":"336","author":"Newman","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1054\/npep.1999.0786_RF28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1164\/ajrccm.157.4.9707039","article-title":"Idiopathic pulmonary fibrosis. Clinical relevance and pathologic classification","volume":"157","author":"Katzenstein","year":"1998","journal-title":"Am J Respi Crit Care Med"},{"key":"10.1054\/npep.1999.0786_RF29","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1164\/ajrccm.157.5.9704116","article-title":"Up-regulation of PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats","volume":"157","author":"Lasky","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1054\/npep.1999.0786_RF30","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1183\/09031936.94.07091678","article-title":"Pulmonar macrophages","volume":"7","author":"Lohmann-Matthes","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1054\/npep.1999.0786_RF31","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1183\/09031936.96.09050984","article-title":"Characterization and quantification of alveolar monocyte-like cells in human chronic inflammatory lung disease","volume":"9","author":"Krombach","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1054\/npep.1999.0786_RF32","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/j.1699-0463.1992.tb00891.x","article-title":"Superoxide anion release from blood monocytes and alveolar macrophages in patients with diffuse lung fibrosis","volume":"100","author":"Sherson","year":"1992","journal-title":"APMIS"},{"key":"10.1054\/npep.1999.0786_RF33","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1164\/ajrccm\/136.2.310","article-title":"Receptor-mediated O2\u2013release by alveolar macrophages and peripheral blood monocytes from smokers and non-smokers","volume":"136","author":"Nakashima","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1054\/npep.1999.0786_RF34","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1006\/bbrc.1998.9586","article-title":"Tobacco smoke induces activation of HSF and inhibition of NF kappaB in human monocytes: effects on TNFalpha release","volume":"252","author":"Vayssier","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1054\/npep.1999.0786_RF35","first-page":"H1624","article-title":"Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes","volume":"270","author":"Shen","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1054\/npep.1999.0786_RF36","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1172\/JCI114251","article-title":"Cigarette smoke induces bronchoconstrictor hyperresponsiveness to substance P and inactivates airway neutral endopeptidase in the guinea pig. Possible role of free radicals","volume":"84","author":"Dusser","year":"1989","journal-title":"J Clin Invest"},{"key":"10.1054\/npep.1999.0786_RF37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(92)94810-I","article-title":"Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal extravasation","volume":"224","author":"Morimoto","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF38","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1152\/jappl.1995.78.6.2260","article-title":"Cigarette smoke-induced bronchoconstriction: cholinergic mechanisms, tachykinins and cyclooxygenase products","volume":"78","author":"Hong","year":"1995","journal-title":"J Appl Physiol"},{"key":"10.1054\/npep.1999.0786_RF39","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/jlb.63.5.602","article-title":"Neuropeptide regulation of proinflammatory cytokine responses","volume":"63","author":"Dickerson","year":"1998","journal-title":"J Leuko Biol"},{"key":"10.1054\/npep.1999.0786_RF40","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0165-5728(93)90267-3","article-title":"Substance P gene expression is regulated by interleukin-1 in cultured sympathetic ganglia","volume":"44","author":"Hart","year":"1991","journal-title":"J Neuroimmunol"},{"key":"10.1054\/npep.1999.0786_RF41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/sj.bjp.0701440","article-title":"Cigarette smoke-inhibition of neurogenic bronchoconstriction in guinea-pigs in vivo: involvement of exogenous and endogenous nitric oxide","volume":"122","author":"Emms","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1054\/npep.1999.0786_RF42","doi-asserted-by":"crossref","first-page":"PL177","DOI":"10.1016\/0024-3205(92)90626-Z","article-title":"Evidence for tachykinin NK-2B-like receptors in guinea-pig alveolar macrophages","volume":"51","author":"Brunelleschi","year":"1992","journal-title":"Life Sci"}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417999907862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417999907862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T05:54:40Z","timestamp":1682142880000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417999907862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0143417999907862"],"URL":"https:\/\/doi.org\/10.1054\/npep.1999.0786","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}