{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:05Z","timestamp":1791156485307,"version":"4.1.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropeptides"],"published-print":{"date-parts":[[2000,12]]},"DOI":"10.1054\/npep.2000.0819","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T15:33:28Z","timestamp":1032449608000},"page":"355-359","source":"Crossref","is-referenced-by-count":15,"title":["Protective effect of the tachykinin NK2receptor antagonist nepadutant in acute rectocolitis induced by diluted acetic acid in guinea-pigs"],"prefix":"10.1054","volume":"34","author":[{"given":"C.","family":"Cutrufo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ciucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Conte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Manzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Maggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1054\/npep.2000.0819_RF1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1023\/A:1018880501437","article-title":"Influence of topical application of drugs on dextran sulphate-induced colitis in rats","volume":"42","author":"Bjorck","year":"1997","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1054\/npep.2000.0819_RF2","first-page":"24P","article-title":"Affinity of the NK2antagonist SR 48,968 at NK3tachykinin and \u03bc-opioid receptors","volume":"108","author":"Boyle","year":"1993","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/sj.bjp.0701587","article-title":"MEN 11420 (Nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2receptor antagonist","volume":"123","author":"Catalioto","year":"1998","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF4","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0014-2999(99)00313-1","article-title":"Effect of MEN 11467, a new tachykinin NK1receptor antagonist, in acute rectocolitis induced by acetic acid in guinea-pigs","volume":"374","author":"Cutrufo","year":"1999","journal-title":"European Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0143-4179(96)90004-9","article-title":"Down-regulation of substance P receptors during colitis induced by trinitrobenzene sulfonic acid in rats","volume":"30","author":"Evangelista","year":"1996","journal-title":"Neuropeptides"},{"key":"10.1054\/npep.2000.0819_RF6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000007504","article-title":"Implications of tachykinins and calcitonin gene-related peptide in inflammatory bowel disease","volume":"59","author":"Holzer","year":"1998","journal-title":"Digestion"},{"key":"10.1054\/npep.2000.0819_RF7","first-page":"411","article-title":"The effect of the NK2receptor antagonist, MEN 11420 on proto-oncogene expression following experimental colitis","volume":"25","author":"Kiss","year":"1999","journal-title":"Society Neuroscience Abstracts"},{"key":"10.1054\/npep.2000.0819_RF8","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1476-5381.1995.tb13374.x","article-title":"Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1receptor blockade","volume":"114","author":"Kranenveld","year":"1995","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF9","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1046\/j.1365-201X.1996.457174000.x","article-title":"Tachykinins increase vascular permeability in the gastrointestinal tract of the rat","volume":"156","author":"L\u00f6rdal","year":"1996","journal-title":"Acta Physiologica Scandinavica"},{"key":"10.1054\/npep.2000.0819_RF10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0167-0115(97)00029-3","article-title":"The effects of tachykinins on inflammatory and immune cells","volume":"70","author":"Maggi","year":"1997","journal-title":"Regulatory Peptides"},{"key":"10.1054\/npep.2000.0819_RF11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0024-3205(98)00271-9","article-title":"Comparative effects of nonpetide tachykinin receptor antagonist on experimental gut inflammation in rats and guinea-pigs","volume":"63","author":"Mazelin","year":"1998","journal-title":"Life Sciences"},{"key":"10.1054\/npep.2000.0819_RF12","first-page":"6560","article-title":"Beneficial effects of local or systemic lidocaine in experimental colitis","volume":"226","author":"McCafferty","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1054\/npep.2000.0819_RF13","first-page":"681","article-title":"Visceral pain and referred hyperalgesia in rats with colon inflammation: role of tachykinins","volume":"25","author":"Olivar","year":"1999","journal-title":"Society Neuroscience Abstracts"},{"key":"10.1054\/npep.2000.0819_RF14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4179(98)90015-4","article-title":"The tachykinin NK1receptor. Part II: distribution and pathophysiological roles","volume":"32","author":"Quartara","year":"1998","journal-title":"Neuropeptides"},{"key":"10.1054\/npep.2000.0819_RF15","first-page":"657","article-title":"Calcitonin gene-related peptide mediates the protective effect of sensory nerves in a model of colonic injury","volume":"286","author":"Reinshagen","year":"1998","journal-title":"Journal of Pharmacological and Experimental Therapeutics"},{"key":"10.1054\/npep.2000.0819_RF16","first-page":"36","article-title":"Preprotachykinin mRNA expression in the colonic tissue during experimental colitis in rats","volume":"55(suppl 2)","author":"Renzi","year":"1994","journal-title":"Digestion"},{"key":"10.1054\/npep.2000.0819_RF17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/sj.bjp.0703040","article-title":"Role of tachykinin NK2receptors in normal and altered rectal sensitivity in rats","volume":"129","author":"Toulouse","year":"2000","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF18","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1476-5381.1993.tb12813.x","article-title":"NK2receptors mediate plasma extravasation in guinea-pig lower airways","volume":"108","author":"Tousignant","year":"1993","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0167-0115(97)01064-1","article-title":"Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis","volume":"73","author":"Wallace","year":"1998","journal-title":"Regulatory Peptides"},{"key":"10.1054\/npep.2000.0819_RF20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1476-5381.1994.tb14041.x","article-title":"Nonspecific actions of the non-peptide tachykinin receptor antagonists, CP 96345, RP 67580 and SR 48968 on neurotransmission","volume":"111","author":"Wang","year":"1995","journal-title":"British Journal of Pharmacology"},{"key":"10.1054\/npep.2000.0819_RF21","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/0016-5085(92)91710-L","article-title":"A comparative analysis of two models of colitis in rats","volume":"102","author":"Yamada","year":"1992","journal-title":"Gastroenterology"}],"container-title":["Neuropeptides"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417900908199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0143417900908199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T20:28:39Z","timestamp":1555014519000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0143417900908199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["S0143417900908199"],"URL":"https:\/\/doi.org\/10.1054\/npep.2000.0819","relation":{},"ISSN":["0143-4179"],"issn-type":[{"value":"0143-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}