{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:34:27Z","timestamp":1791214467389,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1054\/plef.2000.0186","type":"journal-article","created":{"date-parts":[[2002,9,19]],"date-time":"2002-09-19T15:33:28Z","timestamp":1032449608000},"page":"21-25","source":"Crossref","is-referenced-by-count":83,"title":["Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?"],"prefix":"10.1054","volume":"63","author":[{"given":"J.G.","family":"Bell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Sargent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.R.","family":"Tocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.R.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1054\/plef.2000.0186_RF1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF02098832","article-title":"The definition and prevalence of autism: A review","volume":"2","author":"Wing","year":"1993","journal-title":"Eur Child Adolescent Psychia"},{"key":"10.1054\/plef.2000.0186_RF2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1192\/bjp.158.3.403","article-title":"Is autism more common now than ten years ago?","volume":"158","author":"Gillberg","year":"1991","journal-title":"Brit J Psychia"},{"key":"10.1054\/plef.2000.0186_RF3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0165-1781(81)90043-3","article-title":"Sex ratios in early childhood autism and related conditions","volume":"5","author":"Wing","year":"1981","journal-title":"Psychiatry Res"},{"key":"10.1054\/plef.2000.0186_RF4","first-page":"1","article-title":"Diagnosis and definition","author":"Rutter","year":"1978"},{"key":"10.1054\/plef.2000.0186_RF5","first-page":"11","article-title":"Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification","volume":"9","author":"Wing","year":"1979","journal-title":"J Autism Childhood Schiz"},{"key":"10.1054\/plef.2000.0186_RF6","series-title":"Diagnostic and Statistical Manual of mental Disorders","year":"1987"},{"key":"10.1054\/plef.2000.0186_RF7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1365-2788.1993.tb00879.x","article-title":"Autism and related behaviours","volume":"37","author":"Gillberg","year":"1993","journal-title":"J Intellect Disabil Res"},{"key":"10.1054\/plef.2000.0186_RF8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1056\/NEJM199707103370206","article-title":"Autism","volume":"337","author":"Rapin","year":"1997","journal-title":"N Eng J Med"},{"key":"10.1054\/plef.2000.0186_RF9","series-title":"Advances in prostaglandin, thromboxane, and leukotriene research","author":"Samuelsson","year":"1991"},{"key":"10.1054\/plef.2000.0186_RF10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0920-9964(94)90084-1","article-title":"A red cell membrane abnormality in a subgroup of schizophrenic patients: evidence for two diseases","volume":"12","author":"Glen","year":"1994","journal-title":"Schizophr Res"},{"key":"10.1054\/plef.2000.0186_RF11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0952-3278(96)90139-8","article-title":"Membrane fatty acids, niacin flushing and clinical parameters","volume":"55","author":"Glen","year":"1996","journal-title":"Prostaglandins Leukotrienes Essent Fatty Acids"},{"key":"10.1054\/plef.2000.0186_RF12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0952-3278(97)90323-9","article-title":"Confirmation of bimodality of arachidonic acid and docosahexaenoic acid in schizophrenia","volume":"57","author":"Glen","year":"1997","journal-title":"Prostaglandins Leukotrienes Essent Fatty Acids"},{"key":"10.1054\/plef.2000.0186_RF13","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1001\/archpsyc.1994.03950080077012","article-title":"Arachidonic acid: a common link in the biology of schizophrenia?","volume":"51","author":"Peet","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"10.1054\/plef.2000.0186_RF14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0952-3278(96)90148-9","article-title":"Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation","volume":"55","author":"Peet","year":"1996","journal-title":"Prostaglandins Leukotrienes Essent Fatty Acids"},{"key":"10.1054\/plef.2000.0186_RF15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0952-3278(96)90154-4","article-title":"Phospholipase A2and the hypofrontality hypothesis of schizophrenia","volume":"55","author":"Gattaz","year":"1996","journal-title":"Prostaglandins Leukotrienes Essent Fatty Acids"},{"key":"10.1054\/plef.2000.0186_RF16","first-page":"495","article-title":"Increased serum phospholipase A2activity in schizophrenia: a replication study","volume":"28","author":"Gattaz","year":"1990","journal-title":"Biol Psychiatry"},{"key":"10.1054\/plef.2000.0186_RF17","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/schbul\/19.1.35","article-title":"31P nuclear magnetic resonance spectroscopy: neurodevelopment and schizophrenia","volume":"19","author":"Pettegrew","year":"1993","journal-title":"Schizophr Bull"},{"key":"10.1054\/plef.2000.0186_RF18","doi-asserted-by":"crossref","first-page":"11016","DOI":"10.1016\/S0021-9258(17)39141-X","article-title":"Arachidonyl-CoA synthetase: separation from non-specific acyl-CoA synthetase and distribution in various cells and tissues","volume":"260","author":"Laposta","year":"1985","journal-title":"J Biol Chem"},{"key":"10.1054\/plef.2000.0186_RF19","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0306-9877(95)90246-5","article-title":"Possible relevance of phospholipid abnormalities and genetic interactions in psychiatric disorders: the relationship between dyslexia and schizophrenia","volume":"45","author":"Horrobin","year":"1995","journal-title":"Med Hypotheses"},{"key":"10.1054\/plef.2000.0186_RF20","first-page":"271","article-title":"A possible role for phospholipases in autism and Asperger's syndrome","author":"Horrobin","year":"1999"},{"key":"10.1054\/plef.2000.0186_RF21","doi-asserted-by":"crossref","first-page":"11597","DOI":"10.1016\/S0021-9258(18)38001-3","article-title":"Disappearance of plasmalogens from membranes of animal cells subjected to photosensitised oxidation","volume":"263","author":"Morand","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1054\/plef.2000.0186_RF22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(96)00134-5","article-title":"Rapid regulation of neurite outgrowth and retraction by phospholipase A2-derived arachidonic acid and its metabolites","volume":"721","author":"Smalheiser","year":"1996","journal-title":"Brain Res"},{"key":"10.1054\/plef.2000.0186_RF23","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/jn\/94.2.138","article-title":"Requirements of the female rat for linoleic and linolenic acids","volume":"94","author":"Pudelkewicz","year":"1968","journal-title":"J Nutr"},{"key":"10.1054\/plef.2000.0186_RF24","doi-asserted-by":"crossref","first-page":"12559","DOI":"10.1073\/pnas.93.22.12559","article-title":"Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons","volume":"93","author":"Vreugdenhil","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/plef.2000.0186_RF25","first-page":"723","article-title":"Sleep-wake regulation by PGD2and E2","volume":"21B","author":"Hayaishi","year":"1991"},{"key":"10.1054\/plef.2000.0186_RF26","doi-asserted-by":"crossref","first-page":"14115","DOI":"10.1073\/pnas.94.25.14115","article-title":"Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide","volume":"94","author":"Thomas","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1054\/plef.2000.0186_RF27","unstructured":"Richardson, A. J. Co-morbidity of neurodevelopmental disorders, 1999"},{"key":"10.1054\/plef.2000.0186_RF28","first-page":"5","article-title":"Dyslexia, attention deficit disorder, dyspraxia: do fatty acid supplements help?","volume":"9","author":"Stordy","year":"1997","journal-title":"Dyslexia Rev"},{"key":"10.1054\/plef.2000.0186_RF29","first-page":"328","article-title":"Role of neuropeptides in autism and their relationships with classical neurotransmitters","volume":"3","author":"Shattock","year":"1990","journal-title":"Brain Dysfunct"},{"key":"10.1054\/plef.2000.0186_RF30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/38508","article-title":"Phospholipase C isozymes selectively couple to specific neurotransmitter receptors","volume":"389","author":"Kim","year":"1997","journal-title":"Nature"}],"container-title":["Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327800901868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0952327800901868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T06:34:16Z","timestamp":1621146856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0952327800901868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":30,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0952327800901868"],"URL":"https:\/\/doi.org\/10.1054\/plef.2000.0186","relation":{},"ISSN":["0952-3278"],"issn-type":[{"value":"0952-3278","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}